Exercise modifications help manage multiple sclerosis

Regular aerobic exercise has been shown to alleviate symptoms of multiple sclerosis (MS), a disease that affects the central nervous system. Dr Eoin Flanagan, a neurologist at Mayo Clinic, explains how individuals with MS can adjust their exercise routines to avoid worsening symptoms such as poor balance and heat intolerance.

Short-term cognitive boost from exercise may lasts till the next day

Autism and exercise
A study led by researchers at UCL (University College London) found that exercise provides a short-term boost in brain function that lasts the next day. Previous research in a laboratory setting has shown that people’s cognitive performance improves in the hours after exercise, but how long this benefit lasts is unknown.

The new study, published in the International Journal of Behavioral Nutrition and Physical Activity, found that, on average, people aged 50 to 83 who did more moderate to vigorous physical activity than usual on a given day did better in memory tests the day after.
Less time spent sitting and six hours or more of sleep were also linked to better memory test scores the next day.
More deep (slow-wave*) sleep also contributed to memory function, and the research team found this accounted for a small portion of the link between exercise and better next-day memory.
The research team analysed data from 76 men and women who wore activity trackers for eight days and took cognitive tests daily.

Lead author Dr Mikaela Bloomberg (UCL Institute of Epidemiology & Health Care) said: “Our findings suggest that the short-term memory benefits of physical activity may last longer than previously thought, possibly to the next day instead of just a few hours after exercise. More sleep, profound sleep, seems to add to this memory improvement.
“Moderate or vigorous activity means anything that gets your heart rate up – this could be brisk walking, dancing or walking up a few flights of stairs. It doesn’t have to be a structured exercise.
“This was a small study, so it needs to be replicated with a larger sample of participants before we can be certain about the results.”
In the short term, exercise increases blood flow to the brain and stimulates the release of neurotransmitters such as norepinephrine and dopamine, which help with a range of cognitive functions.
These neurochemical changes are understood to last up to a few hours after exercise. However, the researchers noted that other brain states linked to exercise were more long-lasting. For instance, evidence suggests exercise can enhance mood for up to 24 hours.
A 2016 study published by a separate research team also found more synchronised activity in the hippocampus (a marker of increased hippocampal function, which facilitates memory function) for 48 hours after high-intensity interval training (HIIT) cycling.  
Co-author Professor Andrew Steptoe (UCL Institute of Epidemiology & Health Care) said: “Among older adults, maintaining cognitive function is essential for good quality of life, wellbeing, and independence. It’s helpful to identify factors that can affect mental health daily.
“This study provides evidence that the immediate cognitive benefits of exercise may last longer than we thought. It also suggests that good sleep quality contributes to mental performance separately.
“However, we can’t establish from this study whether these short-term boosts to cognitive performance contribute to longer-term cognitive health, and though there is plenty of evidence to suggest physical activity might slow cognitive decline and reduce dementia risk, it’s still a matter of some debate.”
For the new study, the researchers looked at data from wrist-worn activity trackers to determine how much time participants spent being sedentary, doing light physical activity, and doing moderate or vigorous physical activity. They also quantified sleep duration and time spent in lighter (rapid eye movement, or REM) sleep and more profound, slow-wave sleep.
In looking at the links between different types of activity and next-day cognitive performance, the research team adjusted for a wide variety of factors that might have distorted the results, including the amount of moderate or vigorous physical activity participants did on the day of the tests.
They also accounted for participants’ average levels of activity and sleep quality across the eight days they were tracked, as participants who are habitually more active and typically have higher-quality sleep perform better in cognitive tests.
The team found that more moderate or vigorous physical activity compared to a person’s average was linked to better working memory and episodic memory (memory of events) the next day. More sleep overall was linked to improved episodic and working memory and psychomotor speed (a measure of how quickly a person detects and responds to the environment). More slow-wave sleep was linked to better episodic memory.
Conversely, more time spent being sedentary than usual was linked to worse working memory the next day.

Small daily bursts of vigorous incidental activity could almost cut cardiovascular risk in middle-aged women.

Tiny, daily bursts of vigorous incidental physical activity could almost halve cardiovascular risk in middle-aged women

Just four minutes of vigorous daily physical activity significantly lowers the risk of heart attacks and heart failure in middle-aged women.

