Manogepix

Manogepix
Clinical data
Other names	E1210, APX001A
ATC code	None;
Identifiers
	IUPAC name 3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine;
CAS Number	936339-60-5;
PubChem CID	16719049;
ChemSpider	17623449;
UNII	7B1P18ID9L;
ChEMBL	ChEMBL4533578;
CompTox Dashboard (EPA)	DTXSID601045473 ;
Chemical and physical data
Formula	C12H18N4O2
Molar mass	250.302 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1ccnc(c1)OCc2ccc(cc2)Cc3cc(on3)c4cccnc4N;
	InChI InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24); Key:WSEKTEUGRLFBSE-UHFFFAOYSA-N;

Manogepix (E1210) is an pyridine-isoxazole-based broad-spectrum antifungal.^[1] Manogepix targets an enzyme involved in the post-translational modification of fungal proteins.

References

^ Pfaller MA, Hata K, Jones RN, Messer SA, Moet GJ, Castanheira M (October 2011). "In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method". Diagnostic Microbiology and Infectious Disease. 71 (2): 167–170. doi:10.1016/j.diagmicrobio.2011.05.001. PMID 21696907.
^ Badali H, Patterson HP, Sanders CJ, Mermella B, Gibas CF, Ibrahim AS, et al. (May 2021). "Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes". Antimicrobial Agents and Chemotherapy. 65 (6). doi:10.1128/AAC.02343-20. PMC 8315997. PMID 33722886.

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