Advances in the treatment of secondary and tertiary hyperparathyroidism

Front Endocrinol (Lausanne). 2022 Dec 6:13:1059828. doi: 10.3389/fendo.2022.1059828. eCollection 2022.

Abstract

Secondary hyperparathyroidism (SHPT) and tertiary hyperparathyroidism (THPT) are common and complicated clinical endocrine diseases. The parathyroid glands maintain endocrine homeostasis by secreting parathyroid hormone to regulate blood calcium levels. However, structural alterations to multiple organs and systems occur throughout the body due to hyperactivity disorder in SHPT and THPT. This not only decreases the patients' quality of life, but also affects mortality. Since current treatments for these diseases remains unclear, we aimed to develop a comprehensive review of advances in the treatment of SHPT and THPT according to the latest relevant researches.

Keywords: 99mTc-MIBI; parathyroid hormone; parathyroidectomy; secondary hyperparathyroidism; tertiary hyperparathyroidism.

Publication types

  • Review

MeSH terms

  • Humans
  • Hyperparathyroidism, Secondary* / drug therapy
  • Hyperparathyroidism, Secondary* / surgery
  • Hyperparathyroidism, Secondary* / therapy
  • Parathyroid Glands / metabolism
  • Parathyroid Hormone / metabolism
  • Parathyroidectomy
  • Quality of Life

Substances

  • Parathyroid Hormone