The XplorIR Quantification Package provides hazmat responders with the capability to not only identify thousands of gases and vapors, but also quantify them in real-time on scene. This represents the only device of it's kind which can accurately detect, identify, and quantify, thousands of gases in seconds. With this unmatched capability, responders are able to respond swiftly to assess atmospheric conditions and make rapid decisions on PPE selection, exposure potential, mitigation techniques, and influence tactical considerations.
[post_title] => XplorIR Quantification
[post_excerpt] => Read this application note to learn about XplorIR quantification package which allows users to measure the concentration of a hazardous gas or vapor and part-per-million (ppm) levels.
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[post_name] => xplorir-quantification
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[post_modified] => 2024-08-14 10:27:14
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[post_date] => 2024-06-14 09:24:15
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Responders to hazardous materials incidents face significant risks from flammable atmospheres. To manage this threat, teams use structural firefighting gear, SCBA, and various sensors, including LEL sensors, for initial reconnaissance and subsequent entries. However, traditional Catalytic Bead LEL sensors can be inaccurate due to calibration issues with different gases and a limited scope, creating more safety risk. The XplorIR® device allows responders to identify the specific gas or vapor detected. This enables real-time adjustments to the sensor readings, improving safety by reducing the need for action levels, speeding up leak identification, and enhancing overall mitigation efforts.
[post_title] => XplorIR and LEL Sensors for Hazmat Response
[post_excerpt] => Learn about the integration of XplorIR's gas identification capabilities with the common air monitoring tool of the LEL sensor.
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[post_name] => xplorir-and-lel-sensors-for-hazmat-response
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[post_date] => 2024-06-14 09:24:16
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Colorimetric tubes have been a standard in the downrange toolkits of many first responders. Despite their widespread use, they are plagued by high error rates, significant cross-sensitivities, and an inability to conduct continuous gas monitoring. The XplorIR significantly reduces the reliance on individual colorimetric tubes. The XplorIR is the only FTIR analyzer that can provide continuous gas monitoring at operationally relevant concentrations while uniquely identifying over 5600 chemicals and up to 6 components simultaneously within a gas mixture.
[post_title] => Are Colorimetric Tubes Becoming Obsolete for HazMat/CBRN Response
[post_excerpt] => Learn how the XplorIR revolutionizes gas detection by eliminating the drawbacks of traditional colorimetric tubes.
[post_status] => publish
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[post_name] => are-colorimetric-tubes-obsolete-hazmat
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In emergency response, 4-gas or 5-gas air monitors with oxygen sensors ensure sufficient O2 levels for both responder safety and proper function of Catalytic Bead LEL sensors. However, a drop in O2 below 19.5% is considered IDLH by OSHA, signaling the need for supplied air respirators. Even a small decrease in O2 can indicate a large presence of contaminants, as a 0.1% drop in O2 can represent around 5,000 ppm of an unknown substance. If the XplorIR® device is used with these monitors, it can detect contaminants at much lower levels (25-50 ppm) compared to the O2 sensor, enhancing safety and reducing the risk of exposure to potentially dangerous gas clouds. XplorIR'[SW1] s capability to identify over 5,600 gases and vapors at levels well under the detection ability of O2 sensors provides an added layer of safety during reconnaissance operations.
[SW1]only need registered mark on the first mention of product.
[post_title] => XplorIR Solves Oxygen Displacement for Hazmat Response
[post_excerpt] => Learn how XplorIR identifies contaminants lower than an O2 sensor, and why it is deployed with gas monitors during recon entry.
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[post_name] => o2-displacement-and-xplorir
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[post_modified] => 2024-11-01 15:21:27
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[post_date] => 2024-09-10 15:24:09
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In this application note, by using a combination of analytical tools including REBEL and MAVEN, we were able to gain unique insights that allowed us to perform a data-driven optimization of a bioprocess and reach the process development goals with regards to titer, toxic metabolite profiles, and viability. REBEL, an amino acid analyzer streamlines bioprocess optimization by providing rapid, at-line spent-media analysis. It helps optimize nutrient feeding, control toxic metabolites, and improve cell viability, resulting in higher yields, including a 30% titer increase in one case.
[post_title] => Data-driven CHO Bioprocess Optimization and Scale-up with At-line Intelligence of Key Media Components
[post_excerpt] => Accelerate your process development with the fast, at-line REBEL analyzer, which provides amino acid analysis in minutes. Rapid analysis minimizes the time between bioprocess development experiments, helping you optimize nutrient feeding and control toxic metabolite production.
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[post_date] => 2024-06-14 09:24:16
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Learn how XplorIR accurately identifies toxic gases that can give your air monitors false readings or inhibit accurate measurements.
Carbon monoxide (CO) electrochemical sensors, commonly used in 4 or 5-gas air monitors, can give inaccurate readings due to cross-sensitivity with other gases and vapors. Inexperienced operators may incorrectly assume that any CO reading indicates the presence of CO, which can be dangerous.. XplorIR® can complement CO sensors by identifying not only CO but also many of these cross-sensitive gases, improving the accuracy of readings and enhancing responder safety. This pairing ensures a more reliable assessment of hazardous environments.
For reconnaissance teams at hazardous materials incidents, responders typically use a combination of 4-gas monitors, PID sensors, gamma detectors, temperature guns, and colorimetric papers. However, these tools have limitations due to cross-sensitivity issues, leading to potentially inaccurate readings and less reliable risk assessments. The XplorIR® offers a significant improvement by providing real-time identification of gases and vapors, reducing the problem of false readings and enabling more accurate risk assessments. By incorporating XplorIR, responders can more quickly and safely determine the presence of specific hazards, such as Hydrogen Fluoride or Carbon Dioxide, making it an essential addition to standard reconnaissance toolbox.
[post_title] => Building Your Recon Toolbox
[post_excerpt] => Learn how the XplorIR is a logical addition to your set of recon tools.
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[post_name] => building-your-recon-toolbox
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[post_modified] => 2024-11-01 15:37:27
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[post_date] => 2024-06-14 09:24:17
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Photo Ionization Detectors (PIDs) are valuable tools for detecting a broad range of chemicals by measuring ionized gas samples with ultraviolet light. However, PIDs face limitations in accuracy due to their reliance on calibration standards and the need for gas-specific correction factors, which require knowing the identity of the gas. The XplorIR® addresses this challenge by providing real-time gas and vapor identification, enabling operators to apply the correct PID correction factors for more accurate readings and assess toxic risks based on specific contaminants. This advancement significantly enhances risk assessment and response efficiency, allowing for quicker and more accurate identification of hazards and sources, and making XplorIR a major improvement in emergency response technology since the introduction of the PID in the 1970s.
[post_title] => Expanding Your Toolbox: Pairing Your PID with FTIR
[post_excerpt] => Learn about PID entry methods and how continuous air monitoring with XplorIR can identify unknown gases in the hotzone.
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[post_name] => detect-and-identify-with-pid-and-ftir
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[post_modified] => 2024-11-01 15:42:34
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This app note discusses the challenges faced by emergency responders when dealing with mixed chemical products in the field. It highlights the limitations of existing chemical identification technologies and introduces our innovative approach with the XplorIR to identify up to 6 gas components within complex mixtures.
[post_title] => Breaking New Ground: Gas Mixture Analysis with XplorIR
[post_excerpt] => Learn how the XplorIR identifies mixed chemical products and overcomes current chemical detection challenges through its ability to identify up to 6 gas components within complex mixtures.
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[post_name] => breaking-new-ground-gas-mixture-analysis-with-xplorir
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[post_date] => 2024-06-10 09:36:50
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AA analysis is not regularly performed in CAR T-cell experiments due to the complexity and sample volume limitations of traditional methods, but the REBEL device enables rapid analysis, low sample volume requirements and without the need for prior mass spectrometry expertise. Learn how to optimize your cell culture media for enhanced CAR T-cell therapy manufacturing.
This study explores the relationship between CAR T-cell activation, nutrient metabolism, and treatment efficacy. It highlights differences in amino acid (AA) concentrations in spent media between potent CAR T-cell phenotypes and less-active, exhausted ones. By using novel multi-cytokine backpacks (MCBs) in cell culture, the research aims to enhance T-cell manufacturing, focusing on the metabolic profiles linked to different phenotypes. The analysis revealed that certain AAs, such as alanine and glycine, accumulated during culture while others, like arginine, were consumed, indicating active metabolic pathways. With automated quantitation and low sample volume requirements, REBEL facilitated efficient AA quantification, underscoring its potential for optimizing CAR T-cell culture media. Overall, the findings suggest that understanding AA dynamics could improve CAR T-cell therapies.
[post_title] => Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack-Manufactured CAR T-Cells
[post_excerpt] => With automated quantitation and low sample volume requirements, the REBEL device enables rapid AA analysis compared to the many complexities in traditional analysis methods.
[post_status] => publish
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[post_name] => amino-acid-analysis-indicates-metabolic-differences-in-multi-cytokine-backpack-manufactured-car-t-cells
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[post_modified] => 2024-11-03 17:08:26
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[post_date] => 2024-11-15 15:04:30
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ZipChip CE-MS was employed to assess mAb quality attributes directly from spent media, requiring only simple dilution without additional preparation. This technique facilitated daily monitoring of molecular weight, charge, and glycoform heterogeneity in mAbs produced in bioreactors with different glucose feeding strategies. Results showed improved product quality attributes from continuous glucose feeding compared to those produced with bolus glucose feeding, demonstrating ZipChip’s potential as a simple and effective tool for real-time monitoring of product quality in bioprocess development.
ZipChip CE-MS was used to analyze biosimilar mAb candidates, resolving charge variants and glycoforms with high sensitivity and short run times. This approach enabled rapid characterization of critical quality attributes, such as glycosylation and charge modifications, from early-stage cell line candidates. By providing detailed insights into post-translational modifications in a single assay, ZipChip facilitated efficient selection of mAbs closely matching the originator's quality profile, accelerating biosimilar development.
MAVERICK enables real-time monitoring of critical process parameters like glucose, lactate, and biomass in bioprocesses without the need for complex setups or prior modeling. Unlike traditional Raman spectroscopy methods that require extensive configuration and expert knowledge, MAVERICK offers a plug-and-play solution that can be implemented quickly and effectively across various cell lines and culture media. The system utilizes a de novo algorithm that works straight out of the box, measuring both static and dynamic parameters during bioprocess runs. Results from experiments with CHO and HEK293 cell cultures demonstrated that MAVERICK provides accurate readings that align closely with at-line measurements. The technology simplifies the monitoring process and helps ensure optimal cell culture conditions, enhancing overall product quality and yield. Overall, MAVERICK represents a significant advancement in in-line process analytical technology (PAT) for biomanufacturing.
[post_title] => Instant PAT Implementation with Raman-based MAVERICK
[post_excerpt] => Learn about instant PAT implementation, where MAVERICK was used to monitor critical process parameters to create measurement chemometric models.
[post_status] => publish
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[post_name] => instant-pat-implementation-with-raman-based-maverick
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[post_modified] => 2024-11-08 12:19:58
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[post_date] => 2024-02-09 11:43:11
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This document discusses the critical roles of glucose and lactate in bioprocessing, emphasizing the benefits of real-time monitoring using MAVEN. Traditional sampling methods limit process insight, but MAVEN allows for continuous measurement and control of these parameters, enhancing bioprocess characterization and management. The experiments demonstrated that a continuous glucose feeding strategy improves cell culture viability and product quality compared to daily bolus feeding. In particular, MAVEN prevented culture crashes and reduced high-mannose glycan levels in monoclonal antibodies, which can influence efficacy and stability. Overall, MAVEN facilitates more precise control and optimization of bioprocesses, leading to improved outcomes.
[post_title] => Continuous Monitoring and Control of Glucose and Lactate with MAVEN: Impact on Cell Culture Performance and Protein Quality
[post_excerpt] => Traditional sampling methods limit process insight, but MAVEN allows for continuous measurement and control of these parameters, enhancing bioprocess optimization.
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[post_name] => maven-monitoring-glucose-lactate-cell-culture-quality
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[post_title] => Real-time Monitoring of Key Bioprocess Parameters Using MAVERICK In-line Device in Culture Biosciences’ Cloud-connected Bioreactors
[post_excerpt] => Bioprocessing 4.0 aims to leverage advanced digital technologies, automation, and data-driven approaches to transform biopharmaceutical production. The data generated utilizing Culture Bioscience’s bioreactors, cloud-based controllers and software console together with MAVERICK, a novel Raman spectroscopy powered in-line PAT device, was found to track closely with off-line measurements for multiple critical process parameters. The use of PAT in bioreactors provides in-line, continuous data about cell culture conditions, thereby enhancing process understanding and enabling precise bioprocess monitoring and control.
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[post_name] => maverick-application-notes-and-snapshots-real-time-monitoring-of-key-bioprocess
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[post_title] => Microchip CE/MS Peptide Mapping Workflow with Trypsin Digestion for the Analysis of Critical Quality Attributes of Monoclonal Antibodies
[post_excerpt] => Peptide mapping is considered the gold standard for the analysis of biopharmaceuticals, including monoclonal antibodies.
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[post_name] => zipchip-appnote-ls-zc-an-0020
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[post_title] => Glucose Control
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.
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[post_name] => application-report-glucose-control
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[post_title] => Ethanol Dialysis
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of the Ethanol concentration in the fermenter.
[post_status] => publish
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[post_name] => trace-c2-application-report-ethanol
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[post_title] => Methanol Dialysis
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of the methanol concentration in the fermenter and provides the tools for a quick set-up of a feed control strategy
[post_status] => publish
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[post_title] => Glucose & Lactate (in Small Bioreactors)
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside small bioreactors.
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[post_title] => Glucose & Lactate
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.
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[post_title] => Why are Fentanyl and Fake Pills so Deadly
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[post_title] => Rapid characterization of oligonucleotides using microfluidic CE-MS by ZipChip
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[post_title] => Charge variant analysis with ZipChip and maXisII
[post_excerpt] => A ZipChip capillary zone electrophoresis system coupled to Bruker maXis II UHR-QTOF offers an alternative selectivity to separate charge variants prior to MS analysis and affords a more complete intact mass characterization without adding complexity or high salt eluents.
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[post_title] => Glucose and Lactate Raman-Based Monitoring with MAVERICK: Performance in Spent Media
[post_excerpt] => MAVERICK provides a plug-and-play, in-line, Raman based PAT solution for monitoring and control of glucose, lactate, and biomass in up to 6 bioreactors. This Application Snapshot shows the results from experiments to demonstrate the selectivity of glucose and lactate measurements from MAVERICK in complex spent media samples from CHO and HEK293 cultures.
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[post_title] => A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
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[post_title] => From comprehensive characterization to monitoring product degradation characteristics
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[post_name] => zipchip-native-charge-variant-analysis-of-biotherapeutics-using-zipchip-ce-esi-ms
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[post_title] => Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer
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[post_content] =>
[post_title] => High-Throughput Intact Mass Analysis of mAb Based Therapeutics
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[post_title] => RPMI 1640 Medium Analysis with the REBEL: Accuracy and Reproducibility Across Multiple Devices
[post_excerpt] => This extensive fresh media analysis experiment provides an example of the accuracy and reproducibility of the REBEL device obtained with RPMI media.
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[post_title] => Screening for Component Diversity in CHO Cell Culture Media
[post_excerpt] => At-line amino acid analysis can speeds up cell culture media and feeding strategy optimization for bioprocess development.
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[post_title] => High variations of analyte levels in Terrific broth (TB) media
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[post_title] => Application Snapshot Booklet Cell and Gene Therapy
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[post_content] =>
[post_title] => How comparable are different vendors' LB media?
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[post_title] => Investigating the high nutrient variations in Super Optimal Broth
[post_excerpt] => Cultures’ growth rates and productivities may differ when different vendor’s media are used in otherwise identical experiments.
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[post_title] => Probing formulation differences in Super Optimal Broth
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[post_title] => Analysis of Reduced mAbs and ADCs
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[post_title] => Similarities between different vendors’ 2X YT liquid media
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[post_title] => ZipChip for profiling and characterization of antibody charge heterogeneity
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[post_title] => Sciex Flexible Solution for MAM with ZipChip
[post_excerpt] =>
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[post_name] => zipchip_app-note_sciex-charge-variant-liability-analysis-using-the-sciex-flexible-solution-for-mam
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[post_title] => At-line spent media analysis is now a reality
[post_excerpt] => To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.
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[post_title] => Differences in fresh commercially available hybridoma media
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[post_name] => rebel_app-note_fresh-commercially-available-hybridoma-media
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[post_content] =>
[post_title] => Select the best CHO media from the start
[post_excerpt] => Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.
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[post_title] => Screening of chemically-defined media for suspension cultures of HEK293 cells
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[post_title] => Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip
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[post_date] => 2019-10-02 16:11:47
[post_date_gmt] => 2019-10-02 20:11:47
[post_content] =>
[post_title] => Analyze Media without Removing Your mAb on the Rebel
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => analyze-media-without-removing-your-mab-on-the-rebel
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[post_date] => 2019-08-08 17:24:30
[post_date_gmt] => 2019-08-08 21:24:30
[post_content] =>
[post_title] => Identify variations in dry and liquid CHO media
[post_excerpt] => Running a quick fresh media assay prior to feeding the culture ensures consistency of the media components when scaling up or during the transition between liquid-to-dry media blends.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => identify-variations-in-dry-and-liquid-cho-media
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[post_modified] => 2024-05-07 16:03:23
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[post_date] => 2020-06-16 19:57:47
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[post_title] => Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics
[post_excerpt] =>
[post_status] => publish
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[post_date] => 2019-10-02 16:17:00
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[post_content] =>
[post_title] => Serum supplemented media analysis is routine with the Rebel
[post_excerpt] =>
[post_status] => publish
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[post_name] => serum-supplemented-media-analysis-is-routine-with-the-rebel
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[post_date] => 2020-07-31 20:21:21
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[post_content] =>
[post_title] => Supplementing IMDM media with fetal bovine serum
[post_excerpt] =>
[post_status] => publish
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[ping_status] => closed
[post_password] =>
[post_name] => rebel_app-note_supplementing-imdm-media-with-different-amounts-of-fetal-bovine-serum
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[post_content] =>
[post_title] => Supplementing RPMI Media with Fetal Bovine Serum
[post_excerpt] =>
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[post_name] => rebel_app-note_supplementing-rpmi-media-with-different-amounts-of-fetal-bovine-serum
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[post_date] => 2020-07-31 20:12:38
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[post_content] =>
[post_title] => Conventional and chemically-defined T cell medias
[post_excerpt] =>
[post_status] => publish
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[post_name] => rebel-app-note-conventional-and-chemically-defined-t-cell-medias
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[post_title] => Amino acid contents of Sf9 and Sf21 insect cell media
[post_excerpt] => Knowledge of the insect cell metabolism coupled with an understanding of the amino acid content of the cell media allows for a more informed process development analytics strategy.
[post_status] => publish
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[post_title] => Comparing Mesenchymal Stem Cell Media with Supplements on the Rebel
[post_excerpt] => To ensure consistency when culturing MSCs, researchers should understand what is being added to their media.
[post_status] => publish
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[post_name] => rebel-applications-comparing-mesenchymal-stem-cell-media
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[post_content] =>
[post_title] => Don’t sweat your cell media additives
[post_excerpt] =>
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[post_title] => Handle Non-ionic Surfactants in Cell Media Samples with Ease
[post_excerpt] =>
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[post_title] => Basal Cell Media with 10% Fetal Bovine Serum
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[post_date] => 2024-08-14 10:27:13
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[post_content] =>
The XplorIR Quantification Package provides hazmat responders with the capability to not only identify thousands of gases and vapors, but also quantify them in real-time on scene. This represents the only device of it's kind which can accurately detect, identify, and quantify, thousands of gases in seconds. With this unmatched capability, responders are able to respond swiftly to assess atmospheric conditions and make rapid decisions on PPE selection, exposure potential, mitigation techniques, and influence tactical considerations.
In this flyer, learn how you can optimize the performance of your REBEL device with a preventive maintenance plan. There are various parts for the REBEL device and with routine maintenance, you can keep your device running efficiently with optimal analysis. We offer a few options for service plans to support your needs.
Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
1.REBEL Autosampler Sample Needle
Routine PM replacement and alignment of the autosampler needle will reduce chances of leaks, clogs, and potential missed injections during analysis.
2.REBEL Autosampler Sample Syringe
The autosampler syringe is responsible for all the fluidic movement and precise sampling within the REBEL. Over time the seals within the syringe can wear resulting in leaks and lowered analysis precision of fluidic transfer/sample loads.
3.REBEL Gas System Inlet Filter*
Annual PM replacement of the air inlet carbon and HEPA filters is to ensure optimal performance for the gas handling system in the REBEL. If not replaced the filters become less efficient and could result in poor analysis performance and contamination of more expensive components
*Access this on the back of the REBEL
4.REBEL Waste System Filter*
A particulate filter included in the waste system within the REBEL is to prevent material from entering the membranes of the waste pump. Routine replacement prevents clogging and decreased waste removal performance.
*Access underneath outer panels of the REBEL
5.REBEL MS Detector Inlet*
Detector Inlet is the entrance to the mass spectrometer of the REBEL device. Routine maintenance can reduce the chance of clogging, detection issues, and fouling. During PM, the performance of the vacuum system is evaluated along with alignment and detector performance.
*Access underneath outer panels of the REBEL
REBEL “STANDARD” SERVICE PM PLAN
REBEL PREMIUM SERVICE PLAN
Tech support (via email/phone)
Yes (Priority)
Yes (Highest priority)
Software updates (bug fixes)
Yes
Yes
Software upgrades (applicable features)
Yes
Yes
Replacement parts/repair labor
Yes
Yes
Preventative maintenance & IQ/OQ
Once per year
Once per year
On-site application support
Up to two visits included per year
Up to two visits included per year
Certified training
No
One free of charge* per year
Discount on single SMA kit purchase
No
7% through coverage period
Multi-year service plans
Yes
Yes
*For multi-year Premium plan, one free of charge Certified Training is on annual “use it or lose it” basis.
[post_title] => Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
[post_excerpt] => Learn how you can optimize the performance of REBEL with a preventive maintenance plan and see what is included.
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[1] => WP_Post Object
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[post_date] => 2024-07-09 13:02:58
[post_date_gmt] => 2024-07-09 17:02:58
[post_content] =>
Combining Terumo BCT's Quantum Flex platform with 908 Devices’ MAVEN will help cell therapy manufacturers reduce time-consuming manual steps that increase manufacturing costs and risks. It will also help advance the development of life-saving cell and gene therapies by providing insights into and control of one of the largest components of cell therapy development and manufacturing.
908 Devices MAVEN:
Automated monitoring of glucose and lactate on the Quantum Flex Cell Expansion System
Knowing what is happening inside your bioreactor is critical for cell expansion
Glucose and lactate concentrations can serve as leading indicators of the health and growth kinetics of your cells. When considered alongside perfusion rate, these metabolic indicators can help optimize media usage and harvest time. Quantum Flex paired with MAVEN from 908 Devices brings you continuous monitoring of glucose and lactate levels inside your bioreactor.
MAVEN integrates easily with Quantum Flex. The device clamps securely to the Quantum Flex bag pole, and a single-use diffusion flow cell is sterile-welded into the waste line of the Quantum Flex Cell Expansion Set.
Only the small glucose and lactate molecules from the bioreactor medium diffuse through a semi-permeable membrane inside the flow cell, moving into a transport buffer solution. The solution travels through the tubing to a biosensor inside MAVEN.
MAVEN analyzes the glucose and lactate concentrations. Results are available in near-real time and can be read on your computer using installed software.
Glucose measurement range: From 0.01 to 40 g/L concentration
Lactate measurement range: From 0.05 to 10 g/L concentration
Sensor operating life: 5,000 measurements or 30 days
[post_title] => Automated Monitoring on the Quantum Flex
[post_excerpt] => Learn how Terumo Blood and Cell Technologies' Quantum Flex cell expansion system and 908 Devices' MAVEN can work together to help your cells thrive and optimize your cell expansion process.
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This flyer describes the XplorIR's new identification with simultaneous quantification capability. The XplorIR can identify over 5,600 gases/vapors with extreme selectivity within seconds. With the new quantification package, the XplorIR can now quantify nearly 5,000 gases/vapors at parts-per-million (ppm) levels. This is done without any calibration required.
XplorIR Quantification Package
Simultaneously Identify and Quantify Hazardous Gases and Vapors
It’s one thing to know if a hazardous gas or vapor is present at an incident, and another to know what the product is. But what if you could also know how much of the hazard exists in the atmosphere? That requires quantification, and the XplorIR® now provides this critical piece of information.
The XplorIR, based on Fourier transform infrared (FTIR) spectroscopy, can identify over 5,600 gases/vapors with extreme selectivity within seconds. With the new quantification package, the XplorIR can now quantify nearly 5,000 gases/vapors at parts-per-million (ppm) levels. This is done without any calibration required.
FTIR measurements are inherently quantitative, and the spectral response is linear with respect to product concentration. Using a reference library based on known chemical concentrations, the XplorIR can determine the ppm of a product captured within its 2-meter gas cell and report that concentration along with the product identity.
Once the concentration is known, it can easily be compared to the Immediately Dangerous to Life and Health (ILDH) level of the product within the XplorIR software. This allows you to make rapid tactical decisions about remediation and decon with just a few button clicks.
Going further, the XplorIR uses a proprietary, automated process which combines molecular functional groups with measured spectra to estimate quantitative data for nearly all library entries. This extends the quantitative capabilities from a few hundred compounds to several thousand. With its ability to identify and quantify up to 6 mixture components at one time, the XplorIR is a game-changer for chemical response scenarios such as clandestine labs and other situations involving complex gas and vapor environments.
Key Attributes
The only handheld device for rapid trace detection and identification of pesticides at nanogram levels, in the field
Trace capability allows for exterior packaging sampling, reducing exposure risk
Provides actionable data at the point of need with results in less than a minute
Identify numerous pesticides by name to guide clean up efforts and keep personnel on site safe
Developed in partnership with the United States Forest Service (USFS)
Traditional first-entry meters only detect the presence of gases downrange, without accurately identifying their specific chemical compounds. During an explosion at a clandestine meth lab, learn how the XplorIR provides positive gas identification of over 5600 chemicals, even in complex gas mixtures.
It is 2:00 A.M. and your agency has just been dispatched to an explosion at a home in a heavily populated residential area
Once the resulting flames have been extinguished, your recon team performs an initial site assessment. While LEL readings are relatively low, CO and PID readings are extremely high. Neighbors complain of acrid odors and difficulty breathing. It seems you have just stepped into a clandestine meth lab, and you need answers… FAST!
Such incidents are far too common for first responders and mitigating them requires actionable intelligence on the myriad toxic gases and vapors filling the atmosphere. While multi-gas meters and PIDs play a critical role in these scenarios, such first entry devices don’t provide the gas and vapor identification capability required to tell the whole story. That’s where the XplorIR® comes in.
The hand-held XplorIR gas and vapor system can identify over 5,600 chemical products in seconds downrange
And with its sophisticated atmospheric compensation and mixture analysis algorithms, the XplorIR can report up to 6 compounds within the dirtiest of environments with minimal operator interaction. And when expert help is needed in the middle of the night, reach back scientists are on call to review the XplorIR data you upload to the cloud using the TeamLeader app on your smartphone.
Hazardous Chemicals
Chemical Warfare Agents
TICs
Nerve Agents
TOMs
Blister Agents
VOCs
Choking Agents
And many more toxic products
Whether a complex toxic gas release is nefarious or unintentional, the next time your agency is called to secure public and environmental safety, be prepared with the XplorIR. It will definitely save time, and it just might save lives.
[post_title] => XplorIR: Gas Identification for Rapid Response
[post_excerpt] => Learn how the XplorIR provides positive gas identification during an explosion at a clandestine meth lab.
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[post_name] => threat-brief-xplorir-mixture-analysis
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[post_date] => 2024-04-24 13:27:24
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[post_content] =>
Faster Bioprocess Data Visualization
Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers rich, time-course data visualization in less than a minute for run and sample comparisons. Download from our customer support portal and visit JMP.com.
REBEL
Sample comparison, and time-course data visualization from multiple samples, for all analytes, in an instant.
[post_title] => Faster Bioprocess Data Visualization
[post_excerpt] => Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers data visualization in less than a minute for run and sample comparisons.
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[post_name] => faster-bioprocess-data-visualization
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[post_modified] => 2024-08-14 16:26:04
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[post_date] => 2023-01-16 17:15:33
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[post_content] =>
NOW STARTS NOW
MAVEN
ON-LINE MONITORING AND REAL-TIME CONTROL OF GLUCOSE AND LACTATE
MEET MAVEN
OPTIMIZED, AUTOMIZED, DON’T-EVEN-SWEAT-IT GLUCOSE AND LACTATE CONTROL.
Monitoring and control of glucose and lactate concentrations during cell culture and fermentation are critical to achieve optimal process efficiency and productivity for effortless realization of PAT strategies. Real time insights into cellular metabolism are invaluable for media optimization and development of feeding and control strategies.
Detect and react to process changes in real time with on-line monitoring of glucose and lactate as often as every 2 minutes.
Develop advanced process control strategies and identify opportunities for process improvement with up to 720 glucose lactate data points per day.
Preserve precious bioreactor material and reduce process contamination risk with sample-free analysis based on the proprietary selective flow diffusion method.
Reliable and precise biosensor-based measurement technology ensures that optimal glucose concentration can be maintained, even at very low levels.
Reusable and single-use probes and flow cells make it easy to integrate MAVEN with most types and sizes of upstream systems in both the PD lab and GMP manufacturing.
Control the feeding pump directly with the integrated PID controller or easily connect with existing process automation systems via OPC UA, Analog or Serial outputs.
DESIGNED WITH FEATURES TO MAKE YOUR DAY
KNOW EXACTLY WHAT’S HAPPENING IN YOUR BIOREACTOR, MAINTAIN CONTROL OF YOUR PROCESS, AND KEEP YOUR CELLS HAPPY.
Unlike in manual or automated sampling, measurements are performed without any loss of bioreactor volume and without increased risk of process contamination.
Glucose and lactate molecules from the medium diffuse through the semi-permeable membrane into the transport buffer solution circulated between the probe and measuring cell.
HIGHLY PRECISE AND ROBUST BIOSENSORS
The biosensor’s enzymatic recognition and selectivity for glucose and lactate generates an electrical signal proportional to concentration of targeted analytes.
— Sensor type: Enzyme-based electrochemical biosensor — Glucose measurement range: From 0.01 to 40 g/L concentration
— Lactate measurement range: From 0.05 to 10 g/L concentration — Replaceable biosensor service life: 5,000 measurements or 30 days
BE A REBEL AND REAP THE REWARDS.
Combine REBEL’s at-line analysis of amino acids and vitamins with MAVEN’s on-line monitoring and control of glucose and lactate to get unambiguous answers where and when you need them.
HOW WILL YOU USE MAVEN?
MONITOR GLUCOSE AND LACTATE IN YOUR BIOREACTOR IN REAL-TIME. REFINE FEEDING STRATEGIES ON THE FLY.
MAVEN LOVES TO COLLABORATE
LIKE A GOOD LAB PARTNER, MAVEN EASILY INTEGRATES WITH YOUR EXISTING OR NEW UPSTREAM PROCESS DEVELOPMENT OR GMP MANUFACTURING SYSTEMS.
Compatible with Most Bioreactors and Fermenters
Automation Included
Advanced Connectivity
SUDDENLY, YOU'RE THE BOSS OF YOUR BIOREACTOR
Tight control of glucose-lactate concentrations enables development and implementation of dynamic feeding strategies to optimize cellular metabolisms leading to higher productivity and improved quality of biotherapeutics.
[post_title] => MAVEN Brochure
[post_excerpt] => MAVEN offers monitoring and control of glucose and lactate concentrations during cell culture and fermentation. Download this brochure to learn more.
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[post_date] => 2024-08-19 09:20:53
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[post_content] =>
With ongoing focus on the opioid crisis, synthetic opioids such a fentanyl have garnered much attention in the public eye. One emerging class of synthetic opioids, known as nitazenes, are increasing in appearance in the illicit drug market. Nitazenes can be 25 times more toxic than fentanyl and are often found in low concentrations mixed with substances or disguised as prescription pills.
While many bulk chemical detectors may have various nitazenes in their library, they are unlikely to identify these synthetic opioids in the field due to the low concentrations. The capability to identify these powerful synthetic opioids at trace levels (invisible to the eye/nanogram level) is more important than ever before to further investigations while keeping officers safe.
MX908 Advantages
Excellent target coverage of nitazenes and other synthetic opioids
Identification of mixed street drugs such as heroin, cocaine, meth, fentanyl, and nitazenes
Sampling of exterior packaging limits exposure risk to officers
No sample preparation, results in less than 60 seconds
Reachback services for data analysis by 908 Devices Forensic Chemists
“This tool (MX908) not only enhances the safety for our deputies but also significantly decreases the time between seizing a substance and confirming its identity. Our ability to act swiftly means a safer community and more efficient use of our resources.” -COUNTY SHERIFF AND MX908 CUSTOMER
The increasing size of the illegal marijuana market has given rise to an increasing number of trespass cannabis cultivation throughout the world. The heavy use of toxic pesticides by these illegal growers has had significant impact on the environment and wildlife. Many of these pesticides are so toxic, they are heavily restricted or even completely banned by many governments. In addition to the threat these pesticides pose to the environment, they also pose a great threat to responding law enforcement and agencies tasked with dismantling these operations.
With the addition of the pesticide capabilities, the MX908 provides critical identification of toxic pesticides in the field, allowing users to act immediately, while keeping themselves safe. Whether it be on site at an illegal marijuana grow, or at the border identifying smuggled pesticides, the MX908 provides accurate identification of pesticides at trace levels, in a handheld device, for the first time ever.
MX908 Advantages
The only handheld device for rapid trace detection and identification of pesticides at nanogram levels, in the field
Trace capability allows for exterior packaging sampling, reducing exposure risk
Provides actionable data at the point of need with results in less than a minute
Identify numerous pesticides by name to guide clean up efforts and keep personnel on site safe
Developed in partnership with the United States Forest Service (USFS)
Pesticide Targets
Aldicarb
Diazinon
Carbaryl
Imidacloprid
Carbofuran
Malathion
Chlorpyrifos
Methamidophos
A single drop of Carbofuran is enough to kill an adult human. Here a ~1 liter bottle is found at a trespass grow site.
Identifying containers and crop sprayers that have pesticides present reduce the cost of clean up and keep responders safe.
[post_title] => Identify Pesticides at Illegal Marijuana Grows
[post_excerpt] => With the addition of the pesticide capabilities, the MX908 provides critical identification of toxic pesticides in the field, allowing users to act immediately, while keeping themselves safe.
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[post_content] =>
Ensuring User Success with 908 Devices
REBEL Certified User Training
Get the best user experience with the REBEL at-line spent media analyzer. This training course is for new and experienced users who want to refresh their REBEL device operation skills.
The REBEL certified training includes:
Two day in-person instructor-led training at your facility for up to 3 people
Program highlights: REBEL introduction, sample handling and preparation, best practices for operating the REBEL, data handling and processing
Training materials: REBEL Spent Media Analysis consumable kit and extra materials used in the training program
[post_title] => REBEL Certified User Training
[post_excerpt] => Get the best user experience with the REBEL at-line spent media analyzer. Our training course is for new and experienced users who want to refresh their REBEL device
operation skills.
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Cool and Confident
The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
HASSLE-FREE PURCHASING AND SHIPPING OPTIONS
Choose the purchasing style that suits your lab:
One-time: Order one or more kits at full price for shipment.
Subscription: Order 6 or 12 kits at a time, shipped to you on a schedule you choose.
– Buy the 6-kit subscription, 5% discount
– Buy the 12-kit subscription, 10% discount
Thoughtful shipping: No matter how you buy, every kit ships overnight with proper packing to keep critical components chilled between 2-8° C at all times. Buy with a subscription to keep a steady stream of shipments flowing to your lab, without filling up valuable refrigerator space.
