In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates daily rhythms including sleep-wake, hormone release, and gene expression. The cells of the SCN must synchronize to each other to drive these circadian rhythms in the rest of the body. The ontogeny of circadian cycling and intercellular coupling in the SCN remains poorly understood. Recent in vitro studies have recorded circadian rhythms from the whole embryonic SCN. Here, we tracked the onset and precision of rhythms in PERIOD2 (PER2), a clock protein, within the SCN isolated from embryonic and postnatal mice of undetermined sex. We found that a few SCN cells developed circadian periodicity in PER2 by 14.5 d after mating (E14.5) with no evidence for daily cycling on E13.5. On E15.5, the fraction of competent oscillators increased dramatically corresponding with stabilization of their circadian periods. The cells of the SCN harvested at E15.5 expressed sustained, synchronous daily rhythms. By postnatal day 2 (P2), SCN oscillators displayed the daily, dorsal-ventral phase wave in clock gene expression typical of the adult SCN. Strikingly, vasoactive intestinal polypeptide (VIP), a neuropeptide critical for synchrony in the adult SCN, and its receptor, VPAC2R, reached detectable levels after birth and after the onset of circadian synchrony. Antagonists of GABA or VIP signaling or action potentials did not disrupt circadian synchrony in the E15.5 SCN. We conclude that endogenous daily rhythms in the fetal SCN begin with few noisy oscillators on E14.5, followed by widespread oscillations that rapidly synchronize on E15.5 by an unknown mechanism.SIGNIFICANCE STATEMENT We recorded the onset of PER2 circadian oscillations during embryonic development in the mouse SCN. When isolated at E13.5, the anlagen of the SCN expresses high, arrhythmic PER2. In contrast, a few cells show noisy circadian rhythms in the isolated E14.5 SCN and most show reliable, self-sustained, synchronized rhythms in the E15.5 SCN. Strikingly, this synchrony at E15.5 appears before expression of VIP or its receptor and persists in the presence of blockers of VIP, GABA or neuronal firing. Finally, the dorsal-ventral phase wave of PER2 typical of the adult SCN appears ∼P2, indicating that multiple signals may mediate circadian synchrony during the ontogeny of the SCN.

Aims. We study PTF11mnb, a He-poor supernova (SN) whose light curves resemble those of SN 2005bf, a peculiar double-peaked stripped-envelope (SE) SN, until the declining phase after the main peak. We investigate the mechanism powering its light curve and the nature of its progenitor star. Methods. Optical photometry and spectroscopy of PTF11mnb are presented. We compared light curves, colors and spectral properties to those of SN 2005bf and normal SE SNe. We built a bolometric light curve and modeled this light curve with the SuperNova Explosion Code (SNEC) hydrodynamical code explosion of a MESA progenitor star and semi-analytic models. Results. The light curve of PTF11mnb turns out to be similar to that of SN 2005bf until ~50 d when the main (secondary) peaks occur at -18.5 mag. The early peak occurs at ~20 d and is about 1.0 mag fainter. After the main peak, the decline rate of PTF11mnb is remarkably slower than what was observed in SN 2005bf, and it traces well the 56Co decay rate. The spectra of PTF11mnb reveal a SN Ic and have no traces of He unlike in the case of SN Ib 2005bf, although they have velocities comparable to those of SN 2005bf. The whole evolution of the bolometric light curve is well reproduced by the explosion of a massive (Mej = 7.8 MȮ), He-poor star characterized by a double-peaked 56Ni distribution, a total 56Ni mass of 0.59 MȮ, and an explosion energy of 2.2 × 1051 erg. Alternatively, a normal SN Ib/c explosion (M(56Ni) = 0.11 MȮ, EK = 0.2 × 1051 erg, Mej = 1 MȮ) can power the first peak while a magnetar, with a magnetic field characterized by B = 5.0 × 1014 G, and a rotation period of P = 18.1 ms, provides energy for the main peak. The early g-band light curve can be fit with a shock-breakout cooling tail or an extended envelope model from which a radius of at least 30 RȮ is obtained. Conclusions. We presented a scenario where PTF11mnb was the explosion of a massive, He-poor star, characterized by a double-peaked 56Ni distribution. In this case, the ejecta mass and the absence of He imply a large ZAMS mass (~85 MȮ) for the progenitor, which most likely was a Wolf-Rayet star, surrounded by an extended envelope formed either by a pre-SN eruption or due to a binary configuration. Alternatively, PTF11mnb could be powered by a SE SN with a less massive progenitor during the first peak and by a magnetar afterward.

