View source for Darier's disease

{{Infobox medical condition (new)
| name            = Darier's disease
| synonyms        = '''Darier disease''', '''Darier–White disease''',<ref name="Bolognia"/> '''Dyskeratosis follicularis''',<ref name="Bolognia">{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis, MO |year=2007 |isbn=978-1-4160-2999-1 }}</ref> and '''Keratosis follicularis'''<ref name="Fitz2">Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine'' (6th ed.). McGraw-Hill. {{ISBN|0-07-138076-0}}.</ref>{{rp|523}}<ref name="Andrews">James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology'' (10th ed.). Saunders. {{ISBN|0-7216-2921-0}}.</ref>{{rp|567}}
}}
'''Darier's disease''' (DD) is a [[Rare disease|rare]], genetic skin disorder. It is an [[autosome|autosomal]] [[dominance (genetics)|dominant]] disorder, that is, if one parent has DD, there is a 50% chance than a child will inherit DD. It was first reported by French [[Dermatology|dermatologist]] [[Ferdinand-Jean Darier]] in 1889.

Mild forms of the disease are the most common, consisting of skin rashes that flare up under conditions such as high humidity, high stress, or tight-fitting clothes. Short stature, combined with poorly-formed fingernails that contain vertical striations, is diagnostic even for mild forms. Symptoms usually appear in late childhood or early adulthood between the ages of about 15 and 30 years and will vary over the lifespan in an intermittent pattern of relapse (flareups) and remit.
 
More severe cases are characterized by dark crusty patches on the skin that are mildly greasy and that can emit a strong odor. These patches, also known as keratotic [[papule]]s, keratosis follicularis, or dyskeratosis follicularis, most often appear on the arms, chest, back and legs.<ref name="sehgal">{{cite journal |author=Sehgal, V. N. |author2=Srivastava, G. |title= Darier's (Darier-White) disease/keratosis follicularis |journal= International Journal of Dermatology |volume=44| pages=184–192 |year=2005 |doi=10.1111/j.1365-4632.2004.02408.x |pmid=15807723 |issue=3 |s2cid=45303870 }}</ref>

DD was initially studied by dermatologists. Recent research however shows DD has a whole-body effect, including cognitive (learning and intellectual) deficits, and mental health issues, particularly depression.

==Diagnosis and symptoms==
[[File:Darier disease rash.jpg|thumb|<ref name=":2" /> Rash associated with Darier's disease]]
[[File:Darier disease nails.jpg|thumb|Malformed, weak nails with V-shaped chips, a common sign of Darier's disease<ref name=":2" />]]

Diagnosis of Darier disease is often made by the appearance of the skin and nails, family history, and/or [[genetic testing]] for the mutation in the ATP2A2 gene. However, many individuals are never diagnosed because of the mildness of their symptoms. Mild cases present clinically as minor rashes (without odor) that can become exacerbated by heat, humidity, stress, and sunlight.

Clinical symptoms  of the disease:{{citation needed|date=September 2021}}
* Fragile or poorly formed fingernails with vertical striations (as distinct from nail biting). The malformed nails often have V-shaped nicks at the edge of the nail.
* Rash that covers many areas of the body, sometimes with weeping. In severe cases, it is often associated with an unpleasant odor. The rash can be aggravated by heat, humidity, and exposure to sunlight.
* [[Seborrhoeic dermatitis|Seborrhoeic areas]]. Areas where excess oil and sebum is released. Overall greasy or scaly skin either in the central chest and back or in the folds of the skin.
* Painful skin and itching ([[Itch|pruritus]]).