ABOUT THE KIT
Comprehensive package: Each kit includes BGE, diluent, a REBEL chip, standards, and microwell plates.
Packed for 200 runs: Make your buying decision based on kit consumption and your upcoming projects.
[post_title] => REBEL Spent Media Analysis Kits
[post_excerpt] => The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
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[post_content] =>
MX908 Remote App
Export Results, Add Custom Notes, and Access Support
DOWNLOAD THE APP
Get the MX908 Remote App on Google Play or the App Store
STEP 1
Pair the MX908 with a phone or tablet
STEP 2
Send reports, add custom notes and access support with the touch of a button
[post_title] => MX908 Remote App
[post_excerpt] => Download this flyer to learn more about the remote app now available for MX908. The MX908 remote app is available for download on Google Play or Apple App Store.
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[post_date] => 2022-03-25 11:24:22
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[post_content] =>
History of CWA Development & Use
The Evolution of CBRN Threats
Chemical warfare agents have evolved greatly over the last 100 years. Choking and blistering agents were the first to be developed and used broadly in combat. More recently, the development of 3rd and 4th generation agents as well as the use of Pharmaceutical-Based Agents have widely replaced them as the weapons of choice in modern conflict.
Modern Threat Detection
The Evolution of CBRN Technology
As CWAs evolved, detection technologies have evolved with them. Enabling warfighters to detect and identify evolving threats with greater accuracy, closer to the front lines.
Choosing a CWA detector that provides broad coverage of likely threats is critical for success. The MX908 is able to detect and identify 2nd, 3rd, and 4th Generation agents, as well as emerging Pharmaceutical Based Agents, and more. The MX908 provides operators with a tool that can change with emerging threats and evolve to meet future needs.
[post_title] => CBRN History Overview
[post_excerpt] => Chemical warfare agents have evolved greatly over the last 100 years, download this timeline flyer to learn more.
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Third-generation chemical warfare (CW) agents (binary G series and VX) were developed for their lethality, stability, and ease of weaponization. These have been the focus of CBRNE detection and protective equipment by US and NATO forces, which are well trained and equipped to counter these traditional CW agents.
Unfortunately, chemical warfare agents have continued to evolve. Russian developed fourth generation agents represent the latest evolution in the CW landscape. These A-Series Agents, also known as Novichoks, were employed in 2019 in Salisbury, UK in the attempted assassination of the Skripals, and, most recently, in 2020 in an assassination attempt of Russian opposition leader Alexei Navalny. Current global conflicts have increased the concern over use of chemical warfare agents.
Responding to A-Series CW Agents
A-Series agents, potent acetylcholinesterase inhibitors with signs and symptoms similar to traditional G- and V-Series nerve agents, were designed with specific knowledge of existing NATO detection and protective equipment, and ultimately, the goal of countering those detection and protection methods. They tend to be oily liquids which produce little to no vapors. They pose significant cross-contamination and exposure risks due to a combination of high potency and environmental persistence, and consequently a small release can rapidly become a large-area hazard. Due to their increased potency they often require higher antidote doses and can create additional vapor hazards when improperly decontaminated.
Traditional CBRNE detection equipment was designed to detect vapors which are characteristic of G-series and even VX agents, and have not yet evolved to detect or identify A-Series agents. This capability gap poses significant challenges to essential CBRNE tasks such as detection, determining limits of contamination, establishing control zones, selecting decontamination solutions, and verifying decontamination procedures to regenerate combat power in contaminated environments. The US Department of Health and Human Services issued emergency response guidelines for these agents in 2019, where they noted that, “There is a limited fielded capability within hazardous materials teams to detect, characterize, and identify FGAs.” These limitations are also true for traditional military forces.
Responding Pharmaceutical Based Agents
Synthetic opioids such as fentanyl pose a similar risk to nerve agents with their potency and potential lethality. These are often referred to as pharmaceutical based agents (PBAs). While not unique to Russia, these agents were first deliberately weaponized during the Moscow theater crisis where more than 100 people died from respiratory arrest after a PBA mixture was disseminated in aerosol form. Synthetic opioids are readily available through global illicit supply chains and are also synthesized by state actors. There are hundreds to thousands of potential PBA options, none of which are detected by traditional CBRNE detection technology during an aerosol dispersal event.
Aerosols are a fine suspension of liquids or solids in the air. They behave like gases yet are unable to be detected, much less identified, by fielded vapor detectors. This makes aerosolization an incredibly effective deployment method for CWAs and PBAs.
Detection Technology that can Detect and Identify A-Series Agents and PBAs
The MX908 handheld mass spectrometer is the only device able to detect and identify both A-Series Agents and PBAs at trace levels in solid, liquid, vapor, and aerosol forms. Easy to swap sampling modules enable the device to quickly switch from one sample type to another.
As a result, FGA and PBA hazards can now be detected on surfaces and in the air in under 60 seconds regardless of their mode of dissemination. Extensive third-party testing has shown detection efficiencies at or below the toxicologically relevant levels of most agents with a false negative rate of .6% when challenged with A-Series agents of varying purities on operationally relevant surfaces. Advanced software using predictive analytics further expands the detection capability of PBAs by increasing the effective library size to thousands of synthetic opioids.
The MX908 detects and identifies a broad range of priority drugs at trace levels in seconds.
The MX908 has the capability to detect and identify both A-Series Agents and PBAs in solid, liquid, vapor, and aerosol forms
[post_title] => Operational Impact of Fourth Generation Agents and Pharmaceutical Based Agents
[post_excerpt] => The MX908 handheld mass spectrometer is the only device able to detect and identify both A-Series Agents and PBAs at trace levels in solid, liquid, vapor, and aerosol forms.
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Real-Time Threats Real-Time Detection
MX908
MX908 is a multi-mission, handheld mass spectrometer utilized by elite responders conducting chemical, explosive, priority drug, and hazmat operations around the world.
MX908: A CRITICAL TOOL IN THE RESPONDER TOOLKIT
MX908® detects compounds at trace levels and combines unparalleled sensitivity and selectivity, providing users with confident results and actionable intelligence other handheld technologies cannot. The power of high-pressure mass spectrometry™ (HPMS) accurately discriminates priority threats from the broad range of interferents that lead to false alarms with other commonly used technologies.
DETECT AND IDENTIFY CHEMICALS IN ANY PHASE
With the MX908, one device can analyze any sample you encounter regardless of size or phase of matter. This flexibility combined with the MX908 expanding target list ensures that responders have a device that can evolve with new and emerging threats.
MULTI-MODE THREAT DETECTION
MX908 EXCELS WITH SAMPLES ACROSS THE LANDSCAPE
MX908 EXCELS WITH A BROAD RANGE OF SAMPLES AND CONCENTRATIONS
The MX908 is powered by high-pressure mass spectrometry (HPMS) technology, which enables responders to detect and identify chemical hazards from bulk to true trace concentrations. MX908 is up to 1 million times more sensitive than commonly used Raman and FT-IR technologies. Depend on high-fidelity trace and bulk identification, for point detection or remote area monitoring, all with one device
YOUR MISSION DEFINES YOUR MODE
Based on your specific mission objectives, choose an MX908 Mission Mode that leverages specialized software and hardware configurations to optimize performance for hunting certain chemical classes.
DRUG HUNTER
Methamphetamine
Cocaine
Fentanyl and 2000+ Fentanyl Analogs
Heroin
Cannabinoids
Cathinones
And More…
Identify narcotics in low concentration mixtures (well below 5%)
Establish trace chemical evidence linkages for interdiction, checkpoint operations, and more
Improve officer safety with limited exposure risk
Fentanyl Classifier provides coverage for 2000+ fentanyl analogs
Add case information with the MX908 remote application
CW HUNTER
Novichoks or A-series Agents
Legacy Warfare Agents (G, V, and H-series)
Pharmaceutical Based Agents (including fentanyl, carfentanil, and remifentanil)
Only field deployable detector for trace identification of Novichoks
Only field deployable detector for identification of aerosolized threats
Quantify chemical warfare agents in real time
Identifying Novichoks and other CWAs by name is essential for decontamination and medical response
Allow for broad threat coverage in any state with a single device
Remote area monitoring with MX908 Beacon
EXPLOSIVE HUNTER
Homemade Explosives
Military Explosives
Commercial Explosives
Precursors
Identify trace explosive residues
Identify explosives by name to guide response
Analyze samples safely with no threat of igniting sensitive materials
Identify aerosolized chemical threats dispersed from IEDs and other munitions
Establish trace chemical evidence linkages for checkpoint operations, HME lab response, and more
Our ZipChip CVA kit takes the guesswork out of method development. Characterizing your samples with ZipChip capillary electrophoresis coupled to your high-resolution MS, you're able to assess charge heterogeneity, identify basic and acidic variants, acquire accurate mass information, and profile glycoforms, all in a single analysis.
Get more data and streamline your Charge Variant Analysis workflow with ZipChip CVA kit
Easy sample prep and rapid analysis
Little-to-no method development
High performance analysis with full charge variant separation and peak identification
Comparable profiles to commonly used CVA techniques with the added power of mass spec characterization
Dilute Sample and Prepare BGE
Load Sample into ZipChip
Run the CVA on ZipChip-MS
Get straight to it.
Our preconfigured ZipChip CVA kit takes the guesswork out of method development.
SEAMLESS WORKFLOW
ZipChip-MS peak profile is comparable to Capillary Isoelectric Focusing (CiEF), Cation Exchange Chromatography (CEX), and Capillary Zone Electrophoresis (CZE-UV) and delivers seamless workflow for identification of detected unknown variant peaks.
STREAMLINED DESIGN
Analyze multiple biotherapeutic protein CQAs in a single assay - gain the ability to clearly separate and identify acidic and basic species and assess the glycosylation profile.
OPTIMIZED FOR YOU
Characterize a variety of monoclonal antibodies (mAbs) and other biotherapeutic proteins with the ZipChip CVA kit without having to reoptimize your method.
ZipChip CVA Consumables
ZipChip CVA consumables provide everything you need for analysis with no method development and minimal sample prep.
Name
Contents
Sample per kit
Part No.
CVA Assay Kit
CVA Background Electrolyte (BGE), Diluent, and Additive
From complex biologics to small molecules, ZipChip has an assay kit for you.
Take the Guesswork Out of Method Development
3 Easy Steps to Selection
1. Application
2. Chip
3. Kit
Assay kits come with background electrolyte and sample diluent that’s optimized for each application. Just put the bottle of background electrolyte in the autosampler, prep your samples with the sample diluent and you’re off.
1. The Application
From large to small molecule, ZipChip’s got you covered.
Protein Characterization: ZipChip is a one-stop shop for CQA’s—from charge variant analysis to peptide mapping. You’ll get high-resolution separation coupled to MS with simple, streamlined workflows.
Metabolomics: Quickly analyze small polar analytes from a variety of matrices, or monitor dynamic levels of metabolites in real time. Sample prep is quick and easy and results are ready in minutes.
Oligonucleotides: The characterization of nucleic acid-based drugs like oligonucleotides isn’t easy. ZipChip can offer some advantage over LC separations, particularly variations due to charge or shape.
Small Molecules: Analysis is easy and fast with ZipChip. Simply dilute and shoot; there’s no labeling or derivatization. Small polar analyte assays take as little as 2 minutes. Add internal standards for full quantitation on a variety of analytes.
2. The Chips
Choose from a range of chip options to optimize your workflow. Each chip can be used up to 125 injections.
HS: High Speed chip enables fastest separations. Matching BGE kits: Intact Antibody, Peptides, or Metabolites.
HR: High Resolution chip for applications demanding maximum separation capacities. Matching BGE kits: Intact Antibody, Peptides, or Metabolites.
HSN: High Speed chip for fast native protein analysis. Matching BGE kits: Native Antibodies or Charge Variant Analysis.
HRN: High Resolution chip with ultimate separation for native protein analysis. Matching BGE kits: Native Antibodies, or Charge Variant Analysis.
HSB: High Speed Bare Glass chip for high throughput separations. For example: fast oligonucleotides analysis. Matching BGE kit example: Oligos BGE.
HRB: High Resolution Bare Glass chip for high resolution separation of negatively charged analytes such as oligonucleotides. Matching BGE kit example: Oligos BGE.
3. BGE Kits
Background electrolyte (BGE) and sample diluent reduce preparation time for your samples. With ZipChip you just dilute and shoot!
Charge Variant Analysis: Formulated to provide excellent charge variant separations and MS sensitivity for antibodies and other proteins on all mass spectrometers.
Native Antibodies: Excellent charge variant separation of antibodies and other constructs to generate native spectra.
Peptides: Fast, efficient separations of protein digests and peptides utilizing low pH.
Metabolites: Streamlined sample prep and high-speed analysis for small molecules in denaturing conditions at low pH.
Oligonucleotides: Rapid analysis of oligonucleotides without the use of ion-pairing agents.
Ordering Information
ZipChip Assay Kits*
Part Number
Samples Per Kit
Charge Variant Analysis Kit
850-00052
625
Native Antibody Assay
850-00048
625
Metabolites Assat
850-00033
625
Peptide Assay
850-00034
625
Oligos Assay
850-00066
625
Oligos Starter
850-00067
250 Tests
*All kits contain BGE and diluent, and chips need to be ordered separately. The exception is the oligos starter kit which contains BGE, Diluent, chips and a standard.
Chips
Part Number
Chips Per Box
Injections Per Chip
HS
810-00195
5
125
HR
810-00194
5
125
HSN
810-00230
5
125
HRN
810-00227
5
125
HSB
810-00237
5
125
HRB
810-00239
5
125
[post_title] => ZipChip Consumables Guide
[post_excerpt] => Learn how to take the guesswork out of method development with ZipChip. Breeze through your selection in three quick steps.
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HASSLE FREE
Oligo characterization with ZipChip
The newly released ZipChip® oligos kit provides a simple, sensitive, dilute-and-shoot method for rapid analysis of oligonucleotides, applicable to various sizes and modifications.
Benefits:
High-resolution accurate mass identification and quantitation with CE-MS
No ion-pairing agents; no instrument contamination
Orthogonal to LC-based separation
Analysis in minutes with simple sample prep
Part Name
Contents
Samples per kit
Part No.
ZipChip Oligos Starter Kit
Oligos Background electrolyte (BGE) x 2 Diluent x 2 HRB Chip x 2 Oligo standard
250
850-00067
ZipChip Oligos Kit
Oligos BGE x 5 Diluent x 5
625
850-00066
HSB Chip
High Speed Bare Glass Chip (HSB) x 5
625
810-00237
HRB Chip
High Resolution Bare Glass Chip (HRB) x 5
625
810-00239
ZipChip Oligos Standard
20 mer DNA Primer
-
445-02281
Rapid Characterization of Oligos
Separation of Modified ssRNAs
Electropherogram showing separation of biotinylated, glycosylated and phosphorylated 20 mers from the corresponding unmodified 20 mer RNA standard
Rapid characterization of ssRNA with no method development
Base Peak Electropherogram for 20mer unmodified ssRNA standards (left) along with the raw mass spectrum (right).
RAMAN-BASED MONITORING OF MULTIPLE CRITICAL PARAMETERS, READY TO GO IN MINUTES.
MEET MAVERICK
THE ONLY PLUG-AND-PLAY, READY IN MINUTES, IN-LINE MULTIPARAMETER PAT PLATFORM
MAVERICK is powered by Raman spectroscopy and purpose-built de novo model for simultaneous real-time measurements of multiple key process parameters in mammalian cell cultures without the costs, complexities, and risks of conventional methods. There’s no need to deal with complex empirical calibration models, reagents, or unreliable auto-sampling systems to implement in-line bioreactor monitoring.
It’s all in-line gain, with no modeling pain.
Monitoring of multiple bioprocess parameters right out of the box.
Walk-away automation with integrated analog and digital feed controllers and optional secure remote monitoring.
Parallel and continuous monitoring of up to six bioreactors from a single hub.
Analog and OPC UA communication options for plug-and-play integration with automation and data acquisition systems.
Straightforward validation process and CFR 21 part 11 compliance-ready software enable seamless method tech transfer
MAVERICK’s de novo model will continue to evolve, with additional process parameters that can be added through software upgrades
INSTANT INSIGHTS WITH DE NOVO MODEL
QUANTIFICATION OF GLUCOSE, LACTATE AND TOTAL BIOMASS IN CELL CULTURE WITHOUT “BLACK BOX” EMPIRICAL RAMAN CALIBRATION MODELS
Raman spectrum is collected from the bioreactor
Spectrum analyzed and interpreted in real-time by de novo model
Process parameters are quantified and displayed automatically
A SIX BIOREACTOR MULTIPLEX FLEX
EASILY MONITOR AND CONTROL UP TO SIX BIOREACTORS SIMULTANEOUSLY
Control feeding pumps directly or send the measured parameters to an existing automation system
Securely monitor your bioprocess from anywhere with optional remote monitoring via a web browser
INSTANTLY ENHANCE UNDERSTANDING AND CONTROL OF YOUR BIOPROCESS
MEASURE AND CONTROL GLUCOSE CONCENTRATION
Dynamic control of feeding, enabled by real-time glucose measurements, helps optimize cell growth and productivity while minimizing accumulation of toxic metabolites and ensuring product quality
MONITOR LACTATE CONCENTRATION
Continuously monitoring lactate concentration is crucial to prevent potentially toxic effects that can compromise productivity and product quality
TRACK TOTAL BIOMASS
Tracking the biomass trend over the cell culture duration provides valuable insights on cell growth for process optimization and detection of deviations
TAKE IT OUT OF THE BOX AND YOU'RE HALFWAY DONE WITH THE SETUP PROCESS
BIOPROCESS INSIGHTS AT YOUR FINGERTIPS
Take your understanding of bioprocess to the next level by combining real time process insights offered by MAVERICK and at line spent media analysis provided by REBEL.
EVERYTHING YOU NEED TO GET STARTED
OPTICAL IMMERSION PROBE
— Autoclavable probe compatible with standard bioreactor ports
— Automatic probe identification and compliance traceability
— Magnetic probe coupling ensures secure attachment and proper alignment
— No optical isolation of bioreactor required
MEASUREMENT MODULE
— Autonomous operation — Optional direct control of feed pumps — Compact footprint — Electrical interrupt switch for enhanced operator safety
HUB
— Simultaneous control of up to six measurement modules
— Data transfer over Ethernet or OPC UA
High-resolution, color touchscreen interface supports:
— User authentication
— System configuration and operation
— Guided calibration of immersion probes
— Viewing system status, monitoring of real-time measurements and trends
SOFTWARE
— CFR 21 part 11 compliance ready
— Optional remote monitoring from any web browser
— Access to Raman spectral data
CALIBRATION KITS AND ACCESSORIES
— Two-point probe calibration standards
— Probe stand for convenient calibration and probe storage on the bench
[post_title] => MAVERICK Brochure
[post_excerpt] => Real-time bioprocess monitoring and control, right out of the box. In-line measurements of multiple critical parameters across media, across processes, across mammalian cell lines, across scales.
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ZipChip leverages microfluidic-based Capillary Electrophoresis (CE) and electrospray ionization technology to simplify sample preparation, perform high-resolution separations with reduced analysis times, and directly introduce samples into a Thermo Fisher Scientific, Bruker, or Sciex mass spectrometer. Achieve faster results with the ZipChip CE-MS device.
CE-MS DEVICE
ZipChip
ACCELERATE YOUR MS CHARACTERIZATION
Rapid protein characterization and metabolomic analysis with microfluidic technology for highly efficient separations of complex samples.
BIOLOGICAL CHARACTERIZATION
IN MINUTES
GIVE YOUR MASS SPEC SOME ZIP
The ZipChip® platform prepares and separates a wide range of biological samples, then electrosprays them into your mass spec for analysis. Just clip it on. The process takes as little as a few minutes, and it results in better separation quality than most LCs in a fraction of the time. Simple workflows and multiple kit options cover a host of biotherapeutic, metabolomic, and proteomic applications.
EASY ON SAMPLES
Now the kicker. ZipChip plays well with your mass spec and your proteins. Gentle sample prep reagents preserve structural integrity without denaturing or unfolding proteins for fully native mass spectra. No need to remove detergents or desalt. Negative and neutrals are trashed. Only positive analytes head out for cleaner mass spectra and more identified peaks.
EFFICIENCY WITH ADVANCED
MICROCHIP TECHNOLOGY
WITH ZIPCHIP YOU GET THE DATA FASTER, AND BECAUSE OF THAT YOU CAN MAKE QUICK DECISIONS
Associate scientist at Amgen
Easy as 1-2-3
Pick an application, a chip, and a kit. After simply loading the premixed background electrolyte and sample into the autosampler, pop in a ZipChip, and hit run. Use vials or 96-well plates.
It’s hands-off from there. Smart chips tell the system which method to use based on your preferences. Samples are automatically loaded, separated, and electrosprayed. Integrated software cues the mass spec to start analysis.
Efficient Separations
Microfluidic technology integrates capillary electrophoresis (CE) and electrospray ionization (ESI) on the ZipChip. Junctions and dead volumes don’t exist so analytical quality stays high, and no injection bias improves repeatability.
1. Pick your application, kit, and chip
2. Simple sample prep
3. Load reagent and chip, then run
IT'S ALL IN THE CHIP
FROM LARGE TO SMALL MOLECULES,
ZIPCHIP’S GOT YOU COVERED
Protein Characterization:
ZipChip is a one-stop shop for CQAs—with streamlined CE MS workflows for Charge Variant Analysis of basic and acidic species, Rapid Intact Mass Analysis, Subunit Analysis, and Peptide Mapping for deeper characterization.
Oligonucleotides:
The characterization of nucleic acid-based drugs like oligonucleotides isn’t easy. ZipChip can offer some advantage over LC separations, such as no ion-pairing agents to contaminate the instrument
Small Molecules
Analysis is easy and fast with ZipChip. Simply dilute and shoot; there’s no labeling or derivatization. Small polar analyte assays take as little as 2 minutes. Add internal standards for full quantitation on a variety of analytes.
Metabolomics:
Detect, identify and quantitate small polar analytes from a variety of matrices like cell lysates or growth media and monitor dynamic levels of metabolites in real time. Sample prep is quick and easy and results are ready in minutes.
Chemical Warfare Agents (CWAs) continue to evolve from Chlorine gas in World War I to G-series agents in the 1930s and novel agents used in the UK in 2018. Technology must evolve with these threats to ensure responders can quickly and safely act to protect the public. MX908 has expanded its CW Hunter Mode to include A-series agents, also known as Fourth Generation Agents (FGAs) or Novichoks.
Developed to avoid existing detection technologies, Novichok agents are more persistent than other nerve agents and at least as toxic as VX; some estimate as high as 8 times as toxic. There is a significant risk of cross contamination, so secondary exposures can be just as deadly and difficult to identify. Potential delayed onset of symptoms makes early detection even more critical to minimize casualties, limit the spread of contamination, and conduct appropriate decontamination.
MX908 ADVANTAGES
The only field-deployable tool for rapid trace detection and identification of A-230, A-232 and A-234 at low nanogram levels
Includes a wide range of other CWAs including GA, GB, GD, GF, HD, VX and additional V-series agents (VE, VM, VLX, VS, RVX/CVX and VX acid)
Results in 60 seconds to expedite response and increase public and responder safety
Independently tested by MRI Global; results available on request
CW HUNTER MODE:
NOVICHOKS
For more information: Fourth Generation Agents: Reference Guide, January 2019 This new fourth generation agent guidance from CHEMM makes clear the need for trace detection tools that are adaptable, reliable and ready. https://apps.dtic.mil/sti/citations/AD1066891
Source: Chemical Hazards Emergency Medical Management (CHEMM), U.S. Department of Health and Human Service
In upstream bioprocessing, cell culture media development is a key area of focus, and monitoring of the media all the way through manufacturing is critical. Understanding the relationship between cell culture media components and the cells they support can ultimately impact the process Key Performance Indicators (KPIs) and Critical Quality Attributes (CQAs). Analysis of key media components such as amino acids, vitamins, and the metabolites produced as a result of cell growth is beneficial at all stages of process development, including
cell line development, media QC, and media development. This information provides insight not just on media composition and performance, but also on clone selection, feed strategy, optimal harvest time, product quality, and more. The need for more process intensification and process modeling requires frequent real time data that can easily be used for deeper monitoring and control.
Ultimately, having greater insight offers more opportunities to positively impact CQAs and KPIs to create products faster, more cost effectively, and with greater therapeutic success.
GETTING RESULTS ISN'T ALWAYS EASY
Process development groups don’t always have the analytical tools or resources to gain in-depth process understanding. Sending samples to on-site or off-site core labs can take days to weeks and can be costly.
MEET THE
REBEL
The REBEL is a novel, dedicated cell culture media analyzer designed for rapid, easy, and efficient amino acid and nutrient analysis. Combining award winning design with 908 Devices proven capillary electrophoresis and high-pressure mass spectrometry technologies, the REBEL provides process development scientists access to critical data at-line, any time.
ANALYSIS IN 4 EASY STEPS
PULL A SAMPLE
Pull a sample from your bioreactor, shake flask, or well plate. The REBEL only needs 10µL.
SPIN & DILUTE
Spin out your cells and dilute. That’s as complicated as it gets.
LOAD YOUR SAMPLES
Load your samples, reagents, and calibrants.
GENERATE RESULTS
Hit start, get results. Results can quickly be reviewed in a simple report.
REBEL
BENEFITS
EASY TO OPERATE
Designed for simplicity.
MINIMAL SAMPLE PREPARATION
Pull a sample from your bioreactor, shake flask or well plate, then spin out your cells and dilute.
NO MORE WAITING FOR RESULTS
Fully processed at line report for 30+ components in under 10 minutes.
DATA INTEGRATION
For easy data alignment and interpretation with third-party platforms.
A COMPREHENSIVE PANEL TO MEET YOUR NEEDS
THE REBEL SCREENS FOR OVER 30 ANALYTES IN EVERY RUN, ALL IN UNDER 10 MINUTES
AMINO ACIDS
Alanine
Alanyl-Glutamine
Arginine
Asparagine
Aspartic Acid
Cystine
Glutamic Acid
Glutamine
Glycine
Histidine
Isoleucine
Leucine
Lysine
Methionine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Serine
Threonine
Tryptophan
Tyrosine
Valine
VITAMINS
Choline
Nicotinamide
Pyridoxal
Pyridoxine
Thiamine
AMINES
β-Alanine
Citrulline
GABA
Hydroxyproline
Methyl-Histidine
Sarcosine
KNOW WHAT'S IN YOUR MEDIA
Understanding which key nutrients are present in your cell culture media is critical to media screening and optimization efforts. In this experiment, nine commercial CHO media were measured using the REBEL in a media screening evaluation (Figure 1). The amino acid profile reveals high diversity in nutrient composition across the media panel. With the REBEL you can measure key nutrients such as amino acids in both fresh and spent media at-line in real time to gain deeper insight into your process and obtain high titer faster.
CHO MEDIA SCREENING
Analyzed using a simple 100x dilution with 20 replicates.
Figure 1. Diversity of nutrient composition in a panel of chemically defined CHO media.
REBEL measures over 30 analytes including all amino acids, certain vitamins, and bio amines. Plotted here are a subset of amino acids including all essential ones and others in 9 different CHO media. This comparison shows that the concentration of several amino acids such as serine and arginine, two potentially important amino acids for cell growth and protein production, varies widely between the media tested here while other amino acids are more consistent between media.
COMPACT WITHOUT COMPROMISE
The REBEL delivers high method accuracy and reproducibility, ensuring confidence in results. In a spiking experiment, 17 analytes with known concentrations were added into a chemically defined medium and measured using the REBEL. Values obtained with REBEL showed high accuracy (values were within +/- 20% of expected values) and high analytical precision (%RSDs were between 7 to 16%) as demonstrated in Figure 2.
AMINCO ACID RECOVERY IN CHO MEDIUM
Figure 2. Recovery of analyte concentration using the REBEL analyzer. 17 analytes (Sigma AAS18 amino acid standard) were spiked at 1mM and cystine at 0.5mM, into a commercial chemically defined medium in triplicate and measured four times on the REBEL (total of 12 replicates). All analytes were between 93 –118% of expected values.
HOW WILL YOU USE
REBEL?
MONITOR AMINO ACIDS AND VITAMINS THROUGHOUT YOUR BIOREACTOR TIME COURSE. REFINE FEEDING STRATEGIES ON THE FLY. CORRELATE MEDIA SELECTION TO PRODUCT QUALITY AND YIELD.
Expanded Capability for Toxic Aerosol Detection and Identification
The MX908® Aero enables operators to detect and identify aerosolized threats—such as Chemical Warfare Agents (CWAs) and Pharmaceutical-based Agents (PBAs) —which represent a critical gap in existing trace chemical detection solutions.
An aerosol is a suspension of fine solid or liquid particles which maintain the physical properties of their solid or liquid state but behave like a vapor. This combination of physical state and vapor-like behavior make traditional vapor detectors ineffective against aerosol threats. The Aero leverages proven MX908 sampling technologies and analysis mechanics to address this unique threat.
MX908 ADVANTAGES
The only field-deployable tool available now for rapid trace detection and identification of aerosol threats.
Simultaneous monitoring, detection, and identification of both vapor and aerosol threats.
Flexible sampling modules for easy transition from trace solid and liquid sampling to vapor and aerosol sampling.
Optional accessory can be quickly deployed to fielded units or be purchased with new MX908 devices.
Target Group
Targets
A-series agents (Novichoks)
A-230, A-232, A-234
V-series agents
VE, VM, VS, VX, VX Acid RVX/CVX
G-series agents
GA, GB, GD, GF
Blister agents
HD
Fast-acting incapacitating agents
Fentanyl and analogs (2000+), U-series, AH-7921
Lachrymatory agents
Capsaicin
AERO
The MX908 Aero can detect aerosol particulates dispersed from an explosive device.
An operator using the MX908 can conduct post-blast analysis on-site with the Aero.
MX908 with Drug Hunter Mode future-proofs the device against the ever-changing fentanyl landscape. Novel predictive classification algorithms enable alerts in minutes to previously undetectable threats, setting the MX908 apart from library-based tools.
MX908 ADVANTAGES
Identification of most drugs of abuse
Detection of 2,000+ novel fentanyl analogs
No library updates required
Detection of trace fentanyls within bulk cutting agents (street cut drugs)
Immunity to benign cutting agents such as lactose
Simultaneous identification of mixed street drugs such as heroin, cocaine or methamphetamine with trace fentanyls
Exterior package sampling limits exposure risk
Results in 60 seconds to expedite mitigation or prosecution
No sample prep required for heroin
Electronic records preserve data integrity
“We have been using the MX908 for the past few months and it has already proven to be a tremendous asset in the field for maintaining Officer safety while being able to detect trace elements of multiple drugs in as short as 20-30 seconds.”
Patrick Glynn, Lieutenant Det., Commander, Quincy, MA PD
DRUG HUNTER MODE:
FENTANYL
Minimize exposure risk with exterior package sampling.
MX908’s predictive classification algorithms can recognize the molecular structure of more than 2000 previously undetectable fentanyl analogs.
In this flyer, learn how you can optimize the performance of your REBEL device with a preventive maintenance plan. There are various parts for the REBEL device and with routine maintenance, you can keep your device running efficiently with optimal analysis. We offer a few options for service plans to support your needs.
Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
1.REBEL Autosampler Sample Needle
Routine PM replacement and alignment of the autosampler needle will reduce chances of leaks, clogs, and potential missed injections during analysis.
2.REBEL Autosampler Sample Syringe
The autosampler syringe is responsible for all the fluidic movement and precise sampling within the REBEL. Over time the seals within the syringe can wear resulting in leaks and lowered analysis precision of fluidic transfer/sample loads.
3.REBEL Gas System Inlet Filter*
Annual PM replacement of the air inlet carbon and HEPA filters is to ensure optimal performance for the gas handling system in the REBEL. If not replaced the filters become less efficient and could result in poor analysis performance and contamination of more expensive components
*Access this on the back of the REBEL
4.REBEL Waste System Filter*
A particulate filter included in the waste system within the REBEL is to prevent material from entering the membranes of the waste pump. Routine replacement prevents clogging and decreased waste removal performance.
*Access underneath outer panels of the REBEL
5.REBEL MS Detector Inlet*
Detector Inlet is the entrance to the mass spectrometer of the REBEL device. Routine maintenance can reduce the chance of clogging, detection issues, and fouling. During PM, the performance of the vacuum system is evaluated along with alignment and detector performance.
*Access underneath outer panels of the REBEL
REBEL “STANDARD” SERVICE PM PLAN
REBEL PREMIUM SERVICE PLAN
Tech support (via email/phone)
Yes (Priority)
Yes (Highest priority)
Software updates (bug fixes)
Yes
Yes
Software upgrades (applicable features)
Yes
Yes
Replacement parts/repair labor
Yes
Yes
Preventative maintenance & IQ/OQ
Once per year
Once per year
On-site application support
Up to two visits included per year
Up to two visits included per year
Certified training
No
One free of charge* per year
Discount on single SMA kit purchase
No
7% through coverage period
Multi-year service plans
Yes
Yes
*For multi-year Premium plan, one free of charge Certified Training is on annual “use it or lose it” basis.
Lithium-ion batteries are prevalent in our society and used in everything from electric vehicles to personal devices. Disposal of used batteries represents a challenge, as even old or partially charged devices present deflagration hazards if exposed to heat, puncture, or other forms of perturbation. A method for decommissioning Li-ion batteries is to immerse them in a brine solution, which ostensibly de-energizes the electrical cells such that the batteries can be transported and discarded safely. However, this process is not trivial for remediation personnel as it results in the liberation of numerous gases that are highly toxic and flammable. As such, having a means to detect and identify these gases and to determine when they are no longer present is crucial to the decommissioning process.
In a recent case study, an agency was contracted to decommission numerous types of batteries including Li-ion cells and other electrical components that had been damaged in a large- scale fire event. The agency planned to deploy the brine solution method but was also interested in testing its efficacy and learning what gaseous components may be generated. Batteries were soaked in 55-gallon drums and smaller containers, and gaseous samples were extracted from headspaces using Tedlar bags. Initial air monitoring of the headspaces yielded some interesting and unexpected results, which prompted the need for additional gas identification.
The agency’s approach was to use ThreatID™, a portable analyzer for identifying powders, liquids, gas, vapors, and complex mixtures based on Fourier transform infrared (FTIR) technology.
The remnants of an exploded li-ion battery. Source: PETER PEREIRA/The Standard-Times
The ThreatID can identify over 27,600 hazardous chemicals, including over 5,600 gases at low parts-per-million (ppm) levels, in less than 1 minute. A certified instructor was on-site for the endeavor to conduct the measurements and report results back to technical experts. From the headspace sampling, the ThreatID primarily identified methane and ammonia.
Reachback personnel confirmed the results and even identified some very minute components through detailed spectral data review. These additional materials included acetylene, formaldehyde, ethene, and even some unidentifiable substances. The ThreatID gas-phase results were confirmed on-site using colorimetric tubes which detected methane, ammonia, and formaldehyde.
Interestingly, the presence of ammonia and volatile organic compounds (VOCs) was not expected based on initial supposition and readings from basic air monitors. Headspace analyses showed that even after the batteries were deemed “safe,” toxic and flammable materials continued to off-gas. The study proved that after a fire or other disastrous event when batteries are inactive, they may still pose significant hazards and must be properly monitored. By rapidly identifying the liberating gases and using secondary technologies to confirm them, the correct hazard associations can be made and greatly accelerate the time scale of future decommissioning projects.
This event was a success by demonstrating that the brine solution method must be further optimized to fully decommission Li-ion and other battery types to render them safe for transport and disposal. Without FTIR gas identification, the clean-up effort would have been plagued with uncertainties and require significantly more time to properly remediate the lurking potential hazards.
Reachback Spectral Interpretation for sample CNB018a, matching Methane.
Hundreds of ThreatIDs have been deployed by the U.S. Postal Inspection Service for their Dangerous Mail Program. Learn why USPIS chose the ThreatID for advanced screening and detection; distinguishing it from other FTIR technologies.