The hypothesis of the existence of non-baryonic dark matter in our galactic halo is supported by many astrophysical observations at local to cosmological scales. Particles interacting weakly with ordinary matter, with an associated mass of the order of an atomic nucleus (aka WIMPS), are credible candidates for Dark Matter (DM). The direct detection of an elastic collision of a target nuclei on one of these WIMPs has to be discriminated from the signal produced by the neutrons, which leaves the same signal in a detector. Initiating a new generation of directional detectors, the MIMAC (MIcro-tpc MAtrix of Chambers) collaboration has developed an original prototype detector which combines a large pixelated Micromegas coupled with a fast, self-triggering, electronics. A two-chamber module has been in operation in the Underground Laboratory of Modane (LSM) for the past four years. Aspects of the Modane prototype are presented: calibration, characterization of the 222Rn progeny. A new test bench combining a MIMAC chamber with the COMIMAC portable quenching line has been installed at LPSC (Grenoble) so as to characterize the 3D tracks of low energy ions in the MIMAC gas mixture: the setup and the preliminary results thereof will be presented. Future steps and how a low-pressure gaseous TPC like MIMAC compare with other directionnal strategies will be briefly discussed.

MIMAC (MIcro-TPC MAtrix of Chambers) is a directional WIMP Dark Matter detector project. Direct dark matter experiments need a high level of electron/recoil discrimination to search for nuclear recoils produced by WIMP-nucleus elastic scattering. In this paper, we proposed an original method for electron event rejection based on a multivariate analysis applied to experimental data acquired using monochromatic neutron fields. This analysis shows that a 105 rejection power is reachable for electron/recoil discrimination. Moreover, the efficiency was estimated by a Monte-Carlo simulation showing that a 105 electron rejection power is reached with a 86.49 ± 0.17% nuclear recoil efficiency considering the full energy range and 94.67 ± 0.19% considering a 5 keV lower threshold.

The MIMAC experiment is a $\mu$-TPC matrix project for directional dark matter search. Directional detection is a strategy based on the measurement of the WIMP flux anisotropy due to the solar system motion with respect to the dark matter halo. The main purpose of MIMAC project is the measurement of the energy and the direction of nuclear recoils in 3D produced by elastic scattering of WIMPs. Since June 2012 a bi-chamber prototype is operating at the Modane underground laboratory. In this paper, we report the first ionization energy and 3D track observations of nuclear recoils produced by the radon progeny. This measurement shows the capability of the MIMAC detector and opens the possibility to explore the low energy recoil directionality signature.

We present a method for selecting high-redshift Type la supernovae (SNe la) located via rolling SN searches. The technique, using both color and magnitude information of events from only two to three epochs of multiband real-time photometry, is able to discriminate between SNe la and core-collapse SNe. Furthermore, for SNe la the method accurately predicts the redshift, phase, and light-curve parameterization of these events based only on pre-maximum-light data. We demonstrate the effectiveness of the technique on a simulated survey of SNe la and core-collapse SNe, where the selection method effectively rejects most core-collapse SNe while retaining SNe la. We also apply the selection code to real-time data acquired as part of the Canada-France-Hawaii Telescope Supernova Legacy Survey (SNLS). During the period 2004 May to 2005 January in the SNLS, 440 SN candidates were discovered, of which 70 were confirmed spectroscopically as SNe la and 15 as core-collapse events. For this test data set, the selection technique correctly identifies 100% of the identified SNe II as non-SNe la with only a 1%-2% false rejection rate. The predicted parameterization of the SNe la has a precision of | Δz|/(1 + z spec) < 0.09 in redshift and ±2-3 rest-frame days in phase, providing invaluable information for planning spectroscopic follow-up observations. We also investigate any bias introduced by this selection method on the ability of surveys such as SNLS to measure cosmological parameters (e.g., w and Ω M) and find any effect to be negligible. © 2006. The American Astronomical Society. All rights reserved.

