Crimean–Congo hemorrhagic fever

Crimean-Congo hemorrhagic fever orthonairovirus
	Crimean–Congo hemorrhagic fever virus (CCHFV) virion and replication cycle.
Virus classification
(unranked):	Virus
Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Negarnaviricota
Class:	Ellioviricetes
Order:	Bunyavirales
Family:	Nairoviridae
Genus:	Orthonairovirus
Species:	Crimean-Congo hemorrhagic fever orthonairovirus

Crimean–Congo hemorrhagic fever
Crimean–Congo hemorrhagic fever
	Male diagnosed with Crimean–Congo hemorrhagic fever, 1969
Specialty	Infectious disease
Symptoms	Fever, muscle pains, headache, vomiting, diarrhea, bleeding into the skin
Complications	Liver failure
Usual onset	Rapid
Duration	Two weeks
Diagnostic method	Detecting antibodies, the virus's RNA, or viral proteins (antigens).
Differential diagnosis	Dengue fever, Q fever, Ebola virus disease
Treatment	Supportive care, ribavirin (off-label)
Prognosis	Risk of death ~25%

Crimean–Congo hemorrhagic fever (CCHF) is a viral disease.^[1] Symptoms of CCHF may include fever, muscle pains, headache, vomiting due to loss of net saline of basal cells, diarrhea, and bleeding into the skin.^[1] Onset of symptoms is less than two weeks following exposure.^[1] Complications may include liver failure.^[1] Survivors generally recover around two weeks after onset.^[1]

Quick Facts Specialty, Symptoms ...

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The causative agent of CCHF is the CCHF virus, which belongs to the order Bunyavirales. This virus was initially detected in the 1940s, when Soviet troops in Crimea experienced a severe hemorrhagic illness. Decades later, during the 1960s, a similar virus was identified in the Belgian Congo (now the Democratic Republic of Congo). The two viruses were found to share antigenic properties, leading to their classification under the unified name Crimean-Congo Hemorrhagic Fever Virus (CCHFV).^[4] The CCHFV is typically spread by tick bites or close contact with the blood, secretions, organs or other bodily fluids of infected persons or animals.^[1] Groups that are at high risk of infection are farmers and those who work in slaughterhouses.^[1] The virus can also spread between people via body fluids.^[1] Diagnosis can be made by detecting antibodies, the virus's RNA, or viral proteins (antigens).^[1] It is a type of viral hemorrhagic fever.^[1]

There are no FDA- or WHO-approved therapeutics for CCHF, and a vaccine is not commercially available. Prevention involves avoiding tick bites, following safe practices in meat processing plants, and observing universal healthcare precautions.^[1] Treatment is typically with supportive care, and while the medication ribavirin is often used, as of 2023 there is not sufficient, high-quality evidence of its efficacy.^[1]^[5]

CCHF cases are observed in a wide geographic range including Africa, Russia, the Balkans, the Middle East, and Asia.^[1] Typically small outbreaks are seen in areas where the virus is endemic.^[1] In 2013 Iran, Russia, Turkey, and Uzbekistan documented more than 50 cases.^[2] The fatality rate is typically between 10 and 40%, though fatalities as high as 80% have been observed in some outbreaks.^[1] The virus was first observed in Crimea in the 1940s.^[6]

In the past 20 years, CCHF outbreaks have been reported in eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent. CCHF is on WHO's priority list for Research and Development and the US National Institute of Allergy and Infectious Diseases (NIH/NIAID) priority A list, as a disease posing the highest level of risk to national security and public health.

The clinical illness associated with CCHFV (the CCHF virus) is a severe form of hemorrhagic fever.^[7] Following infection by a tick bite, the incubation period is typically two to three days but can last as long as nine days, while the incubation period following contact with infected blood or tissues is usually five to six days with a documented maximum of 13 days. After entering the human body, the virus multiplies within specific target cells, including endothelial cells, macrophages, and epithelial cells. This process activates both the innate and adaptive branches of the immune system.^[4] The onset of symptoms ushering in the pre-hemorrhagic phase is sudden, with fever, myalgia (muscle ache), dizziness, neck pain and stiffness, backache, headache, sore eyes and photophobia (sensitivity to light).

Typical symptoms include nausea, vomiting (which may progress to severe bleeding and can be fatal if not treated), diarrhea, abdominal pain and sore throat early in the acute infection phase, followed by sharp mood swings, agitations and confusion. After several days, agitation may be replaced by sleepiness, depression and lassitude, and the abdominal pain may localize to the upper right quadrant, with detectable liver enlargement.

As the illness progresses into the hemorrhagic phase, large areas of severe bruising, severe nosebleeds, and uncontrolled bleeding at injection sites can be seen, beginning on about the fourth day of illness and lasting for about two weeks. Other clinical signs include tachycardia (fast heart rate), lymphadenopathy (enlarged lymph nodes), and a petechiae (a rash caused by bleeding into the skin) on internal mucosal surfaces, such as in the mouth and throat, and on the skin. The petechiae may give way to larger rashes called ecchymoses, and other haemorrhagic phenomena. There is usually evidence of hepatitis, and severely ill patients may experience rapid kidney deterioration, liver failure or pulmonary failure after the fifth day of illness.

In documented outbreaks of CCHF, fatality rates in hospitalized patients have ranged from 9% to as high as 70%, though the WHO notes a typical range of 10–40%, with death often occurring in the second week of illness. In patients who recover, improvement generally begins on the ninth or tenth day after the onset of illness. The long-term effects of CCHF infection have not been studied well enough in survivors to determine whether or not specific complications exist. However, recovery is slow.

Virology

Quick Facts Virus classification ...

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The Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) is a member of the genus Orthonairovirus, family Nairoviridae of RNA viruses.^[8]

The virions are 80–120 nanometers (nm) in diameter and are pleomorphic. There are no host ribosomes within the virion. Each virion contains three distinct RNA sequences, which together make up the viral genome. The envelope is single layered and is formed from a lipid bilayer 5 nm thick. It has no external protrusions. The envelope proteins form small projections ~5–10 nm long. The nucleocapsids are filamentous and circular with a length of 200–3000 nm.^[9] Viral entry is thought to be clathrin-mediated with the cell surface protein nucleolin playing a role.^[10]

Molecular biology

The genome is circular, negative-sense RNA in three parts – Small (S), Medium (M) and Large (L). The L segment is 11–14.4 kilobases in length while the M and S segments are 4.4–6.3 and 1.7–2.1 kilobases long respectively. The L segment encodes the RNA polymerase, the M segment encodes the envelope glycoproteins (Gc and Gn), and the S segment encodes the nucleocapsid protein.^[9] The mutation rates for the three parts of the genome were estimated to be: 1.09×10⁻⁴, 1.52×10⁻⁴ and 0.58×10⁻⁴ substitutions/site/year for the S, M, and L segments respectively.^[11]

