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Diclofenac research
Research On
Non Steroidal Anti-Inflammatory Drugs
(NSAIDs)
Diclofenac Research
Content :
1- Introduction about The Pharmacological Class.
2- Name of the drug (IUPAC, generic and trade names).
3- Structure of the drug (drawn by Chemsketch program).
4- Synthesis of the drug (drawn by Chemsketch program).
5- Spectral data of the drug (UV, IR, NMR and Mass).
6- Uses, Side effects and Contraindications.
7- A table describing the role of each student in the group in
fulfilling the project.
Diclofenac Research
The Pharmacological Class
•

Diclofenac belongs to the class of acetic acid derivatives
and related substances of non-steroidal antiinflammatory and antirheumatic products.

•

This medicine works by reducing substances in the body
that cause pain and inflammation.

•

Diclofenac is used to treat pain or inflammation caused
by arthritis or ankylosing spondylitis.
Diclofenac Research
IUPAC, Generic & Trade Names
• IUPAC Name:
2-(2,6-dichloranilino) phenylacetic acid.
• Generic Name:
Diclofenac Sodium, Diclofenac Potassium &

epolamine.
• Trade Name:

Diclofenac
Diclofenac Research

Diclofenac Potassium

Diclofenac epolamine

Diclofenac Sodium

Diclofenac (as free acid)
Diclofenac Research
Structure of Drug

Diclofenac_3D
Diclofenac Research
Synthesis of the drug
Diclofenac Research
Spectral Data of the Drug
IR
Diclofenac Sodium
Diclofenac Research
Spectral Data of the Drug
UV
Spectrum of Diclofenac in NaOH
Diclofenac Research
Spectral Data of the Drug
NMR
Diclofenac Research
Spectral Data of the Drug
Mass
Diclofenac Research
Uses
• Diclofenac is used to treat pain, inflammatory disorders,
and dysmenorrhea.
• Diclofenac is used commonly to treat mild to moderate
postoperative or post-traumatic pain, in particular when
inflammation is also present, and is effective against
menstrual pain and endometriosis.
Diclofenac Research
Side Effects
• This medicine may cause life-threatening heart or
circulation problems such as heart attack or stroke,
especially if you use it long term.
• This medicine may also cause serious effects on the
stomach or intestines, including bleeding or perforation
(forming of a hole).
Diclofenac Research
Contraindication
• Do not use diclofenac just before or after heart bypass
surgery (coronary artery bypass graft, or CABG).
• Diclofenac is contraindicated in hypersensitivity, active
peptic ulcer, moderate to severe hepatic disease and in
pregnancy.
• Those with Alcohol abuse, Colitis, Crohn's disease,
diverticulitis, gastric ulcer, Diabetes mellitus,
Hemorrhoids, Hepatitis, renal disease, Rectal irritation.
Diclofenac research

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Diclofenac research

  • 2. Research On Non Steroidal Anti-Inflammatory Drugs (NSAIDs)
  • 3. Diclofenac Research Content : 1- Introduction about The Pharmacological Class. 2- Name of the drug (IUPAC, generic and trade names). 3- Structure of the drug (drawn by Chemsketch program). 4- Synthesis of the drug (drawn by Chemsketch program). 5- Spectral data of the drug (UV, IR, NMR and Mass). 6- Uses, Side effects and Contraindications. 7- A table describing the role of each student in the group in fulfilling the project.
  • 4. Diclofenac Research The Pharmacological Class • Diclofenac belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products. • This medicine works by reducing substances in the body that cause pain and inflammation. • Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis.
  • 5. Diclofenac Research IUPAC, Generic & Trade Names • IUPAC Name: 2-(2,6-dichloranilino) phenylacetic acid. • Generic Name: Diclofenac Sodium, Diclofenac Potassium & epolamine. • Trade Name: Diclofenac
  • 6. Diclofenac Research Diclofenac Potassium Diclofenac epolamine Diclofenac Sodium Diclofenac (as free acid)
  • 7. Diclofenac Research Structure of Drug Diclofenac_3D
  • 9. Diclofenac Research Spectral Data of the Drug IR Diclofenac Sodium
  • 10. Diclofenac Research Spectral Data of the Drug UV Spectrum of Diclofenac in NaOH
  • 13. Diclofenac Research Uses • Diclofenac is used to treat pain, inflammatory disorders, and dysmenorrhea. • Diclofenac is used commonly to treat mild to moderate postoperative or post-traumatic pain, in particular when inflammation is also present, and is effective against menstrual pain and endometriosis.
  • 14. Diclofenac Research Side Effects • This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. • This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole).
  • 15. Diclofenac Research Contraindication • Do not use diclofenac just before or after heart bypass surgery (coronary artery bypass graft, or CABG). • Diclofenac is contraindicated in hypersensitivity, active peptic ulcer, moderate to severe hepatic disease and in pregnancy. • Those with Alcohol abuse, Colitis, Crohn's disease, diverticulitis, gastric ulcer, Diabetes mellitus, Hemorrhoids, Hepatitis, renal disease, Rectal irritation.