Methionine-S-oxide reductase
| Methionine-S-oxide reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.8.4.5 | ||||||||
| CAS no. | 70248-65-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Methionine-S-oxide reductase (EC 1.8.4.5, methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionine:oxidized-thioredoxin S-oxidoreductase) is an enzyme with systematic name L-methionine:thioredoxin-disulfide S-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- L-methionine + thioredoxin disulfide + H2O L-methionine S-oxide + thioredoxin
In the reverse reaction, dithiothreitol can replace reduced thioredoxin.
S-Methionine-S-oxide and R-Methionine-S-oxide require different Methionine-S-oxide reductases, named Methionine-S-oxide reductase A and Methionine-S-oxide reductase B respectively.[4] A Methionine-S-oxide reductase B named AtMSRB plays a large role in salt tolerance in Arabidopsis Thaliana.[5]
References
[edit]- ^ Black, S.; Harte, E.M.; Hudson, B.; Wartofsky, L. (1960). "A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides". J. Biol. Chem. 235 (10): 2910–2916. doi:10.1016/S0021-9258(18)64561-2.
- ^ Ejiri SI, Weissbach H, Brot N (July 1979). "Reduction of methionine sulfoxide to methionine by Escherichia coli". Journal of Bacteriology. 139 (1): 161–4. doi:10.1128/jb.139.1.161-164.1979. PMC 216841. PMID 37234.
- ^ Ejiri SI, Weissbach H, Brot N (March 1980). "The purification of methionine sulfoxide reductase from Escherichia coli". Analytical Biochemistry. 102 (2): 393–8. doi:10.1016/0003-2697(80)90173-6. PMID 6999943.
- ^ Boschi-Muller, Sandrine; Olry, Alexandre; Antoine, Mathias; Branlant, Guy (2005-01-17). "The enzymology and biochemistry of methionine sulfoxide reductases". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. Methionine Oxidation and Methionine Sulfoxide Reductases. 1703 (2): 231–238. doi:10.1016/j.bbapap.2004.09.016. ISSN 1570-9639. PMID 15680231.
- ^ Cai, Yu-Si; Cai, Jung-Long; Lee, Jent-Turn; Li, Yi-Min; Balladona, Freta Kirana; Sukma, Dewi; Chan, Ming-Tsair (2023-03-22). "Arabidopsis AtMSRB5 functions as a salt-stress protector for both Arabidopsis and rice". Frontiers in Plant Science. 14. doi:10.3389/fpls.2023.1072173. ISSN 1664-462X. PMC 10073502. PMID 37035039.
External links
[edit]- Methionine-S-oxide+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