Population genetics

CCHFV is the most genetically diverse of the arboviruses: its nucleotide sequences frequently differ between different strains, ranging from a 20% variability for the viral S segment to 31% for the M segment.^[12] Viruses with diverse sequences can be found within the same geographic area; closely related viruses have been isolated from widely separated regions, suggesting that viral dispersion has occurred possibly by ticks carried on migratory birds or through international livestock trade. Reassortment among genome segments during coinfection of ticks or vertebrates seems likely to have played a role in generating diversity in this virus.^{[citation needed]}

Based on the sequence data, seven genotypes of CCHFV have been recognised: Africa 1 (Senegal), Africa 2 (Democratic Republic of the Congo and South Africa), Africa 3 (southern and western Africa), Europe 1 (Albania, Bulgaria, Kosovo, Russia and Turkey), Europe 2 (Greece), Asia 1 (the Middle East, Iran and Pakistan) and Asia 2 (China, Kazakhstan, Tajikistan and Uzbekistan).^{[citation needed]}

Transmission

Ticks are both "environmental reservoir" and vector for the virus, carrying it from wild animals to domestic animals and humans. Tick species identified as infected with the virus include Argas reflexus, Hyalomma anatolicum, Hyalomma detritum, Hyalomma marginatum marginatum and Rhipicephalus sanguineus.^{[citation needed]} At least 31 different species of ticks from the genera Haemaphysalis and Hyalomma in southeastern Iran have been found to carry the virus.^[13]

Wild animals and small mammals, particularly European hare, Middle-African hedgehogs and multimammate rats are the "amplifying hosts" of the virus. Birds are generally resistant to CCHF, with the exception of ostriches. Domestic animals like sheep, goats and cattle can develop high titers of virus in their blood, but tend not to fall ill.^[14]

The "sporadic infection" of humans is usually caused by a Hyalomma tick bite. Animals can transmit the virus to humans, but this would usually be as part of a disease cluster. When clusters of illness occur, it is typically after people treat, butcher or eat infected livestock, particularly ruminants and ostriches. Outbreaks have occurred in abattoirs and other places where workers have been exposed to infected human or animal blood and fomites ^{[citation needed]} Humans can infect humans and outbreaks also occur in clinical facilities through infected blood and unclean medical instruments.^[15]

Where mammalian tick infection is common, agricultural regulations require de-ticking farm animals before transportation or delivery for slaughter. Personal tick avoidance measures are recommended, such as use of insect repellents, adequate clothing, and body inspection for adherent ticks.^{[citation needed]}

When feverish patients with evidence of bleeding require resuscitation or intensive care, body substance isolation precautions should be taken.^{[citation needed]}

Vaccine

Since the 1970s, several vaccine trials around the world against CCHF have been terminated due to high toxicity.^[16]

As of March 2011^[update], the only available and probably somewhat efficacious CCHF vaccine has been an inactivated antigen preparation then used in Bulgaria.^[16] No publication in the scientific literature related to this vaccine exists, which a Turkish virologist called suspicious both because antiquated technology and mouse brain were used to manufacture it.^[17] More vaccines are under development, but the sporadic nature of the disease, even in endemic countries, suggests that large trials of vaccine efficacy will be difficult to perform. Finding volunteers may prove challenging, given growing anti-vaccination sentiment and resistance of populations to vaccination against contagious diseases. The number of people to be vaccinated, and the length of time they would have to be followed to confirm protection would have to be carefully defined. Alternatively, many scientists appear to believe that treatment of CCHF with ribavirin is more practical than prevention, but some recently conducted clinical trials appear to counter assumptions of drug efficacy.^[16] In 2011, a Turkish research team led by Erciyes University successfully developed the first non-toxic preventive vaccine, which passed clinical trials. As of 2012, the vaccine was pending approval by the US FDA.^[17]

Since the Ebola epidemic, the WHO jumpstarted a "Blueprint for Research and Development preparedness" on emerging pathogens with epidemic potential, against which there are no medical treatments.^[18] CCHF was the top priority on the initial list from December 2015, and is second as of January 2017.^[19]

Treatment is mostly supportive. Ribavirin has shown some efficacy in vitro^[20] and has been used by mouth during outbreaks,^{[citation needed]} but there is uncertain evidence to support its use, and this medication can cause serious side effects including hemolytic anemia and liver damage.^[21]

As of 2011^[update] the use of Immunoglobulin preparations has remained unproven and antibody engineering, which raised hopes for monoclonal antibody therapy, has remained in its infancy.^[16]

CCHF occurs most frequently among agricultural workers, following the bite of an infected tick, and to a lesser extent among slaughterhouse workers exposed to the blood and tissues of infected livestock, and medical personnel through contact with the body fluids of infected persons.^[12]

Geographic distribution

As of 2013^[update] the northern limit of CCHF has been 50 degrees northern latitude, north of which the Hyalomma ticks have not been found.^[7] Per a WHO map from 2008, Hyalomma ticks occurred south of this latitude across all of the Eurasian continent and Africa, sparing only the islands of Sri Lanka, Indonesia and Japan.^[22] Serological or virological evidence of CCHF was widespread in Asia, Eastern Europe, the Middle East (except Israel, Lebanon and Jordan), central Africa, Western Africa, South Africa and Madagascar.^[22]

In 2008, more than 50 cases/year were reported from only 4 countries: Turkey, Iran, Russia and Uzbekistan. 5-49 cases/year were present in South Africa, Central Asia including Pakistan and Afghanistan (but sparing Turkmenistan), in the Middle East only the UAE and the Balkan countries limited to Romania, Bulgaria, Serbia, Montenegro and Albania.^[22]

In Russia, the disease is limited to Southern and North Caucasian Federal Districts, but climate change may cause it to spread into more northerly areas.^[23]

A 2014 map by the CDC shows endemic areas (in red) largely unchanged in Africa and the Middle East, but different for the Balkan, including all countries of the former Yugoslavia, and also Greece, but no longer Romania. India's Northwestern regions of Rajasthan and Gujarat saw their first cases.^[24]

Outbreaks

From 1995 to 2013, 228 cases of CCHF were reported in the Republic of Kosovo, with a case-fatality rate of 25.5%.^[25]

Between 2002–2008 the Ministry of Health of Turkey reported 3,128 CCHF cases, with a 5% death rate.^{[citation needed]} In July 2005, authorities reported 41 cases of CCHF in central Turkey's Yozgat Province, with one death.^{[clarification needed]} As of August 2008, a total of 50 deaths were reported for the year thus far in various cities in Turkey due to CCHF.^{[clarification needed]}

