Erinacine: Difference between revisions
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Main erinacines list updated by adding S and U members of the family. |
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[[Image:Erinacine A-I.gif|thumb|Chemical structures of erinacines A-I]] |
[[Image:Erinacine A-I.gif|thumb|Chemical structures of erinacines A-I]] |
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'''Erinacines''' are natural substances isolated from ''[[Hericium erinaceus]]''. They belong to the group of [[cyathin]] [[diterpenoid]]s (erinacines A-K, P, |
'''Erinacines''' are natural substances isolated from ''[[Hericium erinaceus]]''. They belong to the group of [[cyathin]] [[diterpenoid]]s (erinacines A-K, P, Q, S, U) and are subjects of pharmacological research. |
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==Erinacine A== |
==Erinacine A== |
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Erinacine A, isolated from the cultured mycelia of ''[[Hericium erinaceus]]'', the main representative of this compounds group, has an enhancing effect on [[nerve growth factor]] synthesis ''[[in vitro]]''.<ref>{{Cite journal | journal = Tetrahedron Letters |volume =35 | issue = 10 | date = 1994 | pages= 1569–1572 | title = Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum | author = Hirokazu Kawagishi | author2 = Atsushi Shimada | author3 = Ryoko Shirai | author4 = Kenji Okamoto | author5 = Fumihiro Ojima | author6 = Hideki Sakamoto | author7 = Yukio Ishiguro | author8 = Shoei Furukawa | doi= 10.1016/S0040-4039(00)76760-8}}</ref> It also increases ''[[catecholamine]]'' in the central nervous system of rats.{{citation needed|date=May 2016}} |
Erinacine A, isolated from the cultured mycelia of ''[[Hericium erinaceus]]'', the main representative of this compounds group, has an enhancing effect on [[nerve growth factor]] synthesis ''[[in vitro]]''.<ref>{{Cite journal | journal = Tetrahedron Letters |volume =35 | issue = 10 | date = 1994 | pages= 1569–1572 | title = Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum | author = Hirokazu Kawagishi | author2 = Atsushi Shimada | author3 = Ryoko Shirai | author4 = Kenji Okamoto | author5 = Fumihiro Ojima | author6 = Hideki Sakamoto | author7 = Yukio Ishiguro | author8 = Shoei Furukawa | doi= 10.1016/S0040-4039(00)76760-8}}</ref> It also increases ''[[catecholamine]]'' in the central nervous system of rats.{{citation needed|date=May 2016}} |
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Erinacine A has also been prepared by [[total synthesis]].<ref>{{cite journal | title = Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A | author = Barry B. Snider | author2 = Nha Huu Vo | author3 = Steven V. O'Neil | author4 = Bruce M. Foxman | name-list-style = amp | journal = J. Am. Chem. Soc. | date = 1996 | volume = 118 | issue = 32 | pages = 7644–7645 | doi = 10.1021/ja9615379}}</ref> |
Erinacine A has also been prepared by [[total synthesis]].<ref>{{cite journal | title = Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A | author = Barry B. Snider | author2 = Nha Huu Vo | author3 = Steven V. O'Neil | author4 = Bruce M. Foxman | name-list-style = amp | journal = J. Am. Chem. Soc. | date = 1996 | volume = 118 | issue = 32 | pages = 7644–7645 | doi = 10.1021/ja9615379}}</ref> |
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Latest revision as of 11:09, 16 August 2024
Erinacines are natural substances isolated from Hericium erinaceus. They belong to the group of cyathin diterpenoids (erinacines A-K, P, Q, S, U) and are subjects of pharmacological research.
Erinacine A
[edit]Erinacine A, isolated from the cultured mycelia of Hericium erinaceus, the main representative of this compounds group, has an enhancing effect on nerve growth factor synthesis in vitro.[1] It also increases catecholamine in the central nervous system of rats.[citation needed]
Erinacine A has also been prepared by total synthesis.[2]
Erinacine E
[edit]Erinacine E is a kappa opioid receptor agonist.[3]
References
[edit]- ^ Hirokazu Kawagishi; Atsushi Shimada; Ryoko Shirai; Kenji Okamoto; Fumihiro Ojima; Hideki Sakamoto; Yukio Ishiguro; Shoei Furukawa (1994). "Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum". Tetrahedron Letters. 35 (10): 1569–1572. doi:10.1016/S0040-4039(00)76760-8.
- ^ Barry B. Snider; Nha Huu Vo; Steven V. O'Neil & Bruce M. Foxman (1996). "Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A". J. Am. Chem. Soc. 118 (32): 7644–7645. doi:10.1021/ja9615379.
- ^ Saito T, Aoki F, Hirai H, et al. (November 1998). "Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum". The Journal of Antibiotics. 51 (11): 983–90. doi:10.7164/antibiotics.51.983. PMID 9918390.
Further reading
[edit]- Kenmoku H, Shimai T, Toyomasu T, Kato N, Sassa T (March 2002). "Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete". Bioscience, Biotechnology, and Biochemistry. 66 (3): 571–5. doi:10.1271/bbb.66.571. PMID 12005051. S2CID 46327735.