Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)

Chem Commun (Camb). 2014 Dec 21;50(98):15499-502. doi: 10.1039/c4cc05803h. Epub 2014 Oct 20.

Abstract

Individual micron-sized solid particles from a Salamol® pharmaceutical inhaler are stably captured in air using an optical trap for the first time. Raman spectroscopy of the levitated particles allows online interrogation of composition and deliquescent phase change within a high humidity environment that mimics the particle's travel from inhaler to lung.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Aerosols / administration & dosage*
  • Aerosols / chemistry
  • Albuterol / administration & dosage*
  • Albuterol / chemistry
  • Bronchodilator Agents / administration & dosage*
  • Bronchodilator Agents / chemistry
  • Nebulizers and Vaporizers*
  • Particle Size
  • Spectrum Analysis, Raman

Substances

  • Aerosols
  • Bronchodilator Agents
  • Albuterol