Omega 3 fatty acids and GPR120

Cell Metab. 2012 May 2;15(5):564-5. doi: 10.1016/j.cmet.2012.04.009.

Abstract

Human loss-of-function gene variants in GPR120 have recently been identified that confer increased risk for obesity and metabolic syndrome. In addition, GPR120 KO mice develop obesity, increased inflammation, and insulin resistance, consistent with a role for GPR120 signaling in the metabolic syndrome and diabetes mellitus.

Publication types

  • Review

MeSH terms

  • Animals
  • Fatty Acids, Omega-3 / metabolism*
  • Humans
  • Insulin Resistance / physiology*
  • Metabolic Syndrome / genetics
  • Metabolic Syndrome / metabolism
  • Mice
  • Mice, Knockout
  • Obesity / genetics
  • Obesity / metabolism
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • FFAR4 protein, human
  • FFAR4 protein, mouse
  • Fatty Acids, Omega-3
  • Receptors, G-Protein-Coupled