Other less common or less noticed symptoms are:<ref>{{Cite web|title=Darier disease {{!}} Genetic and Rare Diseases Information Center (GARD) – an NCATS Program|url=https://rarediseases.info.nih.gov/diseases/6243/darier-disease|website=rarediseases.info.nih.gov|access-date=2020-05-08}}</ref>

* [[Acrokeratosis verruciformis]]. Acrokeratosis (AKV) is characterized by several small wart-like and flat-topped bumps that line the skin on typically the hand and feet.<ref>{{Cite book| title = Acrokeratosis Verruciformis of Hopf (StatPearls Internet) | url = https://www.ncbi.nlm.nih.gov/books/NBK537250/ | date = May 1, 2023 | last1 = Williams | first1 = GM | last2 = Lincoln | first2 = M | chapter = Acrokeratosis Verruciformis of Hopf | publisher = StatPearls | pmid = 30725935 }}</ref>
* Hypermelanotic macule. Dark patches on the skin that contain excess pigment.
* Subungual hyperkeratotic fragments. Thickened skin that is often discolored, under nails, on either hands or feet.

== Epidemiology and mental health ==
Worldwide prevalence of DD is estimated as between 1:30,000 and 1:100,000.  Case studies have shown estimated prevalence by country to be 3.8:100,000 in Slovenia,<ref name="pmid16001099">{{cite journal|vauthors=Godic A, Miljkovic J, Kansky A, Vidmar G|date=June 2005|title=Epidemiology of Darier's Disease in Slovenia|journal=Acta Dermatovenerol Alp Pannonica Adriat|volume=14|issue=2|pages=43–8|pmid=16001099}}</ref> 1:36,000 in north-east England,<ref name="pmid1390140">{{cite journal|vauthors=Munro CS|date=August 1992|title=The phenotype of Darier's disease: penetrance and expressivity in adults and children|journal=Br. J. Dermatol.|volume=127|issue=2|pages=126–30|doi=10.1111/j.1365-2133.1992.tb08044.x|pmid=1390140|s2cid=2911858}}</ref> 1:30,000 in Scotland,<ref name="pmid11841374">{{cite journal|vauthors=Tavadia S, Mortimer E, Munro CS|date=January 2002|title=Genetic epidemiology of Darier's disease: a population study in the west of Scotland|journal=Br. J. Dermatol.|volume=146|issue=1|pages=107–9|doi=10.1046/j.1365-2133.2002.04559.x|pmid=11841374|s2cid=42621572}}</ref> and 1:100,000 in Denmark.<ref name="pmid1619075">{{cite journal|vauthors=Burge SM, Wilkinson JD|date=July 1992|title=Darier-White disease: a review of the clinical features in 163 patients|journal=J. Am. Acad. Dermatol.|volume=27|issue=1|pages=40–50|doi=10.1016/0190-9622(92)70154-8|pmid=1619075}}</ref>

DD is seen in males and females equally. Symptoms typically arise between the ages of about 15 and 30, and vary over the lifetime in a relapse and remit pattern, in particular flareups that need to be managed. DD is inherited (genetic), and in particular can be traced in family groups in specific geographic localities.

Darier's disease is a non-communicable disorder, but secondary infections by bacteria and viruses can be spread to others.

DD was initially identified and studied by dermatologists (skin specialists) as a purely skin disease. Recent research however suggests DD has a whole-body effect, including cognitive and mental health issues.<ref name="gordonsmith2010"/>

A study of 100 British individuals diagnosed with Darier's disease reported that affected individuals display elevated frequencies of neuropsychiatric conditions. They had high lifetime rates for mood disorders (50%), including depression (30%), bipolar disorder (4%), suicidal thoughts (31%), and suicide attempts (13%).<ref name="gordonsmith2010">{{cite journal |vauthors=Gordon-Smith K, Jones LA, Burge SM, Munro CS, Tavadia S, Craddock N |date=September 2010 |title=The neuropsychiatric phenotype in Darier disease |journal=Br. J. Dermatol. |volume=163 |issue=3 |pages=515–22|doi=10.1111/j.1365-2133.2010.09834.x |pmid=20456342|s2cid=22856369 }}</ref>

A Swedish study of 770 individuals with DD showed a six-fold risk of being diagnosed with an intellectual disability, compared to matched Swedish population controls.<ref>{{cite journal |vauthors=Cederlof M, Karlsson R, et al. |date=July 2015 |title=Intellectual disability and cognitive ability in Darier disease: Swedish nation-wide study |journal=Br. J. Dermatol. |volume=173 |issue=1 |pages=155–8|doi=10.1111/bjd.13740|pmid=25704118}}</ref>