Ever since anthrax spores were mailed to high value targets in late 2001 and resulted in five deaths and 17 infections of American citizens1, the United States Postal Inspection Service (USPIS) has been concerned about suspicious substances being sent within envelopes and packages. But the USPIS mission of protecting America’s mail has a long history.
Though the Department of Homeland Security (DHS) is the largest U.S. federal law enforcement agency, USPIS is its oldest.1,4 248 years ago, on August 7, 1775, Postmaster General Benjamin Franklin handed a paycheck to the first USPIS Surveyor William Goddard in Philadelphia, Pennsylvania.4 The USPIS has been carrying out its critical duties program ever since, most recently under the auspices of the Dangerous Mail Investigation (DMI) program.
Key to this program has been the adoption of advanced screening and detection technologies to expedite the analysis of potential threat materials in mailed containers.5 Such threats can include actual or hoax biological agents, illicit drugs, or numerous other types of suspicious substances. To that end, the USPIS adopted field-portable Fourier transform infrared (FTIR) technology in 2005 owing to its ease of use and desirable form factor. More recently, as part of a technology refresh initiative, the agency updated its chemical identification fleet with the ThreatID™. Currently, 225 ThreatID systems are deployed by the USPIS at strategic locations around the country.
ThreatID is a portable FTIR analyzer which can identify over 27,600 products including common household materials, hazardous chemicals, explosives, drugs, and much more in less than one minute. Measuring a substance is as simple as placing a minute grain of solid or drop of liquid onto the diamond sensor and following the on-screen prompts.
However, these technical features were not the only aspects the USPIS considered when procuring the ThreatID. As important was the unique level of support provided to the agency.
When inspectors are trained, they receive a tailored program which incorporates the ThreatID into their concept of operations (CONOPS). Specifically, the training addresses how FTIR should be used within the context of other technologies employed by the inspectors during threat assessment. These technologies parallel those used in hazardous materials response including pH paper, radiation detectors, multi-gas monitors, and even biological agent screening tests. USPS Publication 52 documentation on Hazardous, Restricted, and Perishable Mail1 was programmed into the ThreatID software for direct on-board access at the system’s result screen. Service is also paramount, 24/7/365 access is provided to its scientists and engineers for device troubleshooting and spectral data review when they are needed most. Furthermore, the TeamLeader mobile application, a standard no-cost offering to all our customers, fits nicely with the USPS goal of
exploring “cloud capabilities in support of targeting and detection efforts” as part of the DMI initiative.
The ThreatID is a critical component of the USPIS mail protection mission. As part of a tiered screening approach, the ThreatID has proven to be an effective means of protecting USPIS employees and its customers. The agency responds to approximately 2,500 mail inspection calls per year. Though not all calls require a physical response, the ThreatID provides peace of mind to all who encounter suspicious substances, especially when the threat of legitimate attacks still looms in our unsettled world. As a law enforcement arm of the U.S. government, the USPIS can impose strict penalties onto offenders including fines or prosecution. Having the most advanced technologies in hand, these efforts are conducted with more speed and confidence than ever before. Benjamin Franklin would indeed be proud.
References:
Publication 52 – Hazardous, Restricted, and Perishable Mail Standard, pe.usps.com/text/pub52/index.htm, Accessed November 7, 2023.
www.fbi.gov/history/famous-cases/amerithrax-or-anthraxinvestigation, Accessed November 7, 2023.
www.dhs.gov/dhs-law-enforcement-overview, Accessed November 7, 2023.
www.uspis.gov/about/history-of-uspis, accessed November 7, 2023.
U.S. Postal Service Strategy: Combating Illicit Drugs in the Mail, September 2020 Report, www.uspis.gov/combating-illicit-drugsin-the-mail, Accessed November 7, 2023.SU103_AGHS.pdf, Revision 23 August 2018.
[post_title] => ThreatID Case Study: United States Postal Inspection Service
[post_excerpt] => Learn why USPIS chose the ThreatID for advanced screening and detection, distinguishing it from other FTIR technologies.
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Customs organizations are tasked with protecting the border as well as managing the safety and security of passengers, imports, exports and mail centers. It’s a huge operation for every country. Drug detection and seizures are a large aspect of any customs organization. In fact, the New Zealand Customs Service (NZCS) was responsible for responding to nearly 4,300 drug incidents1 in 2023, seizing more than 3,805 kilograms of cocaine, 2,190 kilograms of methamphetamine and 567.8 kilograms of ecstasy.
When faced with dangerous substances and other challenges in the field, customs officers need quick and accurate information about the substances they are handling. Which is why the NZCS turned to 908 Devices’ MX908 trace detection and identification tool. The MX908 is capable of analyzing solid, liquid, vapor and aerosol threats – from street drugs to chemical spills to explosives
These three examples in particular stand out as exemplary use cases.
Case 1 - Narcotics Identification
Suspected Narcotics Identified with Drug Hunter
Drug traffickers go to huge lengths to conceal their contraband, wrapping substances in seemingly innocuous containers, jamming them into the walls of vehicles and more. While multiple technologies, including X-Ray, are deployed to uncover these hiding spots, they can’t tell officers exactly what the packages contain. It’s imperative to verify the substances inside to ensure officer safety and stop illicit drugs from entering their borders.
In one notable instance, NZCS officers identified goods crossing the border that appeared to be multiple large containers of waterproofing material. However, due to suspicious activity, the items were flagged for secondary inspection. The team needed to confirm the presence of illegal substances while maintaining the safety of officers during the search.
Two officers deployed the MX908, swabbing areas of concern—including the bucket handles—which are the most common areas for trace levels of narcotics to be found. Each analysis returned a positive result for methamphetamine, a Schedule II controlled substance that’s highly addictive. The containers were carefully taken apart and numerous extremely small packages of methamphetamine were removed from the waterproofing material, and thereby confiscated. In the words of the NZCS, “the ability of the MX908 to obtain clear and consistent results further encouraged our officers to locate the previously unseen and undetected illicit drugs
Case 2 - Chemical Detection
Identifying Toxic Industrial Chemicals
A freight carrier close to the airport spilled, and an unknown substance that was suspected to be a noxious chemical prompted a response. The NZCS was called in to investigate, however given the proximity to the airport and possible hazards to officers, extreme caution was needed to collect a physical sample. Time was of the essence, and the freight carrier logs were being combed through, but not nearly fast enough to determine the type of substance and remediation protocol.
NZCS officers arrived onsite equipped with the MX908, utilizing the trace vapor capability. A specialist officer donned personal protective equipment and entered the spill site. The MX908 positively identified the presence of dimethylformamide, a solvent for chemical reactions that can impact the eyes, skin, lungs, liver and heart during prolonged exposure. This positive identification enabled officers to properly secure the spill site and implement remediation efforts. The freighter manifest confirmed dimethylformamide, and the spill was contained. The rapid, trace analysis of the MX908 enabled officers to access this information quickly with a high degree of confidence and expedite clean-up.
Case 3 - Explosives Identification
Analyzing Possible Explosives
Bomb threats are always taken seriously, so when a law enforcement agency was contacted by a concerned individual about an abandoned package at a place of worship, the NZCS was called to identify the package. Given the proximity of the venue to public areas, it was ideal to avoid having to evacuate the area, if possible, in order to mitigate undue stress on the public.
The MX908 was again dispatched, this time utilizing the Explosives Hunter Mission Mode, which detects trace levels of military and commercial grade explosives, homemade explosives and relevant precursors. The item was tested with minimal disruption to the package and site, and returned negative results. This gave the agencies involved comfort in mitigating the perceived risk and the ability to downgrade the cordon. This succinct information and inter-agency coordination also enabled officers to clear the scene and move on to their next duties.
Result
Whether using trace identification features for drug traffickers, deploying vapor capabilities to analyze threats or implementing the explosive functionality to assess risk to the public, the NZCS has seen tremendous benefit from 908 Devices' MX908. This multi-mission handheld tool empowers swift response with confidence, helps protect officers and ensures greater public safety and well-being.
Special thanks to the New Zealand Customs Service for their contribution to this Case Study
[post_title] => Trace Drug Identification at the Border: 3 Scenarios from the New Zealand Customs Service
[post_excerpt] => Whether using trace identification features for drug traffickers, deploying vapor capabilities to analyze threats or implementing the explosive functionality to assess risk to the public, the New Zealand Customs Service has seen tremendous benefit from 908 Devices' MX908.
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[ID] => 23145
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[post_date] => 2024-01-25 09:17:49
[post_date_gmt] => 2024-01-25 14:17:49
[post_content] =>
On average, the U.S. Postal Service processes and delivers 421.4 million pieces of mail each day. In fiscal year 2023 (October 2022- August 2023), the United States Postal Inspection Service (USPIS) made 5,014 seizures, of drug substances in U.S. mail. That is an average of nearly 14 seizures per day. The most commonly seized substances were:
Substance
Number of Seizures
Quantity of Substance Seized
Cocaine
1,727
5,393 lbs
Meth
1,607
7,189 lbs
Synthetic Opioids (Fentanyl)
1,554
4,038 lbs
Heroin
126
99 lbs
There are many employees and individuals at risk of exposure to these dangerous substances as mail is processed, handled, and delivered. Substances contained within those packages and envelopes are at risk of being dispersed on the surface of packaging materials, mail handling equipment, or in the air. In 2001, this type of threat was brought to light as anthrax attacks within the United States, delivered by ordinary mail, claimed the lives of five individuals. More recently, in November 2023, suspicious letters containing fentanyl were sent to U.S. voting centers and government buildings in six separate states.
Situation
A task force of federal, state, and local officers were investigating individuals and locations suspected of receiving packages containing illicit substances. They began surveillance on a house known to law enforcement to be a drop spot for packages that would later be collected by a neighbor.
After surveillance, officers set up a controlled delivery of the package to the residence. Officers conducted a stop of the vehicle and began to investigate the package. Suspecting the package contained a controlled substance, the officers used a K-9 which did not alert for any substance. This presented a challenge to law enforcement since they did not have a warrant to open the package. Officers had immediate access to optical chemical identification tools but were unable to utilize them since there was no visible material on the package.
Solution
The officers also had access to an MX908 and decided to test the outside of the package for trace residues of controlled substances. Officers swabbed the outside of the packaging focusing on the seals of the package, as these are the most likely areas for residues to collect. The swabs were analyzed using the MX908 Drug Hunter Mission Mode and returned a result of Cocaine. The presence of cocaine on the outside of the package allowed officers to obtain a warrant to open the package. The package was then opened and 2 lunchboxes were recovered, both containing 1 kilogram of cocaine.
Result
In the above scenario, the material inside the package was cocaine, which is not surprising given it was the most seized drug by the USPIS in FY23. However, it could have just as easily been fentanyl. Fentanyl in any form poses a major risk to health and safety due to its highly toxic nature. The average lethal dose of fentanyl and carfentanil are 2 milligrams and 0.02 milligrams respectively. These materials may be easily aerosolized while opening and handling packages or envelopes. In an envelope or package, fentanyl or its analogs could be found in various amounts and may pose a serious threat without being visible. The MX908 can identify fentanyl and its analogs at levels of tens of nanograms or 10,000 times less than the lethal dose of fentanyl and 100 times less than the lethal dose of carfentanil.
In a mail screening operation, this means that a user could quickly and easily determine whether a package or packages contain a dangerous substance by analyzing the air in a controlled processing area or by swabbing the outside of packages. Identification of trace drug substances, whether aerosolized or deposited on the outside of mail and packages, enables users to take appropriate actions and keep employees and first responders safe when handling these materials.
[post_title] => Identifying Dangerous Materials in Mail
[post_excerpt] => Learn what are the commonly seized substances in everyday mail and how our MX908 is utilized as a screening tool to keep employees safe from harmful substance exposures. A simple swab of a package can reveal the contents inside.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => mx908-identifying-dangerous-materials-in-mail
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[post_modified] => 2024-12-04 16:28:52
[post_modified_gmt] => 2024-12-04 21:28:52
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[4] => WP_Post Object
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[ID] => 22369
[post_author] => 36
[post_date] => 2023-10-30 15:22:42
[post_date_gmt] => 2023-10-30 19:22:42
[post_content] =>
The increasing use of drugs in prisons has become a concerning issue worldwide, posing significant challenges for both correctional facilities and society at large. A primary factor contributing to the rise in drug use within prisons is the ingenuity of inmates and collaborators on the outside. Despite rigorous security measures, contraband substances such as synthetic cannabinoids, cathinones, and opioids find their way into correctional facilities through creative methods like drones or legal mail. The demand for these substances remains high among inmates.
The increasing prevalence of drugs in correctional facilities is well documented:
There has been a 600% increase in inmate deaths in the United States due to drugs or alcohol from 2001- 2018, according to the Bureau of Justice Statistics.1 (See Figure 1)
Contraband demands higher prices in prison than on the street and is a contributing factor to availability in correctional facilities. The profit that can be generated by drug sales in prisons is reported to be up to four times greater than that in the community.2
The most abused drugs in prisons include cocaine, heroin, synthetic cannabinoids, marijuana, and prescription medications obtained illicitly.3
Figure 1. Prison Deaths From Drug/Alcohol Intoxication Have Risen Rapidly. In 2001, there were 35 deaths from drug/alcohol intoxication in state prisons. In 2018, there were 249 — a 611% change from 2001.
Situation
Correctional officers face numerous challenges when attempting to keep illicit substances and contraband out of their facilities. A combination of technologies are used to screen everything from visitors to packages and incoming mail. Mail can be particularly challenging to screen for several reasons. The sheer volume of mail coming into a facility makes searching every piece nearly impossible.
Collaborators on the outside are constantly developing new ways to smuggle contraband to inmates on the inside of these facilities. A tactic growing in popularity for smuggling synthetic cannabinoids and other drugs uses saturated paper. In this tactic, the drug is dissolved in a solvent and a letter, greeting card, or other piece of paper is soaked in the solution. Once the paper is completely saturated, it is allowed to dry, and packaged into an envelope as other normal pieces of mail. These drug saturated papers are often disguised as legal mail, which increases the risk of drug consumption in the prison population as correctional facilities are prohibited from opening and interrogating the contents of legal mail.
After the mail is received by the inmate inside the facility, it is often cut into smaller pieces which can then be consumed sublingually or via smoking. A single, one inch square of K2/Spice paper can be sold within the prison for as much as $400 each. Meaning a single sheet of this saturated paper is worth over $30,000.4
Solution
MX908 Identifying a Synthetic Cannabinoid Imbedded in Paper
At a correctional facility in the United States, officers processing incoming mail observed discoloration in different areas of paper, indicating a substance may have been dissolved into the paper. Officers flagged these pieces of mail on the suspicion of being impregnated with controlled substances and set them aside for further screening. While the officers possessed handheld Raman spectroscopy devices, these optical tools are not adept at identifying drugs imbedded in paper. The officers used trace sampling swabs from their MX908 to directly swab the discolored areas of the paper and envelope. No sample preparation was necessary and officers analyzed the sample using the MX908 Drug Hunter Mission Mode. In less than a minute, the MX908 returned a result for MDMB-4en-PINACA, a synthetic cannabinoid. With this evidence, corrections officers were able to seize the incoming mail and prevent it from entering the facility and subsequently being consumed by inmates.
Results
About MX908 in Correctional Facilities
MX908 leverages high-pressure mass spectrometry to deliver dramatically enhanced sensitivity and broader threat category coverage and has proven to be an exceptionally effective tool for drug detection in correctional facilities. The device's capability to rapidly detect a wide range of narcotics, including synthetic drugs, allows correctional staff to proactively address the evolving landscape of illicit substances by identifying drugs at very low, nanogram levels on difficult samples, such as drugs imbedded in paper.
By enhancing security measures and reducing the prevalence of contraband, the MX908 not only ensures the safety of correctional facilities but also supports rehabilitation efforts, ultimately contributing to a more secure and controlled correctional environment.
[post_title] => Identifying a Synthetic Cannabinoid Imbedded in Paper
[post_excerpt] => Read our latest case study on how MX908 aids correctional staff to proactively identify drugs at nanogram levels via trace detection on difficult samples, such as drugs imbedded in paper.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => identifying-a-synthetic-cannabinoid-imbedded-in-paper
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[pinged] =>
[post_modified] => 2024-12-05 12:41:35
[post_modified_gmt] => 2024-12-05 17:41:35
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[5] => WP_Post Object
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[ID] => 6783
[post_author] => 36
[post_date] => 2022-10-25 14:17:07
[post_date_gmt] => 2022-10-25 18:17:07
[post_content] =>
About Khat
Khat (also known as qat or chat) is a flowering shrub which is native to East Africa and the southwest Arabian Penninsula. The buds and plant leaves of khat are chewed to achieve a stimulant effect similar to amphetamine, although khat is less potent. Cathinone and cathine, the active drug components of khat, are released into the user’s saliva as it’s chewed.
Khat chewing has a long history dating back thousands of years as a social custom and for medical uses in its native regions. Although still legal in a few African and Middle East countries, khat (and/or its active components) has been designated as illegal throughout much of the world. In May of 2022, the U.S. Coast Guard seized 10,000 tons (estimated street value of $3.6 Million) of Khat disguised as tea from Kenya while a few months later, Saudi Arabia’s Border Guard seized 48.6 tons of khat and arrested 146 smugglers.
The Situation
At a major U.S. international airport, a shipment from Sierra Leone in western Africa was flagged for further inspection after an officer observed a plant like material in the shipment. This package was nearly identical to a 27 kg shipment that was delivered to its recipient previously because law enforcement had no way to confirm if the shipment was khat.
Khat leaves - this bitter plant is chewed as a stimulant in East Africa and the Arabian Peninsula.
Knowing the package originated from Africa, where khat is still legal in some countries, the officers took steps to confirm what the material was. The package was opened and the plant material inside was consistent with khat, a bundle of leaves and fresh shoots. Using both a Raman and Fourier Transform Infrared (FTIR) spectrometer, the officers attempted to identify the material, but both technologies gave a “No Target Detected” result. This is not uncommon as these technologies are “bulk detectors” that excel at identifying visible amounts of drug material (typically more than 1 mg).
Suspicious of a possible drug shipment, officers ran the samples in the MX908 Drug Hunter Mission Mode which returned multiple alarms for cathinone, an active drug substance in khat.
MX908 Identifying Drugs When Other Technologies Fail
With no way to identify the suspected khat, responding law enforcement made a call to a nearby agency which had an MX908 and requested their assistance to identify the material. Using the MX908, the officers swabbed various parts of the plant material and packaging to obtain multiple samples. Suspicious of a possible drug shipment, officers ran the samples in the MX908 Drug Hunter Mission Mode which returned multiple alarms for cathinone, an active drug substance in khat. Officers quickly downloaded and sent the data from the scans to 908 Devices to conduct reachback analysis. Reachback analysis by 908 Devices’ forensic chemists supported the on-screen alarms after analyzing the sample and reference spectra. Forensic chemists from 908 Devices also noted that the high sample signal reported on the device was consistent with cathinone given the drugs lower required temperature for vaporization.
The Result
A previous 27 kg shipment of what was presumably khat was delivered to the recipient and likely ended up being sold on the streets. This time, the MX908 was able to provide a positive identification of cathinone, an active component in khat. This positive identification allowed law enforcement to seize the 62 kg shipment and continue their investigation. It also provided them with the confidence to continue to further screen these types of shipments knowing that the MX908 provided a reliable way to identify trace amounts of cathinone where other technologies failed.
About MX908
MX908 leverages high-pressure mass spectrometry to deliver dramatically enhanced sensitivity and broader threat category coverage. This down-range tool increases mission support with unmatched flexibility and trace detection power for first responders in priority drug, chemical, explosive and high-threat hazmat scenarios. MX908 lightens the overall technology burden by displacing other less selective technologies from the response toolkit
References
US Customs and Border Protection, CBP, US Coast Guard Seize more than 10 tons of khat, Department of Justice/DEA Drug Fact Sheet Khat Alcohol and Drug Foundation, What is Khat? European Monitoring Centre for Drugs and Drug Addiction, Khat Drug Profile
MX908 was able to provide a positive identification of cathinone, an active component in khat. This positive identification allowed law enforcement to seize the 62 kg shipment and continue their investigation.
[post_title] => Identifying Smuggled Khat
[post_excerpt] => Suspicious of a possible drug shipment, officers ran the samples in the MX908 Drug Hunter Mission Mode which returned multiple alarms for cathinone, an active drug substance in khat.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => mx908-case-study-khat
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[post_modified] => 2024-12-06 13:30:08
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[6] => WP_Post Object
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[ID] => 6291
[post_author] => 36
[post_date] => 2022-07-22 10:53:57
[post_date_gmt] => 2022-07-22 14:53:57
[post_content] =>
Getting life-changing biologics to patients ASAP
HJB’s goal is to overcome scientific and technical hurdles that inhibit patients’ access to life-changing biologics. To do that, they aim to provide high quality, holistic, and reliable services to innovative biopharma companies.
So how exactly do they hit that lofty goal? The contract development and manufacturing organization (CDMO) based in Zhejiang, China, employs cutting-edge technology that substantially accelerates R&D processes, reduces costs, and fast-tracks commercialization. They offer biopharma clients access to complete, flexible, and reliable development and manufacturing services that include cell line development, bioprocess development, analytical method development, formulation development and GMP manufacturing for all clinical phases and commercial production.
Overcoming hurdles in cell culture media analysis
CHALLENGE: The waiting game
Prior to HJB’s integration of the REBEL™ cell culture media analyzer into their processes, the upstream process development team, led by Vice President Lisa Zheng, sent media samples off to HJB’s analytical sciences group for amino acid analysis. But relying on another team for results meant they were waiting to make decisions and take next steps in their media development processes.
In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
SOLUTION: Answers at-line, anytime
Lisa’s team purchased a REBEL and set it up right next to their bioreactors. They found the device space-friendly and easy to install. Consumables were easy to maintain, and operation was so simple that even their non-technical analysts could conduct analysis. Samples were measured quickly, and with results in less than 10 minutes, scientists were making decisions in near-real time. REBEL is now used routinely for quick analysis to support accelerated media and process improvements.
CONCLUSION: A new milestone in productivity
Because REBEL lets the upstream process development group analyze many samples in a short period of time, the group accumulates a large amount of amino acid data just through daily testing. This lets them quickly investigate deviations during product development, carry out process development/optimization based on REBEL data, and better understand the impacts on culture performance and Product Quality Attributes (PQAs) from process parameter changes.
REBEL was also key in helping HJB accelerate media and process development, which is essential for the development of highly intensified, continuous cell culture perfusion. Earlier this year, the company announced that its continuous perfusion cell culture platform has achieved industry-leading volumetric productivity of greater than 6 g/L per day while maintaining process and product quality attributes in a state of control for a 4-week culture.
“REBEL can analyze a large number of samples in a short period of time to provide valuable data to accelerate cell culture process development. Rather than obtaining amino acid profiles after the run is completed, REBEL provides real-time data for us to make process decisions while the experiments are in progress to maximize successful outcomes.”
-Dr. Christopher Hwang, CTO of HJB
Overcoming hurdles in cell culture media analysis
CHALLENGE: A fair share of challenges with LC
Liming Shi is the VP in charge of the Analytical Science and Quality Control Departments, and responsible for Product & Process Development Operation. HJB’s Analytical Science Department develops and optimizes analytical methods, and provides analytical support for cell lines upstream, downstream, and formulation process development. The group applies the most advanced analytical techniques to perform large molecule characterization, including analysis of mAbs, ADCs, and bispecific antibodies.
Liming’s team was looking for difficult-to-separate charge variants, which is a challenge with LC-based separations. They were also bumping into UHPLC challenges, such as poor separation and analysis with limited sample volumes. Furthermore, their UHPLC-MS separation and analysis had a turn-around time that was too long.
SOLUTION: In comes ZipChip
In their search for analytical tools that could provide higher-quality data and get them to results faster, the Analytical Services team put ZipChip® straight to work.
Because ZipChip enables rapid measurement of Critical Quality Attributes (CQAs) of native and intact monoclonal antibodies (mAbs), the team used it to characterize intact mAbs and assess the root cause of increases in acidic and basic variants under stress at high temperature. The antibody was analyzed at multiple levels, including its intact state under native conditions and subunit and peptide levels. They used the same ZipChip system and method for both analyses, and were able to determine charge heterogeneity speciation and identification in under 10 minutes. This new workflow was 100 times faster with less prep compared to conventional LC, which required them to harvest fractions.
It was also easy to start integrating ZipChip into their other laboratory workflows as minimal method development was needed for different types of proteins. The team noted this was a big benefit when it came to analysis of native proteins.
Liming Shi -
VP of Analytical Science and Quality Control Departments, Product & Process Development Operation
“ZipChip is a capable platform for multiple CQA assays, and for charge variant analysis it is very straightforward to get separation and identification information with minimal method development needed for different types of proteins, especially for the analysis in native conditions. The sample preparation is simple and straightforward, and the sample requirements are at nanogram levels.”
CONCLUSION: ZipChip + MS goes mainstream
The Analytical Science and Quality Control groups at HJB now have ZipChip systems coupled to their Q Exactive and other Thermo Fisher Scientific mass specs. They’ve adopted ZipChip into their intact antibody analysis workflows (denatured and native conditions) and their subunit and peptide mapping analysis as it gives them very clear and in-depth information on antibody molecules. One of the stand-out features in Liming’s opinion is having an online platform that provides straightforward separation and identification of charge variants based on different mechanisms.
The Analytical Science team recently published their work using ZipChip in Analytical Biochemistry, Volume 625, 15 July 2021, 114214: Characterization and monitoring of charge variants of a recombinant monoclonal antibody using microfluidic capillary electrophoresis-mass spectrometry.
[post_title] => REBEL + ZipChip help HJB Overcome Scientific Hurdles and Optimize Processes in Biotherapeutic Development
[post_excerpt] => In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rebel-zipchip-hjb-transcenta-case-study
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[pinged] =>
[post_modified] => 2024-12-09 16:35:34
[post_modified_gmt] => 2024-12-09 21:35:34
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[7] => WP_Post Object
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[ID] => 4799
[post_author] => 36
[post_date] => 2021-10-26 12:26:35
[post_date_gmt] => 2021-10-26 16:26:35
[post_content] =>
Aerosols are simply a solid or liquid that have been suspended in the air. They maintain the physical properties of a solid or liquid but behave more like a gas or vapor. Aerosolized chemicals can be extremely hazardous due to the inhalation hazard they pose. Highly toxic solids and liquids, such as fentanyl analogs and fourth generation chemical warfare agents (Novichoks), are particularly problematic due to their lethality, yet traditional gas detectors are unable to warn users of the threat. Depending on particle size, they may stay suspended in the air for minutes or hours. Opioids, such as fentanyl and carfentanyl, are low volatility anesthetics that result in rapid respiratory arrest when inhaled in aerosol form. Novichoks, such as A-232 which was deployed in Salisbury, England in March 2018 in an attempted assassination attempt, are low volatility nerve agents that can pose an even greater danger when aerosolized
The Situation
Canadian Decon Solutions, based out of Ontario, Canada, specializes in providing customers with economical and safe solutions for complex contamination issues. They have a history of managing high hazard projects for both the private and public sector including chemical, fuel and oil spills, dangerous goods transportation incidents, clandestine drug lab remediation, and catastrophic events.
During the summer of 2021 they received a call to provide decontamination services for a stolen vehicle. The suspect had stolen a small SUV, overdosed behind the wheel, and crashed the vehicle into a tree. While exiting the vehicle, the suspect had cut herself on broken glass and Chris Andrews, President of Canadian Decon Solutions, was contacted due to the biohazard present. The vehicle was towed to Canadian Decon Solutions’ facility to begin remediation of the vehicle.
Using Aero to Detect Airborne Threats
As part of their Standard Operating Procedures, a technician armed with the MX908®, took several swabs of high contact touchpoints within the vehicle. This included places like door handles, steering wheel, center console, glove compartment, and cabin air filters. While opening the glove compartment to access the cabin air filter, the technician observed a visible amount of white powder within the glove box. Suspecting there may be an airborne chemical threat within the vehicle, the technician carefully shut the glove compartment and backed away to reassess the situation. One month, prior, Canadian Decon solutions had purchased an Aero module for their MX908. The Aero gives their technicians the ability to simultaneously detect and identify vapors and aerosolized chemicals.
Unknown white powder discovered in the glove compartment.
The decision was made to survey the vehicle using the MX908 with Aero to determine if any aerosolized chemical threat was present. Armed with the Aero, the technician reapproached the vehicle, as the MX908 and Aero continuously sampled the ambient air. Carefully cracking open the glove compartment with the Aero nearby, resulted in an alarm for fentanyl. The technician now knew there was in fact, an aerosolized fentantyl threat present within the vehicle. Closing the glove box once again to contain the threat, the technician backed away from the vehicle to determine next steps.
As a company that specializes in the decontamination of hazardous material, the technician was well protected in PPE including a Tyvek suit, respirator, and gloves. Had this analysis been done at the scene of the crash, it would have provided first responders on scene with immediate actionable intelligence to dictate PPE response.
While the technician quite literally waited for the dust to settle, they analyzed the swabs that had been taken off the various high contact touchpoints within the vehicle. The MX908 alarmed for the following:
2 Cocaine Alarms
2 Fentanyl Alarms
1 Scopolamine Alarm
1 Sufentanil Alarm
“The MX908 handheld device has been an unparalleled technology for us. With the addition of the Aero module, it gives me the confidence to do our job and the ability to say with the utmost certainty that a vehicle or scene is clear from threats—both on surfaces and in the air.”
Chris Andrews, President Canadian Decon Solutions
The Result
With a thorough analysis of chemical threats present, both from the MX908 with Aero analysis as well as trace analysis from swabbed surfaces, Canadian Decon Solutions could confidently plan for the decontamination of the vehicle. Their primary method of decontaminating a vehicle like this is First Line Technology’s Electrostatic Decon Kit. This kit offers users the easiest, most efficient way to decontaminate threats using Dahlgren Decon applied from an electrostatic spray gun. After the remediation was complete, the MX908 Aero was again employed to confirm that there was no longer a presence of any aerosolized threats. Subsequent swab samples also returned no alarms and the technician could confidently say that there was no longer a chemical threat within the vehicle.
Given the success of the MX908 with Aero in this scenario, Canadian Decon Solutions has now incorporated usage of this device into their standard operating procedures as an initial survey tool as well as to confirm decontamination is complete. The MX908 has become their go-to tool for trace chemical identification to support their mission. According to Chris Andrews, President of Canadian Decon Solutions, his customers have become accustomed to the detailed reports generated by the MX908 which they submit in conjunction with a summary of the services provided.
The MX908 has become the go-to tool for trace chemical identification to support Canadian Decon Solutions‘ mission.
About MX908
MX908 leverages high-pressure mass spectrometry to deliver dramatically enhanced sensitivity and broader threat category coverage. This down-range tool increases mission support with unmatched flexibility and trace detection power for first responders in priority drug, chemical, explosive and high-threat hazmat scenarios. MX908 lightens the overall technology burden by displacing other less selective technologies from the response toolkit.
About the Aero
The Aero is the first comprehensive solution to detect and identify vapor and aerosol threats, such as Chemical Warfare Agents (CWAs) and Pharmaceutical Based Agents (PBAs), simultaneously. The MX908 with Aero can be deployed in diverse applications ranging from initial air monitoring when entering a building or a confined space, to venue protection employing continuous air monitoring, through high throughput mail screening and on-scene evidence packaging. This device continuously samples and analyzes vapors while collecting aerosol particulates on a mesh within the unit. This mesh is periodically flash heated, which vaporizes any aerosol particulates, and allows them to be analyzed. The Aero is one of three modules that allow the MX908 to analyze samples in any state—solids, liquids, vapor, and now aerosols.
MX908 user interface with Drug Hunter Aerosol Mode selected.
The Aero is the first comprehensive solution to detect and identify vapor and aerosol threats simultaneously.
The Aero attaches to the MX908 for an easy transition to vapor and aerosol analysis.
MX908 is the only field deployable device capable of sampling solids, liquids, vapors, and aerosols
[post_title] => Aerosolized Fentanyl During Decontamination
[post_excerpt] => Download this case study on Canadian Decon Solutions' encounter with fentanyl in a vehicle and how the MX908 with Aero provided real-time intel at the point of need.
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[comment_status] => closed
[ping_status] => closed
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[post_name] => mx908-casestudy-aerosolized-fentanyl-during-decontamination
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[pinged] =>
[post_modified] => 2024-12-10 15:08:56
[post_modified_gmt] => 2024-12-10 20:08:56
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[8] => WP_Post Object
(
[ID] => 808
[post_author] => 36
[post_date] => 2018-01-10 16:26:08
[post_date_gmt] => 2018-01-10 21:26:08
[post_content] =>
The opioid abuse crisis is rapidly spreading throughout communities across the United States and the rest of the world. In 2015 alone, opioids were involved in the death of 33,091 US citizens – a number that has quadrupled since 19991. In 2016, the Center for Disease Control (CDC) cited an additional increase of 28%, linking opioid abuse to more than 42,000 fatalities2. At 100 to 10,000 times the strength of morphine, fentanyl is typically used in small quantities and is often combined with other street drugs (such as heroine, cocaine and MDMA) or benign cutting agents to deliver the drug into a person’s system. Even trace amounts that are invisible by the human eye can cause an overdose.
This crisis has first responders on alert and has unleashed a call to action for technology manufacturers to develop powerful solutions to detect and identify trace quantities of this mighty drug. Here we outline a real-world scenario that demonstrates the detection capabilities of several go-to first responder tools.
The Situation
During an incident at a suburban residence, a local HazMat team seized a small sample of what appeared to be street fentanyl. After an independent laboratory verified the presence of fentanyl, we were asked to participate in a technology comparison. We evaluated the effectiveness of three portable techniques: Raman, FT-IR, and high pressure mass spectrometryTM (HPMS).
Analysis by Raman
Raman spectroscopy is a go-to tool because of its high selectivity and ability to differentiate between 10,000+ different compounds through sealed packaging. However, Raman is primarily used as a bulk technique. This means a visible amount of sample is required to make the measurement and it is rarely suitable for detecting trace level concentrations. Here, the Raman analysis failed as fluorescence interfered with the measurement and the estimated run time was upwards of 4 hours.
Analysis by FT-IR
Similar to Raman, FT-IR is more suitable for bulk material identification and is also highly selective. Here, FT-IR was only able to detect a carbohydrate, which serves as a cutting agent used to dilute highly toxic opioids. No fentanyl was detected using this technique, despite the fact that the FT-IR instrument was equipped with a library of fentanyl and its related analogues.
Analysis by HPMS
HPMS is a novel technology that powers the MX908. This analytical technique is both highly selective and sensitive, making it the technology of choice for a wide range of chemical threats. Here, a sample estimated to be in the low nanograms was measured on the MX908 using its Drug Hunter mode. The device was clearly able to identify fentanyl in the prescence of the cutting agent in less than 60 seconds.
MX908’s new Drug Hunter mode unlocks additional resolving power from the device’s existing hardware to dramatically upgrade selectivity, which first responders with optimal detection and identification capabilities for a subset of the devices target list, including a broad range of fentanyls, opioids, and amphetamines.
About MX908
MX908TM leverages high-pressure mass spectrometry to deliver dramatically enhanced sensitivity and broader threat category coverage. This down-range tool increases mission support the unmatched flexibility and trace detection power for responders in priority drug, chemical, explosive and high-threat hazmat scenarios. MX908 lightens the overall technology burden by displacing other less selective technologies from the response toolkit.
About Mission Modes
The MX908's Misison Modes are specialized hardware and software configurations for enhanced operational performance under specified mission objectives. Drug Hunter, which was used in this analysis, is a mission mode for the detection and identification of drugs and pharmaceutical-based agents (PBAs) including fentanyl and fentanyl-analogues, heroin, cocaine, and amphetamines. When Drug Hunter is selected, the MX908 hardware reconfigures to provide optimal efficiency and mass spectral selectivity using sequential fragmentation to selectively create and confirm the expected mass fragments of the drug targets of interest.