In 2003, 38 people were infected with CCHF in Mauritania, including 35 residents of Nouakchott.^[26]

In September 2010, an outbreak was reported in Pakistan's Khyber Pakhtunkhwa province. Poor diagnosis and record keeping caused the extent of the outbreak to be uncertain, though some reports indicated over 100 cases, with a case-fatality rate above 10%.^{[citation needed]}

In January 2011, the first human cases of CCHF in India was reported in Sanand, Gujarat, India, with 4 reported deaths, which included the index patient, treating physician and nurse.^[27]

As of May 2012^[update], 71 people were reported to have contracted the disease in Iran, resulting in 8 fatalities.^{[citation needed]}

In October 2012, a British man died from the disease at the Royal Free Hospital in London. He had earlier been admitted to Gartnavel General Hospital in Glasgow, after returning on a flight from Kabul in Afghanistan.^[28]

In July 2013, seven people died of CCHF in the Karyana village of Babra, Gujarat, India.^[29]^[30]

In August 2013, a farmer from Agago, Uganda was treated at Kalongo Hospital for a confirmed CCHF infection. The deaths of three other individuals in the northern region were suspected to have been caused by the virus.^[31] Another unrelated CCHF patient was admitted to Mulago Hospital on the same day. The Ministry of Health announced on the 19th that the outbreak was under control, but the second patient, a 27-year-old woman from Nansana, died on the 21st. She is believed to have contracted the virus from her husband, who returned to Kampala after being treated for CCHF in Juba, South Sudan.^[32]

In June 2014, cases were diagnosed in Kazakhstan. Ten people, including an ambulance crew, were admitted on to hospital in southern Kazakhstan with suspected CCHF.^{[citation needed]} In July 2014 an 8th person was found to be infected with CCHF at Hayatabad Medical Complex (HMC), Pakistan. The eight patients, including a nurse and 6 Afghan nationals, died between April and July 2014.^[33]

As of 2015^[update], sporadic confirmed cases have been reported from Bhuj, Amreli, Sanand, Idar and Vadnagar in Gujarat, India. In November 2014, a doctor and a labourer in north Gujarat tested positive for the disease. In the following weeks, three more people died from CCHF.^[34] In March 2015, one more person died of CCHF in Gujarat.^[35] As of 2015, among livestock, CCHF was recognized as "widespread" in India, only 4 years after the first human case had been diagnosed.^[36]

In August 2016, the first local case of CCHF in Western Europe occurred in Western Spain. A 62-year-old man, who had been bitten by a tick in Spain died on August 25, having infected a nurse.^[37] The tick bite occurred in the province of Ávila, 300 km away from the province of Cáceres, where CCHF viral RNA from ticks was amplified in 2010.^[38] As of July 2017^[update] it was unclear what specific ecology led to the Spanish cases.^[39]

In August 2016, a number of Pakistani news sources raised concerns regarding the disease.^[40]^[41] Between January and October 2016, CCHF outbreaks in Pakistan were reported with highest numbers of cases and deaths during August 2016, just before the festival of Eid-al-Adha (held on September 13–15 in 2016). It was hypothesized that the festival could play an important part as people could come into contact with domestic or imported animals potentially infected with CCHF virus.^[42] The Pakistani NIH showed there was no correlation, and that CCHF cases have coincided with the peak tick proliferation during the preceding 8–10 years.^[43]

In 2017, the General Directorate of Public Health in Turkey published official records of infections and casualties involving CCHF between 2008 and 2017. Cases declined from 1,318 in 2009 to 343 in 2017 alongside a lowered mortality rate.^[44] Cases are concentrated in rural areas of the Southern Black Sea Region, Central Anatolia Region, and Eastern Anatolia Region during early summer months.^[45]

On February 2, 2020, an outbreak was reported in Mali involving fourteen cases and seven deaths, days before the COVID-19 pandemic in Africa. In May 2020, a single case was reported in Mauritania.^[46]

In 2022, an outbreak occurred in Iraq. Between 1 January and 22 May, 212 cases of CCHF were reported to the WHO. Of the 212 cases, 115 were suspected and 97 laboratory confirmed. Twenty seven deaths were recorded, of which 13 were in laboratory confirmed cases.^[47]

In July 2023, there was a single confirmed fatality of tick-borne CCHF in North Macedonia.^[48]

In July 2024, a lethal tick-borne CCHF case was confirmed in Spain.^[49]^[50]

In August 2024, the first ever recorded laboratory-confirmed tick-borne CCHF case was confirmed in Portugal. The 80-year old male patient did not survive. ^[51]

In ancient Celtic settlements in the Upper Danube area in Germany, the CCHF virus was detected in archaeological blood samples, indicating that it was endemic at the time.^[52] The virus may have evolved around 1500–1100 BC. It is thought that changing climate and agricultural practices around this time could be behind its evolution.^[11]

In the 12th century a case of a hemorrhagic disease reported from what is now Tajikistan may have been the first known case of Crimean–Congo hemorrhagic fever.^{[citation needed]}

In 1944, roughly 200 Soviet military agricultural workers were infected by Crimean hemorrhagic fever (CHF), leading to experiments showing a tick-borne viral etiology.^[53]

In February 1967, virologists John P. Woodall, David Simpson, Ghislaine Courtois and others published initial reports on a virus they called the Congo virus.^[54]^[55] In 1956, the Congo virus had first been isolated by physician Ghislaine Courtois, head of the Provincial Medical Laboratory, Stanleyville, in the Belgian Congo. Strain V3010, isolated by Courtois, was sent to the Rockefeller Foundation Virus Laboratory (RFVL) in New York City and found to be identical to another strain from Uganda, but to no other named virus at that time.^{[citation needed]}

In June 1967, Soviet virologist Mikhail Chumakov registered an isolate from a fatal case that occurred in Samarkand in the Catalogue of Arthropod-borne Viruses.^[56] In 1969, the Russian strain, which Chumakov had sent to the RFVL, was found to be antigenically indistinguishable from the Congo virus.^[57]

In 1973, the International Committee on Taxonomy of Viruses adopted Crimean–Congo hemorrhagic fever virus as the official name.^[58]

These reports include records of the occurrence of the virus or antibodies to the virus from Greece, Portugal, South Africa, Madagascar (the first isolation from there), the Maghreb, Dubai, Saudi Arabia, Kuwait and Iraq.^[59]^[60]^[61]

