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Biostatistics: An Introduction

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Biostatistics: An Introduction

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    1. Biostatistics: An Introduction

    2. Outline

    3. Meaning or Randomness?

    4. Meaning or Randomness?

    5. Decision Making

    6. Decision Making: Diagnosis

    7. Decision Making: Diagnosis

    8. Decision Making: Sensitivity

    9. Decision Making Continued

    10. Decision Making: Specificity

    11. Decision Making: Tradeoff

    12. Graphical Representation of Tradeoffs

    13. Decision Making for Diagnosis: Summary

    14. Scientific Decision Making

    15. Eventual Graphical Representation

    16. Question 2 First

    17. Question 2 Continued

    18. Typical Choice of Cutoff

    19. Power of the Scientific Method

    20. Back to Question 1

    21. A �Law of Large Numbers�

    22. A �Law of Large Numbers�

    23. A �Law of Large Numbers�

    24. A �Law of Large Numbers�

    25. A �Law of Large Numbers�

    26. Summary: Law of Large Numbers

    27. Scientific Decision Making

    28. The Power of the Scientific Method

    29. Scientific Decision Making

    30. Putting it All Together

    31. Quote from An LA BioMed Protocol

    32. Software for Previous Slide

    33. Study Size : May Not be Based on Power

    34. Study Design Considerations Statistical Components of Protocols Target population / source of subjects. Quantification of aims, hypotheses. Case definitions, endpoints quantified. Randomization plan, if one will be used. Masking, if used. Study size: screen, enroll, complete. Use of data from non-completers. Justification of study size (power, precision, other). Methods of analysis. Mid-study analyses.

    35. Resources, Software, and References

    36. Professional Statistics Software Package

    37. Microsoft Excel for Statistics

    38. Typical Statistics Software Package

    39. Free Statistics Software: Mystat

    40. Free Study Size Software

    41. http://gcrc.labiomed.org/biostat

    42. Recommended Textbook: Making Inference

    43. Thank You

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