A study of 76 DD patients found that 41% reported learning difficulties, notably reading difficulties, and 74% reported a family history of learning disabilities.<ref name="dodiuk">{{cite journal |vauthors = Dodiuk-Gad M, Lerner Z, et al. |date=2014 |title = Learning disabilities in Darier's disease patients |journal = J. Eur. Acad. Dermat. Vener. |volume = 28|issue=3 |pages = 314–319|doi=10.1111/jdv.12103 |pmid=23410204 }}</ref> The full range of learning difficulties is not known.

== Etiology and genetics ==
Skin changes in Darier's disease are related to a type of nutritional vitamin A deficiency that is caused by genetic mutations. The skin displays follicular dyskeratosis (degeneration of the skin in hair follicules), which reflects as hypovitaminosis A (systemic Vitamin A deficiency).<ref name = vitamina>{{Citation | last = Gunther | first = S. | title = Vitamin A acid in Darier's disease. | journal =  Acta Derm Venereol Suppl (Stockh) | date = 1975 | volume = 74 | pages = 146–151 | PMID = 1062882}}</ref> The skin reactions are caused by an abnormality in the [[Intermediate filament|desmosome-keratin]] filament complex leading to a breakdown in cell adhesion.<ref name=":1" /><ref name=":2">{{Cite web|title=Darier disease NZ|url=https://dermnetnz.org/topics/darier-disease/ |publisher=DermNet |access-date=2020-05-07}}</ref>

[[Mutation]]s in a single [[gene]], [[ATP2A2]], are the ultimate cause for the development of Darier's disease. It is an [[autosome|autosomal]] [[dominance (genetics)|dominant]] disorder, that is, if one parent has DD, there is a 50% chance than a child will inherit DD.{{efn | name = explaingenetic | The gene ATP2A2 encodes the SERCA2 protein, which is a [[calcium pump]] localized to the membranes of the [[Endoplasmic reticulum|endoplasmic reticulum (ER)]] in nearly all cells and the [[Sarcoplasmic reticulum|sarcoplasmic reticulum (SR)]] in muscle cells. The ER is where protein processing and transport begins for proteins targeted for secretion. The SR is a specialized form of ER found in [[Myocyte|muscle cells]] that sequesters [[calcium]], the regulated efflux of which into the cytosol stimulates muscle fiber contraction. Calcium acts as a second messenger in many cellular signal transduction pathways. [[SERCA]]2 is required for Ca2+ signaling in cells by removing nearly all Ca2+ [[ion]]s from the [[cytoplasm]] and storing them in the ER/SR compartments.<ref>{{Cite journal|last1=Monk| first1=Sarah|last2=Sakuntabhai|first2=Anavaj|last3=Carter|first3=Simon A.|last4=Bryce|first4=Steven D.|last5=Cox|first5=Roger| last6=Harrington| first6=Louise|last7=Levy|first7=Elaine|last8=Ruiz-Perez|first8=Victor L.|last9=Katsantoni| first9=Eleni|last10=Kodvawala|first10=Ahmer| last11=Munro|first11=Colin S.|date=April 1998|title=Refined Genetic Mapping of the Darier Locus to a <1-cM Region of Chromosome 12q24.1, and Construction of a Complete, High-Resolution P1 Artificial Chromosome/Bacterial Artificial Chromosome Contig of the Critical Region|journal=The American Journal of Human Genetics |volume=62| issue=4|pages=890–903| doi=10.1086/301794| issn=0002-9297|pmc=1377034|pmid=9529352}}</ref><ref name=":0">{{Cite journal|last1=Foggia|first1=Lucie|last2=Hovnanian|first2=Alain|date=2004|title=Calcium pump disorders of the skin|journal=American Journal of Medical Genetics Part C: Seminars in Medical Genetics|language=fr|volume=131C|issue=1|pages=20–31|doi=10.1002/ajmg.c.30031|pmid=15468148|s2cid=675895|issn=1552-4876|doi-access=free}}</ref><ref name=":1">{{Cite web|title=Darier disease|url=https://ghr.nlm.nih.gov/condition/darier-disease|last=Reference|first=Genetics Home|website=Genetics Home Reference|language=en|access-date=2020-05-08}}</ref><ref>{{Cite journal|last1=Sakuntabhai|first1=Anavaj|last2=Ruiz-Perez|first2=Victor|last3=Carter|first3=Simon|last4=Jacobsen|first4=Nick|last5=Burge|first5=Susan|last6=Monk|first6=Sarah|last7=Smith|first7=Melanie|last8=Munro|first8=Colin S.|last9=O'Donovan|first9=Michael|last10=Craddock|first10=Nick|last11=Kucherlapati|first11=Raju|date=March 1999|title=Mutations in ATP2A2, encoding a Ca 2+ pump, cause Darier disease|url=https://www.nature.com/articles/ng0399_271|journal=Nature Genetics|language=en|volume=21|issue=3|pages=271–277|doi=10.1038/6784|pmid=10080178|s2cid=38684482|issn=1546-1718}}</ref>