2023 Crimean–Congo hemorrhagic fever outbreak

[1]
"Crimean-Congo Haemorrhagic Fever". World Health Organization. May 23, 2022. Retrieved January 29, 2023.
[2]
Berger S (2017). Crimean-Congo Hemorrhagic Fever: Global Status: 2017 edition. GIDEON Informatics Inc. p. 7. ISBN 978-1-4988-1556-7. Archived from the original on 2017-09-10.
[3]
"Ebola virus infection - Differentials | BMJ Best Practice". bestpractice.bmj.com. Retrieved 21 May 2018.
[4]
Di Bella, Stefano; Babich, Stella; Luzzati, Roberto; Cavasio, Rosario Alessandro; Massa, Barbara; Braccialarghe, Neva; Zerbato, Verena; Iannetta, Marco (2024). "Crimean-Congo haemorrhagic fever (CCHF): present and future therapeutic armamentarium". Le Infezioni in Medicina. 32 (4): 421–433. doi:10.53854/liim-3204-2 (inactive 12 December 2024). ISSN 2532-8689. PMC 11627488. PMID 39660152.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)
[5]
Johnson, S; Henschke, N; Maayan, N; Mills, I; Buckley, BS; Kakourou, A; Marshall, R (5 June 2018). "Ribavirin for treating Crimean Congo haemorrhagic fever". The Cochrane Database of Systematic Reviews. 2018 (6): CD012713. doi:10.1002/14651858.CD012713.pub2. PMC 5994605. PMID 29869797.
[6]
Magill AJ (2013). Hunter's Tropical Medicine and Emerging Infectious Disease, Expert Consult - Online and Print,9: Hunter's Tropical Medicine and Emerging Infectious Disease. Elsevier Health Sciences. p. 334. ISBN 978-1-4160-4390-4. Archived from the original on 2017-08-04.
[7]
"Crimean-Congo haemorrhagic fever, Fact sheet N°208". WHO. January 2013. Archived from the original on 2015-05-20. Retrieved 2015-05-19.
[8]
Virus Taxonomy: 2018 Release, EC 50, Washington, DC, July 2018, Email ratification October 2018 (MSL #33) https://ictv.global/taxonomy
[9]
Carter SD, Surtees R, Walter CT, Ariza A, Bergeron É, Nichol ST, et al. (October 2012). "Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein". Journal of Virology. 86 (20): 10914–23. doi:10.1128/JVI.01555-12. PMC 3457148. PMID 22875964.
[10]
Xiao X, Feng Y, Zhu Z, Dimitrov DS (July 2011). "Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor". Biochemical and Biophysical Research Communications. 411 (2): 253–8. doi:10.1016/j.bbrc.2011.06.109. PMC 3155881. PMID 21723257.
[11]
Carroll SA, Bird BH, Rollin PE, Nichol ST (June 2010). "Ancient common ancestry of Crimean-Congo hemorrhagic fever virus". Molecular Phylogenetics and Evolution. 55 (3): 1103–10. doi:10.1016/j.ympev.2010.01.006. PMID 20074652.
[12]
Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M (October 2013). "Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity". Antiviral Research. 100 (1): 159–89. doi:10.1016/j.antiviral.2013.07.006. PMID 23906741.
[13]
Mehravaran A, Moradi M, Telmadarraiy Z, Mostafavi E, Moradi AR, Khakifirouz S, et al. (February 2013). "Molecular detection of Crimean-Congo haemorrhagic fever (CCHF) virus in ticks from southeastern Iran". Ticks and Tick-Borne Diseases. 4 (1–2): 35–8. doi:10.1016/j.ttbdis.2012.06.006. PMID 23238248.
[14]
Ergönül O, Celikbaş A, Dokuzoguz B, Eren S, Baykam N, Esener H (July 2004). "Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy". Clinical Infectious Diseases. 39 (2): 284–7. doi:10.1086/422000. PMID 15307042.
[15]
Division of High-Consequence Pathogens and Pathology, Viral Special Pathogens Branch (March 5, 2014). "Crimean-Congo Hemorrhagic Fever (CCHF) Transmission". CDC. Archived from the original on April 28, 2014.
[16]
Keshtkar-Jahromi M, Kuhn JH, Christova I, Bradfute SB, Jahrling PB, Bavari S (May 2011). "Crimean-Congo hemorrhagic fever: current and future prospects of vaccines and therapies". Antiviral Research. 90 (2): 85–92. doi:10.1016/j.antiviral.2011.02.010. PMID 21362441.
[17]
sitesi, milliyet.com.tr Türkiye'nin lider haber. "Keneye aşı müjdesi". Gundem.milliyet.com.tr. Archived from the original on 2013-12-19.
[18]
Kieny MP (20 May 2015). "After Ebola, a Blueprint Emerges to Jump-Start R&D". Scientific American Blog Network. Archived from the original on 20 December 2016. Retrieved 13 December 2016.
[19]
"R&D Blueprint. List of Blueprint priority diseases". World Health Organization. January 2017. Archived from the original on 10 September 2017. Retrieved 13 July 2017.
[20]
Watts DM, Ussery MA, Nash D, Peters CJ (November 1989). "Inhibition of Crimean-Congo hemorrhagic fever viral infectivity yields in vitro by ribavirin". The American Journal of Tropical Medicine and Hygiene. 41 (5): 581–5. doi:10.4269/ajtmh.1989.41.581. PMID 2510529.
[21]
Johnson S, Henschke N, Maayan N, Mills I, Buckley BS, Kakourou A, Marshall R, et al. (Cochrane Infectious Diseases Group) (June 2018). "Ribavirin for treating Crimean Congo haemorrhagic fever". The Cochrane Database of Systematic Reviews. 2018 (6): CD012713. doi:10.1002/14651858.CD012713.pub2. PMC 5994605. PMID 29869797.
[22]
"Geographic distribution of Crimean-Congo haemorrhagic fever (CCHF)". WHO. 2008. Archived from the original on 2016-05-13.
[23]
"Крымская-Конго геморрагическая лихорадка".
[24]
Division of High-Consequence Pathogens and Pathology, Viral Special Pathogens Branch (March 5, 2014). "Crimean-Congo Hemorrhagic Fever (CCHF) Distribution Map". CDC. Archived from the original on June 18, 2017.
[25]
Fajs L, Jakupi X, Ahmeti S, Humolli I, Dedushaj I, Avšič-Županc T (2014). "Molecular epidemiology of Crimean-Congo hemorrhagic fever virus in Kosovo". PLOS Neglected Tropical Diseases. 8 (1): e2647. doi:10.1371/journal.pntd.0002647. PMC 3886908. PMID 24416468.
[26]
Nabeth, Pierre; Cheikh, Dah Ould; Lo, Baidy; Faye, Ousmane; Vall, Idoumou Ould Mohamed; Niang, Mbayame; Wague, Bocar; Diop, Djibril; Diallo, Mawlouth; Diallo, Boubacar; Diop, Ousmane Madiagne; Simon, François (December 2004). "Crimean-Congo Hemorrhagic Fever, Mauritania". Emerging Infectious Diseases. 10 (12): 2143–2149. doi:10.3201/eid1012.040535. PMC 3323392. PMID 15663851.
[27]
Syed Khalique Ahmed, Tanvir A Siddiqui, Anuradha Mascarenhas, Anuradha Mascarenhas, Tanvir A Siddiqui, Syed Khalique Ahmed : Pune, Ahmedabad Deadly virus-makes first appearance in india kills three in gujarat Archived 2011-03-04 at the Wayback Machine indianexpress.com, 19 January 2011
[28]
"Congo Fever: Patient dies in hospital". BBC News. 6 October 2012. Archived from the original on 7 October 2012.
[29]
"Congo Fever: Seven Die In Amreli In A Week Mobile Site". IndiaTv. Indiatvnews. 2013-07-15. Archived from the original on 2016-03-04. Retrieved 2015-03-28.
[30]
"Congo Fever Confirmed in Amreli Village". The Times of India. July 15, 2013. Retrieved January 29, 2023.