We show that Type Ia supernovae (SNe Ia) are formed within both very young and old stellar populations, with observed rates that depend on the stellar mass and mean star formation rates (SFRs) of their host galaxies. Models in which the SN Ia rate depends solely on host galaxy stellar mass are ruled out with >99% confidence. Our analysis is based on 100 spectroscopically confirmed SNe Ia, plus 24 photometrically classified events, all from the Supernova Legacy Survey (SNLS) and distributed over 0.2 < z < 0.75. We estimate stellar masses and SFRs for the SN Ia host galaxies by fitting their broadband spectral energy distributions with the galaxy spectral synthesis code PÉGASE.2. We show that the SN Ia rate per unit mass is proportional to the specific SFR of the parent galaxies - more vigorously star-forming galaxies host more SNe Ia per unit stellar mass, broadly equivalent to the trend of increasing SN Ia rate in later type galaxies seen in the local universe. Following earlier suggestions for a simple "two-component" model approximating the SN Ia rate, we find bivariate linear dependencies of the SN Ia rate on both the stellar masses and the mean SFRs of the host systems. We find that the SN Ia rate can be well represented as the sum of 5.3 ± 1.1 × 10-14 SNe yr -1M⊙-1 and 3.9 ± 0.7 × 10-4 SNe yr-1 (M⊙ yr-1) -1 of star formation. We also demonstrate a dependence of distant SN Ia light-curve shapes on star formation in the host galaxy, similar to trends observed locally. Passive galaxies, with no star formation, preferentially host faster declining/dimmer SNe Ia, while brighter events are found in systems with ongoing star formation. © 2006. The American Astronomical Society. All rights reserved.

The use of Type Ia supernovae as distance indicators led to the discovery of the accelerating expansion of the universe a decade ago. Now that large second generation surveys have significantly increased the size and quality of the high-redshift sample, the cosmological constraints are limited by the currently available sample of ~50 cosmologically useful nearby supernovae. The Nearby Supernova Factory addresses this problem by discovering nearby supernovae and observing their spectrophotometric time development. Our data sample includes over 2400 spectra from spectral timeseries of 185 supernovae. This talk presents results from a portion of this sample including a Hubble diagram (relative distance vs. redshift) and a description of some analyses using this rich dataset.

We estimate systematic errors due to K-corrections in standard photometric analyses of high-redshift Type Iasupernovae. Errors due to K-correction occur when the spectral template model underlying the light curve fitterpoorly represents the actual supernova spectral energy distribution, meaning that the distance modulus cannot berecovered accurately. In order to quantify this effect, synthetic photometry is performed on artificially redshiftedspectrophotometric data from 119 low-redshift supernovae from the Nearby Supernova Factory, and the resultinglight curves are fit with a conventional light curve fitter. We measure the variation in the standardized magnitudethat would be fit for a given supernova if located at a range of redshifts and observed with various filter setscorresponding to current and future supernova surveys. We find significant variation in the measurements of thesame supernovae placed at different redshifts regardless of filters used, which causes dispersion greater than?0.05 mag for measurements of photometry using the Sloan-like filters and a bias that corresponds to a 0.03 shift inw when applied to an outside data set. To test the result of a shift in supernova population or environment at higherredshifts, we repeat our calculations with the addition of a reweighting of the supernovae as a function of redshiftand find that this strongly affects the results and would have repercussions for cosmology. We discuss possiblemethods to reduce the contribution of the K-correction bias and uncertainty.