"The opiod abuse criss is rapidly spreading throughout communitites across the country. In 2015 alone, opiods were involved in the death of 33,091 US citizens - a number that has quadrupled since 1999."
The abuse of fentanyl and other opioids is a crisis within communities all across the country. Due to their potency, fentanyls can be present at very low levels and still pose a severe hazard to first responders and civilians alike.
As demonstrated in this case study, Raman and FTIR are not practical technologies for the detection of trace substances. While great for bulk material identification, they cannot detect minor mixture components below the 5-10% level.
Here, HPMS demonstrated the capability to positively identify a trace amount of fentanyl in less than 60 seconds. The sensitivity of MX908 enables the identification of fentanyl and its analogues down to 0.1%, even in a complex mixture.
MX908 Mission Modes enhance performance using specialized software configurations to optimize operational performance for mission objectives.
Drug Hunter: is a mission mode for the detection of drugs and pharmaceutical-based agents (PBAs) such as: fentanyl and fentanyl analogues, along with other high priority drugs-of-abuse.
Explosives Hunter: is a mission mode for the detection of priority threats from military and commercial grade explosives, to homemade energetics and relevant precursors.
CWA Hunter: is a mission mode for the detection of priority chemical warfare agents, including real time vapor quantification.
[post_title] => Analysis Comparison of Fentanyl
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Researchers at the Dana-Farber Cancer Institute and Harvard Medical School leveraged the ZipChip® in a combined structural biology-phosphoproteomic study to decipher key topological features and post-translational modifications on the kinase BRAF. Like most cellular proteins, BRAF does not work alone, but rather assembles with other proteins into ‘molecular machines’ which work in concert to orchestrate the cellular ‘circuitry’ required for normal physiology. However, genetic mutation can commandeer and re-direct the activity of these protein machines leading to human tumors. In fact, BRAF mutations contribute to a large number of different human cancers.
The rapid-fire, 10-minute injection-to-injection throughput provided by the ZipChip enabled the researchers to analyze hundreds of samples spanning different BRAF mutations, protein partners, and proteolytic enzymes.
Unfortunately, the myriad of structural features, interaction surfaces, and post translational modifications on BRAF and its associated proteins make it challenging to understand how the kinase functions in normal physiology and how genetic mutations hijack the kinase and drive human cancer.
The Dana-Farber team generated purified forms of normal and mutant BRAF in addition to its key protein partners typically found in cells, and then assembled these to produce detailed molecular structures by cryo-electron microscopy. In addition, the researchers digested small aliquots of these complexes with a combination of proteolytic enzymes and then used the ZipChip on a Thermo Q-Exactive HF mass spectrometer to identify phosphorylation sites on BRAF and its co-regulatory protein partners. The rapid-fire, 10-minute injection-to injection throughput
provided by the ZipChip enabled the researchers to analyze hundreds of samples spanning different BRAF mutations, protein partners, and proteolytic enzymes. The multitude of ‘targeted’ and ‘unbiased’ CE-MS/ MS data sets enabled the researchers to read-out phosphorylation stoichiometry at key sites on BRAF which control its kinase activity and interaction with other co-regulatory proteins.
The Team combined their proteomic and structural data to better understand how BRAF mutations disrupt its normal cellular function. These results provide important insight to guide development of new, precision drugs which may improve clinical outcomes for patients with BRAF driven cancers.
To view the full article published in Nature Magazine click here.
CE-MS analysis for in-depth comparison of biosimilars
The ZipChip® platform couples microfluidic capillary zone electrophoresis (CE) separation of intact proteins with direct electrospray ionization mass spectrometry (ESI-MS) analysis, facilitating the evaluation of drug product heterogeneity and comparison between originator and biosimilars.
The high number of components confidently identified and quantified allows fast assessment of biologics similarity.
The ZipChip platform facilitates the evaluation of drug product heterogeneity and comparison between originator and biosimilars.
Materials & Methods
Sample Prep:
100 µg of each monoclonal antibody were buffer-exchanged according to the ZipChip protocol for intact antibody charge variant analysis with 0.5 mL spin-filters with 10KDa MWCO and concentrated to 0.5 mg/mL.
ZipChip Protocol
Boosting Sensitivity for Intact Antibody Charge Variant Analysis
Assay Kit
Native Antibodies Kit
Chip Type
ZipChip HRN
Field Strength
500 V/cm
Run Time
15 minutes
Mass Spec Type
Thermo Scientific QExactive™ Plus Hybrid Quadrupole Orbitrap mass spectrometer
Introduction
According to the FDA “a biosimilar is a biological product that is highly similar to and has no clinically meaningful differences from an existing FDA approved reference product” and similarity is assessed “by extensively analyzing (i.e., characterizing) the structure and function of both the reference product and the proposed biosimilar” and only “minor differences between the reference product and the proposed biosimilar product in clinically inactive components are acceptable”1. Assessment of biosimilarity is usually performed by extensively analyzing the structure and function of both the reference product and the proposed biosimilar. Based on their high similarity with already approved drugs and their ability to lower the cost of current treatment, a shorter pathway has been designed for biosimilar approval under the Biologics Price Competition and Innovation (BPCI) Act, approved in the US in 2010. As a consequence, biopharmaceutical companies have interest in analytical tools that facilitate in-depth characterization of therapeutics to assess biosimilarity, in particular, the micro-heterogeneities present in the originator product. For this purpose, usually multiple orthogonal analyses are needed. For biosimilar approval the major effort is needed in terms of analytical rather than clinical studies (Fig 1).
In the present case study we evaluated the suitability of ZipChip platform to investigate biosimilarity by analyzing two commercially available infliximab drug products: Remicade the originator product, approved in the US in 1998; targeting TNF-α, it is indicated for the treatment of several autoimmune disease, including Crohn’s disease and its biosimilar, Inflectra, the first biosimilar approved by EU regulatory agencies in 2013.
Results
In the assessment of biosimilarity there is a need for bioanalytical tools that enable fast and confident evaluation of a candidate’s micro heterogeneity with increased dynamic range to verify that no critical quality attributes demonstrate significant differences from the originator.
Charge variant analysis is a regulatory requirement and is usually performed through CE or LC methodology to assess the charge variant profile2. Hyphenation of charge sensitive
Figure 1: Difference between approval process for originator and biosimilar therapeutic proteins.
separation methods with mass spectrometry has been shown to be a powerful characterization technique to understand the distribution and contribution of posttranslational modifications to the overall charge variant profile3,4. Infliximab drug products have a complex charge variant pattern, derived from the C-terminal lysine heterogeneity, with proteoforms presenting both, one or no terminal lysine residues5. In this complex pattern, low abundant proteoforms arising from N-glycan heterogeneity6, could easily be hidden below main species if only optical detection were used; MS hyphenation ensures low abundant species are not missed, especially with the high sensitivity attainable on the ZipChip platform.
Moreover, the minimal sample preparation required ensures no artificially induced modifications are introduced during the analysis, allowing a more reflective comparison of drug originator product and biosimilar candidates.
Figure 2 shows the electropherogram obtained from the Remicade drug product, with 3 main peaks identified and several minor species, all presenting complex glycoform heterogeneity, yielding a total of almost 100 proteoforms for both molecules, confidently identified with mass accuracies < 20 ppm. On the most acidic main peak (A), it is possible to observe a complex heterogeneity arising from deamidation and sialylation (peaks A1-A6). The same pattern is visible for peaks B and C even though most of the low abundant species migration times overlap with more abundant species in peak A and B, respectively. It is clear that in this case the evaluation of data acquired through optical detection only would not allow correct evaluation of all charge variants.
From the data obtained it was possible to generate evaluation of overall deamidation abundance, N-glycan profiling and lysine variants differences in the two monoclonal antibodies, including species as low as 0.1 %. In particular, Inflectra drug product is characterized by a higher level of C-terminal lysine cleavage and higher levels for terminal galactose on Fc N-glycan.
The excellent data quality and sensitivity, together with the short analysis time required by this platform, are key for a quick and in-depth screening and evaluation of biosimilarity across biologics.
Figure 2: Electropherogram obtained from CE-MS analysis on infliximab Remicade® drug product.
Authors: Sara Carillo1, Craig Jakes, Florian Füssl, Jonathan Bones1,2
1. National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Co. Dublin, Ireland. 2. School of Chemical and Bioprocess Engineering, University College Dublin, Dublin 4.
References
1. https://www.fda.gov/drugs/biosimilars/biosimilar-and-interchangeable-products 2. Sosic Z, Houde D Blum A, Carlage T, Lyubarskaya Y, Electrophoresis 2008; 29(21): 4368-4376. 3. Redman EA, Mellors JS, Starkey JA, Ramsey JM. Anal Chem. 2016; 88(4): 2220-2226. 4. Füssl F, Cook K, Scheffler K, Farrell A, Mittermayr S, Bones J. Anal Chem. 2018; 90(7): 4669-4676. 5. Redman EA, Batz NG, Mellors JS, Ramsey JM. Anal Chem. 2015, 87(4): 2264-2272. 6. Marti SM, Delporte C, Farrell A, Iglesias NN, McLoughlin N, Bones J. Analyst 2015, 140: 1442-1447.
The demonstrated ZipChip® method is fast, simple, sensitive and uses the fully-automated microchip electrophoresis platform.
Cell culture media can be directly analyzed using ZipChip after simple dilution with no further sample manipulation required.
Amino acids can be monitored in less than 3 minutes using ZipChip, which is a faster alternative than conventional methods.
Demonstrated ease of use for screening and monitoring amino acids in cell culture media.
Amino acids can be monitored in less than 3 minutes using ZipChip, which is a faster alternative than conventional methods.
Materials & Methods
Sample Prep:
Spent media samples were prepared following the ZipChip protocol for quantifying amino acids in growth media. Briefly, spent media was diluted 20x with LC-MS grade water and then 10x with sample diluent from the ZipChip Metabolites Kit.
Cell Line and Cell Culture Conditions:
CHO cells were adapted to grow in suspension. The culture experiments were initiated by seeding 0.3 x 106 cells/mL in 250 mL polycarbonate Erlenmeyer flasks containing 100 mL of chemically defined CHO cell culture media supplemented with 4mM of L-glutamine on day 0 in triplicate. All cultures were incubated at 37°C during the 10 days. Sampling was made daily by removing 1 mL aliquots, which were centrifuged, filtered and the supernatant stored at -20 °C for further analysis.
ZipChip Protocol
Quantification of Amino Acids in Growth Media
Assay Kit
Metabolites Kit
Chip Type
ZipChip HS
Field Strength
1000 V/cm
Run Time
3 minutes
Mass Spec Type
Thermo Scientific QExactive™ Plus Hybrid Quadrupole Orbitrap mass spectrometer
Introduction
The biopharmaceutical industry has grown significantly over recent years with further expansion predicted based on packed pipelines of recombinant proteins, monoclonal antibodies and peptide drugs. Chinese Hamster Ovary (CHO) cells have been widely utilized for expression of recombinant proteins, which require media to support growth and therapeutic protein production1,2. The composition of cell culture media requires a blend of amino acids, vitamins, nucleosides, lipids, carbohydrates, trace elements and other components. Among these classes of compounds, amino acids are crucial as they are the constituent of proteins and are intermediates of many cellular metabolic pathways. As cells grow and produce therapeutic proteins certain amino acids are rapidly consumed. Monitoring the dynamic depletion of amino acids from culture media is important for media design and feeding strategy development. Supplementation with optimal amount of depleted amino acids is required to assure healthy growth, high productivity and to avoid formation of toxic or undesired metabolites3,4.
Various methods have been employed to analyze amino acids in spent media including LC-UV, LC-MS, GC-MS and CE-MS. However, these methods require sample preparation such as derivatization, solid phase extraction or microextraction or other steps in the experimental procedure prior to analysis. Derivatisation of some media components is required to enable optical detection using absorbance or fluorescence or for matrix simplification5, 6.
Miniaturized devices and microfluidic techniques offer the advantage of reduced analysis times and reduced consumption of reagents and therefore an environmentally friendly alternative to conventional methods.
In this study, we describe a simple, rapid, and automated microfluidic ZipChip ESI-MS method to monitor amino acids in spent media from an IgG1 producing CHO cell line using batch culture over a period of 10 days. The analysis facilitated identification of amino acids consumed during cell growth.
Results
During cell growth, amino acids are depleted from the culture media. Monitoring amino acid behaviour is crucial to understand the dynamic conditions and to adjust the concentration for each amino acid in the cell culture media to obtain the maximum possible production of monoclonal antibody. A simple, rapid and automated microfluidic
ZipChip ESI-MS method was developed to monitor amino acids in spent media from IgG1 producing CHO cells growing over a period of 10 days using batch culture.
The base peak electropherogram for the separation of 17 amino acids in water (reference standard) and in cell culture media employing ZipChip ESI-MS is shown in Figure 1. The separation is based on the difference of electrophoretic mobility, related to the charge and size of the analytes. The amino acid migration order observed was the highest positively charged amino acids migrate first, followed by the neutral amino acids and finally the acidic amino acids. The separation of 17 amino acids in 3 minutes showed symmetric peaks and good resolution. Some of the amino acids are unresolved, co-migration of certain amino acid pairs are commonly described in CE applications. However, with high resolution MS detection, co-migrating pairs can be easily distinguished based on differences in m/z.
The method was applied to study samples of conditioned cell culture media collected from flasks over the course of the 10-day batch culture. The culture media is rich in essential amino acids. Figure 2 shows the decline of signal intensity for the majority of the amino acids from day 0 to day 10.
All the amino acids can be quantified by this method. Figure 3 shows the patterns of leucine across the ten days of cell culture. As expected, the amount of the leucine is reduced during the 10-day culture.
Results
ZipChip ESI-MS facilitates rapid quantitative analysis of amino acid in cell culture media using an automated platform generating excellent separation within 3 minutes. The method provides good resolution, selectivity and requires minimal sample preparation and sample handling.
The ZipChip is suitable for screening and monitoring changes in cell culture media during therapeutic protein production with a short analysis time with reliable peak identification due to the coupling of CE with MS.
Figure 1: A mix of amino acids was diluted in CE buffer to optimize the separation via chip CE-ESI-MS. (a) Base peak electropherogram for a 500µM of amino acids mix standard.
Figure 2: Base peak electropherograms of cell culture growth from different days. (a) Day 1 and (b) Day 10
Figure 3: (a) Pattern of consumption of leucine during 10 days of cell culture growth (b) Extracted ion electropherograms of Leucine during 10 days of cell culture growth.
Authors: Meire Ribeiro da Silva, Izabela Zaborowska, Sara Carillo, Jonathan Bones
National Institute for Bioprocessing Research & Training, Dublin, Ireland
References
1.https://www.fda.gov/drugs/biosimilars/biosimilar-and-interchangeable-products 2. Sosic Z, Houde D Blum A, Carlage T, Lyubarskaya Y, Electrophoresis 2008; 29(21): 4368-4376. 3. Redman EA, Mellors JS, Starkey JA, Ramsey JM. Anal Chem. 2016; 88(4): 2220-2226. 4. Füssl F, Cook K, Scheffler K, Farrell A, Mittermayr S, Bones J. Anal Chem. 2018; 90(7): 4669-4676. 5. Redman EA, Batz NG, Mellors JS, Ramsey JM. Anal Chem. 2015, 87(4): 2264-2272. 6. Marti SM, Delporte C, Farrell A, Iglesias NN, McLoughlin N, Bones J. Analyst 2015, 140: 1442-1447.
Performing highly selective charge variant separation of complex pharmaceuticals using the ZipChip® platform for native intact antibodies.
Generation of excellent quality MS data which allows for in-depth analysis of also extremely low abundant charge variants.
Demonstration of outstanding method sensitivity based on the identification of more than 200 Cetuximab isoforms with a sample consumption of only 2 ng of protein.
ZipChip is particularly beneficial in cases where only very limited quantities of sample are available.
Materials & Methods
Cetuximab was buffer exchanged to intact antibody sample diluent using Amicon Ultra-0.5 ML spin filters with a 30 kDa size cut-off to yield a 1 mg/mL concentration.
ZipChip Protocol
Boosting Sensitivity for Intact Antibody Charge Variant Analysis
Assay Kit
ZipChip Native Antibody Kit
Chip Type
ZipChip HRN
Field Strength
500 V/cm
Run Time
20 minutes
Mass Spec Type
Thermo Scientific QExactive™ Plus Hybrid Quadrupole Orbitrap with Biopharma Option
Introduction
With the rise of precision medicine, the monoclonal antibody (mAb) market has expanded enormously during recent years. Monoclonal antibodies are large biomolecules that are produced by recombinant means and therefore can be highly heterogeneous. For therapeutic use, knowledge of this microheterogeneity is mandated by authorities to guarantee patient safety.
Charge variant analysis on the intact protein level represents an extremely powerful tool to distinguish protein isoforms based on differential surface charge, requiring minimal sample preparation and short analysis times. Recently, efforts were undertaken to combine charge variant separation of proteins with powerful detection modes such as mass spectrometry, creating new and exciting methods for protein characterisation1,2. Here, we explore the potential of ZipChip for the in-depth analysis of Cetuximab, a mAb that exceeds conventional mAbs in terms of complexity, as it contains four N-glycans, two in the conserved Fc region and another two in the Fab region (Figure 1) which can be complex and heavily sialylated. These additional Fab glycans are the cause of extremely high glycan heterogeneity and along with other charge altering modifications of the primary sequence are responsible for the complex peak pattern usually observed during charge variant analysis of Cetuximab. This charge variant and glycoform complexity makes Cetuximab a highly challenging molecule for in-depth characterization on the intact protein level.
Charge variant analysis is a regulatory requirement and is usually performed through CE or LC methodology to assess the charge variant profile2. Hyphenation of charge sensitive
Figure 1: General structure of Cetuximab. The Fc region contains simple, bi-antennary glycans also found on other mAbs whereas the Fab glycans can be larger, more complex and sialylated.
Results
Analysis of Cetuximab was performed using generic instrument parameters without the need for molecule specific optimization. The complex charge variant separation obtained can be seen in Figure 2. In total 8 Cetuximab charge variant peaks were distinguished, varying in abundance. Notably, all peaks are base-line separated which is important for subsequent MS-based isoform annotation and quantification. The averaged mass spectrum of the main charge variant peak is shown in blue in Figure 2. The spectral quality is excellent and allows for deconvolution and the characterization of even low abundant glycoforms. The averaged mass spectrum of the lowest abundant charge variant peak is shown in red in Figure 2. Spectral quality is sufficient for analysis, even for isoforms with relative abundance values of <1%.
Spectral deconvolution and analysis confirmed the expected charge variant migration in order of increasing negative protein net charge. The net charges are shown above each peak in Figure 3. Positive charges are caused by miss-cleaved C-terminal lysine, either on one or both heavy chains whereas negative charges are due to the presence
Figure 2: Charge variant separation of Cetuximab. The averaged spectra of the most (blue) and least (red) abundant charge variant peaks is shown n the right panel.
of N-glycolyl neuraminic acid (NGNA) residues on the Fab glycans, as indicated in Figure 3. Net charges are ranging from +2 which corresponds to Cetuximab with 2 C-terminal lysine residues and no NGNA to -5 which represents Cetuximab without C-terminal lysine residues and five NGNA units attached. Importantly, each charge variant peak contains the characteristic glycosylation pattern of Cetuximab, giving rise to a range of isoforms found across the electropherogram.
More than 200 different isoforms were detected and quantified with relative abundance values of down to 0.1%. Considering that the run time required is only 15 minutes and a sample consumption of 2 ng, these results clearly demonstrate the power of the ZipChip for in-depth analysis of biopharmaceuticals. While ZipChip based CE-MS can be effectively employed for mAb characterization, it is in particular beneficial in cases where only very limited quantities of sample are available. This makes microfluidic CE-MS highly attractive for application in early stages of the biopharmaceutical production pipeline.
Figure 3: Assignment of protein net charge states to individual charge variant peaks. C-terminal lysine residues are labelled “K” and are shown in blue, N-glycolylneuraminic acids are labelled “NGNA” and are shown in turquois.
Authors:
Florian Füssl, Sara Carillo, Craig Jakes†, Jonathan Bones† *National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Co. Dublin, Ireland. † School of Chemical and Bioprocess Engineering, University College Dublin, Dublin 4.
References
1. Redman, E. A.; Batz, N. G.; Mellors, J. S.; Ramsey, J. M. Anal Chem 2015, 87, 2264-2272. 2. Fussl, F.; Cook, K.; Scheffler, K.; Farrell, A.; Mittermayr, S.; Bones, J. Anal Chem 2018, 90, 4669-4676. 3. 908devices. https://908devices.zendesk. com, 2019.
Charge variant analysis of top selling monoclonal antibodies.
Demonstrated ease of use, speed and depth of analysis obtained using the ZipChip® system, which couples microfluidic capillary zone electrophoresis (CE) separation of intact charge variants with direct electrospray ionization mass spectrometry (ESI-MS) analysis.
The benefits of the ZipChip system include: -Minimal sample preparation involved for many monoclonal antibody formulations. -In the same fast analysis, a charge variant profile is obtained and is coupled with on-line MS identification in native conditions.
“Using the ZipChip system provides us with the ability to obtain charge variant separation in less than 15 minutes. This is a real advantage for our lab.„
Sara Carillo APPLICATION DEVELOPMENT TEAM LEADER, NIBRT
Materials & Methods
100 μg of each monoclonal antibody were prepared at a concentration of 0.5 mg/mL following the ZipChip protocol for intact antibody charge variant analysis.
ZipChip Protocol
Boosting Sensitivity for Intact Antibody Charge Variant Analysis
Assay Kit
ZipChip Native Antibody Kit
Chip Type
ZipChip HRN
Field Strength
500 V/cm
Run Time
15 minutes
Mass Spec Type
Thermo Scientific QExactive™ Plus Hybrid Quadrupole Orbitrap with Biopharma Option
Introduction
The biopharmaceutical industry continues to develop mAb-based biotherapeutics for several applications and disease treatments. The complexity of these molecules creates a considerable challenge for the analytical technologies used to monitor the product quality attributes (PQAs) that need to be measured and controlled to guarantee safety and efficacy1. According to ICH guidelines, one of the features that needs to be monitored during biopharmaceutical development, and during approval and batch release post authorization, is the charge variant profile of a biotherapeutic. Standardized methods include the use of capillary electrophoresis using either zone or isoelectric focusing separation modes or the use of ion exchange liquid chromatography with UV detection (IEX-UV)2. The recent development of native mass spectrometry has facilitated the use of such separation techniques with Orbitrap mass spectrometry detection to obtain on-line MS identification of the charge variant proteoforms3,4. Native MS offers several advantages that include fast analysis and minimal sample preparation when combined with an upfront analytical separation, thus avoiding artificially-induced modification on the analyte.
ZipChip is a fast and reproducible tool for qualitative and quantitative charge variant analysis.
We tested the performance of the ZipChip system with a QExactive™ Plus Hybrid Quadrupole Orbitrap mass spectrometer to perform native MS experiments on the intact charge variants separated by ZipChip. The drug products tested in this work are rituximab, bevacizumab and trastuzumab.
Craig Jakes, PhD student, prepares the ZipChip system to begin a charge variant separation run
Results
The deep structural characterization of biotherapeutics is widely reported as a key step in new drug development and quality control to assess product safety and potency. Charge variant analysis is one of the product quality attributes that needs to be monitored during development and lot release to assess process robustness. In this study the ZipChip microfluidic capillary electrophoresis platform was applied for charge variant profiling of three top-selling drug products: rituximab, bevacizumab and trastuzumab.
For all the samples charge variant separation was obtained with little sample preparation and using a unique method for both CE separation and MS data acquisition. Moreover, the separation was obtained in less than 15 minutes in all the cases, providing a fast and reproducible tool for qualitative and quantitative charge variant analysis.
Figure 1: Zoom of the electropherograms obtained after ZipChip CE-ESI-MS analysis on bevacizumab (A), trastuzumab (B) and rituximab (C) drug products
Figure 1 shows the electropherograms obtained from the three drug products. For each molecule at least 10 proteoforms were identified, all presenting glycoform heterogeneity, with a total of up to 52 proteoforms identified for trastuzumab drug product. The use of QExactive™ plus mass spectrometer enables the fast acquisition of MS data using resolution setting of 35,000 at 200 m/z, routinely providing experimental masses with mass accuracies mostly below 20 ppm.
Due to the separation of the charge variants during the ZipChip separation, in addition to information on the glycoforms and C terminal lysine clipping, it was possible to determine pyro-glutamate formation and the presence of succinimide containing variants as well as deamidation
levels. These post-translational modifications are usually difficult to monitor due to the molecular mass of these variants being near isobaric to the main variant.
Overall, modifications with less than 0.1% abundancy have been confidently identified concluding that the ZipChip system is a powerful tool for biotherapeutics analysis.
Authors:
Sara Carillo, Craig Jakes, Jonathan Bones National Institute for Bioprocessing Research & Training, Dublin, Ireland
References
1.Tassi M, De Vos J, Chatterjee S, Sobott F, Bones J, Eeltink S., J Sep Sci., 2018; 41(1): 125-144. 2. Sosic Z, Houde D Blum A, Carlage T, Lyubarskaya Y, Electrophoresis 2008; 29(21): 4368-4376. 3. Redman EA, Mellors JS, Starkey JA, Ramsey JM. Anal Chem. 2016; 88(4): 2220-2226.
Lithium-ion batteries are prevalent in our society and used in everything from electric vehicles to personal devices. Disposal of used batteries represents a challenge, as even old or partially charged devices present deflagration hazards if exposed to heat, puncture, or other forms of perturbation. A method for decommissioning Li-ion batteries is to immerse them in a brine solution, which ostensibly de-energizes the electrical cells such that the batteries can be transported and discarded safely. However, this process is not trivial for remediation personnel as it results in the liberation of numerous gases that are highly toxic and flammable. As such, having a means to detect and identify these gases and to determine when they are no longer present is crucial to the decommissioning process.
In a recent case study, an agency was contracted to decommission numerous types of batteries including Li-ion cells and other electrical components that had been damaged in a large- scale fire event. The agency planned to deploy the brine solution method but was also interested in testing its efficacy and learning what gaseous components may be generated. Batteries were soaked in 55-gallon drums and smaller containers, and gaseous samples were extracted from headspaces using Tedlar bags. Initial air monitoring of the headspaces yielded some interesting and unexpected results, which prompted the need for additional gas identification.
The agency’s approach was to use ThreatID™, a portable analyzer for identifying powders, liquids, gas, vapors, and complex mixtures based on Fourier transform infrared (FTIR) technology.
The remnants of an exploded li-ion battery. Source: PETER PEREIRA/The Standard-Times
The ThreatID can identify over 27,600 hazardous chemicals, including over 5,600 gases at low parts-per-million (ppm) levels, in less than 1 minute. A certified instructor was on-site for the endeavor to conduct the measurements and report results back to technical experts. From the headspace sampling, the ThreatID primarily identified methane and ammonia.
Reachback personnel confirmed the results and even identified some very minute components through detailed spectral data review. These additional materials included acetylene, formaldehyde, ethene, and even some unidentifiable substances. The ThreatID gas-phase results were confirmed on-site using colorimetric tubes which detected methane, ammonia, and formaldehyde.
Interestingly, the presence of ammonia and volatile organic compounds (VOCs) was not expected based on initial supposition and readings from basic air monitors. Headspace analyses showed that even after the batteries were deemed “safe,” toxic and flammable materials continued to off-gas. The study proved that after a fire or other disastrous event when batteries are inactive, they may still pose significant hazards and must be properly monitored. By rapidly identifying the liberating gases and using secondary technologies to confirm them, the correct hazard associations can be made and greatly accelerate the time scale of future decommissioning projects.
This event was a success by demonstrating that the brine solution method must be further optimized to fully decommission Li-ion and other battery types to render them safe for transport and disposal. Without FTIR gas identification, the clean-up effort would have been plagued with uncertainties and require significantly more time to properly remediate the lurking potential hazards.
Reachback Spectral Interpretation for sample CNB018a, matching Methane.
Cell therapy manufacturing continues to advance through innovation in bioreactor design, and the integration of process analytical technology (PAT) to monitor, control, and improve processes. Real-time and in-line and on-line monitoring of key metabolic parameters, such as glucose and lactate, enables improved control strategies for optimized cell culture. This, in turn, leads to more reliable and cost-effective manufacturing, ultimately helping make therapies more accessible to patients in need. Discover how the synergy between automated cell expansion systems and real-time analyzers revolutionizes cell culture processes.
This poster, developed in partnership with Quantum Flex and Terumo Blood and Cell Technologies, was featured at Advanced Therapies 2024.
[post_title] => Advancing Cell Therapy Manufacturing with Bioreactor and Bioprocess Control Solutions
[post_excerpt] => Discover how the synergy between automated cell expansion systems and real-time analyzers revolutionizes cell culture processes. This poster was featured at Advanced Therapies 2024.
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[post_content] =>
Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis.
This poster was a collaboration with Terumo Blood and Cell Technologies and was part of the poster program at the 2024 ISCT EU Conference.
