Draft:Acceptor splice region

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Last edited by HC226 (talk | contribs) 2 months ago. (Update)

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An acceptor splice region or acceptor splice site, also known as 3' splice site, is the downstream part of an intron, found at its 3' end.^[1]^[2] The spliced site usually conserves the consensus dinucleotide AG.^[2] This region, along with the donor site (5' end of the intron)^[3] and branch site (near the 3' end of the intron), is essential for the accurate RNA splicing, to allow accurate removal of its corresponding intron from the RNA transcript. An acceptor splice region spans, on average, 28 bases.^[3]^[1]

Mechanism of action

Types

There are several types of acceptor splice regions, classified by their nucleotide sequence and other factors.

Canonical acceptor splice sites

This type of site is the most common, being present in

Mutations

References

^ ^a ^b "RNA Splicing | Learn Science at Scitable". www.nature.com. Retrieved 2024-09-11.
^ ^a ^b Baten, AKMA; Chang, BCH; Halgamuge, SK; Li, Jason (2006-12-18). "Splice site identification using probabilistic parameters and SVM classification". BMC Bioinformatics. 7 (5): S15. doi:10.1186/1471-2105-7-S5-S15. ISSN 1471-2105. PMC 1764471. PMID 17254299.
^ ^a ^b Caminsky, Natasha; Mucaki, Eliseos J.; Rogan, Peter K. (2014-11-18). "Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis". F1000Research. 3: 282. doi:10.12688/f1000research.5654.1. ISSN 2046-1402. PMC 4329672. PMID 25717368.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[:1-1] "RNA Splicing | Learn Science at Scitable". www.nature.com. Retrieved 2024-09-11.

[:0-2] Baten, AKMA; Chang, BCH; Halgamuge, SK; Li, Jason (2006-12-18). "Splice site identification using probabilistic parameters and SVM classification". BMC Bioinformatics. 7 (5): S15. doi:10.1186/1471-2105-7-S5-S15. ISSN 1471-2105. PMC 1764471. PMID 17254299.

[:2-3] Caminsky, Natasha; Mucaki, Eliseos J.; Rogan, Peter K. (2014-11-18). "Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis". F1000Research. 3: 282. doi:10.12688/f1000research.5654.1. ISSN 2046-1402. PMC 4329672. PMID 25717368.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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