Ombitasvir

Ombitasvir
Clinical data
Trade names	Viekira Pak, Viekira XR (with ombitasvir, paritaprevir, ritonavir and dasabuvir),; Technivie (with ombitasvir, paritaprevir, and ritonavir);
Other names	ABT-267
License data	EU EMA: by INN;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	Not determined
Protein binding	~99.9%
Metabolism	Amide hydrolysis followed by oxidation
Onset of action	~4 to 5 hours
Elimination half-life	21 to 25 hours
Excretion	Mostly with feces (90.2%)
Identifiers
	IUPAC name Dimethyl N,N′-{[(2S,5S)-1-(4-tert-butylphenyl)pyrrolidene-2,5-diyl]-bis-{[(4,1-phenyleneazanediyl)carbonyl][(2S)-pyrrolidine-2,1-diyl]}[(2S)-3-methyl-1-oxobutane-1,2-diyl])}biscarbamate;
CAS Number	1258226-87-7;
PubChem CID	54767916;
ChemSpider	31136214;
KEGG	D10576 ;
ChEBI	CHEBI:85183 ;
CompTox Dashboard (EPA)	DTXSID201027920 ;
Chemical and physical data
Formula	C50H67N7O8
Molar mass	894.11 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)Nc2ccc(cc2)[C@@H]3CC[C@H](N3c4ccc(cc4)C(C)(C)C)c5ccc(cc5)NC(=O)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC;
	InChI InChI=1S/C50H67N7O8/c1-30(2)42(53-48(62)64-8)46(60)55-28-10-12-40(55)44(58)51-35-20-14-32(15-21-35)38-26-27-39(57(38)37-24-18-34(19-25-37)50(5,6)7)33-16-22-36(23-17-33)52-45(59)41-13-11-29-56(41)47(61)43(31(3)4)54-49(63)65-9/h14-25,30-31,38-43H,10-13,26-29H2,1-9H3,(H,51,58)(H,52,59)(H,53,62)(H,54,63)/t38-,39-,40-,41-,42-,43-/m0/s1; Key:PIDFDZJZLOTZTM-KHVQSSSXSA-N;

Ombitasvir is an antiviral drug for the treatment of hepatitis C virus (HCV) infection by AbbVie. In the United States, it is approved by the Food and Drug Administration for use in combination with paritaprevir, ritonavir and dasabuvir in the product Viekira Pak for the treatment of HCV genotype 1,^[1]^[2] and with paritaprevir and ritonavir in the product Technivie for the treatment of HCV genotype 4.^[3]^[4]

Ombitasvir is an NS5A inhibitor that acts by inhibiting the HCV protein NS5A.^[5]

References

^ "VIEKIRA PAK™ (ombitasvir, paritaprevir and ritonavir tablets; dasabuvir tablets), for Oral Use. Full Prescribing Information" (PDF). AbbVie Inc., North Chicago, IL 60064. Retrieved 30 July 2015.
^ "FDA approves Viekira Pak to treat hepatitis C". Food and Drug Administration. December 19, 2014.
^ "TECHNIVIE™ (ombitasvir, paritaprevir and ritonavir) Tablets, for Oral Use. Full Prescribing Information" (PDF). AbbVie Inc., North Chicago, IL 60064. Retrieved 28 July 2015.
^ "FDA approves Technivie for treatment of chronic hepatitis C genotype 4". Food and Drug Administration. July 24, 2015.
^ Jordan J. Feld; Kris V. Kowdley; Eoin Coakley; Samuel Sigal; David R. Nelson; Darrell Crawford; Ola Weiland; Humberto Aguilar; Junyuan Xiong; Tami Pilot-Matias; Barbara DaSilva-Tillmann; Lois Larsen; Thomas Podsadecki; Barry Bernstein (2014). "Treatment of HCV with ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin" (PDF). N Engl J Med. 370 (17): 1594–1603. doi:10.1056/NEJMoa1315722. PMID 24720703. {{cite journal}}: Unknown parameter |last-author-amp= ignored (|name-list-style= suggested) (help)

Grebely, J.; Puoti, M.; Wedemeyer, H.; Cooper, C.; Sulkowski, M. S.; Foster, G. R.; Berg, T.; Villa, E.; Rodriguez-Perez, F.; Wyles, D. L.; Schnell, G.; Alami, N. N.; Zhang, Z.; Dumas, E.; Dore, G. J. (October 2018). Safety and efficacy of ombitasvir/paritaprevir/ritonavir/dasabuvir plus ribavirin in patients over 65 years with HCV genotype 1 cirrhosis. Vol. 46. pp. 607–615. doi:10.1007/s15010-018-1157-x. OCLC 1105037362. PMC 6222025. PMID 30430131. {{cite book}}: |journal= ignored (help)
Petta, Salvatore; Marzioni, Marco; Russo, Pierluigi; Aghemo, Alessio; Alberti, Alfredo; Ascione, Antonio; Antinori, Andrea; Bruno, Raffaele; Bruno, Savino; Chirianni, Antonio; Gaeta, Giovanni Battista; Giannini, Edoardo G.; Merli, Manuela; Messina, Vincenzo; Montilla, Simona; Perno, Carlo Federico; Puoti, Massimo; Raimondo, Giovanni; Rendina, Maria; Silberstein, Francesca Ceccherini; Villa, Erica; Zignego, Anna Linda; Pani, Luca; Craxì, Antonio; Tabone, Marco; Andreoni, Massimo; Teti, Elisabetta; Angelico, Mario; Persico, Marcello; Masarone, Mario (April 10, 2017). Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with cirrhosis (ABACUS): a prospective observational study. Vol. 2. pp. 427–434. doi:10.1016/S2468-1253(17)30048-1. hdl:11390/1119739. OCLC 1105031357. PMID 28404110. Archived from the original on August 21, 2019 – via archive.is. {{cite book}}: |journal= ignored (help); External link in |via= (help); Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)

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[1] "VIEKIRA PAK™ (ombitasvir, paritaprevir and ritonavir tablets; dasabuvir tablets), for Oral Use. Full Prescribing Information" (PDF). AbbVie Inc., North Chicago, IL 60064. Retrieved 30 July 2015.

[2] "FDA approves Viekira Pak to treat hepatitis C". Food and Drug Administration. December 19, 2014.

[3] "TECHNIVIE™ (ombitasvir, paritaprevir and ritonavir) Tablets, for Oral Use. Full Prescribing Information" (PDF). AbbVie Inc., North Chicago, IL 60064. Retrieved 28 July 2015.

[4] "FDA approves Technivie for treatment of chronic hepatitis C genotype 4". Food and Drug Administration. July 24, 2015.

[5] Jordan J. Feld; Kris V. Kowdley; Eoin Coakley; Samuel Sigal; David R. Nelson; Darrell Crawford; Ola Weiland; Humberto Aguilar; Junyuan Xiong; Tami Pilot-Matias; Barbara DaSilva-Tillmann; Lois Larsen; Thomas Podsadecki; Barry Bernstein (2014). "Treatment of HCV with ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin" (PDF). N Engl J Med. 370 (17): 1594–1603. doi:10.1056/NEJMoa1315722. PMID 24720703. {{cite journal}}: Unknown parameter |last-author-amp= ignored (|name-list-style= suggested) (help)

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Ombitasvir

See also

References

Further reading