[post_title] => Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
[post_excerpt] => The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding, characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
[post_status] => publish
[comment_status] => closed
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[post_name] => enhancing-cell-and-gene-therapy-manufacturing-processes-by-in-line-on-line-and-at-line-bioprocess-analytical-technologies
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[post_modified] => 2024-09-09 13:14:46
[post_modified_gmt] => 2024-09-09 17:14:46
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[2] => WP_Post Object
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[ID] => 24564
[post_author] => 15
[post_date] => 2024-05-23 19:23:12
[post_date_gmt] => 2024-05-23 23:23:12
[post_content] =>
[post_title] => Optimization of Scalable rAAV Production for Gene Therapy – Utilizing At-Line Amino Acid Measurements for Bioprocess
[post_excerpt] => The REBEL device enabled data-driven bioprocess development for rAAV manufacturing in HEK293 cells by accurately and precisely quantitating amino acids, leading to deeper process understanding. This poster was a collaboration with MIT and highlighted at the following 2024 Conferences-ASGCT, ISCT, ISCT EU and ESACT.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => optimization-of-scalable-raav-production-for-gene-therapy-utilizing-at-line-amino-acid-measurements-for-bioprocess
[to_ping] =>
[pinged] =>
[post_modified] => 2024-09-09 10:08:26
[post_modified_gmt] => 2024-09-09 14:08:26
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[3] => WP_Post Object
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[ID] => 24562
[post_author] => 29
[post_date] => 2024-05-23 19:04:45
[post_date_gmt] => 2024-05-23 23:04:45
[post_content] =>
[post_title] => In-Line and On-Line Monitoring of Key Cell Culture Parameters for Robust Cell and Gene Therapy Bioprocess
[post_excerpt] => The instant PAT implementation with MAVERICK, versatility, and sensitivity of MAVEN and point of need availability of amino acids analysis with REBEL, enable deeper knowledge and actionable information of Cell and GeneTherapy bioprocesses. Further, the devices informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization and control. This poster was highlighted at the 2024 ASGCT Conference.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => in-line-and-on-line-monitoring-of-key-cell-culture-parameters-for-robust-cell-and-gene-therapy-bioprocess
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-29 09:55:27
[post_modified_gmt] => 2024-07-29 13:55:27
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[guid] => https://908devices.com/?post_type=resource&p=24562
[menu_order] => 104
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[4] => WP_Post Object
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[ID] => 24537
[post_author] => 29
[post_date] => 2024-05-23 13:27:45
[post_date_gmt] => 2024-05-23 17:27:45
[post_content] =>
[post_title] => Microchip CE-MS Analysis of Nucleic Acids – From Characterization of Synthetic Oligonucleotides to Sequence Mapping of RNAs
[post_excerpt] => This work will showcase how the ZipChip enables a simple and rapid workflow for the analysis of nucleic acids with noion-pairing reagents needed This poster was highlighted at the 2024 TIDES Conference.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => microchip-ce-ms-analysis-of-nucleic-acids-from-characterization-of-synthetic-oligonucleotides-to-sequence-mapping-of-rnas
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 10:55:48
[post_modified_gmt] => 2024-08-01 14:55:48
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[menu_order] => 105
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[5] => WP_Post Object
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[ID] => 23822
[post_author] => 29
[post_date] => 2024-03-25 09:32:04
[post_date_gmt] => 2024-03-25 13:32:04
[post_content] =>
[post_title] => Investigation of Drug-To-Antibody Ratio for FORCE Oligonucleotide Conjugates Using Microchip CE-MS
[post_excerpt] => ZipChip microchip CE-MS resolves DAR species electrophoretically and enables generation of superior MS spectra. This poster was presented as a collaboration with Dyne Therapeutics at ASMS 2023 as poster WP045.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => investigation-of-drug-to-antibody-ratio
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-29 09:58:16
[post_modified_gmt] => 2024-07-29 13:58:16
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=23822
[menu_order] => 106
[post_type] => resource
[post_mime_type] =>
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[6] => WP_Post Object
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[ID] => 23824
[post_author] => 15
[post_date] => 2024-03-25 09:37:58
[post_date_gmt] => 2024-03-25 13:37:58
[post_content] =>
[post_title] => In-depth Characterization of Adeno-Associated Viruses using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
[post_excerpt] => Rapid microchip CE-MS can be utilized for the in-depth characterization of AAVs including viral capsid protein analysis and peptide mapping. This poster was presented as a collaboration with NIBRT at ASMS 2023 as poster WP730.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => in-depth-characterization-of-adeno-associated-viruses
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-25 09:56:23
[post_modified_gmt] => 2024-03-25 13:56:23
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=23824
[menu_order] => 107
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[7] => WP_Post Object
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[ID] => 23966
[post_author] => 29
[post_date] => 2024-04-01 13:05:13
[post_date_gmt] => 2024-04-01 17:05:13
[post_content] =>
[post_title] => Rapid In-Depth Characterization of Biologics by Microchip CE-MS: mAbs, AAVs and Nucleic Acids
[post_excerpt] => Microchip capillary electrophoresis (CE) coupled with mass spectrometry (MS) has revolutionized the characterization of therapeutic modalities in biopharmaceuticals. Here, we present the applications of an integrated workflow that couples the microfluidic CE system (ZipChip) with MS in characterization of biotherapeutics. This was poster A03 at BPS Europe 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rapid-in-depth-characterization-of-biologics
[to_ping] =>
[pinged] =>
[post_modified] => 2024-05-07 16:06:30
[post_modified_gmt] => 2024-05-07 20:06:30
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[guid] => https://908devices.com/?post_type=resource&p=23966
[menu_order] => 108
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[8] => WP_Post Object
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[ID] => 23963
[post_author] => 29
[post_date] => 2024-04-01 12:35:51
[post_date_gmt] => 2024-04-01 16:35:51
[post_content] =>
[post_title] => Know Your Process: On-line and At-line Analytics for Upstream Bioprocess Key Nutrients
[post_excerpt] => Bioprocess development requires analytics to monitor critical process parameters. This poster discusses two discuss two key technologies to characterize, optimize and control bioprocess. In 2024, this poster has been highlighted at BPI Europe and BPS Europe.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => know-your-process-on-line-and-at-line-analytics
[to_ping] =>
[pinged] =>
[post_modified] => 2024-10-22 13:09:38
[post_modified_gmt] => 2024-10-22 17:09:38
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=23963
[menu_order] => 109
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[9] => WP_Post Object
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[ID] => 23826
[post_author] => 15
[post_date] => 2024-03-25 10:02:00
[post_date_gmt] => 2024-03-25 14:02:00
[post_content] =>
[post_title] => Raman-based In-line Monitoring of Key Process Parameters in Mammalian Bioprocesses without the Need for Chemometric Model Building
[post_excerpt] => This poster describes a new technology called MAVERICK that uses Raman spectroscopy for continuous monitoring of mammalian cell cultures, specifically those using CHO and HEK293 cells. In 2024 this poster has been highlighted at BPI US West, BPS Europe, BPI Europe, BPI USA and most recently Advanced Therapies.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => raman-based-in-line-monitoring-of-key-process-parameters-in-mammalian
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:35:31
[post_modified_gmt] => 2024-11-18 20:35:31
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23826
[menu_order] => 110
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[10] => WP_Post Object
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[ID] => 23828
[post_author] => 32
[post_date] => 2024-03-25 10:10:07
[post_date_gmt] => 2024-03-25 14:10:07
[post_content] =>
[post_title] => 5’ mRNA Analysis By Microchip CE-MS Using an Internal Cleavage Motif for RNase H Digestion
[post_excerpt] => The subject of this poster was the investigation of an internal DNA motif to produce a shorter digestion product while simultaneously maintaining the length of the probe at 25nt for hybridization specificity. The shorter oligo results in easier detection using Microchip CE-MS approach. This poster was presented at ASMS 2023 as poster THP575.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => 5-mrna-analysis-by-microchip-ce-ms
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-26 14:32:16
[post_modified_gmt] => 2024-03-26 18:32:16
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23828
[menu_order] => 111
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[11] => WP_Post Object
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[ID] => 23830
[post_author] => 15
[post_date] => 2024-03-25 10:15:07
[post_date_gmt] => 2024-03-25 14:15:07
[post_content] =>
[post_title] => Improved Performance of Phosphopeptides Characterization Using Online Capillary Electrophoresis Coupling with Ion Mobility Mass Spectrometry (CE-IM-MS)
[post_excerpt] => This poster will highlight a novel strategy for characterization of therapeutic peptide that was developed based on microchip CE-MS pure liquid separation and ion mobility gas phase separation, combing with mass spectrometry identification. The poster was presented in collaboration with Ningbo University at ASMS 2023 as poster THP609.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improved-performance-of-phosphopeptides-characterization
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-25 10:15:12
[post_modified_gmt] => 2024-03-25 14:15:12
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23830
[menu_order] => 112
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[12] => WP_Post Object
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[ID] => 23832
[post_author] => 15
[post_date] => 2024-03-25 10:20:12
[post_date_gmt] => 2024-03-25 14:20:12
[post_content] =>
[post_title] => Amino Acid Quantitation in Over 50 Mammalian Cell Culture Media with an Integrated CE-MS Analyzer
[post_excerpt] => Characterizing cell culture nutrients such as amino acids in growth media is critical for maximizing cell growth and improving key quality attributes of the cells. This poster was presented at ASMS 2023 as poster THP625.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => amino-acid-quantitation-in-over-50-mammalian-cell-culture-media
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 14:18:02
[post_modified_gmt] => 2024-08-01 18:18:02
[post_content_filtered] =>
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[13] => WP_Post Object
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[ID] => 23820
[post_author] => 15
[post_date] => 2024-03-25 09:27:20
[post_date_gmt] => 2024-03-25 13:27:20
[post_content] =>
[post_title] => Rapid Identification of Conjugation Sites in Antibody Drug Conjugates Using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
[post_excerpt] => CE/MS method is optimized with NISTmAb digest as a reference control. Good MS/MS coverage of NISTmAb is obtained with narrow peak width and fast separation. This poster was presented as a collaboration with Bruker at ASMS 2023 as poster WP041.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rapid-identification-of-conjugation-sites-in-antibody-drug
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-25 09:28:04
[post_modified_gmt] => 2024-03-25 13:28:04
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[guid] => https://908devices.com/?post_type=resource&p=23820
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[14] => WP_Post Object
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[ID] => 23818
[post_author] => 29
[post_date] => 2024-03-25 09:13:48
[post_date_gmt] => 2024-03-25 13:13:48
[post_content] =>
[post_title] => Conformation of Native Antibody-Drug Conjugate Charge Variants Revealed by Microchip Capillary Electrophoresis Coupled with Trapped Ion Mobility
[post_excerpt] => The combination of microchip capillary electrophoresis and trapped ion mobility enables a rapid, informative method for native monoclonal antibody and antibody-drug conjugate charge variant analysis. This poster was a collaboration with Bruker and NIH and presented at ASMS 2023 as poster WP040.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => conformation-of-native-antibody-drug-conjugate-charge-variants
[to_ping] =>
[pinged] =>
[post_modified] => 2024-05-07 14:29:50
[post_modified_gmt] => 2024-05-07 18:29:50
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[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23818
[menu_order] => 115
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[15] => WP_Post Object
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[ID] => 23798
[post_author] => 15
[post_date] => 2024-03-21 11:02:11
[post_date_gmt] => 2024-03-21 15:02:11
[post_content] =>
[post_title] => Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis - Mass Spectrometry (CE-MS)
[post_excerpt] => Presenting a novel strategy for characterization of therapeutic peptides was developed based on microchip CE-MS and linkage-specific derivatization. This poster was presented in collaboration with Ningbo University at ASMS 2023 as poster TP544.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => fast-screening-and-characterization-of-therapeutic-peptide
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 11:02:12
[post_modified_gmt] => 2024-03-21 15:02:12
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=23798
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[16] => WP_Post Object
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[ID] => 23796
[post_author] => 15
[post_date] => 2024-03-21 10:52:20
[post_date_gmt] => 2024-03-21 14:52:20
[post_content] =>
[post_title] => Continuing the Investigation of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry in the Bottom-Up Characterization of Progressively Larger RNAs
[post_excerpt] => Exploring the merits of capillary-zone electrophoresis (CZE)-mass spectrometry to analyze digestion mixtures of large RNAs and attain sequence information. This poster was presented as a collaboration with UConn and Bruker at ASMS 2023 and was poster TP532.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => continuing-the-investigation-of-microchip-capillary-electrophoresis
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 14:18:20
[post_modified_gmt] => 2024-08-01 18:18:20
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[guid] => https://908devices.com/?post_type=resource&p=23796
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[ID] => 23794
[post_author] => 15
[post_date] => 2024-03-21 10:38:52
[post_date_gmt] => 2024-03-21 14:38:52
[post_content] =>
[post_title] => Determination of ATP, ADP, AMP, and Adenosine Levels by Microchip Capillary Electrophoresis Coupled with High Resolution Mass Spectrometry
[post_excerpt] => In this study, we present a novel ZipChip coupled with a QEHF for adenosine nucleotide analysis. This poster was presented at ASMS 2023 as poster TP489.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => determination-of-atp-adp-amp-and-adenosine-levels
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 14:18:43
[post_modified_gmt] => 2024-08-01 18:18:43
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[guid] => https://908devices.com/?post_type=resource&p=23794
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[18] => WP_Post Object
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[ID] => 23789
[post_author] => 15
[post_date] => 2024-03-21 10:26:35
[post_date_gmt] => 2024-03-21 14:26:35
[post_content] =>
[post_title] => Amino Acid Quantitation of Cell Culture Media Matrices via an Integrated CE-MS Analyzer
[post_excerpt] => Optimization of cell culture media and process conditions are critical for achieving optimal cell growth, productivity, and product quality. This poster was presented at ASMS 2023 as poster TP 398.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => amino-acid-quantitation-of-cell-culture-media
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 10:33:40
[post_modified_gmt] => 2024-03-21 14:33:40
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[guid] => https://908devices.com/?post_type=resource&p=23789
[menu_order] => 119
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[19] => WP_Post Object
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[ID] => 23787
[post_author] => 15
[post_date] => 2024-03-21 10:20:58
[post_date_gmt] => 2024-03-21 14:20:58
[post_content] =>
[post_title] => Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS
[post_excerpt] => This poster was presented in collaboration with Protein Metrics and highlights how the ZipChip coupled to HRMS provides a streamlined analytical approach to rapidly assess the heterogeneity of the investigated therapeutic proteins through the comprehensive interrogation of the different charge variants and their intact MS spectra. This poster was presented at ASMS 2023 as poster TP 384.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => sample-to-result-workflow-for-the-investigation-of-biosimilars-vs-innovator-cetuximab
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 10:20:58
[post_modified_gmt] => 2024-03-21 14:20:58
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=23787
[menu_order] => 120
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[20] => WP_Post Object
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[ID] => 23785
[post_author] => 15
[post_date] => 2024-03-21 10:15:48
[post_date_gmt] => 2024-03-21 14:15:48
[post_content] =>
[post_title] => Peptide Mapping Workflow for Direct Microchip CE-MS Analysis of Biopharmaceuticals
[post_excerpt] => In this study we demonstrated the suitability of a modified digestion workflow for peptide mapping analysis via CE separation. This poster was presented at ASMS 2023 in collaboration with NIBRT. It was poster MP619.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => peptide-mapping-workflow-for-direct-microchip
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 10:15:49
[post_modified_gmt] => 2024-03-21 14:15:49
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[guid] => https://908devices.com/?post_type=resource&p=23785
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[21] => WP_Post Object
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[ID] => 23781
[post_author] => 15
[post_date] => 2024-03-21 09:57:40
[post_date_gmt] => 2024-03-21 13:57:40
[post_content] =>
[post_title] => Combining Capillary Electrophoresis and Trapped Ion Mobility Spectrometry Mass Spectrometry to Analyze Epitranscriptomic Marks Mediating Virus-Host Interactions in Infectious Diseases
[post_excerpt] => This poster evaluates the merits of capillary-zone electrophoresis (CZE)-MS. This poster was presented at ASMS 2023 as a collaboration with UCONN. It was poster MP548.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => combining-capillary-electrophoresis-and-trapped-ion-mobility-spectrometry-mass-spectrometry
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:57:41
[post_modified_gmt] => 2024-03-21 13:57:41
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[guid] => https://908devices.com/?post_type=resource&p=23781
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[22] => WP_Post Object
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[ID] => 23779
[post_author] => 15
[post_date] => 2024-03-21 09:38:33
[post_date_gmt] => 2024-03-21 13:38:33
[post_content] =>
[post_title] => Use of Microchip Capillary Electrophoresis – Mass Spectrometry for Automated Rapid Measurement of Enzyme Reaction Kinetics
[post_excerpt] => This approach allows rapid measurement of enzymatic cleavage dynamics in real time. It can be applied to almost any enzyme substrate reaction and is highly tolerable to various buffers, thanks to the CE Chip-MS configuration. This poster was presented at ASMS 2023 with collaborators as poster MP547.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => use-of-microchip-capillary-electrophoresis
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:55:53
[post_modified_gmt] => 2024-03-21 13:55:53
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[23] => WP_Post Object
(
[ID] => 24540
[post_author] => 29
[post_date] => 2024-05-23 13:58:57
[post_date_gmt] => 2024-05-23 17:58:57
[post_content] =>
[post_title] => Optimization of Scalable rAAV Production for Gene Therapy – Leveraging At-Line Amino AcidMeasurements for Bioprocess Modeling-Driven Approaches
[post_excerpt] => Spent media analysis from an at-line analyzer, the REBEL, was used to further understanding of AAV production process and identify correlation between key nutrient consumptions and capsid titers in fed-batch and continuous processes. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 43.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => scalable-aav-production-gene-therapy
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 12:39:26
[post_modified_gmt] => 2024-08-01 16:39:26
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=24540
[menu_order] => 125
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[24] => WP_Post Object
(
[ID] => 23776
[post_author] => 15
[post_date] => 2024-03-21 09:29:35
[post_date_gmt] => 2024-03-21 13:29:35
[post_content] =>
[post_title] => Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
[post_excerpt] => N-glycan profiling is a critical step of biopharmaceuticals analysis as N-glycans play an important part in both activity and safety of monoclonal antibodies and other glycosylated biotherapeutics. This poster was presented at ASMS 2023 as poster MP291.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rapid-ce-ms-analysis-of-released-n-glycan
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:35:32
[post_modified_gmt] => 2024-03-21 13:35:32
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=23776
[menu_order] => 126
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[25] => WP_Post Object
(
[ID] => 26486
[post_author] => 15
[post_date] => 2024-11-26 16:19:49
[post_date_gmt] => 2024-11-26 21:19:49
[post_content] =>
Process intensification in biomanufacturing often involves increasing cell densities and product titers, which can lead to increased glucose consumption and potential accumulation of toxic metabolites. High glucose concentrations can also negatively impact protein quality attributes. To address these challenges, we developed MAVERICK, a novel Raman-based PAT approach that enables real-time monitoring and control of CHO cell cultures without the need for prior model building. This versatile approach can be applied across various cell lines, media systems, reactor scales, and culture modes. By implementing a continuous dynamic feeding strategy guided by MAVERICK, we can enhance process performance and improve protein quality attributes like glycosylation, glycation, and charge variants.
MAVERICK, a novel Raman-based PAT technology, was showcased at the ECI Integrated Continuous Biomanufacturing Conference 2024. This technology allows for immediate monitoring of critical process parameters like glucose, lactate, and biomass without the need for extensive preliminary work or model building. By implementing a continuous glucose feeding strategy guided by MAVERICK, researchers were able to significantly improve process titer, cell-specific productivity, and protein quality attributes. This straightforward approach highlights the potential of MAVERICK to revolutionize biomanufacturing processes.
[post_title] => Novel Approach for Instant Implementation of Raman-based PAT with Integrated Real-Time Process Control
[post_excerpt] => The innovative technology of Maverick allows for immediate monitoring of critical process parameters like glucose, lactate, and biomass without the need for extensive preliminary work or model building.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => novel-approach-for-instant-implementation-of-raman-based-pat-with-integrated-real-time-process-control
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-26 16:19:49
[post_modified_gmt] => 2024-11-26 21:19:49
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=26486
[menu_order] => 127
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[26] => WP_Post Object
(
[ID] => 25226
[post_author] => 29
[post_date] => 2024-07-09 11:04:45
[post_date_gmt] => 2024-07-09 15:04:45
[post_content] =>
Understanding of cell culture metabolism in biologics manufacturing has increased tremendously in the past decade; however, the lack of feasible methods of high coverage, quantitative information on the interplay between nutrients and metabolites has hindered the efforts to fully characterize processes in the different biological phases. Several published models support cell growth phase but lack the kinetic information to be applicable to the phases that follow. We discuss a method for measuring hundreds of metabolites in dozens of pathways that streamlines sample preparation from spent media and cells, enables fast data-analysis times and supports quantitative analysis of key metabolites to gain far richer and more reliable data sources for process characterization, modelling and understanding. The method uses microchip CE/MS and incorporates stable isotope internal standards for both quantitation and migration time indexing. This work explores the information that can be obtained from the extracellular growth media and intracellular metabolites extracted from the CHO cells.
The poster was on display at Bioprocessing Summit, and ESACT #253 in 2024.
[post_title] => In-depth Metabolic Characterization at Different Phases of Cell Culture with a Turnkey CE-ESI-HRMS Workflow
[post_excerpt] => Learn about a turnkey CE-MS metabolomics workflow solution used to characterize media metabolites and intracellular metabolites of CHO bioreactors. The poster was on display at Bioprocessing Summit, and ESACT #253 in 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => correlation-of-soluble-metabolites-with-lactate-switch-observed-in-hek293-culture-using-novel-ce-ms-metabolomics-workflow
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-25 16:13:49
[post_modified_gmt] => 2024-11-25 21:13:49
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25226
[menu_order] => 128
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)
[27] => WP_Post Object
(
[ID] => 26149
[post_author] => 15
[post_date] => 2024-10-11 13:20:46
[post_date_gmt] => 2024-10-11 17:20:46
[post_content] =>
Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis. This poster was developed with Terumo Blood and Cell Technologies and was showcased at BPI USA and Advanced Therapies 2024.
[post_title] => Innovations in Analytical Technology for Cell & Gene Therapy Manufacturing
[post_excerpt] => This poster highlights our at-, on-, and in-line analytical solutions that contribute to an enhanced understanding, characterization, and control of bioprocesses in the development and manufacturing of cell and gene therapies.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => innovations-in-analytical-technology-for-cell-gene-therapy-manufacturing
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:32:59
[post_modified_gmt] => 2024-11-18 20:32:59
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=26149
[menu_order] => 130
[post_type] => resource
[post_mime_type] =>
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)
[28] => WP_Post Object
(
[ID] => 25218
[post_author] => 29
[post_date] => 2024-07-09 10:54:09
[post_date_gmt] => 2024-07-09 14:54:09
[post_content] =>
The introduction of the ZipChip Intact Antibodies Reagent Kit marked a significant milestone in the ZipChip portfolio, enabling the first tailored solution of charge variant analysis (CVA) of monoclonal antibodies on the CE-MS platform. However, there was room for enhancement in preserving the native conformation of the proteins under analysis, as well as in enhancing the separation between variant peaks. The next generation kits, the Native Antibodies Kit and Charge Variant TOF Kit, significantly improved peak separation and producing spectra more indicative of native protein structures. This was poster # TP642 at ASMS 2024.
[post_title] => Optimized Native Conditions for Charge Variant Analysis Using a Microfluidic CE-MS Platform Yield Higher Quality Data and Enables Analysis of Lower Titer Samples
[post_excerpt] => Learn about the improvements made in the new Charge Variant Analysis kit, compared to the previous Intact Antibodies and Native Antibodies kits. ASMS 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => optimized-native-conditions-for-charge-variant-analysis-using-a-microfluidic-ce-ms-platform-yield-higher-quality-data-and-enables-analysis-of-lower-titer-samples
[to_ping] =>
[pinged] =>
[post_modified] => 2024-09-23 12:16:29
[post_modified_gmt] => 2024-09-23 16:16:29
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25218
[menu_order] => 131
[post_type] => resource
[post_mime_type] =>
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)
[29] => WP_Post Object
(
[ID] => 25213
[post_author] => 29
[post_date] => 2024-07-09 10:28:00
[post_date_gmt] => 2024-07-09 14:28:00
[post_content] =>
As the field of bioprocessing continues to mature, there is a need for better analytics applied closer to the bioprocess. We have seen recent advancements in the technology used to measure small molecules within bioreactors (glucose/lactate, amino acids), but there is also a need to directly measure the critical quality attributes of the proteins being produced. To that end, we are assessing the ability of microfluidic CE-ESI-MS to perform charge variant - MS analysis of proteins pulled directly from a bioreactor. We know that excessive salt concentrations can cause band-broadening for this separation, so the key question is whether a desalting step is required, or if a simple dilute and shoot approach can work, and how much information can be obtained. Here we compare a simple dilute and shoot method to a method that buffer exchanges the sample before ZipChip analysis and demonstrates the use of this method for analysis of 4 different bioreactor growth conditions. This poster was on display at ASMS 2024 as poster # TP638.
[post_title] => Charge Variant Analysis of IgGs Directly from Cell Culture Supernatant Using Microfluidic CE-ESI-MS
[post_excerpt] => This poster describes the application of Microfluidic CE-ESI-MS for analyzing protein charge variants directly from a bioreactor. It investigates the feasibility of a "dilute and shoot" approach compared to a buffer exchange method for sample preparation. ASMS 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => charge-variant-analysis-of-iggs-directly-from-cell-culture-supernatant-using-microfluidic-ce-esi-ms
[to_ping] =>
[pinged] =>
[post_modified] => 2024-09-23 12:20:01
[post_modified_gmt] => 2024-09-23 16:20:01
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25213
[menu_order] => 132
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[30] => WP_Post Object
(
[ID] => 25249
[post_author] => 15
[post_date] => 2024-07-09 18:00:38
[post_date_gmt] => 2024-07-09 22:00:38
[post_content] =>
Raman spectroscopy offers relatively non-invasive access to the estimation of critical quality attributes and parameters in bioprocesses. Current approaches to predicting these parameters rely heavily on latent variable/regularized empirical calibration methods, with partial least-squares (PLS) being the most dominant. Although one advantage of these approaches is that they require zero detailed understanding of the underlying system (physics/chemistry/biology), there are several significant disadvantages to modelling bioprocess under these frameworks. This was poster #391 at ESACT 2024.
[post_title] => De Novo Approaches for Bioprocess Parameter Estimation Using Raman Spectroscopy
[post_excerpt] => This research proposes a novel method for real-time bioprocess parameter prediction with de novo models using Raman spectroscopy. Unlike traditional methods, this approach requires no training data and offers a priori performance estimates.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => de-novo-approaches-for-bioprocess-parameter-estimation-using-raman-spectroscopy
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-09 18:00:39
[post_modified_gmt] => 2024-07-09 22:00:39
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25249
[menu_order] => 138
[post_type] => resource
[post_mime_type] =>
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)
[31] => WP_Post Object
(
[ID] => 25246
[post_author] => 15
[post_date] => 2024-07-09 14:48:37
[post_date_gmt] => 2024-07-09 18:48:37
[post_content] =>
The power of Raman spectroscopy for bioprocess monitoring is well-known , but the expertise required to develop ROBUST and SUSTAINABLE multivariate models is a massive impediment. Our goal was to develop an in-line device, termed MAVERICK, that provides immediate value for glucose, lactate and biomass estimation without the need for cumbersome model training/re-training with an ease-of-use similar to that of a pH probe. This was poster # 390 at ESACT 2024.
[post_title] => New Era of Real-time Bioprocess Monitoring and Control –Raman-based Direct Measurements with De Novo Model
[post_excerpt] => MAVERICK offers real-time bioprocess monitoring of glucose, lactate, and biomass through a Raman-based sensor, eliminating the need for complex setup and training data.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => new-era-of-real-time-bioprocess-monitoring-and-control-raman-based-direct-measurements-with-de-novo-model
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-09 14:48:38
[post_modified_gmt] => 2024-07-09 18:48:38
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25246
[menu_order] => 139
[post_type] => resource
[post_mime_type] =>
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[filter] => raw
)
[32] => WP_Post Object
(
[ID] => 25245
[post_author] => 15
[post_date] => 2024-07-09 14:32:05
[post_date_gmt] => 2024-07-09 18:32:05
[post_content] =>
The biopharmaceutical industry is increasingly motivated to improve process control, understanding, and repeatability using process analytical technologies (PAT). More specifically, Raman-based optical, in-line measurement methods have shown promise as a way to monitor critical performance parameters, including glucose and lactate concentrations, in real-time. Recently, this has translated to the implementation of Raman-based glucose feeding strategies to modulate productivity and product quality in Chinese hamster ovary (CHO) cell cultures. The current work implements a novel Raman-based solution that does not require any chemometric models for glucose, lactate and biomass measurements. MAVERICK was directly, without any training in the specific bioprocess, deployed to dynamically control lactate feeding. We compared feeding strategies as means of modulating product quality and improving culture conditions, primarily through decreased ammonia accumulation. This was poster #358 at ESACT 2024 and was also highlighted at the Bioprocessing Summit 2024.
[post_title] => Raman-based Lactate Feeding Impact on Culture Characteristics and Product Quality in Mammalian Cell Cultures
[post_excerpt] => This research explores Raman spectroscopy for real-time glucose monitoring and feeding strategies in CHO cell cultures, aiming to improve product quality.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => raman-based-lactate-feeding-impact-on-culture-characteristics-and-product-quality-in-mammalian-cell-cultures
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-23 14:16:28
[post_modified_gmt] => 2024-08-23 18:16:28
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25245
[menu_order] => 140
[post_type] => resource
[post_mime_type] =>
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[filter] => raw
)
[33] => WP_Post Object
(
[ID] => 25242
[post_author] => 15
[post_date] => 2024-07-09 14:23:13
[post_date_gmt] => 2024-07-09 18:23:13
[post_content] =>
Biologics production development for intensified processes aims to achieve desired product quality attributes and high productivity. Running multiple micro-bioreactors in parallel enables expedited optimization, but low microbioreactor volumes limit the media available for daily sampling for analysis. Cell culture media (CCM) optimization can be a lengthy and complex process involving multiple DOEs. Fast, at the point-of-need, analytical tools with only minimal sample consumption, are required to assess key-nutrient consumption and provide feedback to enable feed strategy optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
[post_title] => Data-driven Feed Strategy Optimization and Scale-up of mAb-expressing CHO Cell Line Bioprocess
[post_excerpt] => This poster explores utilizing micro-bioreactors for expedited biologics production development, highlighting challenges with limited sample volume for media analysis and proposing real-time, point-of-need analytical tools for efficient CCM optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => data-driven-feed-strategy-optimization-and-scale-up-of-mab-expressing-cho-cell-line-bioprocess
[to_ping] =>
[pinged] =>
[post_modified] => 2024-10-02 13:40:29
[post_modified_gmt] => 2024-10-02 17:40:29
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25242
[menu_order] => 141
[post_type] => resource
[post_mime_type] =>
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)
[34] => WP_Post Object
(
[ID] => 25192
[post_author] => 15
[post_date] => 2024-07-08 15:11:04
[post_date_gmt] => 2024-07-08 19:11:04
[post_content] =>
Through the work highlighted in this poster we found that when the manufactured cells are antigen-stimulated, CAR/VIPRa T-cells become significantly more energetic. In contrast, CAR T-cells become less energetic and more glycolytic, which are known features of T-cell exhaustion. Further, metabolic assessment with multiple methods produced findings that correlated with this assessment, such oxygen consumption and certain amino acid levels in spent media. Finally, CAR T-cell activity, potency, and cytotoxicity assessments showed a correlation with anti-tumor activity. Together, this work demonstrates that distinct metabolic features allow CAR/VIPRa T cells, when antigen-stimulated, to have enhanced functions against tumors. Developed in partnership with Emory University and the Winship Cancer Institute, this poster has made waves at the 2024 ISCT & ISCT EU Conference, the ESACT Conference, and Advanced Therapies 2024.
[post_title] => Spent Media Analysis Aids in Determining Metabolic Mechanisms of Superior CAR T-Cell Products
[post_excerpt] => As the use of CAR T-cell therapies advances, testing different CAR T-cells, and associating metabolic characteristics to well-performing, desired phenotypes of CAR T-cells enables optimization of CAR constructs and manufacturing processes.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => spent-media-analysis-aids-in-determining-metabolic-mechanisms-of-superior-car-t-cell-products
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:37:35
[post_modified_gmt] => 2024-11-18 20:37:35
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25192
[menu_order] => 142
[post_type] => resource
[post_mime_type] =>
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)
[35] => WP_Post Object
(
[ID] => 25189
[post_author] => 15
[post_date] => 2024-07-08 14:47:24
[post_date_gmt] => 2024-07-08 18:47:24
[post_content] =>
This poster highlights the HEK-mediated adeno-associated virus (AAV) production process and the development of an open-source production platform incorporating a chemically defined serum-free medium. Initial attempts using an open-source CHO-medium resulted in cell aggregation, slow growth, and an inability to transfect and produce AAV. Therefore, we explored creating an HEK-friendly medium and process conducive to healthy cell growth, transfection, and vector production. Nutrient consumption rates were studied to elucidate metabolic activity associated with AAV production. This poster was #835 at ISCT 2024
[post_title] => Open-sourced Production Platform for Raav in HEK Data-driven Cell Culture Media Optimization
[post_excerpt] => This poster highlights the HEK-mediated adeno-associated virus (AAV) production process and the development of an open-source production platform incorporating a chemically defined serum-free medium.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => open-sourced-production-platform-for-raav-in-hek-data-driven-cell-culture-media-optimization
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-08 14:47:25
[post_modified_gmt] => 2024-07-08 18:47:25
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25189
[menu_order] => 143
[post_type] => resource
[post_mime_type] =>
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)
[36] => WP_Post Object
(
[ID] => 23438
[post_author] => 15
[post_date] => 2024-02-20 17:24:46
[post_date_gmt] => 2024-02-20 22:24:46
[post_content] =>
[post_title] => Improving Cell and Gene Therapy Manufacturing Processes by Automated On-line and In-line Bioprocess Analytical Technologies
[post_excerpt] => Recent advances in cell and gene therapy bioprocess analytical technology regimes, approaches to de novo analytical modeling/calibration of these systems, and how their informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 29. This poster was also on display as #843 at ISCT 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improving-cell-gene-therapy-manufacturing
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-08 13:01:02
[post_modified_gmt] => 2024-07-08 17:01:02
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23438
[menu_order] => 144
[post_type] => resource
[post_mime_type] =>
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)
[37] => WP_Post Object
(
[ID] => 23435
[post_author] => 29
[post_date] => 2024-02-20 17:15:13
[post_date_gmt] => 2024-02-20 22:15:13
[post_content] =>
[post_title] => Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack - Manufactured CAR T-Cells
[post_excerpt] => Novel reagents that aid in the consistent manufacturing of
Novel reagents that aid in consistent manufacturing of CAR T-cells with well-defined phenotypes are needed to improve treatment outcomes in patients. View poster #17 from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => multi-cytokine-backpack-car-t-cells
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 11:11:58
[post_modified_gmt] => 2024-08-01 15:11:58
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23435
[menu_order] => 145
[post_type] => resource
[post_mime_type] =>
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)
[38] => WP_Post Object
(
[ID] => 23432
[post_author] => 15
[post_date] => 2024-02-20 17:03:02
[post_date_gmt] => 2024-02-20 22:03:02
[post_content] =>
[post_title] => Optimization of Cell Culture Media and Culture Conditions for HEK293 for Improved Cell Growth and Reduced Cell Clumping for the Effective Production of Viral Vectors
[post_excerpt] => This study demonstrates the power of at-line cell culture analyzers such as the REBEL to gain process understanding quickly to adjust media components for improved cell culture performance. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 18.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improved-cell-growth-production-viral-vectors
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:09:37
[post_modified_gmt] => 2024-03-21 13:09:37
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[post_date] => 2023-02-27 11:46:37
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[post_content] =>
[post_title] => Automated Glucose Feeding Based On Online Glucose And Lactate Measurements
[post_excerpt] => This poster note describes an automated control strategy for cell growth and biologics production. It leverages MAVEN, a reliable, easy-to-operate, online (sample-free) device for monitoring of glucose and lactate.
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[post_date] => 2022-11-30 20:16:00
[post_date_gmt] => 2022-12-01 01:16:00
[post_content] =>
[post_title] => Process Optimization by the Use of Substrate Feeding Strategies
[post_excerpt] => Online glucose monitoring is possible by using Trace C2 Control system. Feed control without online glucose monitoring causes acetate formation due to overflow metabolism.
[post_status] => publish
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[post_content] =>
[post_title] => Optimized Fed-Batch Fermentation by Use of Online Glucose Measurement
[post_excerpt] => This poster presentation features an integrated multivariate glucose measuring tool combined with software solutions which allow different types of feeding-strategies.
[post_status] => publish
[comment_status] => closed
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[post_date] => 2022-11-30 19:53:12
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[post_content] =>
[post_title] => High Frequency Glucose and Lactate Measurements in Multi-Bioreactor Vessels
[post_excerpt] => TRACE C2 is an online analyzer for monitoring and controlling glucose and lactate concentrations in bioreactors. With the extension M4 it is possible to monitor Glucose and Lactate in up to four simultaneous bioprocesses.
[post_status] => publish
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[post_date] => 2022-11-30 19:44:36
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[post_content] =>
[post_title] => Online-Controlling of Glucose in Cultivations and Fermentations
[post_excerpt] => TRACE C2 Control is a new online analyzer for monitoring and controlling of glucose concentrations in bioprocesses. In disturbance reaction experiments and in an E.coli fermentation it can be successfully shown that a reliable control is possible.
[post_status] => publish
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[post_modified] => 2024-04-03 18:43:23
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[post_date] => 2022-11-30 19:33:56
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[post_content] =>
[post_title] => Implementation of a New Method for Online Glucose Control in a 10L CHO Bioprocess
[post_excerpt] => This poster shows how glucose concentration can be directly measured based on an enzymatic reaction. This method is then used to control the glucose level in a fed-batch fermentation at a
constant level.
[post_status] => publish
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[post_date] => 2022-11-30 19:05:04
[post_date_gmt] => 2022-12-01 00:05:04
[post_content] =>
[post_title] => Single-Use Bioreactor for High Density Bacterial Fermentation
[post_excerpt] => Glucose measurement is performed on-line using the TRACE C2 analyzer. This allows to follow-up glucose uptake rate and monitor fed batch culture with retro-control on the glucose pump such as maintain glucose level at predefined set point.
[post_status] => publish
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[post_name] => trace-c2-poster-single-use-bioreactor
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[post_modified] => 2024-04-03 18:45:30
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[post_date] => 2022-09-22 15:09:32
[post_date_gmt] => 2022-09-22 19:09:32
[post_content] =>
[post_title] => Optimization of Scalable rAAV Production for Gene Therapy
[post_excerpt] => This poster showcases spent media analysis leveraging REBEL, which requires only 10 μL per sample and 10 minutes analysis time.
[post_status] => publish
[comment_status] => closed
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[post_name] => rebel-ps-13
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[post_modified] => 2023-12-26 10:04:40
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[post_date] => 2022-09-22 15:04:14
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[post_content] =>
[post_title] => Empowering Process Optimization for a mAb-Expressing CHO Cell Line
[post_excerpt] => Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.
[post_status] => publish
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[post_name] => rebel-ps-14
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[post_date] => 2022-06-11 02:59:33
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[post_content] =>
[post_title] => Bottom-Up Analysis of Progressively Larger RNAs by CZE-MS and CZE-MS/MS
[post_excerpt] => In this poster from ASMS 2022, researchers from University of Connecticut and Bruker showed that capillary zone electrophoresis performed on a chip proved to be an effective alternative to liquid chromatography as a front-end separation system to analyze both pure samples and complex digestion mixtures of nucleic acids.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-uconn
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[post_content] =>
[post_title] => Multi-level Expeditious Characterization of Adeno-associated Virus (AAV) Capsid Proteins Using ZipChip Microfluidic CE Coupled with HRMS
[post_excerpt] => In this poster from ASMS 2022, scientists from Thermo Fisher Scientific and 908 Devices present a novel approach using microchip CE-MS for the characterization of AAVs.
[post_status] => publish
[comment_status] => closed
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[post_name] => zipchip-poster-asms2022-thermo
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[post_modified] => 2023-12-26 12:42:52
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[post_date] => 2022-06-11 02:42:23
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[post_content] =>
[post_title] => A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS
[post_excerpt] => In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.
[post_status] => publish
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[post_date] => 2022-06-11 02:37:28
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[post_title] => Combining μSPE ZipChip CE with PRM-LIVE on a timsTOF Pro for Warp-speed Selectivity Profiling of Deubiquitinase (DUB) Small Molecule Inhibitors
[post_excerpt] => In this ASMS 2022 poster, researchers from Dana Farber Cancer Institute and Harvard Medical School developed a ZipChip-based method for facilitating high-throughput identification
of new small molecule inhibitors.
[post_status] => publish
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[post_content] =>
[post_title] => Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
[post_excerpt] => In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.
[post_status] => publish
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[post_modified] => 2023-12-26 12:40:53
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[53] => WP_Post Object
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[post_content] =>
[post_title] => CE-MS of Oligonucleotides using a ZipChip
[post_excerpt] => This ASMS 2022 poster from Boehringer Ingelheim explores the use of ZipChip coupled to a high resolution mass spectrometer as an orthogonal method to chromatography for oligonucleotide analysis.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-boehringer
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[post_modified] => 2023-12-26 12:39:52
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[post_date] => 2022-06-11 02:14:51
[post_date_gmt] => 2022-06-11 06:14:51
[post_content] =>
[post_title] => Rapid Characterization of Oligos and Related Impurities Using Microchip CE-MS without Ion-pairing Reagents
[post_excerpt] => This poster from ASMS 2022 describes a simple & fast method for oligonucleotide characterizations using a Microchip CE-MS platform.
