When the drugs don't work: treatment-resistant schizophrenia, serotonin and serendipity

Penelope Lowe; Amir Krivoy; Lilla Porffy; Erna Henriksdottir; Whiskey Eromona; Sukhwinder S Shergill

doi:10.1177/2045125317737003

When the drugs don't work: treatment-resistant schizophrenia, serotonin and serendipity

Ther Adv Psychopharmacol. 2018 Jan;8(1):63-70. doi: 10.1177/2045125317737003. Epub 2017 Nov 2.

Authors

Penelope Lowe¹, Amir Krivoy², Lilla Porffy³, Erna Henriksdottir⁴, Whiskey Eromona⁵, Sukhwinder S Shergill⁵

Affiliations

¹ National Psychosis Service, South London and Maudsley NHS Foundation Trust, UK.
² Psychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, 16 De Crespigny Park, London, SE5 8AF, UK.
³ Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
⁴ National Psychosis Service, South London and Maudsley NHS Foundation Trust, UK. University of Iceland, Iceland.
⁵ National Psychosis Service, South London and Maudsley NHS Foundation Trust, UK. Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

Abstract

Treatment-resistant schizophrenia is a serious clinical problem. We adopt a systems-level approach positing a greater role for cognitive control mechanisms in the development of psychotic symptoms and illustrate the clinical application of this via a case report of treatment-resistant patients treated successfully with adjunct pro-cognitive serotonergic medication.

Keywords: cognition; novel treatment; refractory schizophrenia.

Abstract

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