[[Image:Autosomal dominant - en.svg|thumb|right|Darier's disease has an autosomal dominant pattern of [[heredity|inheritance]].]]
The [[mutation]] is inherited in an [[Dominance (genetics)|autosomal dominant]] pattern. This means that only one allele needs to be mutated in order to express the trait. This also means that someone who is born to one parent with DD has a 50% chance of inheriting the mutant allele and having the disease. Loss-of-function mutations typically display recessive inheritance while the gain-of-function or hyperactive function of proteins is characteristic of dominant mutations. The observation that only one mutated allele of the SERCA2 is sufficient to produce clinical symptoms suggests that proper "[[gene dosage]]" is necessary for maintaining Ca2+ homeostasis in cells.<ref name=":0" /> This means that two wild type copies of ATP2A2 are needed for proper cell function, which provides a logical basis for dominant phenotypes arising from loss-of-function [[allele]]s. Most ATP2A2 mutations are [[haploinsufficiency]] mutations, which means that only having only one functional copy of the functional gene results in a reduced level of protein expression that is not sufficient for wild type function for making enough of the coded protein for the cell to function properly. However, there is significant variability in disease severity in how the mutations are expressed even within families that have the same mutation. It is currently unclear in the current research why a reduction in SERCA2 expression/activity causes clinical symptoms restricted to the [[epidermis]]. One hypothesis is that other cell types express additional "back-up" Ca2+ pumps that can compensate for the reduced function or expression of the SERCA2 protein, while skin cells rely exclusively on the SERCA2 gene for calcium sequestration, meaning only they are affected by its reduction in expression.<ref name=":1" />}}

=== Subtypes of Darier's disease ===
[[File:Darier's disease.jpg|thumb|Linear Darier's disease]]

Subtypes of DD have been preliminarily suggested. A large number of mutant alleles of ATP2A2 have been identified in association with Darier's Disease. One study of 19 families and 6 sporadic cases found 24 specific, novel mutations associated with DD symptoms. This study reported a loose, imperfect correlation between the severity of ATP2A2 mutations with the severity of the condition. Significant variability in disease severity between members of the same family carrying the same mutation was also reported by this study, suggesting that genetic modifiers contribute to the [[Phenotype|phenotypic]] [[penetrance]] of certain mutations.<ref>{{Cite journal|last1=Ruiz-Perez|first1=Victor L.|last2=Carter|first2=Simon A.|last3=Healy|first3=Eugene|last4=Todd|first4=Carole|last5=Rees|first5=Jonathan L.|last6=Steijlen|first6=Peter M.|last7=Carmichael|first7=Andrew J.|last8=Lewis|first8=Helen M.|last9=Hohl|first9=D.|last10=Itin|first10=Peter|last11=Vahlquist|first11=Anders|date=1999-09-01|title=ATP2A2 Mutations in Darier's Disease: Variant Cutaneous Phenotypes Are Associated with Missense Mutations, But Neuropsychiatry Features Are Independent of Mutation Class|url=https://academic.oup.com/hmg/article/8/9/1621/814081|journal=Human Molecular Genetics|language=en|volume=8|issue=9|pages=1621–1630|doi=10.1093/hmg/8.9.1621|pmid=10441324|issn=0964-6906|doi-access=free}}</ref>