[post_status] => publish
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[ping_status] => closed
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[post_name] => zipchip-poster-asms2022-kulkarni
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[post_modified] => 2024-08-01 14:18:58
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[post_date] => 2022-06-11 02:20:24
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[post_content] =>
[post_title] => Glycosylation Profiling of mAB Subunits with CZE-MS
[post_excerpt] => This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-glycosylation-profiling
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[post_modified] => 2024-08-01 14:19:13
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[post_date] => 2022-06-10 20:16:47
[post_date_gmt] => 2022-06-11 00:16:47
[post_content] =>
[post_title] => Pushing the Boundaries of Speed and Sensitivity in Proteomics
[post_excerpt] => To overcome sample loading limitations in CE-MS, the poster authors engineered a 1 mm SPE bed within the chip geometry, allowing 100-fold improvements in concentration sensitivity limit for CE-MS.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-thompson
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[post_date] => 2022-06-10 19:14:29
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[post_content] =>
[post_title] => A Broad Application of Migration Time Indexing and Metabolite Libraries to Evaluate Quantitative Coverage in Microchip CE-MS Metabolomics
[post_excerpt] => In the field of metabolomics, microchip capillary electrophoresis (mCE) has a number of potential advantages over traditional liquid chromatography (LC), including higher throughput due to decreased separation times, increased separation efficiency, and lower required sample volumes.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-metabolomics-raiche
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[post_content] =>
[post_title] => A Microchip CE-MS Based End-to-End Solution for the Analysis of Synthetic Oligonucleotides
[post_excerpt] => This poster showcases a workflow using microchip CE-MS that is coupled with a vendor-neutral informatics platform
as a complete solution for the analysis of synthetic oligos.
[post_status] => publish
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[post_content] =>
[post_title] => Microchip CE-MS with Integrated Solid Phase Extraction
[post_excerpt] =>
[post_status] => publish
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[post_name] => zipchip-poster-microchip-cebrms-with-integrated-solid-phase-extraction
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[post_content] =>
[post_title] => Microchip CE-MS of Oligonucleotides: What Can It Separate?
[post_excerpt] =>
[post_status] => publish
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[post_name] => zipchip-poster-microchip-ce-ms-of-oligonucleotides-what-can-it-separate
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[post_date] => 2017-10-05 18:10:30
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[post_content] =>
[post_title] => Fast Chip-CEMS for Characterization of Protein/PTM Changes
[post_excerpt] =>
[post_status] => publish
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[post_name] => poster-fast-chip-cems-characterization-proteinptm-changes
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[post_title] => Combined Top-down and Bottom-up Proteomics
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[post_title] => ZipChip for Glycomics and Glycoproteomics
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[post_title] => Fast and Efficient Biopharmaceutical Characterization
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[post_title] => Characterization of charge heterogeneity of mAb
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[post_title] => Rapid, Multi-level Analysis of Complex Proteins
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[post_title] => Oligonucleotide Analysis via Microfluidic CE-MS
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[post_title] => Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF
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[post_title] => 96 Bottles of Beer: Metabolic Profiling of Spent Growth Media
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[post_title] => Using genomic and spent media analysis to characterize stressed CHO cultures
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[post_title] => Native Analysis of Monoclonal Antibodies
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[post_title] => Characterization of Protein/PTM Changes
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[post_title] => Native CE-MS for Biopharmaceutical Characterization
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[post_title] => A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
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[post_title] => Bioprocessing of Monoclonal Antibody Based Therapies
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[post_title] => NIBRT Presents Native MS for Charge Variants using ZipChip
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[post_title] => NIBRT Presents ZipChip for Native Charge Heterogeneity
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[post_title] => Monitoring Amino Acid Composition of Cell Culture Media
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Cell therapy manufacturing continues to advance through innovation in bioreactor design, and the integration of process analytical technology (PAT) to monitor, control, and improve processes. Real-time and in-line and on-line monitoring of key metabolic parameters, such as glucose and lactate, enables improved control strategies for optimized cell culture. This, in turn, leads to more reliable and cost-effective manufacturing, ultimately helping make therapies more accessible to patients in need. Discover how the synergy between automated cell expansion systems and real-time analyzers revolutionizes cell culture processes.
This poster, developed in partnership with Quantum Flex and Terumo Blood and Cell Technologies, was featured at Advanced Therapies 2024.
908 Devices expanded its chemical detection capabilities by acquiring RedWave Technology, combining its high-pressure mass spectrometry (HPMS) expertise with RedWave’s advanced Fourier-transform infrared (FTIR) technology. This acquisition creates a more comprehensive solution for detecting and identifying chemicals across various scenarios, from field forensics to hazardous material response. The move also opens new opportunities for cross-selling, shared training, and customer support, positioning 908 Devices as a key player in both public safety and military markets.
[post_title] => Catching a RedWave
[post_excerpt] => Explore how 908 Devices' acquisition of RedWave Technology is revolutionizing chemical detection with advanced mass spectrometry and FTIR solutions, expanding capabilities for public safety and military applications.
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The novel 13C tracer-based metabolomics method using microfluidic capillary electrophoresis-mass spectrometry (CE-MS) enables rapid and accurate analysis of isotopomer patterns in proteinogenic amino acids from minimal sample sizes, revealing central carbon metabolism and amino acid biosynthesis pathways in microbes such as Methanothermobacter thermautotrophicus. This method, utilizing a ZipChip CE system and an Orbitrap Fusion Tribrid mass spectrometer, demonstrated high sensitivity and precision, detecting metabolic pathways and fluxes even under biomass-restricted conditions. The approach also highlights the presence of alternative enzymes and biosynthesis pathways not captured by existing public databases, thus enhancing the prediction and understanding of microbial metabolic and genetic capabilities.
Download Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product. For products where multiple SDS are available, please check the part number and concentration.
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Download Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product. For products where multiple SDS are available, please check the part number and concentration.
Confidently identify thousands of chemical threats anywhere with the portable ProtectIR. Compact and lightweight, it’s the ideal “grab and go” platform for rapidly assessing chemical threats.
Identify 23,000+ Solids and Liquids:
Hazardous Chemicals
TICs
TIMs
VOCs
Narcotics, including fentanyls
Explosives
Features:
Clear, visible results in seconds
Simple operation
24/7/365 Reachback
Designed for use in harsh environments
Built-in wireless communications
Specifications
Technology:
FTIR (Fourier Transform Infrared Spectroscopy)
Sample Type:
Solids, Liquids
Sample Interface:
Diamond ATR (Attenuated Total Reflectance)
Size:
6.5” × 9.25” × 3” (16.51cm × 23.5 cm × 7.62cm)
Weight:
5 lbs (2.27 kgs)
Frequency Range:
4000–650 cm
Resolution:
4 cm
Display:
4.3”, 480 × 272
Connections:
USB 2.0 WiFi (802.11 G)
Durability:
IP67, Mil spec 810G
Search Technique:
Automated Mixture & Consumer Product Searches
Alarms:
Protein, Explosive, CWA, Water (as an interferent)
Rechargeable Li Ion battery, 6 hour run time Line power transformer, 100–240 VAC, 50/60 Hz
Database:
ThreatAssist; integrated chemical information database
Decon:
Spray, wipe-down or dunk with bleach or detergent
Warranty:
1 Year Warranty 24/7/365 Support Reachback with data analysis
Remote Data Access:
TeamLeader App available for download on Apple or Google Play
[post_title] => ProtectIR Specification Sheet
[post_excerpt] => Learn about the features and performance of ProtectIR, a portable FTIR device designed for analyzing solid and liquid threats.
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Accurate, Actionable Gas Identification
XplorIR® is the only handheld gas/vapor detector that can accurately detect and identify 5,600+ unknown chemical threats in seconds. Use XplorIR to continuously monitor and receive immediate answers during high-threat operations, or transition to point-and-shoot mode for isolated target intelligence.
Continuously monitor 5,600+ gas/vapors:
Chemical Warfare Agents
Nerve Agents
Blister Agents
Choking Agents
Hazardous Chemicals
TICs
TIMs
VOCs
Features:
Clear, visible results in seconds
Quantification of thousands of hazardous chemicals
Adaptive atmospheric corrections
Part per million (ppm) level sensitivity
Simple operation
Designed for use in harsh environments
24/7/365 Reachback
Provides accurate ID of up to 6 components in real-time even within complex gas mixtures.
InterceptIR™ is the only gas/vapor sensor designed for robotic applications to accurately detect and identify 5,600+ unknown chemical threats in seconds.
Warfighters and responders face a myriad of unknown and unseen threats that often require personnel to confront life-threatening situations. Remote chemical threat identification can be used for screening large areas before sending personnel in, gaining access to seemingly hard- to-reach areas, and establishing safety perimeters. The integration of the InterceptIR onto remote platforms now allows operators to sense, screen, and move safely into seemingly inaccessible environments. InterceptIR was designed for integration onto a variety of robotic platforms using the provided power and communication. This pairs the gas identification capability of the InterceptIR with the remote control features of the unmanned system, providing safer site characterization.
The InterceptIR has a low SWaP (Size Weight and Power) payload and the ability to identify over 5,600 gases and vapors autonomously, making it ideal for identifying threats in real-time without risking human life. With its widely used and accepted JavaScript Object Notation (JSON) messaging, the InterceptIR API can easily integrate into a variety of communication platforms.
Use InterceptIR to continuously monitor and identify threats without endangering human life.
ThreatID™ gives emergency and military responders the ability to accurately identify a vast range of chemical threats with a single, portable, battery-operated system.
No alignment, calibration, or configuration required
Simple operation
Designed for use in harsh environments
No downtime from oversaturation
24/7/365 Reachback
Built-in wireless communication
Ability to create your own custom search libraries
Specifications
Technology:
FTIR (Fourier Transform Infrared Spectroscopy)
Sample Type:
Powders, Liquids, Gases Interchangeable
Solids Measurement:
Diamond ATR (Attenuated Total Reflectance)
Gas Measurement:
4 meter, multi-pass gas cell, 160ml volume
Size:
14” × 11” × 6” (35.56cm × 27.94 cm × 15.24)
Weight:
15 lbs (6.8 kgs)
Integrated Computer:
Quad-core 64-bit CPU, 4GB RAM, 64GB SSD
Operating System:
Android
Display:
10” HDMI, Touchscreen
Connections:
USB 2.0 WiFi (802.11 G) Bluetooth Ethernet
Camera:
Integrated sample surface camera
Power Connector:
Rugged, waterproof, IP67
Alarms:
Protein, Explosive, CWA, Water, Mixture, Low Signal
Libraries:
23,000 powder and liquid 5,600 gas and vapor TICs, Narcotics, CWA, Explosives, Consumer Products, Chemicals, Pharmaceuticals
Search Techniques:
Primary (Correlation) Automated Mixture Search Functional Groups
Database:
ThreatAssist; integrated chemical information database
Decon:
Spray or wipe-down with bleach or detergent
Reachback:
24/7/365 Support Automated Reachback Email On-line support and troubleshooting
[post_title] => ThreatID Specification Sheet
[post_excerpt] => Learn about the features and performance of ThreatID, a portable FTIR device designed for analyzing solids, liquids, gases, and complex mixtures.
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[post_date] => 2023-07-25 13:50:24
[post_date_gmt] => 2023-07-25 17:50:24
[post_content] =>
High Priority Threat Coverage
Chemical warfare agents (CWAs) have been a persistent concern in global security, posing a grave threat to areas in conflict. Recent years have witnessed disturbing incidents of their use across various parts of the world.
The emergence of pharmaceutical-based agents (PBAs) adds to this threat. Originally designed for medical purposes, drugs like carfentanil have become a cause for concern due to their toxicity and extreme ease of manufacturing and procurement. The idea of weaponizing drugs like fentanyl represents a dangerous escalation in the ongoing battle against illicit substances. It poses significant challenges to militaries and first responders as traditional security measures may not be sufficient to counteract this new threat.
Filling The Gap In Area Monitoring
MX908 is deployed by militaries and first responders around the world for detection and identification of chemical threats.
With the addition of MX908 Beacon™, operators can augment their area monitoring capability to provide real-time identification of aerosol and vapor chemical warfare agents (CWAs) and pharmaceutical based agents (PBAs) for extended durations, adding a layer of protection for special events, hazmat response and critical infrastructure. A remote communications package allows users to operate and monitor multiple Beacons from anywhere in the world while sharing realtime data with their team.
Area Monitoring For:
Hazmat response
Key events
Military operations
Critical infrastructure
Exclusion zone monitoring
Decontamination monitoring
VIP Protection
Clandestine lab operations
CBRN Vehicles
Threat Categories:
A-series agents (Novichoks)
V-series agents
G-series agents
HD Mustard
Pharmaceutical-based agents
Lachrymatory agents
Beacon Advantages:
Only area monitor for vapor and aerosol identification
Remote monitoring anywhere in the world
Compatible with any MX908 device
Discreet, environmentally hardened case
Trace identification (low-mid ppb/ng) of threats
Extended operation and standby time
Easy data sharing capability
Specifications
Size
22 x 17.9 x 10.4 in
Weight
< 30 lbs
Power
Imbedded Li Ion batteries or shore power for 8+ hours of continuous operations
Communications
User-provided cellular device/WiFi hotspot to secure web page
Sample Introduction
Continuous gas/vapor analysis with periodic aerosol analysis via thermal desorption
Data Export
Data export from secure web server
Remote Management
- Monitor multiple sessions in a single portal. Start/stop scans, monitor results, share data. - Alerts are sent discreetly to user connected computer or mobile devices
The MX908 Beacon Portal provides real-time results and allows the user to remotely control multiple units simultaneously.
The MX908 Beacon is a remote area monitoring solution that provides real-time identification of aerosol and vapor chemical warfare agents (CWAs) and pharmaceutical based agents (PBAs) for extended durations.
Continuous Monitoring and Real-time Control of Ethanol and Methanol in Microbial Fermentations
TRACE C2 offers online monitoring of methanol or ethanol and enables real-time control of substrate feeding.
There’s no direct sampling, so there’s no volume loss. Only real-time insights and real-time control for optimal productivity of your fermentation process.
Ethanol and Methanol are Key Parameters in Fermentation
Ethanol is a growth-inhibiting byproduct in yeast fermentation of biotherapeutics
In alcoholic fermentations, ethanol is monitored to assess product yield
Methanol is a carbon source and inducer for efficient recombinant protein production in yeast fermentations
Accelerate Process Development and Improve Process Robustness with TRACE C2
Gain reliable monitoring of quickly changing process conditions with up to 30 measurements per hour
Improve process understanding and develop more optimized feeding and control strategies
Automate feeding right out of the box with integrated PID controller and dedicated feeding pump
Specifications
Measured analytes:
Methanol or Ethanol
Measurement frequency:
Up to 30 per hour (every 2 minutes). User-configurable.
Measuring range:
Methanol: 0.5 to 20 g/L Ethanol: 1 to 40 g/L
Measurement precision:
Methanol: <5% at 1.0 g/L Ethanol: <5% at 2.0 g/L
Probe/flow cell connections:
1
On-board peristaltic feed pumps:
1 (4.9 mL/min max flow rate)
Measuring principle:
Selective flow-diffusion analysis with biosensor and enzyme reactor integrated with tube set
Biosensor service life:
5,000 measurements or 15 days
Biosensor storage temperature:
5 °C to 25 °C (41 °F to 77 °F)
Enzyme reactor storage temperature:
4 °C to 10°C (39°F to 50°F)
Enzyme reactor shelf life:
6 months
Physical dimensions (W x H x D):
120 mm x 170 mm x 200 mm
Weight:
1.8 kg
Ambient operating temperature:
15°C - 35°C (59°F - 95°F)
Ambient operating humidity:
10 - 90% RH (non-condensing)
System storage temperature:
5°C - 60°C (41°F - 140°F)
pH range of bioreactor medium:
4.8 to 9.2
Safety/Compliance:
UL/CSA/IEC 61010-1; CE marked
Software:
Installed on PC
Software requirements:
Operating system Windows XP, Windows 7, 8, 10, 11 , Windows Server 2012 R2
Power requirements:
100-120, 220-240 VAC; 50-60 Hz
Device battery:
Lithium (0.09 g, UN test 38.3) Type CR2430 (3V, 270 mAh
Analog output options:
0 to 10 V; 0 to 20 mA; 4 to 20 mA
Communication interfaces:
RS232, Ethernet
Data exchange modes:
OPC UA, Modbus TCP
Integrated controllers:
PID, On/Off
Included components:
Power adapter, power plug, crossover ethernet cable, user manual and PCSoftware
MX908® leverages high-pressure mass spectrometry™ (HPMS) to deliver dramatically enhanced sensitivity and broader threat category coverage. This second-generation tool increases mission support with unmatched flexibility and trace detection power for elite responders in chemical, explosive, drug and priority hazmat scenarios.
Reliable Field Analysis
With the enhanced selectivity of HPMS, users can conduct field analysis of unknown substances at trace levels to identify drugs while keeping officers safe. The MX908 allows operators to rapidly assess threat levels, establish reliable probable cause, and prioritize investigatory resources accordingly, all while reducing operator exposure.
Missions:
Drug Interdictions and Investigations
Clandestine Laboratory Exploitation
EOD
Border Security
HazMat Response
Checkpoint Security
Postal Security
Event Security
Threat Categories:
Fentanyls/Synthetic Opioids
Synthetic Cannabinoids
Synthetic Cathinones
Traditional drugs such as:
Cocaine
Heroin
Meth
MDMA, and more
Precursors
Operational Strengths:
Nanogram level detection identifies threats while keeping officers safe
Establish probable cause with trace evidence
24/7 Reachback support for data analysis by forensic chemists
Attributes:
Fast start up
Results in <45s
Trace detection (low - mid nanograms)
Powered by mass spectrometry
Heightened sensitivity and selectivity
Unmistakable audio and visual alerts
Simple interface
Low maintenance
MX908 Mission Modes enhance performance for specific mission objectives.
Drug Hunter is a mission mode for the detection of drugs such as: fentanyl and fentanyl analogs, along with other high priority controlled substances.
Drug Hunter unlocks detection capabilities for more than 2000 fentanyl variants.
Fentanyl Analog Classifier future-proofs your MX908 against the ever-changing fentanyl analog landscape. The MX908 is the only device capable of classifying fentanyl analogs without a library-based approach allowing users to stay ahead of new and emerging fentanyl analogs.
Specifications
Size:
29.8 x 21.6 x 12.2 cm (11.8 x 8.5 x 4.8 in)
Power:
Replaceable, hot swappable batteries with >3 hours of continuous operation (2 spare batteries included)
Display:
Adjustable ultra-bright backlit display for direct sunlight and nighttime conditions, 12.7 cm (5 in)
Weight:
≤4.3 kg (9.5 lbs); varies based on module, accessories
Rapid trace-to-bulk solid/liquid analysis via thermal desorption swabs; continuous gas/vapor analysis with periodic aerosol analysis via thermal desorption
Alarm Type:
Audio and visual for both detection and identification
Software:
Embedded, self-contained, on-board analytics
Data Export:
Export wirelessly via Bluetooth connection with any compatible iOS or Android device Export manually using included USB drive
Decontamination:
IP-54 rated, chemical resistant housing spray/splash and wipe down
Operating Temperature:
0°–40° C (32°-110° F)
Storage Temperature:
-20°–60° C (-4°-140° F)
Ruggedness:
MIL-STD-810G
MX908 is equipped with modular accessories for ease of transition between solid, liquid, vapor, and aerosol sample types.
MX908 is rugged and meets the requirements for use in harsh environments.
The enhanced selectivity of MX908 allows for even broader threat category coverage.
[post_title] => MX908 Specifications for Priority Drugs
[post_excerpt] => With the enhanced selectivity of HPMS, users can conduct field analysis of unknown substances at trace levels to generate actionable intelligence in real time.
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[post_name] => priority-drug-spec-sheet
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[post_content] =>
MULTI-THREAT DETECTION
MX908® leverages high-pressure mass spectrometry™ (HPMS) to deliver dramatically enhanced sensitivity and broader threat category coverage. It provides identification across a broad range of drugs such as synthetic opioids, phenethylamines, cathinones, and cannabinoids.
RELIABLE TRACE ANALYSIS
MX908 provides trace identification (nanogram/invisible level) of many drugs commonly smuggled into corrections facilities. The ability to detect and identify invisible amounts of drugs allows the MX908 to defeat common smuggling tactics like spraying substances onto paper and mail. Accurate and rapid trace level identification also reduces exposure risk to officers and inmates by enabling exterior sampling of packages and ultimately keeping illicit drugs out of the facility.
MISSIONS:
Mail screening
Unknown powder identification
Overdose response
THREAT CATEGORIES:
Fentanyls/synthetic opioids
Phenethylamines
Cathinones
Cannabinoids
CWAs, Explosives, TICs, Precursors
MX908 ADVANTAGES:
Trace identification of many drugs including: fentanyl, fentanyl analogs, methamphetamine, synthetic cathinones, and synthetic cannabinoids
MX908 provides excellent target coverage of common cannabinoids, cathinones, and phenethylamines often seized in corrections facilities
Mail screening for trace identification of drugs sprayed onto paper or delivered by mail
Increased officer safety by enabling non-intrusive sampling
Accurate and rapid results allow officers to act quickly and with confidence
Reachback analysis of mass spectra
MX908 Mission Modes enhance performance for specific mission objectives.
Drug Hunter is a mission mode for the detection of drugs such as: fentanyl and fentanyl-analogs, along with other high priority controlled substances
Drug Hunter unlocks detection capabilities for more than 2000 fentanyl variants.
This Mission Mode future-proofs your MX908 against the ever-changing Fentanyl analog landscape with a novel classification algorithm that sets MX908 apart from any library-based techniques.
SPECIFICATIONS
Size:
29.8 x 21.6 x 12.2 cm (11.8 x 8.5 x 4.8 in)
Power:
Replaceable, hot swappable batteries with >3 hours of continuous operation (2 spare batteries included)
Display:
Adjustable ultra-bright backlit display for direct sunlight and nighttime conditions, 12.7 cm (5 in)
Weight:
≤4.3 kg (9.5 lbs); varies based on module, accessories
MX908® leverages high-pressure mass spectrometry™ (HPMS) to deliver dramatically enhanced sensitivity for identification of chemical warfare agents (CWAs), toxic industrial chemicals (TICs) and more. In addition to traditional agents and threat materials, MX908 is a field-deployable tool that can identify A-series CWAs, also known as fourth generation agents (FGAs) or Novichoks, at trace levels.
Closing the Capability Gap
As the threat landscape continues to evolve, responders must adapt to ensure they’re equipped to address threats as they arise. Whether identifying military grade warfare agent, mitigating an active incident, or validating decontamination, responders need the selectivity to distinguish between threats and the sensitivity for high fidelity trace detection. With MX908, elite federal, military and civilian responders have the quick, confident intelligence they need to ensure the safety of their team and the public.
With the addition of MX908 Beacon™, operators can provide real-time, remote identification of aerosol and vapor for extended durations, adding a layer of protection for special events, hazmat response and critical infrastructure.Threat Categories:
Missions:
Area Monitoring
Site Exploitation
Border Security
HazMat Response
Checkpoint Security
Postal Security
Event Security
Threat Categories:
CWAs (including Novichoks)
Fentanyls/Opioids
Emerging threats
Explosives
TIC/TIM
Precursors
Trace Level Sampling Modes:
Vapors
Aerosols
Solids and liquids
Operational Strengths:
MX908 Beacon accessory for remote area monitoring
Fast start up
Rapid analysis
Trace detection (low - mid ppb)
Powered by mass spectrometry
Heightened sensitivity and selectivity
Unmistakable audio and visual alerts
Simple interface
Low maintenance
Mission Modes Use Specialized Software To Optimize Performance For Specific Mission Objectives
CW Hunter is a mission mode for the detection of priority chemical warfare agents, including A-series (Novichoks). Delivers real-time vapor quantification.
Drug Hunter is a mission mode for the detection of drugs such as: fentanyl and fentanyl-analogs, along with other high priority drugs-of-abuse.
Explosives Hunter is a mission mode for the detection of priority threats from military and commercial grade explosives, to homemade energetics and relevant precursors.
Specifications
Size:
29.8 x 21.6 x 12.2 cm (11.8 x 8.5 x 4.8 in)
Power:
Replaceable, hot swappable batteries with >3 hours of continuous operation (2 spare batteries included)
Display:
Adjustable ultra-bright backlit display for direct sunlight and nighttime conditions, 12.7 cm (5 in)
Weight:
≤4.3 kg (9.5 lbs); varies based on module, accessories
Rapid trace-to-bulk solid/liquid analysis via thermal desorption swabs; continuous gas/vapor analysis with periodic aerosol analysis via thermal desorption
Alarm Type:
Audio and visual for both detection and identification
Software:
Embedded, self-contained, on-board analytics
Data Export:
Export wirelessly via Bluetooth connection with any compatible iOS or Android device Export manually using included USB drive
Decontamination:
IP-54 rated, chemical resistant housing spray/splash and wipe down
Operating Temperature:
0°–40° C (32°-110° F)
Storage Temperature:
-20°–60° C (-4°-140° F)
Ruggedness:
MIL-STD-810G
MX908 is rugged and meets the requirements for use in harsh environments.
MX908 Beacon accessory for remote area monitoring
The enhanced selectivity of MX908 allows for even broader threat category coverage.
An obvious user interface guides users through each mission mode.
[post_title] => MX908 Specifications for Hazmat
[post_excerpt] => With MX908, elite federal, military and civilian responders have the quick, confident intelligence they need to ensure the safety of their team and the public.
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[post_date] => 2017-09-01 14:40:59
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All Hazard Threat Detection
MX908® leverages high-pressure mass spectrometry™ (HPMS) to deliver dramatically enhanced sensitivity and broader threat category coverage. This second-generation tool increases mission support with unmatched flexibility and trace detection power for elite responders in chemical, explosive, drug and priority hazmat scenarios. MX908 lightens the overall technology burden by displacing other less selective technologies from the response toolkit.
Lightening The Load
With the enhanced proficiency of HPMS, users can lighten the technology load of tools required downrange. With sensitivity levels comparable to ion mobility mass spectrometry (IMS) and significantly enhanced selectivity, MX908 can detect trace quantities (low - mid ppb) of priority threats amongst the myriad of interferents that plague other less selective technologies.
Missions:
Site Exploitation
EOD
Border Security
HazMat Response
Checkpoint Security
Postal Security
Event Security
Threat Categories:
CWA
Fentanyls/Opioids
Emerging threats
Explosives
TIC/TIM
Precursors
Attributes:
Fast start up
Rapid analysis
Trace detection (low - mid ppb)
Powered by mass spectrometry
Heightened sensitivity and selectivity
Unmistakable audio and visual alerts
Simple interface
Low maintenance
Operational Strengths:
Trace-level vapors, aerosols, solids, and liquids
Mission Modes Use Specialized Software To Optimize Performance For Specific Mission Objectives
CW Hunter is a mission mode for the detection of priority chemical warfare agents, including A-series (Novichoks). Delivers real-time vapor quantification.
Drug Hunter is a mission mode for the detection of drugs such as: fentanyl and fentanyl-analogs, along with other high priority drugs-of-abuse.
Explosives Hunter is a mission mode for the detection of priority threats from military and commercial grade explosives, to homemade energetics and relevant precursors.
Specifications
Size:
29.8 x 21.6 x 12.2 cm (11.8 x 8.5 x 4.8 in)
Power:
Replaceable, hot swappable batteries with >3 hours of continuous operation (2 spare batteries included)
Display:
Adjustable ultra-bright backlit display for direct sunlight and nighttime conditions, 12.7 cm (5 in)
Weight:
≤4.3 kg (9.5 lbs); varies based on module, accessories
Continuous gas/vapor analysis with periodic aerosol analysis via thermal desorption; rapid trace to-bulk solid/liquid analysis via thermal desorption swabs
Alarm Type:
Audio and visual for both detection and identification
Software:
Embedded, self-contained, on-board analytics
Data Export:
Export wirelessly via Bluetooth connection with any compatible iOS or Android device Export manually using included USB drive
Decontamination:
IP-54 rated, chemical resistant housing spray/splash and wipe down
Operating Temperature:
0°–40° C (32°-110° F)
Storage Temperature:
-20°–60° C (-4°-140° F)
Ruggedness:
MIL-STD-810G
MX908 is rugged and meets the requirements for use in harsh environments.
MX908 is equipped with modular accessories for ease of transition between solid, liquid, vapor, and aerosol sample types.
The enhanced selectivity of MX908 allows for even broader threat category coverage.
An obvious user interface guides users through each mission mode.
[post_title] => MX908 Specifications for EOD
[post_excerpt] => Detection and ID of priority threats from military and commercial grade explosives, to homemade energetics and relevant precursors.
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[post_content] =>
ZipChip Interface
Capillary electrophoresis-mass spectrometry (CE-MS) has never been more convenient. The compact design of the ZipChip Interface seamlessly integrates all fluidics and electronics—just clip it on your mass spec and off you go!
- Standalone ZipChip acquisition software - Integrates with your MS software
Dimensions:
7” W x 6.5” H x 11” D /18cm W x 17cm H x 28cm D
Weight:
16 lbs / 7.3 Kg
Power Requirements:
24V DC, 65W
Laser Type:
Class 1 Laser Product*
*This equipment contains a 520 nm, 4.5 mW Class 3R laser diode with a beam divergence of 1.5 mrad but is classified as a Class 1 Laser Product as an end-use as evaluated to IEC 60825-1:2014. Avoid direct eye exposure to the beam and do not remove the laser for any other purpose.
Autosampler*
Achieve unattended sample runs from samples vials or 96-well plates. The platform allows you to choreograph sample runs using ZipChip software.
Specifications
Sample Format:
Vials or standard well plates (47 mm max height)
Sample Capacity:
Two sample trays that hold 48 vial racks or 96-well plates
Sample Tray Cooling:
- Built-in Peltier cooling - Minimum: 4°C ± 2°C - Maximum: ambient temperature –3°C (Measured as air temperature in sample compartment for maximum air temperature 25°C and maximum humidity 80%)
Dimensions:
11.75” W x 14.25” H x 22” D /30cm W x 36cm H x 57.5cm D
Weight:
46.3 lbs / 21 kg
Power Requirements:
100–240 VAC +/-10%, 50–60Hz, 200 VA
*Required for ZipChip Interface, Autosampler version
[post_title] => ZipChip Hardware Specification Sheet
[post_excerpt] => The compact interface seamlessly integrates all fluidics and electronics. Just clip it on your mass spec and off you go!
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[post_date] => 2019-09-11 15:09:41
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[post_content] =>
Get cell media analysis at-line, anytime.
The REBEL puts the control in your hands.
Its small, self-contained footprint fits right on your bench allowing you to run samples at-line in less than 10 minutes.
SAMPLE INFO
Get quantitative identification and analysis on a panel of 30+ analytes including key amino acids, biogenic amines, and water-soluble vitamins.
Analysis time: <10 minutes per well Volume and format: 10 µL minimum volume (prior to dilution) 96-well plate or chromatography vials Cooled sample storage Type: Fresh or spent cell media from mammalian or microbial cultures and fermentations
Confidently identify thousands of chemical threats anywhere with the portable ProtectIR. Compact and lightweight, it’s the ideal “grab and go” platform for rapidly assessing chemical threats.
Identify 23,000+ Solids and Liquids:
Hazardous Chemicals
TICs
TIMs
VOCs
Narcotics, including fentanyls
Explosives
Features:
Clear, visible results in seconds
Simple operation
24/7/365 Reachback
Designed for use in harsh environments
Built-in wireless communications
Specifications
Technology:
FTIR (Fourier Transform Infrared Spectroscopy)
Sample Type:
Solids, Liquids
Sample Interface:
Diamond ATR (Attenuated Total Reflectance)
Size:
6.5” × 9.25” × 3” (16.51cm × 23.5 cm × 7.62cm)
Weight:
5 lbs (2.27 kgs)
Frequency Range:
4000–650 cm
Resolution:
4 cm
Display:
4.3”, 480 × 272
Connections:
USB 2.0 WiFi (802.11 G)
Durability:
IP67, Mil spec 810G
Search Technique:
Automated Mixture & Consumer Product Searches
Alarms:
Protein, Explosive, CWA, Water (as an interferent)
This technical note is a detailed analysis of how XplorIR's Limit of Identification can be determined for a given meter and chemical product under specific operational conditions.
[post_title] => Understanding Limits of Identification of the XplorIR
[post_excerpt] => XplorIR's Limit of Identification can be determined for a given meter and chemical product under specific operational conditions.
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[post_name] => understanding-limit-of-identification-of-the-xplorir
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[post_title] => Glucose & Lactate Dialysis
[post_excerpt] => These data were compiled in order to give an overview of the system and sensor performance in the normal concentration range using the dialysis sampling method.
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[post_title] => Glucose & Lactate Dialysis (Low)
[post_excerpt] => These data were compiled in order to give an overview of typical system and sensor performance in the low concentration range using the dialysis-low sampling method. Operational temperature in the bioreactor was set to 37°C.
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[post_title] => Pressure Stability of the Dialysis Probe
[post_excerpt] => The TRACE dialysis probe can be safely used in large reactors. Its dialysis membrane does not suffer from higher pressure due to hydrostatic and/ or pressurized conditions.
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[post_title] => Interference of Other Sugars on Glucose and Lactate Measurements
[post_excerpt] => Most sugars have no influence on glucose measurement. The only exception is mannose, which shows a low positive interference on the glucose measurement.
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[post_title] => Instant Implementation of Raman-based PAT with MAVERICK for Monitoring Glucose and Lactate
[post_excerpt] => MAVERICK is easy to set up and enables instant implementation of PAT generating accurate, precise, linear and selective in-line measurements across a wide range of media used typically in mammalian (including CHO and HEK293 media) cell culture for the production of biotherapeutics.
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[post_title] => Determining Total Cell Count with MAVERICK Biomass Measurements
[post_excerpt] => MAVERICK provides an in-line, Raman-based PAT solution for monitoring and control of glucose, lactate, and biomass in up to six bioreactors right out of the box.
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[post_title] => On-line Measurement of Glucose and Lactate with Automated Feedback Control
[post_excerpt] => MAVEN answers the urgent need for on-line measurements and automated control of glucose levels, which reduces manual labor, lowers risk of contamination from sampling, decreases risk of human error with feeding, and reduces the stress that cells may experience from variable glucose levels.
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[post_content] =>
[post_title] => Multi-Mission Threat Detection with Handheld HPMS
[post_excerpt] => Download this tech note to learn more about how MX908 utilizes high pressure mass spec.
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[post_title] => Next-Generation Handheld High-Pressure Mass Spectrometry
[post_excerpt] => Download tech note 1.0 to learn about MX908 with APCI Dual-Polarity Source for Threat Detection and Identification.
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[post_title] => How It Works
[post_excerpt] => Download this ZipChip Tech Note to learn how the system works.
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[post_title] => Performance Validation Study
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[post_title] => Analysis of Fentanyl and Its Analogs with a Handheld API Mass Spectrometer and In-Source CID
[post_excerpt] => In this work we report on the results of optimization of an insource CID sequence and subsequent characterization of the handheld API mass spectrometer/algorithm performance for the analysis of both neat and heavily cut samples containing various fentanyl analogs.
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[post_title] => Using the ZipChip Infusion Function
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[post_title] => Using Field Strength Gradients
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[post_title] => ZipChip and Detergents
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[post_title] => Evaluation of Sample Carryover
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[post_title] => Aerosol Detection and Identification with MX908
[post_excerpt] => Read this tech note full of field test data to understand how the MX908 with Aero works when detecting
aerosolized chemicals.
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[post_content] =>
This technical note dives into how the XplorIR achieves accurate gas sample identification.
Our TeamLeader mobile app lets you view results in real-time outside the hotzone. Get detailed sample information via our Threat Assist database on a vast collection of chemical compounds.
[post_title] => MX908 Beacon Product Video
[post_excerpt] => Watch this video to see how MX908 Beacon can be deployed to provide remote area monitoring to provide real-time identification of airborne hazards.
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[post_title] => Protein Characterization with ZipChip
[post_excerpt] => Hear from 908 Devices, Kelly Biggers, Life Sciences Field Sales Manager on the benefits of using ZipChip for protein characterization in your lab.
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[post_title] => Bioprocessing International Interview
[post_excerpt] => Bioprocess International interviews with Kevin J. Knopp, CEO of 908 Devices, on our bioprocessing devices, specifically MAVERICK. With MAVERICK, your team can stay at the forefront of Bioprocessing 4.0 and fully harness the advantages of real-time in-line bioprocess analysis and control to get to market faster.
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Ready to easily start your bioprocess run?
