Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma

Apeng Chen; Yinan Jiang; Zhengwei Li; Lingxiang Wu; Ulises Santiago; Han Zou; Chunhui Cai; Vaibhav Sharma; Yongchang Guan; Lauren H McCarl; Jie Ma; Yijen L Wu; Joshua Michel; Yi Shi; Liza Konnikova; Nduka M Amankulor; Pascal O Zinn; Gary Kohanbash; Sameer Agnihotri; Songjian Lu; Xinghua Lu; Dandan Sun; George K Gittes; Qianghu Wang; Xiangwei Xiao; Dean Yimlamai; Ian F Pollack; Carlos J Camacho; Baoli Hu

doi:10.1172/JCI147552

Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma

J Clin Invest. 2021 Aug 16;131(16):e147552. doi: 10.1172/JCI147552.

Authors

Apeng Chen^{1

2}, Yinan Jiang^{2

3}, Zhengwei Li^{1

2

4}, Lingxiang Wu⁵, Ulises Santiago⁶, Han Zou^{1

2}, Chunhui Cai⁷, Vaibhav Sharma^{1

2}, Yongchang Guan^{1

2

8}, Lauren H McCarl^{1

2}, Jie Ma^{2

3}, Yijen L Wu^{2

9}, Joshua Michel², Yi Shi¹⁰, Liza Konnikova¹¹, Nduka M Amankulor¹, Pascal O Zinn¹, Gary Kohanbash^{1

2}, Sameer Agnihotri^{1

2}, Songjian Lu⁷, Xinghua Lu⁷, Dandan Sun¹², George K Gittes^{2

3}, Qianghu Wang⁵, Xiangwei Xiao^{2

3}, Dean Yimlamai¹³, Ian F Pollack^{1

2}, Carlos J Camacho⁶, Baoli Hu^{1

2

14}

Affiliations

¹ Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
² John G. Rangos Sr. Research Center, University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
³ Department of Pediatric Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
⁴ Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China.
⁵ Department of Bioinformatics, Nanjing Medical University, Nanjing, China.
⁶ Department of Computational and Systems Biology and.
⁷ Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
⁸ Department of Neurosurgery, The Fourth Hospital of China Medical University, Shenyang, Liaoning, China.
⁹ Department of Developmental Biology and.
¹⁰ Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
¹¹ Section of Neonatal, Perinatal Medicine, Department of Pediatrics and Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA.
¹² Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
¹³ Section of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
¹⁴ Cancer Biology Program, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.

Abstract

Keywords: Brain cancer; Cancer; Macrophages; Oncology.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Proteins / immunology
Blood Proteins / metabolism
Brain Neoplasms / immunology*
Brain Neoplasms / metabolism*
Brain Neoplasms / therapy
Cell Line, Tumor
Cellular Reprogramming / immunology
Chitinase-3-Like Protein 1 / genetics
Chitinase-3-Like Protein 1 / immunology*
Chitinase-3-Like Protein 1 / metabolism*
Female
Galectins / immunology
Galectins / metabolism
Glioblastoma / immunology*
Glioblastoma / metabolism*
Glioblastoma / therapy
Heterografts
Humans
Immune Tolerance
Immunotherapy
Macrophages / immunology*
Macrophages / metabolism*
Macrophages / pathology
Male
Mice
Mice, Inbred C57BL
Mice, SCID
Models, Molecular
Signal Transduction / immunology
Tumor Escape
Tumor Microenvironment / immunology

Substances

Blood Proteins
CHI3L1 protein, human
Chil1 protein, mouse
Chitinase-3-Like Protein 1
Galectins
LGALS3 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding