SSR-180,575

SSR-180,575
Clinical data
ATC code	None;
Identifiers
	IUPAC name 7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide;
CAS Number	220448-02-2 ;
PubChem CID	9930560;
ChemSpider	8106191;
UNII	4K8W47WK2L;
CompTox Dashboard (EPA)	DTXSID10433007 ;
Chemical and physical data
Formula	C21H19ClN4O2
Molar mass	394.86 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cn2c3cc(Cl)ccc3c1c2c(=O)n(nc1CC(=O)N(C)C)-c4ccccc4;
	InChI InChI=1S/C21H19ClN4O2/c1-24(2)18(27)12-16-19-15-10-9-13(22)11-17(15)25(3)20(19)21(28)26(23-16)14-7-5-4-6-8-14/h4-11H,12H2,1-3H3; Key:HJSQVJOROCIILI-UHFFFAOYSA-N;
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SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain, which may be linked to its neuroprotective action.^[1]^[2]^[3]^[4]

References

^ Ferzaz B, Brault E, Bourliaud G, Robert JP, Poughon G, Claustre Y, et al. (June 2002). "SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair". The Journal of Pharmacology and Experimental Therapeutics. 301 (3): 1067–78. doi:10.1124/jpet.301.3.1067. PMID 12023539. S2CID 16732360.
^ Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, et al. (September 2003). "Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion". The Journal of Pharmacology and Experimental Therapeutics. 306 (3): 828–37. doi:10.1124/jpet.103.052068. PMID 12928523. S2CID 1101660.
^ Kunduzova OR, Escourrou G, De La Farge F, Salvayre R, Séguélas MH, Leducq N, et al. (August 2004). "Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion". Journal of the American Society of Nephrology. 15 (8): 2152–60. doi:10.1097/01.ASN.0000133563.41148.74. PMID 15284300.
^ Veenman L, Gavish M (June 2006). "The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development". Pharmacology & Therapeutics. 110 (3): 503–24. doi:10.1016/j.pharmthera.2005.09.007. PMID 16337685.

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[1] Ferzaz B, Brault E, Bourliaud G, Robert JP, Poughon G, Claustre Y, et al. (June 2002). "SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair". The Journal of Pharmacology and Experimental Therapeutics. 301 (3): 1067–78. doi:10.1124/jpet.301.3.1067. PMID 12023539. S2CID 16732360.

[2] Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, et al. (September 2003). "Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion". The Journal of Pharmacology and Experimental Therapeutics. 306 (3): 828–37. doi:10.1124/jpet.103.052068. PMID 12928523. S2CID 1101660.

[3] Kunduzova OR, Escourrou G, De La Farge F, Salvayre R, Séguélas MH, Leducq N, et al. (August 2004). "Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion". Journal of the American Society of Nephrology. 15 (8): 2152–60. doi:10.1097/01.ASN.0000133563.41148.74. PMID 15284300.

[4] Veenman L, Gavish M (June 2006). "The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development". Pharmacology & Therapeutics. 110 (3): 503–24. doi:10.1016/j.pharmthera.2005.09.007. PMID 16337685.

[1]

[2]

[3]

[4]

v t e Translocator protein modulators
Agonists	Alpidem DAA-1097 DAA-1106 DBI 17-50 fragment Deuterated etifoxine Dithranol (anthralin) Diazepam Diazepam binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08
Antagonists	PK-11195

See also

References