Woman walking upstairs Credit Shutterstock

Research from the University of Sydney reveals that an average of just four minutes of incidental vigorous physical activity each day could nearly reduce the risk of major cardiovascular events, such as heart attacks, by half for middle-aged women who do not participate in structured exercise.

“A study led by Professor Emmanuel Stamatakis, Director of the Mackenzie Wearable Hub at the Charles Perkins Centre and the Faculty of Medicine and Health, found that engaging in at least 1.5 minutes to an average of 4 minutes of vigorous physical activity each day—completed in short bursts of up to 1 minute—was linked to improved cardiovascular health outcomes in middle-aged women who do not participate in structured exercise.”

High-intensity physical activity incorporated into a daily routine is “vigorous intermittent lifestyle physical activity” (VILPA). Longer sessions of VILPA are associated with a significantly lower risk of cardiovascular disease. Researchers suggest that since less than 20 per cent of middle-aged and older adults participate in regular structured exercise, engaging in VILPA could be a beneficial alternative.

“Adopting short bursts of vigorous physical activity as a regular habit could be a beneficial option for women who may not enjoy structured exercise or are unable to engage in it for various reasons. To start, this can be as simple as incorporating a few minutes of activities throughout the day such as climbing stairs, carrying groceries, walking uphill, playing tag with a child or pet, or engaging in power walking,” said Professor Stamatakis.

The study analyzed data from 22,368 participants, consisting of 13,018 women and 9,350 men aged 40 to 79, who reported not engaging in regular structured exercise. This data was collected from the UK Biobank, where participants wore physical activity trackers nearly 24 hours a day for a week, between 2013 and 2015.

Cardiovascular health was monitored through hospital and mortality records, tracking major adverse cardiovascular events (MACE), such as heart attack, stroke, and heart failure, until November 2022. 

After accounting for factors such as lifestyle, socioeconomic status, cardiovascular health, co-existing conditions, and ethnicity, the researchers found that women who engaged in more vigorous intermittent lifestyle physical activity (VILPA) had a lower risk of experiencing major cardiovascular events. Specifically, women who averaged just 3.4 minutes of VILPA daily were 45 percent less likely to encounter a major cardiovascular event. Additionally, they were 51 per cent less likely to suffer a heart attack and 67 per cent less likely to develop heart failure compared to women who did not engage in any VILPA.

Even when daily VILPA levels were lower than 3.4 minutes, they were still linked to lower cardiovascular event risk. A minimum of 1.2 to 1.6 minutes of VILPA per day was associated with a 30 per cent lower risk of total major cardiovascular events, a 33 per cent lower risk of heart attack, and a 40 per cent lower risk of heart failure. 

However, men reaped fewer benefits from tiny bursts of VILPA. Those who averaged 5.6 minutes daily were only 16 per cent less likely to experience a major cardiovascular event compared with men who did none. A minimum of 2.3 minutes per day was associated with only an 11 per cent risk reduction. 

Professor Stamatakis said more testing was needed to understand how VILPA may improve cardiovascular health.  

“To date, it hasn’t been clear whether short bursts of VILPA lower the risk of specific types of cardiovascular events, like heart attack or stroke. We aimed to identify minimum daily thresholds and feasible amounts for testing in community programs and future trials,” he said. 

“Importantly, the beneficial associations we observed were in women who committed to short bursts of VILPA almost daily. This highlights the importance of habit formation, which is not always easy. VILPA should not be seen as a quick fix—there are no magic bullets for health. But our results show that even a little bit higher intensity activity can help and might be just the thing to help people develop a regular physical activity – or even exercise – habit,” he said. 

Live well, think well: Research shows healthy habits tied to brain health

Type 2 diabetes and prediabetes are associated with accelerated brain ageing, according to a new study from Karolinska Institutet in Sweden published in the journal Diabetes Care. The good news is that this may be counteracted by a healthy lifestyle.

In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled, combined with not following certain healthy habits, including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life,. 

The eight cardiovascular and brain health factors, known as the American Heart Association’s Life’s Essential 8, are being active, eating better, maintaining a healthy weight, not smoking, maintaining healthy blood pressure, getting enough sleep, and controlling cholesterol and blood sugar levels.