One subtype is '''linear Darier's disease'''. These cases result from [[Somatic cell|somatic]] mutations to ATP2A2 in epidermal stem cells. Such individuals display phenotypic mosaicism, where the Darier's phenotype only affects the subset of epidermal tissue arising from the mutated progenitor cell.  Somatic mutations are not inherited by the offspring of such individuals.<ref>{{Cite journal |last1=Sakuntabhai|first1=Anavaj|last2=Dhitavat|first2=Jittima|last3=Hovnanian |first3=Alain|last4=Burge|first4=Susan|date=December 2000|title=Mosaicism for ATP2A2 Mutations Causes Segmental Darier's Disease|journal=Journal of Investigative Dermatology|volume=115|issue=6|pages=1144–1147| doi=10.1046/j.1523-1747.2000.00182.x|pmid=11121153|issn=0022-202X|doi-access=free}}</ref>

== Treatment ==
Two recent reviews of the medical literature have evaluated treatment strategies for DD.  Management and treatment of Darier disease depends on the severity of the presented clinical symptoms. Mild symptoms are often treated with moisturising creams, and more severe symptoms with topical and oral retinol or other medications (oral medications having higher strength than topical equivalents), and medical procedures.<ref name="hanna">{{cite journal | vauthors = Hanna N, Lam M, Fleming, P, Lynde CW | title = Therapeutic options for the treatment of Darier's disease: A comprehensive review of the literature | journal = J. Cutan. Med. Surg. | volume = 26 | issue = 3 | pages = 280–290 | date = May–June 2022 | doi = 10.1177/12034754211058405 | pmid = 34841914 | pmc = 9125141 }}</ref><ref name="haber">{{cite journal | vauthors = Haber RM, Dib NG| title = Management of Darier disease: A review of the literature and update| journal = Indian J. Dermatol. Venereol. Leprol. | volume = 87 | issue = 1 | pages = 14–21 | date = Jan–Feb 2021 | doi = 10.25259/IJDVL_963_19 | pmid = 33580925| doi-access = free }}</ref>

In many mild cases, DD can be managed by avoiding excessive perspiration and non-breathable and abrasive clothing (producing contact dermatitis), washing with salty water, and gentle abrasion with a gauze pad. This is supplemented by moisturising lotions and topical sunscreens. Most patients with Darier's disease can live normal healthy lives.

In more severe cases of DD, application of topical and oral medications, particularly retinoids, is prescribed. Hospitalisation may be required for seriously affected individuals who display frequent relapse and remit patterns and severe infections.

Rapid resolution of rash symptoms can be complicated by the increased vulnerability of affected skin surfaces to secondary bacterial or viral infections. Bacterial overgrowth can produce an odour. The main bacteria is epidermal [[Staphylococcus aureus]]. The main viruses are [[Human papillomavirus infection|human papillomavirus]] (HPV) and [[herpes simplex virus]] (HSV). Infections are treated with antibiotics (for bacteria) and antiviral medications (for viruses).{{citation needed|date=July 2024}}

Treatments that have evidence-based support (though not for all persons treated) can be classified into a number of groups.<ref name="hanna"/> Because DD is a product of systemic Vitamin A deficiency, [[retinoids]], chemical compounds (molecules) that are forms of (or related to) [[Vitamin A]], are often recommended. Vitamin A acid compounds are often preferred as being less toxic than Vitamin A itself.<ref name = vitamina/>

1. '''Topical medications''': Retinoids ([[Adapalene]], [[Tretinoin]], Isotretinoin, [[Tazarotene|Tazarotene gel]]). Topical retinoids help in the reduction of hyperkeratosis. They work by causing the skin cells in the top layers to die and be shed off.
* Vitamin A analogs (Calciptriol, Tacalitol).