[31]
Biryabarema E (17 August 2013). "Three die in Uganda from Ebola-like fever: Health Ministry". Yahoo News. Reuters. Archived from the original on 20 August 2013. Retrieved 16 August 2013.
[32]
Otto A (22 August 2013). "High Alert Over Crimean Fever". The Observer. Kampala. Archived from the original on 14 July 2014. Retrieved 26 August 2013.
[33]
Khan H (2014-07-11). "Stemming outbreaks: Eighth patient dies of Congo hemorrhagic fever at HMC". Archived from the original on 13 July 2014. Retrieved 13 July 2014.
[34]
Bhatia, Vimal (26 January 2015). "Health Officials Confirm Congo Fever Death of Jaisalmer Man". The Times of India. Retrieved January 23, 2023.
[35]
"Kutch resident dies of Confo fever". The Indian Express. March 29, 2015. Archived from the original on April 3, 2015. Retrieved March 29, 2015.
[36]
"Crimean-Congo hemorrhagic fever spreads across India - Outbreak News Today". 9 October 2015. Archived from the original on 20 December 2015.
[37]
"First Local Case of Tick-Borne Disease Kills Man in Spain". Scientif American. n.d. Archived from the original on 2016-09-02. Retrieved 2016-09-03.
[38]
Negredo A, de la Calle-Prieto F, Palencia-Herrejón E, Mora-Rillo M, Astray-Mochales J, Sánchez-Seco MP, et al. (July 2017). "Autochthonous Crimean-Congo Hemorrhagic Fever in Spain". The New England Journal of Medicine. 377 (2): 154–161. doi:10.1056/NEJMoa1615162. hdl:20.500.12105/11849. PMID 28700843.
[39]
Spengler JR, Bente DA (July 2017). "Crimean-Congo Hemorrhagic Fever in Spain - New Arrival or Silent Resident?". The New England Journal of Medicine. 377 (2): 106–108. doi:10.1056/NEJMp1707436. PMC 5922251. PMID 28700846.
[40]
"Congo virus: Doctors warn against outbreak of disease". The Express Tribune. 17 August 2016. Archived from the original on 6 September 2016.
[41]
"Karachi: Congo virus claims another life - Pakistan - Dunya News". 14 February 2008. Archived from the original on 2016-09-04.
[42]
Karim AM, Hussain I, Lee JH, Park KS, Lee SH (April 2017). "Surveillance of Crimean-Congo haemorrhagic fever in Pakistan". The Lancet. Infectious Diseases. 17 (4): 367–368. doi:10.1016/S1473-3099(17)30119-6. PMID 28346174.
[43]
Alam MM, Khurshid A, Rana MS, Aamir UB, Salman M, Ahmad M (August 2017). "Surveillance of Crimean-Congo haemorrhagic fever in Pakistan". The Lancet. Infectious Diseases. 17 (8): 806. doi:10.1016/S1473-3099(17)30403-6. PMID 28741546.
[44]
"KKKA İstatistik Verileri". Archived from the original on 2021-04-12. Retrieved 2021-04-12.
[45]
Shahhosseini, Nariman; Wong, Gary; Babuadze, George; Camp, Jeremy V.; Ergonul, Onder; Kobinger, Gary P.; Chinikar, Sadegh; Nowotny, Norbert (September 9, 2021). "Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe". Microorganisms. 9 (9): 1907. doi:10.3390/microorganisms9091907. ISSN 2076-2607. PMC 8471816. PMID 34576803.
[46]
Greene, Leah; Uwishema, Olivier; Nicholas, Aderinto; Kapoor, Arushi; Berjaoui, Christin; Adamolekun, Emmanuel; Khoury, Carlo; Mohammed, Fatima Elbasri Abuelgasim; Onyeaka, Helen (2022-06-01). "Crimean-Congo haemorrhagic fever during the COVID-19 pandemic in Africa: Efforts, recommendations and challenges at hand". African Journal of Emergency Medicine. 12 (2): 117–120. doi:10.1016/j.afjem.2022.02.004. ISSN 2211-419X. PMC 8858690. PMID 35223387.
[47]
"Crimean-Congo Hemorrhagic Fever - Iraq". World Health Organization. 1 June 2022. Retrieved 1 June 2022.
[48]
"Karbinci woman dies of virus caused by tick bite". 30 July 2023.
[49]
"Castilla-La Mancha confirma el primer caso de fiebre hemorrágica de Crimea-Congo en la región | Gobierno de Castilla-La Mancha". www.castillalamancha.es. Retrieved 2024-07-22.
[50]
Madrid, Comunidad de (2024-07-22). "Sanidad activa el protocolo de actuación tras detectar el caso de un ciudadano afectado por fiebre hemorrágica Crimea-Congo". Comunidad de Madrid (in Spanish). Retrieved 2024-07-22.
[51]
"DSG confirma caso de febre hemorrágica da Crimeia-Congo detectado em Portugal |". 23 August 2024.
[52]
Garry Shaw (2016), "Human blood, organs, and a surprising virus detected in ancient pottery", Science (in German), doi:10.1126/science.aal0490
Conner J. Wiktorowicz et al.: Hemorrhagic fever virus, human blood, and tissues in Iron Age mortuary vessels. In: Journal of Archaeological Science. Band 78, 2017, S. 29–39, doi:10.1016/j.jas.2016.11.009 (Online-Vorabveröffentlichung vom Dezember 2016)
[53]
Whitehouse, Chris A. (2004-12-01). "Crimean–Congo Hemorrhagic Fever". Antiviral Research. 64 (3): 145–160. doi:10.1016/j.antiviral.2004.08.001. ISSN 0166-3542. PMID 15550268. S2CID 9776329.
[54]
Simpson DI, Knight EM, Courtois G, Williams MC, Weinbren MP, Kibukamusoke JW (February 1967). "Congo virus: a hitherto undescribed virus occurring in Africa. I. Human isolations--clinical notes". East African Medical Journal. 44 (2): 86–92. PMID 6040759.
[55]
Woodall JP, Williams MC, Simpson DI (February 1967). "Congo virus: a hitherto undescribed virus occurring in Africa. II. Identification studies". East African Medical Journal. 44 (2): 93–8. PMID 6068614.
[56]
Chumakov MP, Butenko AM, Shalunova NV, Mart'ianova LI, Smirnova SE, Bashkirtsev Iu, et al. (May–June 1968). "[New data on the viral agent of Crimean hemorrhagic fever]". Voprosy Virusologii (in Russian). 13 (3): 377. PMID 4235803.
[57]
Casals J (May 1969). "Antigenic similarity between the virus causing Crimean hemorrhagic fever and Congo virus". Proceedings of the Society for Experimental Biology and Medicine. 131 (1): 233–6. doi:10.3181/00379727-131-33847. PMID 5770109. S2CID 30654789.
[58]
Ergönül O, Whitehouse CA (2007). "Personal Reflections, Jack Woodall". Congo Hemorrhagic Fever: A Global Perspective. Netherlands: Springer. p. 23. ISBN 978-1-4020-6105-9.
[59]
Crowcroft NS, Morgan D, Brown D (March 2002). "Viral haemorrhagic fevers in Europe--effective control requires a co-ordinated response". Euro Surveillance. 7 (3): 31–2. doi:10.2807/esm.07.03.00343-en. PMID 12631941.
[60]
Al-Tikriti SK, Al-Ani F, Jurji FJ, Tantawi H, Al-Moslih M, Al-Janabi N, et al. (1981). "Congo/Crimean haemorrhagic fever in Iraq". Bulletin of the World Health Organization. 59 (1): 85–90. PMC 2396030. PMID 6790183.
[61]
Okorie TG (March 1991). "Comparative studies on the vector capacity of the different stages of Amblyomma variegatum Fabricius and Hyalomma rufipes Koch for Congo virus, after intracoelomic inoculation". Veterinary Parasitology. 38 (2–3): 215–23. doi:10.1016/0304-4017(91)90131-e. PMID 1907050.