Get fast, in-line analysis of critical process parameters in minutes. These videos show you how easy it is to set up MAVERICK and start your bioprocess run. MAVERICK is powered by Raman spectroscopy and a purpose-built de novo model that automatically processes spectra from a wide variety of media types and cell lines. There's no modeling or development required. With MAVERICK, you can quickly develop cell culture media and design feeding and control strategies.
Calibrate
Autoclave
Start Bioprocess Run
[post_title] => MAVERICK Demo: Ready to Go in Minutes
[post_excerpt] => Watch these MAVERICK demos to see how easy it is to start a bioprocess run.
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[post_title] => MAVERICK: Raman-based Monitoring of Multiple Critical Parameters, Ready to Go in Minutes
[post_excerpt] => MAVERICK is powered by Raman spectroscopy and purpose-built de novo model for simultaneous real-time measurements of multiple key process parameters in mammalian cell cultures without the costs, complexities, and risks of conventional methods.
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[post_title] => MAVERICK: Monitoring of Multiple Bioprocess Parameters Right Out of the Box
[post_excerpt] => There’s no need to deal with complex empirical calibration models, reagents, or unreliable auto-sampling systems to implement in-line bioreactor monitoring.
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Host Rizwan Chaudhrey from RSK Media visited our Boston office bioprocessing lab. Check out this video lab tour with Senior Scientist Stephanie Klaubert and Product Manager Nick Randall as they discuss bioprocessing trends, including incorporating automated technologies into the lab and learn what makes 908 Devices unique and different.
[post_title] => RSK Media Interview: Bioprocessing Lab Tour with Nick and Steph
[post_excerpt] => In this interview with Nick and Steph, you will get to explore inside the 908 Devices bioprocessing lab set-up and see MAVEN, MAVERICK and REBEL.
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[post_date] => 2024-10-23 12:12:07
[post_date_gmt] => 2024-10-23 16:12:07
[post_content] =>
RSK Media, Rizwan Chaudhrey, interviews 908 Devices CEO and co-founder, Kevin J. Knopp. This interview highlights:
A background on 908 Devices and why they started the company.
What the key drivers are behind 908 Devices product launches.
Why 908 Devices acquired RedWave Technology.
Kevin J. Knopp provides his thoughts on the future for Life Science.
Explains what differentiates 908 Devices from other companies.
[post_title] => Interview: RSK Media Interviews Kevin J. Knopp
[post_excerpt] => RSK Media, Rizwan Chaudhrey, visited Boston and met with 908 Devices CEO, Kevin J. Knopp. Topics included key business drivers, the RedWave Technology acquisition, and the future of life sciences.
[post_status] => publish
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[post_name] => interview-rsk-media-interviews-kevin-j-knopp
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[post_date] => 2023-12-21 14:47:20
[post_date_gmt] => 2023-12-21 19:47:20
[post_content] =>
[post_title] => Ultimate Bioprocess Monitoring and Control
[post_excerpt] => Quickly get data at the point of need with our REBEL, MAVEN, and MAVERICK devices. Take control of your bioprocess and get to market faster.
[post_status] => publish
[comment_status] => closed
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[post_name] => maverick-maven-rebel-ultimate-bioprocess-monitoring-and-control
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[post_date] => 2022-09-21 11:20:18
[post_date_gmt] => 2022-09-21 15:20:18
[post_content] =>
[post_title] => MX Files – Episode 2: Destruction of Evidence
[post_excerpt] => Watch this episode of the MX Files to see how the MX908 identified trace levels of residue left from drug evidence before it was destroyed.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => mx908-video-mx-files-destruction-of-evidence
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[post_modified] => 2024-09-05 14:16:22
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[post_date] => 2022-04-04 18:26:43
[post_date_gmt] => 2022-04-04 22:26:43
[post_content] =>
[post_title] => Whiteboard Explainer: Avoiding the Stickiness of Oligo Analysis
[post_excerpt] => If you have worked with oligos before, you know this can be a challenging application. Fortunately, ZipChip offers a way to make workflows faster and easier.
[post_status] => publish
[comment_status] => closed
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[post_name] => 908-explainer-sidestepping-a-key-hassle-of-oligo-analysis
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[post_date] => 2023-01-16 17:44:50
[post_date_gmt] => 2023-01-16 22:44:50
[post_content] =>
Controlling Essential Amino Acid Levels in CHO Cell Cultures Using A Genome-Scale Nutrient Minimization Forecast Algorithm
Our own Milla Neffling moderates a discussion with three authors of a recent peer-reviewed article in Biotechnology & Bioengineering. The 18-minute discussion ranges from the importance of process modeling to the critical role of new tools like REBEL.
Key Discussion Points:
How media optimization strategies evolved to help the biopharma industry
The benefit of genome-scale models
The importance of input data quality
The relevance of amino acids and their importance in genome-scale models
Speakers:
Michael Betenbaugh, Ph.D Professor, Johns Hopkins University
Yiqun Chen, Ph.D Graduate Student, Johns Hopkins University
Watch a dialogue about the current emerging chemical threats and the solutions that FTIR technology provides in response; featuring Dr. Christina Baxter, CEO of Emergency Response TIPS.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
[post_title] => The Pivotal Role of FTIR in Hazmat/Emergency Response
[post_excerpt] => This webinar discussion highlights current emerging chemical threats and the solutions that FTIR technology provides in response.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => the-pivitol-role-of-ftir-in-hazmat-emergency-response
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[pinged] =>
[post_modified] => 2024-09-20 13:47:24
[post_modified_gmt] => 2024-09-20 17:47:24
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[1] => WP_Post Object
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[post_date] => 2024-06-14 09:24:14
[post_date_gmt] => 2024-06-14 13:24:14
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This webinar offers an in-depth look at the role of FTIR technology in accidental industrial chemical releases, featuring Dr. Christina Baxter, CEO of Emergency Response TIPS, and Dr. John Seelenbinder of 908 Devices. The discussion will focus on high-concern TICs, PBAs as weapons, 4th generation agents, and biological threats. While FTIR is a well-known solution for identifying powders and liquids, 908 Devices now provides a solution for the challenges responders face in gas identification. The ThreatID can measure over 5,600 gases at low concentrations and over 23,000 powders and liquids, with an easy transfer between modules.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
[post_title] => FTIR for Industrial Chemicals - Responding to Emerging Threats
[post_excerpt] => Dr. Christina Baxter, CEO of Emergency Response TIPS, discusses how FTIR technology can be deployed in industrial chemical accidents.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => ftir-for-industrial-chemicals-responding-to-emerging-threats
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[post_modified] => 2024-09-20 13:48:29
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[post_date] => 2023-11-06 08:59:40
[post_date_gmt] => 2023-11-06 13:59:40
[post_content] =>
908 Devices was featured on The HazMat Guys Podcast to discuss how our technology has evolved along with the need to provide broad coverage of chemical warfare and pharmaceutical based agents. This podcast covers everything from our handheld MX908 with Aero module to the development of the new MX908 Beacon that provides remote area monitoring of aerosol and vapor chemical threats.
[post_title] => The New MX908 Beacon for Area Monitoring
[post_excerpt] => We recently caught up with The HazMat Guys Podcast to discuss what's new from 908 Devices for area monitoring missions.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => podcast-the-new-mx908-beacon-for-area-monitoring
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[post_modified] => 2024-10-18 12:10:22
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[post_date] => 2024-06-14 09:24:14
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[post_content] =>
This webinar provides critical information on how innovative FTIR solutions are countering the threat of chemical suicides, featuring Dr. Christina Baxter of Emergency Response TIPS & Hazard3 and Dr. John Seelenbinder of 908 Devices.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
[post_title] => FTIR for Chemical Suicides - Responding to Emerging Threats
[post_excerpt] => Dr. Christina Baxter of Emergency Response TIPS discusses how innovative FTIR solutions are countering the threat of chemical suicides.
[post_status] => publish
[comment_status] => closed
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[post_name] => responding-to-chemical-suicides
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[post_modified] => 2024-09-20 13:49:31
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[post_date] => 2024-06-14 09:24:15
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Join industry experts as they discuss a groundbreaking FTIR technology designed to bridge the gap in gas identification for hazmat and CBRNe response. Most tools used by hazmat responders focus on real-time quantification of suspected gases without uniquely identifying them. The XplorIR addresses this issue with its ability to detect and identify gases in near real-time. This webinar also includes a comparison of the XplorIR to alternate methods of mass spectroscopy and colorimetric solutions.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
Note: As of June 2024, the XplorIR Quantification Package is now available; offering real-time detection, identification, and quantification of nearly 5,000 gases and vapors in seconds.
[post_title] => How FTIR is Filling the Gas Identification Gap
[post_excerpt] => Industry experts discuss how FTIR technology is used to address gas identification in hazmat/CBRNe response.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => how-ftir-is-filling-the-gas-identification-gap
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[pinged] =>
[post_modified] => 2024-09-26 18:03:14
[post_modified_gmt] => 2024-09-26 22:03:14
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[post_date] => 2024-06-14 09:24:15
[post_date_gmt] => 2024-06-14 13:24:15
[post_content] =>
Listen to a dynamic panel of industry experts discuss the current methods for gas detection in hazmat/CBRNe applications.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
[post_title] => Transformative Impact of Gas Phase FTIR on Hazmat Operations
[post_excerpt] => Listen to a panel discuss current methods for gas detection in the hazmat/CBRNe applications.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => transformative-impact-gas-phase-ftir-for-hazmat-operations
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[post_modified] => 2024-09-20 13:46:12
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[post_date] => 2024-06-14 09:24:15
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[post_content] =>
Listen as Dr. John Seelenbinder discusses with the Hazmat Guys how the XplorIR achieves accurate gas sample identification even with humidity and carbon dioxide interference.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
[post_title] => Adaptive Atmospheric Correction - XplorIR
[post_excerpt] => Dr. John Seelenbinder discusses with the Hazmat Guys how the XplorIR achieves accurate gas sample identification, even with humidity and carbon dioxide interference.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => xplorir-adaptive-atmospheric-correction
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[post_modified] => 2024-09-20 13:50:08
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[post_date] => 2024-06-14 09:24:15
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Join us for a conversation with industry experts about real-world gas threats and the pivotal role of FTIR technology. Recent events and case studies of discussion include chemical suicides, accidental pesticide exposures, transportation accidents, and more. Our experts determine the top five chemicals causing acute injuries in the United States and address the challenges current detection meters face. Discover how the FTIR solution, XplorIR, is essential for identifying unknown gas threats beyond standard detection levels.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
[post_title] => Expert Panel Discussion - The Gas Threat Response
[post_excerpt] => Learn about real-world gas threats, including chemical suicides, accidental pesticide exposures, and transportation accidents, and the pivotal role of FTIR technology.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => expert-roundtable-the-gas-threat-response
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[post_modified] => 2024-09-20 13:50:32
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[ID] => 24650
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[post_date] => 2024-06-14 09:24:15
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[post_content] =>
Listen as Lt. Brandon Gayle discusses with the Hazmat Guys the importance of knowing the identity and concentration of toxic gases. The Hazmat Guys present examples of chemical incidents to highlight current industry detection standards. Lt. Gayle shares insights on how the XplorIR enhances the capabilities of a PID, 4-Gas, and 5-Gas meters by providing precise and actionable gas identification.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
[post_title] => Traditional Air Monitoring and How FTIR Gas Identification is Changing the Game
[post_excerpt] => Listen as Lt. Brandon Gayle discusses with the Hazmat Guys the importance of knowing the identity and concentration of toxic gases.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => ondemand-webinar-pid-and-ftir
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[post_modified] => 2024-09-20 13:50:45
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[post_date] => 2024-06-14 09:24:16
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Listen as Dr. John Seelenbinder discusses with the Hazmat Guys how the XplorIR now enables accurate identification of up to 6 gas components in-real time within complex mixtures.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
[post_title] => XplorIR's Gas Mixtures Analysis
[post_excerpt] => Dr. John Seelenbinder discusses with the Hazmat Guys how the XplorIR now identifies up to 6 gas components in-real time within complex mixtures.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => xplorirs-gas-mixtures-analysis
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[post_modified] => 2024-09-20 13:51:21
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[ID] => 24475
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[post_date] => 2024-05-13 13:01:09
[post_date_gmt] => 2024-05-13 17:01:09
[post_content] =>
About this Webinar
While the US is facing a severe synthetic opioid crisis, law enforcement is facing a trace identification problem. The outcome is a significant increase in overdose deaths related to fentanyl substances and their analogs. Transnational criminal organizations are exploiting the situation, especially in High Intensity Drug Trafficking Areas (HIDTA), by introducing new synthetic psychoactive substances for substantial profits. Advanced trace-level identification technology is essential to combat this growing problem, as it surpasses mere detection capabilities.
Our panel of speakers describes how advanced trace-level identification technologies go beyond mere detection. The latest technology arms law enforcement and public safety agencies with new capabilities that can help disrupt and dismantle criminal organizations responsible for killing hundreds of thousands of Americans.
Key Webinar Takeaways:
Learn about the latest advancements in trace-level identification technologies
Explore strategies for implementing these technologies through HIDTAs and beyond
Who Should Watch?
HIDTA personnel
Partner agency law enforcement professionals
Public health officials
Policymakers
Forensic scientists
Substance abuse and mental health service providers
Discover how field chemical analysis is being revolutionized by the handheld and portable technologies from 908 Devices. XplorIR, ProtectIR, ThreatID, and MX908 will be highlighted in this webinar to demonstrate their quick, non-destructive chemical detection and analysis capabilities.
Key Webinar Takeaways:
XplorIR: Quick identification and measurement of vapors and gases utilizing FTIR technology
ProtectIR: Rugged design for trustworthy chemical identification of liquids and large solids
ThreatID: Complete identification for liquids, gasses, and solids
MX908: High-performance, trace-level chemical identification that gives first responders real-time information
[post_title] => Empowering Field Operations: Integrated Chemical Analysis
[post_excerpt] => This on demand webinar is designed for emergency response teams, defense personnel and security professionals needing quick, accurate integrated chemical analysis.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => empowering-field-operations-integrated-chemical-analysis
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[post_modified] => 2024-08-22 09:29:11
[post_modified_gmt] => 2024-08-22 13:29:11
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[ID] => 26356
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[post_date] => 2024-11-15 14:18:18
[post_date_gmt] => 2024-11-15 19:18:18
[post_content] =>
About this Webinar
This webinar introduces a cutting-edge solution for substance detection and identification in correctional facilities, combining the advanced capabilities of MX908 and MailSecur® technologies. As illicit substances continue to threaten the safety and security of these environments, the integration of these tools provides a powerful, comprehensive approach for law enforcement and corrections professionals.
RaySecur’s innovative terahertz (T-ray) imaging technology enables non-invasive detection of concealed substances within sealed mail and personal items, offering real-time visualization of potential threats. Complementing this capability, the MX908 employs high-pressure mass spectrometry (HPMS) for precise substance identification. Together, these technologies deliver a seamless process: identifying, localizing, and accurately characterizing threats to enable rapid response and effective containment.
This integrated system addresses critical challenges in correctional facilities by improving the speed and accuracy of substance detection and identification. It enhances safety protocols, reduces security risks, and streamlines operations, resulting in a safer environment for staff and inmates while optimizing resources and efficiency.
Designed for corrections officers, facility administrators, and law enforcement professionals, this webinar provides an in-depth exploration of the MX908-MailSecur system. Participants will gain valuable insights into its technical capabilities, operational workflows, and the strategic benefits of adopting this innovative solution to strengthen substance control measures.
[post_title] => Improving Substance Detection and Identification in Correctional Facilities
[post_excerpt] => Watch this webinar to learn more about MX908 for Corrections Screening and pairing with RaySecur's MailSecur system for robust narcotics identification in correctional facilities.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improving-substance-detection-and-identification-in-correctional-facilities
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[post_modified] => 2024-11-15 16:23:39
[post_modified_gmt] => 2024-11-15 21:23:39
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[ID] => 26616
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[post_date] => 2024-12-12 09:19:40
[post_date_gmt] => 2024-12-12 14:19:40
[post_content] =>
About this Webinar
Join us for an insightful webinar featuring Phil Ambrose as he explores how advanced technologies like Fourier Transform Infrared (FTIR) and High Pressure Mass Spectrometry (HPMS) can simplify hazmat response operations. Moderated by Dr. Mark Norman, this discussion will cover everything from routine calls, such as carbon monoxide and odor detection, to more complex incidents involving multiple chemical substances.
Through real-world examples, you’ll learn how combining basic gas detectors with advanced tools can enhance your hazmat response capabilities. Whether you’re part of a first due engine company using essential gas detection equipment or a dedicated hazmat team with extensive resources, this session will demonstrate how integrating FTIR and HPMS into your protocols can accelerate decision-making and improve outcomes. Both recon operators and incident commanders will gain valuable insights into how these technologies can boost safety for responders, the public, and property during chemical incidents.
[post_title] => Simplifying Everyday Hazmat Calls with Advanced Technology
[post_excerpt] => From routine calls such as carbon monoxide and odor detection, to more complex incidents involving multiple chemical substances learn how hazmat response tools like XplorIR and MX908 allow responders to work smarter.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => simplifying-everyday-hazmat-calls-with-advanced-technology
[to_ping] =>
[pinged] =>
[post_modified] => 2024-12-12 09:25:58
[post_modified_gmt] => 2024-12-12 14:25:58
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[ID] => 24431
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[post_date] => 2024-05-10 09:18:20
[post_date_gmt] => 2024-05-10 13:18:20
[post_content] =>
About this Webinar
Join us for an informative webinar on how to effectively employ First Line Technology's cutting-edge decontamination systems, including the innovative MX908, to decontaminate jails, cars, and hotel rooms. Our expert panel provides detailed information on how to use these sophisticated technologies to ensure thorough and effective decontamination processes in a variety of scenarios. Whether you work in law enforcement, facility management, or public health, this webinar will provide you with practical knowledge to improve your decontamination practices and protect your surroundings.
By Watching This Webinar, You Will be Able to:
Demystify fentanyl risks: Understand the real dangers of fentanyl, rather than prevalent falsehoods, to help establish accurate awareness and suitable response plans
Identify pollutants: Learn how to use the MX908 to quickly identify a variety of chemical hazards and contaminants, which is essential for targeted decontamination efforts
Investigate disinfection methods and technology: Identify innovative decontamination methods and technologies, and then learn how to incorporate them into current protocols to improve efficiency and efficacy in specific contexts
Ensure safety and compliance. Learn the best practices for complying with health and safety requirements while conducting decontamination techniques
Assess decontamination efficacy: Learn how to measure the success of decontamination activities, guaranteeing a safe and contaminant-free environment after cleanup
[post_title] => Maximizing Decon Efficiency: Solutions for Dangerous Drugs
[post_excerpt] => Watch this webinar to learn how First Line Technology and 908 Devices products work together to provide robust decon solutions.
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[post_name] => maximizing-decon-efficiency-solutions-for-fentanyl-and-other-drugs
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[post_modified] => 2024-08-21 10:42:03
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[post_date] => 2024-04-23 09:17:43
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About this Webinar
This webinar will equip law enforcement officers with essential insights into the geopolitical factors driving the shift from fentanyl to even more potent synthetic drugs. Participants will learn why new substances, such as xylazine and medetomidine, are emerging more frequently. In the face of a rapid escalation in drug production and distribution, the safety of law enforcement personnel hinges on their understanding of diverse drug classifications.
By Watching This Webinar, You Will Learn:
Powerful novel drugs that may replace fentanyl
Which novel drugs are skyrocketing in use
How geopolitics play a role in emerging drugs
By tuning into this webinar, law enforcement officers will be better equipped to understand and adapt to the evolving drug crisis, ensuring their safety and enhancing their ability to respond effectively to drug-related challenges.
[post_title] => Staying Ahead of the Curve: Navigating Emerging Drugs for Law Enforcement
[post_excerpt] => Learn about diverse drug classifications and why new substances, such as xylazine and medetomidine, are emerging more frequently. Stay ahead of the curve and navigate these emerging drug trends.
[post_status] => publish
[comment_status] => closed
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[post_name] => staying-ahead-of-the-curve-navigating-emerging-drugs-for-law-enforcement
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[post_modified] => 2024-08-01 12:58:24
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[ID] => 25942
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[post_date] => 2024-09-24 12:24:35
[post_date_gmt] => 2024-09-24 16:24:35
[post_content] =>
About this Webinar
Overview:
Liquid chromatography-mass spectrometry (LC-MS) is used in various applications across the biotherapeutic protein manufacturing workflow pertaining to drug product quality. Mass spectrometry-based applications range from evaluating glycan distributions in monoclonal antibody products to optimization of the cell culture process development by monitoring amino acid and metabolite consumption. Given its analytical flexibility, LC-MS has the capacity to address complex questions; however, LC-MS instrumentation requires a high level of technical experience and more method development than other analytical procedures. Additionally, media development and feed studies in cell culture process optimization are labor-intensive and time-consuming. There is a growing interest in implementing efficient and simplified methods for cell culture media analysis to push for faster innovative processes in biomanufacturing. Newer analytical equipment does not attempt to address the complexity of LC-MS applications specifically targeted for high throughput media analysis of cell culture. This capillary electrophoresis-mass spectrometry (CE-MS)-based Amino Acid Analyzer is a device with simple procedures that provide a similar ability to the traditional LC-MS to specifically identify and quantitate an array of amino acids and several other important metabolites while providing a user-friendly interface and process.
Key Takeaways:
Ascertain the capabilities and limitations of the Amino Acid Analyzer.
Compare the Amino Acid Analyzer, a new generation of CE-MS analytical platform, against traditional LC-MS methods.
Evaluate the data quality, trade-offs in operation, and resourcefulness of the analytical platforms.
[post_title] => Keeping up with New Emerging Analytical Technology
[post_excerpt] => Explore advancements in emerging analytical technologies like Process Analytical Technology (PAT) and mass spectrometry, improving drug development through enhanced bioprocess monitoring and control.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => keeping-up-with-new-emerging-analytical-technology
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[post_modified] => 2024-09-24 12:24:36
[post_modified_gmt] => 2024-09-24 16:24:36
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[ID] => 25368
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[post_date] => 2024-07-18 12:48:57
[post_date_gmt] => 2024-07-18 16:48:57
[post_content] =>
About this Webinar
Overview:
Current cell therapy manufacturing processes often face challenges, including reliance on manual intervention, inconsistencies, and excessive costs. However, transitioning from manual protocols to automated processing can help overcome these hurdles and significantly improve cell therapy manufacturing.
Join Boris Aleynik (Director of Strategy and Product Marketing, 908 Devices) and Mindy Miller (Senior Scientist/Manager, Terumo Blood and Cell Technologies) as they explore how efficient monitoring of glucose and lactate levels during cell expansion can significantly improve cell therapy production.
Key Takeaways:
Explore methodologies to achieve greater robustness and lower cost of goods in cell therapy manufacturing.
Understand the benefits and considerations in real-time monitoring of key process parameters such as glucose and lactate.
Learn how to enable the creation and maintenance of optimal cell expansion conditions.
[post_title] => Improving Cell Therapy Manufacturing with On-line Monitoring
[post_excerpt] => This webinar will explore how automated monitoring and control of glucose and lactate levels can significantly improve the cell therapy process.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improving-cell-therapy-manufacturing-with-on-line-monitoring
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[pinged] =>
[post_modified] => 2024-07-18 12:48:57
[post_modified_gmt] => 2024-07-18 16:48:57
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[post_date] => 2024-05-29 17:33:30
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[post_content] =>
About this Webinar
In this webcast, 908 Devices explores approaches to address these technological gaps. This involves utilizing engineered devices, mechanistic model predictions, high-throughput metabolic screening, and molecular biology techniques to facilitate cost-effective and scalable vector production at a personalized level. The presentation by Prasanna Srinivasan, PhD and Graziella Piras, PhD will delve into strategies employing rapid and straightforward analytical tools at the point of use to swiftly assess key nutrient consumption, providing feedback to optimize feed and supplement addition strategies. Additionally, the use of continuous culture for rAAV production from the triple-plasmid transfection HEK293 system will be discussed.
Key Takeaways:
Use of model-driven approach to design, predict, test, and optimize VV production processes.
Benefit of using high-throughput metabolite screening to optimize AAV production using triple transfection method.
Scale up and transfer to a continuous process at a bioreactor scale.
Want to read a summary on the webinar? Download the resource.
[post_title] => Moving Towards a Scalable AAV Vector Production at High Volumetric Efficiency
[post_excerpt] => In this on-demand webinar, Graziella Piras and Prasanna Srinivasan explore approaches to facilitate a cost-effective and scalable vector production at a personalized level. You will learn how you can get the data where and when you need it.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => moving-towards-a-scalable-aav-vector-production-at-high-volumetric-efficiency
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 10:56:19
[post_modified_gmt] => 2024-08-01 14:56:19
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[ID] => 24908
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[post_date] => 2024-06-10 11:07:46
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About this Webinar
This webinar will discuss the crucial role of gas detection in hazmat management, comparing existing methods and emphasizing the advanced application of handheld FTIR devices.
By Attending This Webinar, You Will:
Gain an understanding of the fundamental principles behind various gas detection methods used in hazmat response.
Explore the advantages and limitations of traditional gas detection techniques compared to handheld FTIR technology.
Learn about the consequences of inadequate gas detection on safety, emergency response, and the environment.
Review case studies illustrating how imprecise gas identification can escalate hazard levels and pose challenges for emergency response.
Find out how handheld FTIR devices can improve situational awareness and decision-making in real time during hazmat incidents.
Identify strategies for integrating handheld FTIR technology into existing hazmat response protocols, thereby enhancing overall safety and efficacy.
[post_title] => Critical Gaps in Gas Detection Methods in Hazmat Scenarios
[post_excerpt] => This webinar will discuss the crucial role of gas detection in hazmat management, comparing existing methods and emphasizing the advanced application of handheld FTIR devices.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => critical-gaps-in-gas-detection-methods-in-hazmat-scenarios
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[post_modified] => 2024-06-10 14:06:24
[post_modified_gmt] => 2024-06-10 18:06:24
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About this Webinar
The Challenges of the Opioid Crisis
Join us for an educational webinar designed specifically for law enforcement and law enforcement grant writers who are on the front lines of the battle against the fentanyl crisis and are looking to acquire the MX908. This webinar provides you with strategies to navigate the complexities of the state and federal grant programs including opioid settlement funding.
Topics Covered
Details on various grant sources and their different requirements.
How to craft compelling grant proposals that stand out.
Ways to align your department’s needs with grantor priorities.
Tips on navigating legalities and requirements when applying for and utilizing grant funds.
Expert insight on grant writing and government affairs professionals.
Whether you’re seeking to enhance your department’s resources or aiming to make a significant impact on the fentanyl epidemic, this webinar arms you with the knowledge and tools necessary for success. Don’t miss this opportunity to learn from the experts and take your grant acquisition skills to the next level.
What Attendees Liked From This Presentation
“The instructors were very clear and extremely good speakers, making the information easy to understand. Instructors were also very knowledgeable.”
“This webinar provided valuable information about how to find different grants, and gave places to look for them.”
“I appreciate all the information provided. I found it all very helpful.”
“It was specific to our needs and the guidance was to-the-point.”
Meet the Speaker
Samantha L. Dorm
Samantha L. Dorm is a senior grant consultant for Lexipol, serving FireGrantsHelp.com, EMSGrantsHelp.com and PoliceGrantsHelp. She first began working as a consultant for the grants division of Praetorian Digital (now Lexipol) in 2010. Dorm has been instrumental in providing grant writing guidance to various public safety and non-profit agencies throughout the United States to enable them to obtain alternative funding as well as provide instruction on statistical compilation, analysis and program development. Dorm is a reviewer for several federal agencies and also instructs grant writing workshops
[post_title] => Grant Writing Strategies for Public Safety
[post_excerpt] => Are you seeking to enhance your department's resources or make a significant impact on the fentanyl epidemic? Watch this webinar to learn about law enforcement grant writing and applications, to aid in acquiring technologies that are used on the front lines for public safety.
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[comment_status] => closed
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[post_name] => grant-writing-strategies-for-public-safety
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[post_modified] => 2024-05-23 17:40:31
[post_modified_gmt] => 2024-05-23 21:40:31
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[ID] => 22934
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[post_date] => 2023-12-12 17:23:49
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About this Webinar
The Challenges of the Opioid Crisis
The opioid crisis has plagued the United States for more than a decade and is now expanding globally. According to current DEA laboratory statistics, six out of ten fentanyl-laced fraudulent prescription tablets contain a potentially deadly amount of fentanyl. The particular challenge offered by these low-concentration yet very potent counterfeit tablets necessitates specialized training for law enforcement to investigate. This webinar presents an overview of the opioid epidemic in the United States, focusing on the growth of fentanyl. Real-life case studies will be used to teach you how to safely respond to and investigate an overdose incident. This webinar also teaches you to operate as an undercover agent, using social media to locate and investigate suspected distributors of counterfeit pills and fentanyl powder.
What Attendees Liked About this Presentation
“Up-to-date information, videos and knowledge.”
“The event was well-detailed. It opened my eyes to how important it is to keep watch on our kids.”
“It was very informative. The use of actual photographs, videos, and stories assisted in learning.”
“Very informative and very fast. No wasting time.”
“Speakers were knowledgeable and well-spoken.”
Meet the Speakers
Dean Cardinale
Dean Cardinale, a Detective of the Fresno Police Department (FPD). Dean has spent the previous ten years in the Major Narcotics Unit, where he has conducted over 300 drug investigations. Dean has worked as a DEA Task Force Officer in Fresno, CA, since 2016, and he just established the Fentanyl Overdose Resolution Team, which includes DEA and HSI agents. Dean appeared in the Emmy-nominated documentary "Killer High: The Silent Crisis." Dean has educated the California Narcotics Officers Association on fentanyl overdoses and investigations, and he has garnered multiple accolades for his efforts in drug crime teaching and investigations.
Bruce Gentner
Bruce Gentner is the Senior Law Enforcement Trainer for 908 Devices. Bruce retired from the Las Vegas Metropolitan Police Department after serving more than 24 years in law enforcement, including patrol, narcotics, and federal drug task forces. Bruce spent 18 years as a case agent and undercover detective, with substantial experience in nightclub drug investigations, underground methamphetamine labs, marijuana grow operations, and fentanyl/synthetic drug operations. Bruce has served on a HIDTA interdiction and DEA task force, as well as with the FBI, HSI, and Nevada Gaming. Bruce is the Executive Director and Past President of the Nevada Narcotics Officers Association. He founded the Narcotics Education Foundation of Nevada, whose aim was to train and educate law enforcement officers about narcotics-related topics and occurrences.
[post_title] => Deadly Drug Investigations
[post_excerpt] => This webinar provides an overview of the rise of the opioid epidemic in the U.S.. Through the use of real-life case studies, you will learn how to safely respond and investigate the scene of an overdose.
[post_status] => publish
[comment_status] => closed
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[post_name] => mx908-webinars-fentanyl-and-other-deadly-drug-investigations
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[post_modified] => 2024-05-23 17:41:30
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[post_date] => 2023-11-20 11:47:37
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[post_content] =>
The Rise of Chemical Warfare and Pharmaceutical-based Agents
In addition to traditional chemical warfare threats such as G/V-Series agents and blister agents, the emergence of unconventional chemical threats such as fentanyl and other pharmaceutical-based agents, as well as A-series agents (Novichoks), poses a unique set of challenges to Hazmat and CBRN organizations worldwide. Join us for an in-depth look at the newest tactics, detection techniques, and processes for existing and emerging threats. We provide insights from real-life incident responses to help you prepare for the ever-changing danger landscape that first responders encounter around the world. By watching this on-demand webinar you will:
Get up-to-date information on emerging threats and responses, such as chemical warfare agents (CWAs) and pharmaceutical-based agents (PBAs).
Explain the distinction between aerosolized and vapor hazards, as well as existing detection systems.
Discover MX908 Beacon, an area monitoring device for identifying CWAs and PBAs.
Discuss recommended methods for dealing with these dangers.
What Attendees Liked About this Presentation
“Very informative and thought-provoking presentation about the newest generations of chemical products.”
“Excellent presentation, linking it to real-world events.”
“Solid content by a speaker with infield background.”
Meet the Speakers
David A. Godin
David A. Godin is the Director of Field Forensic Applications for 908 Devices in Boston, Massachusetts. He holds a Masters of Forensic Sciences Degree from Boston University, and a B.S. degree in Chemistry from the United States Military Academy. Mr. Godin served five years as a US Army Chemical Officer in the 110th Chemical Battalion, Technical Escort. During that time, he served as Chemical Analyst and Officer in Charge of the Combined Explosive Exploitation Cell-North in support of Operation Iraqi Freedom. He has trained hundreds of Emergency Response personnel in the field analysis of controlled substances, HAZMAT Operations, and CBRNE Response.
[post_title] => Responding to Chemical Warfare and Pharmaceutical Based Agents
[post_excerpt] => A must watch for CBRN first responders. Receive the latest info on dangerous chemical threats, chemical warfare, and pharmaceutical based agents.
[post_status] => publish
[comment_status] => closed
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[post_password] =>
[post_name] => on-demand-webinar-responding-to-chemical-warfare-and-pharmaceutical-based-agents
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[post_modified] => 2024-11-19 10:47:41
[post_modified_gmt] => 2024-11-19 15:47:41
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[post_date] => 2023-06-28 09:15:05
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About this Webinar
Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieves a durable complete response (dCR). DCR has been correlated with CAR T cell products enriched with T cells of memory phenotypes. Therefore, reagents that consistently promote memory phenotypes during the manufacturing of CAR T cell products have the potential to significantly improve clinical outcomes. Researchers at Emory University, led by Dr. Sarwish Rafiq, have developed a novel modular multi-cytokine backpack (MCB) platform that combines the signals necessary for activation, co-stimulation, and cytokine support into a single “all-in-one” reagent for CAR T cell manufacturing.
This platform allows for the assembly and screening of compositionally diverse MCB libraries to identify formulations tailored to promote specific phenotypes with a high degree of flexibility. We leveraged this platform to identify unique MCB formulations that increase the proportion of memory phenotype CAR T cells. MCB-manufactured CAR T cell products exhibit increased proportions of memory-like phenotypes in diffuse large B cell lymphoma (DLBCL) patient CAR T cells and demonstrate superior anti-tumor efficacy in mouse models of lymphoma and ovarian cancer through enhanced persistence.
In addition, we saw indications of differences in the metabolism of the MCB-manufactured T cells through spent media amino acid analysis. This analysis was performed with 908 Devices REBEL at-line analyzer and showed nutrient consumption and metabolite accumulation profiles which may indicate different metabolic pathways being active in memory-like phenotype CAR T-cell products.
Our findings serve as a proof-of-principle of the powerful utility of the MCB platform to identify reagents that can improve the effectiveness of cell therapy products through optimal manufacturing.
Key Takeaways
About a novel multi-cytokine backpack MCB activation, co-stimulation, ad cytokine support for effective CAR T cell product manufacturing
A proof-of-principle of the powerful utility of the MCB platform to identify reagents that can improve the effectiveness of cell therapy products through optimal manufacturing
Indications of differences in the metabolism of the MCB-manufactured T cells through spent media amino acid analysis
[post_title] => Engineering Functionally Improved CAR T cells with a Multi-Cytokine Backpack Platform with Insights into Metabolism
[post_excerpt] => Researchers at Emory University, led by Dr. Sarwish Rafiq, have developed a novel modular multi-cytokine backpack (MCB) platform that combines the signals necessary for activation, co-stimulation, and cytokine support into a single “all-in-one” reagent for CAR T cell manufacturing.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rebel-webinars-ls-rb-wb-0018
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[pinged] =>
[post_modified] => 2024-12-09 15:17:48
[post_modified_gmt] => 2024-12-09 20:17:48
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[post_date] => 2023-07-24 11:19:48
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[post_content] =>
About this Webinar
A broad range of separation techniques are now routinely combined with mass spectrometry for in-depth biopharmaceutical characterization. Simultaneously, MS software tools have evolved to support the storage, processing, and reporting of the expanding MS data oceans. Here recent progress, challenges, and learnings from MS-based workflows of biopharmaceutical charge variants will be presented and illustrated through case-studies.
