Multiple sclerosis (MS) it is a chronic neurological disease, characterized by demyelisation. The impact of multiple sclerosis on QoL is usually quite dramatic. A reported that the somatic symptoms of MS affect the functioning life, family life, economic condition, social interaction and autonomy. The aim of the present study is to examine the Influences of neurological disability in quality of life in patients with multiple sclerosis. The study is cross-sectional and correlational and utilised the Expanded Disability Status Scale (EDSS) and MSQoL-54 Quantifying neurological disability in multiple sclerosis and MSQoL (SF-54): The results in correlations between EDSS and the domains of MSQOL-54, demonstrate de strong relation in every body dimensions of quality of life with neurological disability. These results are more important in dimensions: Physical Health and Physical Role Limitations Conclusion neurological Disability can play an important role in the quality of life of patients with multiple sclerosis.