World Health Organization fact sheet
Ergönül O (April 2006). "Crimean-Congo haemorrhagic fever". The Lancet. Infectious Diseases. 6 (4): 203–14. doi:10.1016/S1473-3099(06)70435-2. PMC 7185836. PMID 16554245.

[WHO2013-1] [1]
"Crimean-Congo Haemorrhagic Fever". World Health Organization. May 23, 2022. Retrieved January 29, 2023.

[Gid2017-2] [2]
Berger S (2017). Crimean-Congo Hemorrhagic Fever: Global Status: 2017 edition. GIDEON Informatics Inc. p. 7. ISBN 978-1-4988-1556-7. Archived from the original on 2017-09-10.

[3] [3]
"Ebola virus infection - Differentials | BMJ Best Practice". bestpractice.bmj.com. Retrieved 21 May 2018.

[Di_Bella-4] [4]
Di Bella, Stefano; Babich, Stella; Luzzati, Roberto; Cavasio, Rosario Alessandro; Massa, Barbara; Braccialarghe, Neva; Zerbato, Verena; Iannetta, Marco (2024). "Crimean-Congo haemorrhagic fever (CCHF): present and future therapeutic armamentarium". Le Infezioni in Medicina. 32 (4): 421–433. doi:10.53854/liim-3204-2 (inactive 12 December 2024). ISSN 2532-8689. PMC 11627488. PMID 39660152.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)

[CochraneRibavirin-5] [5]
Johnson, S; Henschke, N; Maayan, N; Mills, I; Buckley, BS; Kakourou, A; Marshall, R (5 June 2018). "Ribavirin for treating Crimean Congo haemorrhagic fever". The Cochrane Database of Systematic Reviews. 2018 (6): CD012713. doi:10.1002/14651858.CD012713.pub2. PMC 5994605. PMID 29869797.

[6] [6]
Magill AJ (2013). Hunter's Tropical Medicine and Emerging Infectious Disease, Expert Consult - Online and Print,9: Hunter's Tropical Medicine and Emerging Infectious Disease. Elsevier Health Sciences. p. 334. ISBN 978-1-4160-4390-4. Archived from the original on 2017-08-04.

[auto-7] [7]
"Crimean-Congo haemorrhagic fever, Fact sheet N°208". WHO. January 2013. Archived from the original on 2015-05-20. Retrieved 2015-05-19.

[ICTV-8] [8]
Virus Taxonomy: 2018 Release, EC 50, Washington, DC, July 2018, Email ratification October 2018 (MSL #33) https://ictv.global/taxonomy

[carter-9] [9]
Carter SD, Surtees R, Walter CT, Ariza A, Bergeron É, Nichol ST, et al. (October 2012). "Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein". Journal of Virology. 86 (20): 10914–23. doi:10.1128/JVI.01555-12. PMC 3457148. PMID 22875964.

[Xiao2011-10] [10]
Xiao X, Feng Y, Zhu Z, Dimitrov DS (July 2011). "Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor". Biochemical and Biophysical Research Communications. 411 (2): 253–8. doi:10.1016/j.bbrc.2011.06.109. PMC 3155881. PMID 21723257.

[Carroll2010-11] [11]
Carroll SA, Bird BH, Rollin PE, Nichol ST (June 2010). "Ancient common ancestry of Crimean-Congo hemorrhagic fever virus". Molecular Phylogenetics and Evolution. 55 (3): 1103–10. doi:10.1016/j.ympev.2010.01.006. PMID 20074652.

[Bente2013-12] [12]
Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M (October 2013). "Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity". Antiviral Research. 100 (1): 159–89. doi:10.1016/j.antiviral.2013.07.006. PMID 23906741.

[Mehravaran2012-13] [13]
Mehravaran A, Moradi M, Telmadarraiy Z, Mostafavi E, Moradi AR, Khakifirouz S, et al. (February 2013). "Molecular detection of Crimean-Congo haemorrhagic fever (CCHF) virus in ticks from southeastern Iran". Ticks and Tick-Borne Diseases. 4 (1–2): 35–8. doi:10.1016/j.ttbdis.2012.06.006. PMID 23238248.