2. '''Other topical medications'''. 
* 5-fluouracil, a chemotherapeutic agent.
* Benzoyal peroxide 5% gel. Antibacterial effect and removes dead skin, but frequent use can cause skin irritation and other side effects, as well as bleaching of hair and clothes.{{citation needed|date=July 2024}}
* Topical [[corticosteroids]].{{citation needed|date=July 2024}}

3. '''Oral medications''': Retinoids (Acitretin, Isotretinoin). If symptoms are severe, oral retinoids have been proven to be very effective. However, there can be many adverse (and sometimes serious) side-effects associated with prolonged use.<ref name="hanna"/>
* Systemic Vitamin A analogs.

4. '''Medical Procedures''': Surgical excision and dermabrasion, laser procedures, radiation procedures (grenz-ray, X-ray, radiology).
* Dermabrasion. Removal of the top layer of skin to help smooth and stimulate new growth of the skin.<ref>{{Cite web|title=Dermabrasion: MedlinePlus Medical Encyclopedia|url=https://medlineplus.gov/ency/article/002987.htm|website=medlineplus.gov|language=en|access-date=2020-05-08}}</ref>
* [[Electrosurgery]]. Used to help stop bleeding and remove abnormal skin growths.

== Support groups ==
Further information on and advocacy work for Darier's disease are provided by support groups.
*  FIRST Skin Foundation (Foundation for Ichthyosis and Related Skin Disorders, Colmar, Pennsylvania).<ref>{{Citation | title = FIRST Skin Foundation | url = http://www.firstskinfoundation.org}}</ref> Ichthyosis refers to a group of skin disorders characterised by dry, scaly or thickened skin (mostly inherited, including DD).

== History ==
Darier's disease was first described by the French dermatologist [[Ferdinand-Jean Darier]] in the journal ''Annales de dermatologie et de syphilographie''.<ref name=Crissey2013>{{cite book |last1=Crissey |first1=John Thorne |last2=Parish |first2=Lawrence C. |last3=Holubar |first3=Karl |title=Historical Atlas of Dermatology and Dermatologists |date=2013 |publisher=CRC Press |isbn=978-1-84184-864-8 |page=75|chapter-url=https://books.google.com/books?id=7ThZDwAAQBAJ&pg=PA75|chapter=Late nineteenth century French dermatology|language=en}}</ref> Darier was a well-regarded dermatologist of the time who was the head of the medical department at the Hôpital Saint-Louis. Darier was an early proponent of histopathology, or the examination of samples of diseased flesh under a microscope to determine the cause of illnesses. Using this technique, he was able to uncover the origins of Darier's disease and a host of others that also bear his name.<ref>{{Cite web|title=Ferdinand-Jean Darier • LITFL|url=https://litfl.com/ferdinand-jean-darier/|last=Cadogan|first=Dr Mike|date=2019-03-01|website=Life in the Fast Lane • LITFL • Medical Blog|language=en-US|access-date=2020-05-08}}</ref>

[[James Clarke White (dermatologist)|James Clarke White]], a dermatologist at Harvard Medical School, independently characterized and published his observations on this dermatological disorder in the same year as Darier (1889), which is why DD is sometimes referred to as Darier-White disease.<ref>{{Cite journal |date=2020-10-01 |title=Keratosis Follicularis (Darier Disease): Background, Pathophysiology, Epidemiology |url=https://emedicine.medscape.com/article/1107340-overview |website=[[Medscape]]}}</ref>

