Neil Brockdorff

British biochemist (born 1958) From Wikipedia, the free encyclopedia

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Neil Brockdorff

Neil Alexander Steven Brockdorff (born 1958) is a British biochemist who is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford.[5][6] Brockdorff's research investigates gene and genome regulation in mammalian development.[7] His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.[7]

Quick Facts Born, Education ...
Neil Brockdorff
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Neil Brockdorff at the Royal Society in London, July 2018
Born
Neil Alexander Steven Brockdorff

1958 (age 6566)[1]
EducationHampstead School[1]
Alma materUniversity of Sussex (BSc)
University of Glasgow (PhD)[2]
AwardsEMBO Member (1999)[3]
Scientific career
FieldsDevelopmental epigenetics
X inactivation[4]
InstitutionsUniversity of Oxford
ThesisThe effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus (1985)
Websitewww.bioch.ox.ac.uk/research/brockdorff
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Education

Brockdorff was educated at Hampstead School, the University of Sussex (BSc)[1] and the University of Glasgow (PhD).[2]

Career and research

X inactivation is an important model for understanding how epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology.[7][8] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process.[9][10] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing.[7][11][12][13]

Awards and honours

Brockdorff is a member of the European Molecular Biology Organization (EMBO), a Fellow of the Royal Society (FRS), a Fellow of the Academy of Medical Sciences (FMedSci) and a Fellow of the Royal Society of Biology (FRSB).

References

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