[14] [14]
Ergönül O, Celikbaş A, Dokuzoguz B, Eren S, Baykam N, Esener H (July 2004). "Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy". Clinical Infectious Diseases. 39 (2): 284–7. doi:10.1086/422000. PMID 15307042.

[trans-15] [15]
Division of High-Consequence Pathogens and Pathology, Viral Special Pathogens Branch (March 5, 2014). "Crimean-Congo Hemorrhagic Fever (CCHF) Transmission". CDC. Archived from the original on April 28, 2014.

[auto1-16] [16]
Keshtkar-Jahromi M, Kuhn JH, Christova I, Bradfute SB, Jahrling PB, Bavari S (May 2011). "Crimean-Congo hemorrhagic fever: current and future prospects of vaccines and therapies". Antiviral Research. 90 (2): 85–92. doi:10.1016/j.antiviral.2011.02.010. PMID 21362441.

[gundem-17] [17]
sitesi, milliyet.com.tr Türkiye'nin lider haber. "Keneye aşı müjdesi". Gundem.milliyet.com.tr. Archived from the original on 2013-12-19.

[sablog-18] [18]
Kieny MP (20 May 2015). "After Ebola, a Blueprint Emerges to Jump-Start R&D". Scientific American Blog Network. Archived from the original on 20 December 2016. Retrieved 13 December 2016.

[WHOlist-19] [19]
"R&D Blueprint. List of Blueprint priority diseases". World Health Organization. January 2017. Archived from the original on 10 September 2017. Retrieved 13 July 2017.

[20] [20]
Watts DM, Ussery MA, Nash D, Peters CJ (November 1989). "Inhibition of Crimean-Congo hemorrhagic fever viral infectivity yields in vitro by ribavirin". The American Journal of Tropical Medicine and Hygiene. 41 (5): 581–5. doi:10.4269/ajtmh.1989.41.581. PMID 2510529.

[21] [21]
Johnson S, Henschke N, Maayan N, Mills I, Buckley BS, Kakourou A, Marshall R, et al. (Cochrane Infectious Diseases Group) (June 2018). "Ribavirin for treating Crimean Congo haemorrhagic fever". The Cochrane Database of Systematic Reviews. 2018 (6): CD012713. doi:10.1002/14651858.CD012713.pub2. PMC 5994605. PMID 29869797.

[map-22] [22]
"Geographic distribution of Crimean-Congo haemorrhagic fever (CCHF)". WHO. 2008. Archived from the original on 2016-05-13.

[23] [23]
"Крымская-Конго геморрагическая лихорадка".

[cdc-24] [24]
Division of High-Consequence Pathogens and Pathology, Viral Special Pathogens Branch (March 5, 2014). "Crimean-Congo Hemorrhagic Fever (CCHF) Distribution Map". CDC. Archived from the original on June 18, 2017.

[Kosovo-25] [25]
Fajs L, Jakupi X, Ahmeti S, Humolli I, Dedushaj I, Avšič-Županc T (2014). "Molecular epidemiology of Crimean-Congo hemorrhagic fever virus in Kosovo". PLOS Neglected Tropical Diseases. 8 (1): e2647. doi:10.1371/journal.pntd.0002647. PMC 3886908. PMID 24416468.

[26] [26]
Nabeth, Pierre; Cheikh, Dah Ould; Lo, Baidy; Faye, Ousmane; Vall, Idoumou Ould Mohamed; Niang, Mbayame; Wague, Bocar; Diop, Djibril; Diallo, Mawlouth; Diallo, Boubacar; Diop, Ousmane Madiagne; Simon, François (December 2004). "Crimean-Congo Hemorrhagic Fever, Mauritania". Emerging Infectious Diseases. 10 (12): 2143–2149. doi:10.3201/eid1012.040535. PMC 3323392. PMID 15663851.

[27] [27]
Syed Khalique Ahmed, Tanvir A Siddiqui, Anuradha Mascarenhas, Anuradha Mascarenhas, Tanvir A Siddiqui, Syed Khalique Ahmed : Pune, Ahmedabad Deadly virus-makes first appearance in india kills three in gujarat Archived 2011-03-04 at the Wayback Machine indianexpress.com, 19 January 2011

[28] [28]
"Congo Fever: Patient dies in hospital". BBC News. 6 October 2012. Archived from the original on 7 October 2012.

[indiatvnews_2013-29] [29]
"Congo Fever: Seven Die In Amreli In A Week Mobile Site". IndiaTv. Indiatvnews. 2013-07-15. Archived from the original on 2016-03-04. Retrieved 2015-03-28.

[30] [30]
"Congo Fever Confirmed in Amreli Village". The Times of India. July 15, 2013. Retrieved January 29, 2023.

[31] [31]
Biryabarema E (17 August 2013). "Three die in Uganda from Ebola-like fever: Health Ministry". Yahoo News. Reuters. Archived from the original on 20 August 2013. Retrieved 16 August 2013.

[Otto-32] [32]
Otto A (22 August 2013). "High Alert Over Crimean Fever". The Observer. Kampala. Archived from the original on 14 July 2014. Retrieved 26 August 2013.

[33] [33]
Khan H (2014-07-11). "Stemming outbreaks: Eighth patient dies of Congo hemorrhagic fever at HMC". Archived from the original on 13 July 2014. Retrieved 13 July 2014.

[The_Times_of_India_Mobile_Site_2015-34] [34]
Bhatia, Vimal (26 January 2015). "Health Officials Confirm Congo Fever Death of Jaisalmer Man". The Times of India. Retrieved January 23, 2023.

[Cities2015-35] [35]
"Kutch resident dies of Confo fever". The Indian Express. March 29, 2015. Archived from the original on April 3, 2015. Retrieved March 29, 2015.

[36] [36]
"Crimean-Congo hemorrhagic fever spreads across India - Outbreak News Today". 9 October 2015. Archived from the original on 20 December 2015.

[37] [37]
"First Local Case of Tick-Borne Disease Kills Man in Spain". Scientif American. n.d. Archived from the original on 2016-09-02. Retrieved 2016-09-03.

[nejmspain-38] [38]
Negredo A, de la Calle-Prieto F, Palencia-Herrejón E, Mora-Rillo M, Astray-Mochales J, Sánchez-Seco MP, et al. (July 2017). "Autochthonous Crimean-Congo Hemorrhagic Fever in Spain". The New England Journal of Medicine. 377 (2): 154–161. doi:10.1056/NEJMoa1615162. hdl:20.500.12105/11849. PMID 28700843.