=== Court case ===
In Singapore, a man escaped the death penalty for murder as a result of Darier's disease. [[Ong Teng Siew]], a Malaysian chicken slaughterer aged 27, was charged with murdering an 82-year-old opium addict Ng Gee Seh in December 1995.<ref>{{cite news |title=Was he murdered? |url=https://eresources.nlb.gov.sg/newspapers/digitised/article/newpaper19951229-1.2.11.1 |newspaper=The New Paper |date=29 December 1995 }}</ref><ref>{{cite news |title=Chicken slaughterer charged with murder|url=https://eresources.nlb.gov.sg/newspapers/digitised/article/straitstimes19960104-1.2.39.9 |newspaper=The Straits Times |date= 4 January 1996 }}</ref> Ong was [[Capital punishment in Singapore|sentenced to death]] in August 1996 after the trial court found him guilty of murder,<ref>{{cite news |title=Man gets death for murdering opium addict, 82|url=https://eresources.nlb.gov.sg/newspapers/digitised/article/straitstimes19960813-1.2.29.15 |newspaper=The Straits Times |date= 13 August 1996 }}</ref> and while he was appealing against his conviction, Ong was hospitalized in September 1996 for an outbreak of Darier's disease, which had previously went undiagnosed. After his lawyer discovered that the disease had a causal link to psychiatric disorders, this new evidence enabled Ong to successfully apply for a re-trial.<ref>{{cite news |title=Did man's skin disease lead him to kill addict?|url=https://eresources.nlb.gov.sg/newspapers/digitised/article/straitstimes19980224-1.2.41.6 |newspaper=The Straits Times |date=24 February 1998 }}</ref> The court accepted the new evidence and that Ong was suffering from diminished responsibility as a result of Darier's disease, and therefore he was found guilty of a lesser offence of manslaughter and was re-sentenced to [[Life imprisonment in Singapore|life imprisonment]].<ref>{{cite news |title=Skin disease may save man's life|url=https://eresources.nlb.gov.sg/newspapers/digitised/article/straitstimes19980418-1.2.4 |newspaper=The Straits Times |date= 18 April 1998 }}</ref><ref>{{cite news |title=Skin disease saves man's neck|url=https://eresources.nlb.gov.sg/newspapers/digitised/article/straitstimes19980528-1.2.42.12 |newspaper=The Straits Times |date= 28 May 1998 }}</ref>

== See also ==
* [[Linear Darier disease]]
* [[List of cutaneous conditions]]
* [[Darier's sign]]
*[[Familial disseminated comedones without dyskeratosis]]

== Notes ==
{{Notelist}}

=== References ===
{{Reflist}}

=== Sources ===
* {{Cite journal |last1=Cardoso |first1=Camila Lopes |last2=Freitas |first2=Patrícia |last3=Taveira |first3=Luís Antônio de Assis |last4=Consolaro |first4=Alberto |date=2006 |title=Darier disease: case report with oral manifestations |url=https://scielo.isciii.es/pdf/medicorpa/v11n5/04.pdf |journal=Medicina Oral Patologia Oral y Cirugia Bucal |volume=11 |issue=E404-6 |pages=E404-6 |pmid=16878056 |eissn=1698-6946}}

{{Medical resources
|  DiseasesDB      = 3467
|  ICD10           = {{ICD10|Q|82|8|q|80}} ([[ILDS]] Q82.868)
|  ICD9            = {{ICD9|757.39}}
|  ICDO            =
|  OMIM            = 124200
|  MedlinePlus     =
|  eMedicineSubj   = derm
|  eMedicineTopic  = 209
|  MeshID          = D007644
|Orphanet=218|ICD11={{ICD11|EC20.2}}|GARDNum=6243|GARDName=darier-disease}}
{{Diseases of the skin and appendages by morphology}}
{{Congenital malformations and deformations of integument}}
{{Ion pump disorders}}
{{oral pathology}}
{{Authority control}}

[[Category:Autosomal dominant disorders]]
[[Category:Conditions of the skin appendages]]
[[Category:Genodermatoses]]
[[Category:Oral mucosal pathology]]
[[Category:Papulosquamous hyperkeratotic cutaneous conditions]]
[[Category:Rare diseases]]
[[Category:Diseases named after discoverers]]