“Brain health is paramount for the optimal well-being of every person, enabling us to function at our highest level and constantly adapt in the world,” said study author Santiago Clocchiatti-Tuozzo, MD, MHS, of Yale University in New Haven, Connecticut, and member of the American Academy of Neurology. “Our study found that making these healthy lifestyle choices in middle age can have meaningful impacts on brain health later in life.”

For the study, researchers evaluated data from 316,127 people, with an average age of 56, who were followed over five years.

Researchers analyzed participants’ scores across the eight essential cardiovascular health factors and organized them into three categories: optimal, intermediate, and poor.

Of the total group, 64,474 had optimal scores, 190,919 had intermediate scores, and 60,734 had poor scores.

Researchers then evaluated health records to identify who developed any of the following neurological conditions: stroke, dementia or late-life depression. Poor brain health was defined as developing these conditions during the follow-up years.

1.2% of participants met the definition for poor brain health, with 3,753 conditions. Of those with optimal Life’s Essential Eight scores, 0.7% met the definition of poor brain health, compared to 1.2% with intermediate scores and 1.8% with poor scores.

After adjusting for factors that could affect the risk of these three neurological conditions, such as age, sex, race and ethnicity, researchers found that people with poor scores on the healthy lifestyle factors were more than twice as likely to develop any of the three neurological conditions compared to those people with optimal scores. Researchers also found that people with an intermediate score had a 37% higher risk of having one of the three neurological conditions than those with an optimal score.

“Because the risk factors we looked at are all ones that people can work to improve, our findings highlight the potential benefits of using these eight cardiovascular and brain health factors to guide healthy lifestyle choices,” Clocchiatti-Tuozzo said. “More research is needed to understand this link between lifestyle habits and brain health, as well as how social factors like race and ethnicity can influence this connection.”

Simple secret to living a longer life

Life expectancy in the USA for 4-year-olds, by physical activity level

Lennert Veerman, Griffith University

• Americans over the age of 40 could live an extra 5.3 years if all were as active as the top 25% of the population

• For the least active 25% of Americans aged 40+, an extra hour’s walk could add an average of 6.3 hours of additional life expectancy.

According to a new study led by Griffith University researchers, if everyone in the United States population was as active as the top 25 per cent, individuals over 40 could add five years to their lives.  

Physical activity has long been recognized as beneficial for health; however, estimates have varied regarding the extent of benefits derived from specific amounts of activity, both for individuals and populations.

This latest study used accelerometry to gain an accurate view of the population’s physical activity levels instead of relying on survey responses, as in other studies. It found that the benefits were around twice as substantial as previous estimates.  

It found the most active quarter of people in the community had a 73 per cent lower risk of death than their least active counterparts. 

For the least active quartile, a one-hour walk could potentially provide around six additional hours of life.  

Lead researcher Professor Lennert Veerman said this least-active cohort had the most significant potential for health gains.  

“If you’re already very active or in that top quartile, an extra hour’s walk may not make much difference as you’ve, in a sense, already ‘maxed out’ your benefit,” he said.   

“If the least active quartile of the population over age 40 were to increase their activity level to that of the most active quartile, however, they might live, on average, about 11 years longer.  

“This is not an unreasonable prospect, as 25 per cent of the population is already doing it.  

“It can be any type of exercise but roughly the equivalent of just under three hours of walking per day.” 

The research team suggested low levels of physical activity could even rival the adverse effects of smoking, with other research finding each cigarette could take 11 minutes from a smoker’s life.  

By extension, a more active lifestyle could also offer protective effects against heart disease, stroke, certain cancers, and other chronic illnesses. The study’s findings highlight a need for national physical activity guidelines to be revisited using these methods.  

Dr Veerman said physical activity had been vastly underestimated in its capacity to improve health outcomes, suggesting even modest increases in movement could lead to significant life-extension benefits.  

“If there’s something you could do to more than halve your risk of death, physical activity is enormously powerful,” he said.  

“If we could increase investment in promoting physical activity and creating living environments that promote it, such as walkable or cyclable neighbourhoods and convenient, affordable public transport systems, we could increase longevity and reduce pressure on our health systems and the environment.”