[spain-39] [39]
Spengler JR, Bente DA (July 2017). "Crimean-Congo Hemorrhagic Fever in Spain - New Arrival or Silent Resident?". The New England Journal of Medicine. 377 (2): 106–108. doi:10.1056/NEJMp1707436. PMC 5922251. PMID 28700846.

[40] [40]
"Congo virus: Doctors warn against outbreak of disease". The Express Tribune. 17 August 2016. Archived from the original on 6 September 2016.

[41] [41]
"Karachi: Congo virus claims another life - Pakistan - Dunya News". 14 February 2008. Archived from the original on 2016-09-04.

[statefair-42] [42]
Karim AM, Hussain I, Lee JH, Park KS, Lee SH (April 2017). "Surveillance of Crimean-Congo haemorrhagic fever in Pakistan". The Lancet. Infectious Diseases. 17 (4): 367–368. doi:10.1016/S1473-3099(17)30119-6. PMID 28346174.

[43] [43]
Alam MM, Khurshid A, Rana MS, Aamir UB, Salman M, Ahmad M (August 2017). "Surveillance of Crimean-Congo haemorrhagic fever in Pakistan". The Lancet. Infectious Diseases. 17 (8): 806. doi:10.1016/S1473-3099(17)30403-6. PMID 28741546.

[44] [44]
"KKKA İstatistik Verileri". Archived from the original on 2021-04-12. Retrieved 2021-04-12.

[45] [45]
Shahhosseini, Nariman; Wong, Gary; Babuadze, George; Camp, Jeremy V.; Ergonul, Onder; Kobinger, Gary P.; Chinikar, Sadegh; Nowotny, Norbert (September 9, 2021). "Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe". Microorganisms. 9 (9): 1907. doi:10.3390/microorganisms9091907. ISSN 2076-2607. PMC 8471816. PMID 34576803.

[46] [46]
Greene, Leah; Uwishema, Olivier; Nicholas, Aderinto; Kapoor, Arushi; Berjaoui, Christin; Adamolekun, Emmanuel; Khoury, Carlo; Mohammed, Fatima Elbasri Abuelgasim; Onyeaka, Helen (2022-06-01). "Crimean-Congo haemorrhagic fever during the COVID-19 pandemic in Africa: Efforts, recommendations and challenges at hand". African Journal of Emergency Medicine. 12 (2): 117–120. doi:10.1016/j.afjem.2022.02.004. ISSN 2211-419X. PMC 8858690. PMID 35223387.

[47] [47]
"Crimean-Congo Hemorrhagic Fever - Iraq". World Health Organization. 1 June 2022. Retrieved 1 June 2022.

[48] [48]
"Karbinci woman dies of virus caused by tick bite". 30 July 2023.

[49] [49]
"Castilla-La Mancha confirma el primer caso de fiebre hemorrágica de Crimea-Congo en la región | Gobierno de Castilla-La Mancha". www.castillalamancha.es. Retrieved 2024-07-22.

[50] [50]
Madrid, Comunidad de (2024-07-22). "Sanidad activa el protocolo de actuación tras detectar el caso de un ciudadano afectado por fiebre hemorrágica Crimea-Congo". Comunidad de Madrid (in Spanish). Retrieved 2024-07-22.

[51] [51]
"DSG confirma caso de febre hemorrágica da Crimeia-Congo detectado em Portugal |". 23 August 2024.

[52] [52]
Garry Shaw (2016), "Human blood, organs, and a surprising virus detected in ancient pottery", Science (in German), doi:10.1126/science.aal0490
Conner J. Wiktorowicz et al.: Hemorrhagic fever virus, human blood, and tissues in Iron Age mortuary vessels. In: Journal of Archaeological Science. Band 78, 2017, S. 29–39, doi:10.1016/j.jas.2016.11.009 (Online-Vorabveröffentlichung vom Dezember 2016)

[53] [53]
Whitehouse, Chris A. (2004-12-01). "Crimean–Congo Hemorrhagic Fever". Antiviral Research. 64 (3): 145–160. doi:10.1016/j.antiviral.2004.08.001. ISSN 0166-3542. PMID 15550268. S2CID 9776329.

[54] [54]
Simpson DI, Knight EM, Courtois G, Williams MC, Weinbren MP, Kibukamusoke JW (February 1967). "Congo virus: a hitherto undescribed virus occurring in Africa. I. Human isolations--clinical notes". East African Medical Journal. 44 (2): 86–92. PMID 6040759.

[55] [55]
Woodall JP, Williams MC, Simpson DI (February 1967). "Congo virus: a hitherto undescribed virus occurring in Africa. II. Identification studies". East African Medical Journal. 44 (2): 93–8. PMID 6068614.

[56] [56]
Chumakov MP, Butenko AM, Shalunova NV, Mart'ianova LI, Smirnova SE, Bashkirtsev Iu, et al. (May–June 1968). "[New data on the viral agent of Crimean hemorrhagic fever]". Voprosy Virusologii (in Russian). 13 (3): 377. PMID 4235803.

[57] [57]
Casals J (May 1969). "Antigenic similarity between the virus causing Crimean hemorrhagic fever and Congo virus". Proceedings of the Society for Experimental Biology and Medicine. 131 (1): 233–6. doi:10.3181/00379727-131-33847. PMID 5770109. S2CID 30654789.

[58] [58]
Ergönül O, Whitehouse CA (2007). "Personal Reflections, Jack Woodall". Congo Hemorrhagic Fever: A Global Perspective. Netherlands: Springer. p. 23. ISBN 978-1-4020-6105-9.

[59] [59]
Crowcroft NS, Morgan D, Brown D (March 2002). "Viral haemorrhagic fevers in Europe--effective control requires a co-ordinated response". Euro Surveillance. 7 (3): 31–2. doi:10.2807/esm.07.03.00343-en. PMID 12631941.

[BullWHO-60] [60]
Al-Tikriti SK, Al-Ani F, Jurji FJ, Tantawi H, Al-Moslih M, Al-Janabi N, et al. (1981). "Congo/Crimean haemorrhagic fever in Iraq". Bulletin of the World Health Organization. 59 (1): 85–90. PMC 2396030. PMID 6790183.

[vector-61] [61]
Okorie TG (March 1991). "Comparative studies on the vector capacity of the different stages of Amblyomma variegatum Fabricius and Hyalomma rufipes Koch for Congo virus, after intracoelomic inoculation". Veterinary Parasitology. 38 (2–3): 215–23. doi:10.1016/0304-4017(91)90131-e. PMID 1907050.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

[53]

[54]

[55]

[56]

[57]

[58]

[59]

[60]

[61]