In this webinar, you will learn:
The crucial role that CE-MS plays in a biopharma development lab for the comprehensive characterization of biopharmaceuticals.
How CE-MS can be used to improve the efficiency of characterization workflows by eliminating method development and increasing the throughput while gaining deeper insights through in-depth analysis of biopharmaceuticals.
Who should attend:
Scientists working in protein characterization labs for biotherapeutics
Analytical scientists working in biopharmaceutical labs
CDMO labs looking to optimize workflows and improve efficiency
[post_title] => Charge Variant Analysis for Intact Protein Characterization in a Biopharmaceutical Development Lab – Lessons Learned and the Road Ahead
[post_excerpt] => How CE-MS can be used to improve the efficiency of characterization workflows by eliminating method development and increasing the throughput while gaining deeper insights through in-depth analysis of biopharmaceuticals.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-webinars-ls-zc-wb-0018
[to_ping] =>
[pinged] =>
[post_modified] => 2024-12-09 15:40:42
[post_modified_gmt] => 2024-12-09 20:40:42
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[guid] => https://908devices.com/?post_type=resource&p=20885
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[post_date] => 2024-04-29 09:27:59
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[post_content] =>
Improve Process Intensification
Process intensification requires a thorough understanding of the process to achieve desired yields while improving resource utilization and maintaining consistent product quality. Continuous monitoring of glucose and lactate provides deeper process understanding. Dynamic glucose control can lead to better cell viability, lower levels of lactate production, and therefore, higher titer and better control of quality attributes (CQAs) in fed-batch and intensified processes. Learn how you can make more informed decisions with in-line, on-line and at-line analytics of key process parameters
[post_title] => Data-driven Process Intensification – Utilizing Smart Analytics to Achieve your Bioprocess Goals
[post_excerpt] => This BPI presentation discusses process intensification and rapid analytics of critical parameters for cell culture, which is necessary to control the process and end product. See how fast and simple analytics significantly speed up the development and optimization processes.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => data-driven-process-intensification-utilizing-smart-analytics-to-achieve-your-bioprocess-goals
[to_ping] =>
[pinged] =>
[post_modified] => 2024-09-11 10:58:39
[post_modified_gmt] => 2024-09-11 14:58:39
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[ID] => 22804
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[post_date] => 2023-11-30 15:13:07
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[post_content] =>
About this Webinar
In today's bioprocessing industry, speeding up timelines and cutting costs are essential goals. However, it is crucial to maintain product quality when making changes to processes. Utilizing at-line and on-line technologies to monitor bioprocess parameters and cell-feeding strategies is necessary for creating efficient processes that produce top-notch products while also lowering production expenses.
The Centre for Process Innovation (CPI) collaborates with partners in various industries in the UK and globally to advance innovative technologies and help reduce the risks and costs of product development. Dr. Chris Schultz, at CPI, led a project in partnership with 908 Devices to enhance a CHO bioprocess. The main objective was to improve monoclonal antibody production and CHO cell health by making informed decisions when selecting and using suitable cell culture media and feeds. In this webinar, Schultz shares insights on utilizing at-line spent media analysis and online monitoring of glucose and lactate levels to optimize feeding strategies.
Key Takeaways
Accelerate process development by data-driven decision making.
Reduce manufacturing costs while improving process efficiency.
Use at-line and on-line technology to characterize bioprocesses and improve product yield.
[post_title] => Accelerate Upstream Process Development with Data-driven Feeding Strategy Optimization
[post_excerpt] => At-line and on-line technologies that inform bioprocess parameters and cell-feeding strategies are needed to develop processes that deliver high-quality products while reducing manufacturing costs. In this webinar, Chris Schultz, PhD from CPI provides insights on using at-line spent media analysis and on-line glucose and lactate monitoring for the optimization of feeding strategy.
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[post_date] => 2024-04-17 13:43:11
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About this Webinar
In this webinar, we discuss the implementation of MAVERICK for continuous CHO feed control, including novel feeding approach. While empirical Raman spectroscopy models are convenient due to their 'black box' properties, they may prove impractical and insufficiently robust for deployment as Process Analytical Technology (PAT) solutions in complex upstream bioprocesses. In contrast, the MAVERICK platform, based on Raman technology with a de novo approach, operates as effortlessly as a pH-meter, providing real-time measurements of key process parameters such as glucose, lactate, and biomass.
[post_title] => Instant Implementation of Raman-based Monitoring and Control for Key Upstream Bioprocessing Parameters
[post_excerpt] => In this webinar, we discuss the implementation of MAVERICK for continuous CHO feed control, including novel feeding approach.
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[comment_status] => closed
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[post_name] => instant-implementation-of-raman-based-monitoring
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[post_modified] => 2024-09-26 16:31:41
[post_modified_gmt] => 2024-09-26 20:31:41
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[post_date] => 2023-09-15 12:51:26
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[post_content] =>
About this Webinar
Drs. Chris Brown and Graziella Piras provide information about a new and transformative means to instantly implement in-line monitoring for multiple key process parameters, right out of the box.
It’s been nearly 20 years since the FDA and EMA published guidelines on process analytical technologies (PAT) to drive the advancement of Biopharma 4.0, with the ultimate aim of predictive control and Quality by Design. Over the years several multivariate optical sensing technologies have demonstrated tremendous promise for in-line continuous monitoring of a range of parameters. These technologies offer the promise of hands-off, non-destructive, and easy-to-integrate multi-parameter analysis with feedback control loop. Yet, they often require substantial expert configuration and set-up time that can take months or years, and substantial expense. In this webinar, review the current state of several optical technology approaches and their associated strengths and limitations. A new platform that greatly accelerates successful implementation of in-line monitoring of key bioprocess parameters is discussed.
Key Takeaways:
Current state of state-of-the-art in-line upstream bioprocess analytics
A new solution overcoming major hurdles of implementation of in-line multivariate bioprocess analysis
[post_title] => Rapid Clone Screening of Biosimilar Candidates Using Microfluidic CE-MS
[post_excerpt] => In this GEN webinar, our expert speakers, Erin Redman, PhD, and Ruben Cageling, will describe how the ZipChip microfluidic CE-MS technology enables rapid early-stage clone screening for biotherapeutics development. They will present a case study where the ZipChip was used to select clonal cell lines based on their charge variants and glycosylation profile. Furthermore, they will also highlight the new CVA kit, which enabled better separation and sensitivity in charge variant analysis of biotherapeutics.
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[comment_status] => closed
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[post_name] => rapid-clone-screening-of-biosimilar-candidates-using-microfluidic-ce-ms
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[post_date] => 2023-01-19 12:27:14
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[post_content] =>
Detecting and Identifying Narcotics that Infiltrate Corrections Facilities
It is difficult to detect and identify narcotics as they enter correctional facilities. Drugs like K2/spice and synthetic cathinones can be sprayed onto paper and discreetly hidden inside a piece of mail, or drugs can be thrown over barriers and into facilities. This webinar will cover the challenges related with drug use in correctional facilities, as well as the drug landscape.
Guidelines for protecting police and detainees from potential risks.
Case studies from prison facilities.
What Attendees Liked About this Presentation
“The speaker was very knowledgeable and presented the material so it was easy to understand.”
“Very informative. I got a lot of good information I previously did not have about the levels of the different drugs/substances that are dangerous/lethal as well as statistics on the level of use in institutions and the fatality rates.”
“Very informative, great information. Excellent presentation.”
Meet the Speaker
Jeremy VanAuker
Jeremy VanAuker is the field forensic application scientist for 908 Devices. He earned both his Master and Bachelor of Science degrees in chemistry from Pittsburg State University in Pittsburg, Kansas and is currently working on his Master of Business Administration from the University of Texas at Dallas. After earning his B.S., he briefly worked at an explosives manufacturing facility as a laboratory chemist. He then worked as firefighter/EMT-Basic in Joplin, Missouri for almost five years, specializing in hazardous-material response and technical rescue. Before joining 908 Devices, Jeremy was a forensic drug chemist II for almost nine years with the Southwestern Institute of Forensic Sciences in Dallas, Texas, where he analyzed unknown materials for the presence or absence of controlled substances.
[post_title] => Trace Identification of Fentanyl, Synthetic Cathinones, and Other Drugs in Corrections
[post_excerpt] => Watch this on demand webinar to learn more about the challenges associated with the increased presence of drugs and how to protect officers and inmates from potential exposures.
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[post_name] => trace-identification-of-fentanyl-synthetic-cathinones-and-other-drugs-in-corrections
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[post_date] => 2023-03-22 16:26:14
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[post_title] => Field Detection of Pesticides: Suicide, Seizures, and Sickness
[post_excerpt] => Watch this new on demand webinar as we explore the dangers of illegal marijuana grow operations and how to detect and identify toxic pesticides used in the cultivation process.
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[post_name] => field-detection-of-pesticides-suicide-seizures-and-sickness
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[post_title] => Responding to Emerging Threats: Detect, Decon, and Verify
[post_excerpt] => Watch this webinar to learn more about the latest tactics, detection techniques, and procedures related to current and emerging threats. From fentanyl to unconventional chemical threats this is a must-watch for any first responder.
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[post_name] => responding-to-emerging-threats
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[post_date] => 2022-10-31 13:47:38
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[post_title] => Harness the Power of At-line Spend Media Analysis using the REBEL to Optimize a CHO mAb Fed-batch Process
[post_excerpt] => This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.
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[post_name] => rebel-webinar-biopharm-2022
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[post_date] => 2022-10-18 18:45:01
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[post_title] => Power Up Your Process Control with Rapid At-Line MS-based Metabolite Monitoring
[post_excerpt] => Graziella Piras spoke at BPI 2022 about how amino acids can present a goldilocks problem for bioprocessing: too little and they starve; too much and they favor growth over protein production.
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About this Webinar
This webinar consists of two parts: Dr. Adi Kulkarni begins by providing a brief introduction to the ZipChip CE-MS technology, highlighting its features and benefits, followed by Dr. Josh Smith from NIBRT, with a deep dive of the ZipChip CE-MS technology applied to the characterization of AAVs.
Commonly utilized liquid chromatography-mass spectrometry (LC-MS) characterization strategies are time consuming and sample intensive. Capillary electrophoresis (CE) is often adapted as an orthogonal alternative for biotherapeutic characterization because of its speed and sensitivity. However, the utility of CE is generally limited by poor compatibility with MS. ZipChip/MS overcomes these incompatibility issues enabling rapid in-depth characterization of biotherapeutics.
In the first part of the webinar, Dr. Kulkarni will provide an overview of the ZipChip/MS technology and explain the fundamental concepts behind how ZipChip/MS works. In the second part of the webinar, Dr. Smith will present results obtained by applying the ZipChip/MS to the characterization of Adeno-Associated Virus (AAV) capsid proteins. AAVs are viral vectors increasingly investigated for their clinical potential as delivery systems of gene therapy targets. Characterization of intact AAV capsids, their viral proteins (VPs), and their post-translational modifications (PTMs) is critical to monitoring and ensuring product quality and efficacy.
Dr. Smith will demonstrate how microchip CE-MS can be applied to the characterization of AAVs, specifically VP characterization and peptide mapping. Performed across a spectrum of AAV serotypes, we discuss how this platform quickly provides crucial information related to the characteristics of AAVs including the presence of VP proteoforms and PTMs.
[post_title] => In-Depth Adeno-Associated Virus Characterization with Microchip Capillary Electrophoresis-Mass Spectrometry
[post_excerpt] => This webinar consists of two parts: Dr. Adi Kulkarni from 908 Devices begins by providing a brief introduction to the ZipChip CE-MS technology, highlighting its features and benefits. In part two, Dr. Josh Smith from NIBRT, demonstrates how microchip CE-MS can be applied to the characterization of AAVs, specifically VP characterization and peptide mapping.
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[post_name] => zipchip-in-depth-adeno-associated-virus-characterization
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[post_title] => Enabling Faster Feed Strategy Optimization with Rapid Spent Media Analysis and Data Visualization Tools
[post_excerpt] => Learn how to take charge of your bioprocess development via at-line amino acid analysis empowered by a dedicated bioprocess software tool.
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[post_name] => rebel-webinars-ls-rb-wb-0017
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About this Webinar
Faster development cycles, intensified processes, and automation of process control are key initiatives in biotherapeutics manufacturing. However, monitoring critical and time-sensitive process parameters are commonly used for offline analytics, requiring manual intervention.
In this webinar, explore a new, automated approach for optimal growth and production. This new approach leverages sensitive, on-line (sample-free) monitoring of glucose and lactate with automated feed control. Understand its impact on growth/viability, lower toxic metabolite, and improved PQA.
Key Takeaways
Explore strategies to reduce toxic metabolites, achieve higher yield and improve product quality through continuous monitoring and dynamic control of substrate feeding.
Discover how selective flow-diffusion technology enables highly sensitive and accurate online measurements of glucose and lactate.
Learn from case studies in cell culture and fermentation upstream applications.
Meet the Speaker
Nick Randall
As the Bioprocessing Product Manager at 908 Devices, Nick Randall is passionate about empowering and supporting customers at the forefront of biotechnology development. He has ten years of experience as a cross-functional scientist specializing in process and product development, operations, manufacturing, automation, and analytical technologies. Nick attempts to leverage this experience to help develop and launch products with critical-to-life applications.
Peptide mapping is considered the gold standard for the analysis of biopharmaceuticals. Classical analysis is performed through long workflows involving extensive sample handling and long liquid chromatography (LC-MS) analysis times.
The distinct advantages of short analysis times and unique separation mechanisms makes Capillary Electrophoresis (CE-MS) an attractive alternative for the peptide mapping analysis. Nevertheless, most existing sample preparation protocols are either incompatible with CE-MS analysis or require additional steps for salt removal that may increase sample handling.
Key Takeaways
An overview of the ZipChip Microchip CE-MS technology and its typical application space
How to optimize CE-MS compatible sample preparation using a total workflow length of 2 hours
Data analysis will provide full sequence coverage and accurate quantitation of product quality attributes
Wide applicability of the workflow to different IgG subclasses will be demonstrated
A panel discussion (Q&A) at the end
Microchip CE-MS technology, its capabilities, and typical application space
How CE-MS technology can enhance peptide mapping throughput
Coupling peptide mapping sample preparation of monoclonal antibodies to CE-MS analysis
CE-MS analysis provides robust determination of quality attributes in less than 15 minutes
Meet the Speakers
Sara Carillo
Dr. Sara Carillo completed her Ph.D. in Chemical Sciences in 2013 at the University of Naples “Federico II”. Under the guidance of Prof. Corsaro, she focused on the structural characterisation of polysaccharides and glyco-conjugates from Gram-negative bacteria via NMR and mass spectrometry techniques, focusing on the immunological properties and potentials of extremophiles endotoxins. After a period at the University College of Dublin, in 2015 she joined Dr. Jonathan Bones’s research group in NIBRT working on understanding of the effects of extractables and leachables from single-use bioreactors on CHO cells N-glycome and produced monoclonal antibodies. She is now working in NIBRT as Bioanalytical Research Lead and is mainly interested in the development of new analytical approaches to ensure a deeper and easier understanding of biomanufacturing processes and biopharmaceuticals’ structural complexity.
Adi Kulkarni
Adi Kulkarni is a Principal Scientist. Adi has extensive experience in applying CE-MS in biopharma characterization workflows using different mass spec platforms. He has developed novel applications based on the ZipChip technology and managing strategic collaborations and partnerships. Prior to working at 908 Devices, Adi was an applications scientist at Bruker Daltonics where he worked on Bruker’s Q-TOF line of products. He received his Ph.D. at the University of Massachusetts in 2011 where he developed novel methodologies for the synthesis of nitrogen-containing heterocycles. After his Ph.D., Adi was a postdoctoral fellow at University of Southern California’s Loker Hydrocarbon Research Institute where he discovered new reagents for applications in organofluorine chemistry. He has authored 18 peer-reviewed articles.
Jonathan Bones
Jonathan Bones is the principal investigator of the Characterisation and Comparability Laboratory at NIBRT. An analytical chemist by training, Jonathan’s research group specializes in the development and application of analytical solutions for problems associated with the manufacture and characterization of biopharmaceuticals. This includes recombinant proteins, monoclonal antibodies, and advanced therapies like AAV based gene therapy, cell therapy, and mRNA using their core excellence in analytical separations coupled to mass spectrometry.
Erin Redman
Erin Redman is a Principal Scientist in the Research and Development division of 908 Devices. She joined the company in 2016 and has worked to develop protein characterization assays using the ZipChip technology and further the innovation microfluidic CE separations coupled to mass spectrometry. Prior to starting her career at 908 Devices, she received her Ph.D. under the direction of Professor J. Michael Ramsey at the University of North Carolina at Chapel Hill. There she developed microfluidic technology for interfacing high resolution separations with electrospray mass spectrometry for the characterization of intact biotherapeutic proteins and proteins from biofluids.
[post_title] => A Versatile Platform for Small Molecules, Intact Proteins & Beyond
[post_excerpt] => ZipChip can be used for applications ranging from proteins and peptides in biopharmaceuticals, to oligonucleotides and AAVs in cell and gene therapy applications.
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[post_name] => zipchip-webinar-lcgc-esymposium
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[post_title] => Multi-Component At-Line Cell Culture Media Analysis for Accelerated Process Development of a mAb-Expressing Cell Line
[post_excerpt] => In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.
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[post_title] => Biopharma 4.0 and Cell Media Optimization & At-line Methods for Cell Media Analysis
[post_excerpt] => Graziella Piras, bioprocess segment director for 908 Devices, spoke at BPI Europe 2022 on the benefits of at-line nutrient monitoring.
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[post_title] => The Critical Role of Cell Culture Media Analysis in Cell and Gene Therapies Development
[post_excerpt] => Does cell culture analysis matter for CGT development? This short webinar explores what is already known, reviews at-line methods for cell culture media analysis, and shares recent data from two case studies.
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[post_title] => Expert Roundtable: Trends in Illicit Drug Identification
[post_excerpt] => Learn from a panel of law enforcement experts as they discuss challenges in keeping pace with an evolving drug landscape, and how they use new technology to detect and identify drugs in the field.
[post_status] => publish
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[post_name] => expert-roundtable-trends-in-illicit-drug-identification
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[post_title] => Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data
[post_excerpt] => Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.
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[post_name] => biopharma-4-0-finding-opportunities-to-leverage-new-at-line-data
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[post_title] => Aerosol Hazard Management 101 with The Haz Mat Guys
[post_excerpt] => In this webinar you'll learn the definition and properties of aerosol threats, aerosol hazards and the challenge they present to first responders, why aerosols have been traditionally difficult to detect and identify with legacy technologies, and how to respond to and protect yourselves and the public from aerosol threats.
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About this Webinar
Join us for a discussion of the Russian Novichok attack in Salisbury, England and its impacts on today’s first responders and military personnel. By watching this on-demand webinar you will:
Learn details of the high-profile poisoning attack known as the “Salisbury Incident” on March 4, 2018, involving the use of a nerve agent known as a Novichok
Gain insights into the response in England that can guide future encounters
Explore how the MX908 can support responders who may be facing a Novichok in the field
Meet the Speakers
Mr. Rick Edinger
Rick served in the fire service for over 45 years, retiring in 2018 as the Deputy Chief of a large Metro Fire and EMS Agency in Chesterfield County, Virginia. He previously served as the Vice Chairperson of the International Association of Fire Chiefs Hazardous Materials Committee and currently serves as the chairperson for the National Fire Protection Association Technical Committee on Hazardous Materials Response.
Dr. Christina Baxter
Dr. Baxter has her PhD in Analytical Chemistry and she is currently the CEO of Emergency Response Tips. She was previously the CBRN Program Manager at the Combating Terrorism Technical Support Office. And she currently chairs the NFPA Technical Committee on Hazardous Materials: Protective Clothing and Equipment, in addition to participating in various levels on several other NFPA committees.
[post_title] => Emerging Chemical Threats: Novichoks, The Newcomers
[post_excerpt] => This webinar focuses on England's "Salisbury Incident", the dangers of chemical weapons, and the importance of preparedness and response measures in dealing with Novichok threats . Learn how the MX908 can empower responders in addressing potential Novichoks.
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[post_title] => The Expanding Value of Technology in Investigations and Court
[post_excerpt] => Watch this on demand webinar to learn how MX908 technology can be leveraged in investigations and court.
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[post_title] => NIBRT presents ZipChip for biopharma characterization
[post_excerpt] => In this webinar NIBRT demonstrates ZipChip's ease of use and flexibility from the control of upstream processes to downstream biotherapeutics characterisation.
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[post_name] => nibrt-presents-zipchip-for-biopharma-characterization
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[post_date] => 2024-06-14 09:24:13
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Watch a dialogue about the current emerging chemical threats and the solutions that FTIR technology provides in response; featuring Dr. Christina Baxter, CEO of Emergency Response TIPS.
In April 2024, 908 Devices acquired RedWave Technology, a leading provider of portable FTIR spectroscopic analyzers for rapid chemical identification of bulk substances.
Learn About Advantages Over Traditional Chemometrics Models
Read about the seven reasons why Raman spectroscopy with PLS models is challenging for bioprocess applications. Learn how MAVERICK's purpose-built de novo model eliminates the need for complex empirical calibration models, reagents, or unreliable auto-sampling systems for in-line bioreactor monitoring. This white paper is written in summary of the white paper “De novo Approaches for Bioprocess Parameter Estimation”. Please view the full version for detailed explanations, figures, and references.
[post_title] => De novo Models for Raman: Comparison to and Advantages Over Traditional Chemometrics Models
[post_excerpt] => Learn how the de novo model eliminates the need for complex empirical calibration models, reagents, or unreliable auto-sampling systems for in-line bioreactor monitoring.
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MAVERICK is powered by Raman spectroscopy and purpose-built de novo model for simultaneous real-time measurements of multiple key process parameters in mammalian cell cultures without the costs, complexities, and risks of conventional methods. There’s no need to deal with complex empirical calibration models, reagents, or unreliable auto-sampling systems to implement in-line bioreactor monitoring. Read this white paper summary to learn about de novo approaches for bioprocess parameter estimation.
[post_title] => De novo Approaches for Bioprocess Parameter Estimation
[post_excerpt] => Learn about Raman spectroscopy and purpose-built de novo model to minimize complexities for fast measurements.
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[post_title] => Microchip CE-MS: A Powerful Tool for Biotherapeutic Characterization
[post_excerpt] => To help explain the power of this game-changing technology, we partnered with LCGC on a new ebook that covers the topic in-depth.
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[post_title] => 'What's In Your Media?' Ebook
[post_excerpt] => Learn about the critical role of cell culture media analysis in biotherapeutics development, including biologics and cell and gene therapies.
[post_status] => publish
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[post_title] => Using MX908 in Investigations and Court
[post_excerpt] => Users can conduct field analysis of unknown substances at trace levels to generate actionable intelligence in real time to assess threat levels, establish probable cause, and prioritize investigatory resources accordingly, all while reducing operator exposure.
[post_status] => publish
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[post_title] => Actionable Information from High Pressure Mass Spectrometry
[post_excerpt] => The detection and identification of chemicals with HPMS carries sufficient information to warrant definitive action, medical treatment and communication.
[post_status] => publish
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[post_title] => Trace Detection in the Field Expedites Prosecution
[post_excerpt] => Mass spectrometry is classified as a Category A technique by the Scientific Working Group on Seized Drug Analysis (SWGDRG) and ASTM 2329-17 and has been admissible in court for more than 50 years. Download to read more.
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[post_title] => Aerosol Hazard Management 101
[post_excerpt] => Read this white paper to learn more about the hazard posed by aerosolized chemicals. You will learn about aerosols and their properties and how to successfully address them in the field.
[post_status] => publish
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[post_title] => Operational Response to Fourth Generation Agents
[post_excerpt] => Read this whitepaper written by Christina Baxter Ph.D., to prepare responders with commercially available solutions to detect, identify, decontaminate, destroy, and confirm the destruction of the A-series agents.
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[post_title] => A New Approach to Trace Detection
[post_excerpt] => Today’s emergency responders and security personnel need detection capabilities which address both categories with high sensitivity (the ability to detect threat materials below harmful levels) and high fidelity (the ability to detect reproducibly and reliably).
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[post_title] => White Paper: Area Monitoring for Chemical Warfare and Pharmaceutical Based Agents
[post_excerpt] => Learn more about area monitoring and how MX908 Beacon is the only area monitor on the market to identify chemical warfare agents, etc.
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[post_title] => The HazMat Guys Podcast, Part 2: Measuring Aerosols
[post_excerpt] => Listen to Episode 291, Part 2 of the HazMat Guys Podcast on Aerosols. The guys discuss common techniques used to measure aerosols and how to keep safe while responding to aerosolized threats.
[post_status] => publish
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[post_name] => measuring-and-understanding-aerosol-threats
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[post_title] => The HazMat Guys Podcast, Part 1: What are Aerosols?
[post_excerpt] => Listen to Episode 290, Part 1 of the HazMat Guys Podcast to learn more about aerosol threats and the challenges they pose to responders.
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[post_title] => Raman-based In-line Monitoring of Key Process Parameters in Mammalian Bioprocesses without the Need for Chemometric Model Building
[post_excerpt] => This poster describes a new technology called MAVERICK that uses Raman spectroscopy for continuous monitoring of mammalian cell cultures, specifically those using CHO and HEK293 cells. In 2024 this poster has been highlighted at BPI US West, BPS Europe, BPI Europe, BPI USA and most recently Advanced Therapies.
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[post_title] => 5’ mRNA Analysis By Microchip CE-MS Using an Internal Cleavage Motif for RNase H Digestion
[post_excerpt] => The subject of this poster was the investigation of an internal DNA motif to produce a shorter digestion product while simultaneously maintaining the length of the probe at 25nt for hybridization specificity. The shorter oligo results in easier detection using Microchip CE-MS approach. This poster was presented at ASMS 2023 as poster THP575.
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[post_title] => Improved Performance of Phosphopeptides Characterization Using Online Capillary Electrophoresis Coupling with Ion Mobility Mass Spectrometry (CE-IM-MS)
[post_excerpt] => This poster will highlight a novel strategy for characterization of therapeutic peptide that was developed based on microchip CE-MS pure liquid separation and ion mobility gas phase separation, combing with mass spectrometry identification. The poster was presented in collaboration with Ningbo University at ASMS 2023 as poster THP609.
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[post_title] => Amino Acid Quantitation in Over 50 Mammalian Cell Culture Media with an Integrated CE-MS Analyzer
[post_excerpt] => Characterizing cell culture nutrients such as amino acids in growth media is critical for maximizing cell growth and improving key quality attributes of the cells. This poster was presented at ASMS 2023 as poster THP625.
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[post_title] => Rapid Identification of Conjugation Sites in Antibody Drug Conjugates Using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
[post_excerpt] => CE/MS method is optimized with NISTmAb digest as a reference control. Good MS/MS coverage of NISTmAb is obtained with narrow peak width and fast separation. This poster was presented as a collaboration with Bruker at ASMS 2023 as poster WP041.
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[post_name] => rapid-identification-of-conjugation-sites-in-antibody-drug
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[post_title] => Conformation of Native Antibody-Drug Conjugate Charge Variants Revealed by Microchip Capillary Electrophoresis Coupled with Trapped Ion Mobility
[post_excerpt] => The combination of microchip capillary electrophoresis and trapped ion mobility enables a rapid, informative method for native monoclonal antibody and antibody-drug conjugate charge variant analysis. This poster was a collaboration with Bruker and NIH and presented at ASMS 2023 as poster WP040.
[post_status] => publish
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[post_name] => conformation-of-native-antibody-drug-conjugate-charge-variants
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[post_title] => Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis - Mass Spectrometry (CE-MS)
[post_excerpt] => Presenting a novel strategy for characterization of therapeutic peptides was developed based on microchip CE-MS and linkage-specific derivatization. This poster was presented in collaboration with Ningbo University at ASMS 2023 as poster TP544.
[post_status] => publish
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[post_name] => fast-screening-and-characterization-of-therapeutic-peptide
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[post_title] => Continuing the Investigation of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry in the Bottom-Up Characterization of Progressively Larger RNAs
[post_excerpt] => Exploring the merits of capillary-zone electrophoresis (CZE)-mass spectrometry to analyze digestion mixtures of large RNAs and attain sequence information. This poster was presented as a collaboration with UConn and Bruker at ASMS 2023 and was poster TP532.
[post_status] => publish
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[post_name] => continuing-the-investigation-of-microchip-capillary-electrophoresis
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[post_title] => Determination of ATP, ADP, AMP, and Adenosine Levels by Microchip Capillary Electrophoresis Coupled with High Resolution Mass Spectrometry
[post_excerpt] => In this study, we present a novel ZipChip coupled with a QEHF for adenosine nucleotide analysis. This poster was presented at ASMS 2023 as poster TP489.
[post_status] => publish
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[post_name] => determination-of-atp-adp-amp-and-adenosine-levels
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[post_title] => Amino Acid Quantitation of Cell Culture Media Matrices via an Integrated CE-MS Analyzer
[post_excerpt] => Optimization of cell culture media and process conditions are critical for achieving optimal cell growth, productivity, and product quality. This poster was presented at ASMS 2023 as poster TP 398.
[post_status] => publish
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[post_title] => Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS
[post_excerpt] => This poster was presented in collaboration with Protein Metrics and highlights how the ZipChip coupled to HRMS provides a streamlined analytical approach to rapidly assess the heterogeneity of the investigated therapeutic proteins through the comprehensive interrogation of the different charge variants and their intact MS spectra. This poster was presented at ASMS 2023 as poster TP 384.
[post_status] => publish
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[post_name] => sample-to-result-workflow-for-the-investigation-of-biosimilars-vs-innovator-cetuximab
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[post_title] => Peptide Mapping Workflow for Direct Microchip CE-MS Analysis of Biopharmaceuticals
[post_excerpt] => In this study we demonstrated the suitability of a modified digestion workflow for peptide mapping analysis via CE separation. This poster was presented at ASMS 2023 in collaboration with NIBRT. It was poster MP619.
[post_status] => publish
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[post_name] => peptide-mapping-workflow-for-direct-microchip
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[post_title] => Combining Capillary Electrophoresis and Trapped Ion Mobility Spectrometry Mass Spectrometry to Analyze Epitranscriptomic Marks Mediating Virus-Host Interactions in Infectious Diseases
[post_excerpt] => This poster evaluates the merits of capillary-zone electrophoresis (CZE)-MS. This poster was presented at ASMS 2023 as a collaboration with UCONN. It was poster MP548.
[post_status] => publish
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[post_name] => combining-capillary-electrophoresis-and-trapped-ion-mobility-spectrometry-mass-spectrometry
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[post_title] => Use of Microchip Capillary Electrophoresis – Mass Spectrometry for Automated Rapid Measurement of Enzyme Reaction Kinetics
[post_excerpt] => This approach allows rapid measurement of enzymatic cleavage dynamics in real time. It can be applied to almost any enzyme substrate reaction and is highly tolerable to various buffers, thanks to the CE Chip-MS configuration. This poster was presented at ASMS 2023 with collaborators as poster MP547.
[post_status] => publish
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[post_name] => use-of-microchip-capillary-electrophoresis
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[post_title] => Optimization of Scalable rAAV Production for Gene Therapy – Leveraging At-Line Amino AcidMeasurements for Bioprocess Modeling-Driven Approaches
[post_excerpt] => Spent media analysis from an at-line analyzer, the REBEL, was used to further understanding of AAV production process and identify correlation between key nutrient consumptions and capsid titers in fed-batch and continuous processes. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 43.
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[post_name] => scalable-aav-production-gene-therapy
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[post_title] => Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
[post_excerpt] => N-glycan profiling is a critical step of biopharmaceuticals analysis as N-glycans play an important part in both activity and safety of monoclonal antibodies and other glycosylated biotherapeutics. This poster was presented at ASMS 2023 as poster MP291.
[post_status] => publish
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[post_name] => rapid-ce-ms-analysis-of-released-n-glycan
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[post_title] => ZipChip Customer Experience: NIBRT - 908 Devices Exceeds in Support
[post_excerpt] => Dr. Josh Smith from NIBRT discusses the incredible customer support he receives from 908 Devices.
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[post_name] => zipchip-testimonials-ls-zc-tm-0008
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[post_title] => ZipChip Customer Experience: University of Wisconsin - ZipChip is easy to use
[post_excerpt] => Ye Ge from the University of Wisconsin discusses how easy ZipChip is to use, with fast separations, and minimal training.
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[post_title] => ZipChip Customer Experiences
[post_excerpt] => Hear from our various experts on why they use ZipChip in their lab.
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[post_title] => ZipChip Customer Experience: NIBRT - Unique ZipChip Advantages
[post_excerpt] => Hear from Dr. Sara Carillo from NIBRT on the unique advantages of ZipChip for charge variant analysis.
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[post_title] => ZipChip Customer Experience: University of Wisconsin - Speed up Analysis for Complex Biological Matrices
[post_excerpt] => Hear from Li Lingjun from the University of Wisconsin on how ZipChip's separation techniques speed up analysis and simplify workflows in the academic lab.
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[post_title] => ZipChip Customer Experience: Symphogen - Charge Variant Separation
[post_excerpt] => Listen to Dan Bach Kristensen, a principal scientist at Symphogen, as he shares how ZipChip helps him with charge variant separation.
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[post_title] => Interview: The Key to Unsolved Insights into RNA Characterization?
[post_excerpt] => Recorded at ASMS 2022, Dan Fabris from the University of Connecticut shares his experience with RNA characterization using ZipChip.
[post_status] => publish
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[post_title] => Interview: Oligonucleotide Analysis with ZipChip at Boehringer Ingelheim
[post_excerpt] => Recorded at ASMS 2022, Vladimir Papov shares his experience with oligo analysis using ZipChip.
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[post_title] => Hear from Our Users: The Need for Speed in the Lab
[post_excerpt] => Listen to ZipChip and REBEL users from The Dana Farber Cancer Institute, Sartorius, and Amgen discuss the impact of faster workflows in the lab.
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[post_title] => ThreatID - Gas Cell Module Demonstration
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[post_title] => XplorIR - Handheld FTIR for Over 5,600 Gases/Vapors
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[post_title] => MX908 Beacon Product Video
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[post_title] => Protein Characterization with ZipChip
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[post_title] => Whiteboard Explainer: Avoiding the Stickiness of Oligo Analysis
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[post_title] => Benefits of the MX908 with Aero
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[post_title] => MX908 Demo - Trace Analysis of Suspected Explosive
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[post_title] => MX908 with Aero
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[post_title] => The Pivotal Role of FTIR in Hazmat/Emergency Response
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[post_title] => FTIR for Industrial Chemicals - Responding to Emerging Threats
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[post_title] => The New MX908 Beacon for Area Monitoring
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[post_title] => How FTIR is Filling the Gas Identification Gap
[post_excerpt] => Industry experts discuss how FTIR technology is used to address gas identification in hazmat/CBRNe response.
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[post_title] => Transformative Impact of Gas Phase FTIR on Hazmat Operations
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[post_title] => Adaptive Atmospheric Correction - XplorIR
[post_excerpt] => Dr. John Seelenbinder discusses with the Hazmat Guys how the XplorIR achieves accurate gas sample identification, even with humidity and carbon dioxide interference.
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[post_title] => Expert Panel Discussion - The Gas Threat Response
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[post_title] => Traditional Air Monitoring and How FTIR Gas Identification is Changing the Game
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[post_title] => XplorIR's Gas Mixtures Analysis
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[post_title] => Beyond Detection: The Imperative for Advanced Trace-Level Identification of Synthetic Opioids
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[post_title] => Empowering Field Operations: Integrated Chemical Analysis
[post_excerpt] => This on demand webinar is designed for emergency response teams, defense personnel and security professionals needing quick, accurate integrated chemical analysis.
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[post_title] => Improving Substance Detection and Identification in Correctional Facilities
[post_excerpt] => Watch this webinar to learn more about MX908 for Corrections Screening and pairing with RaySecur's MailSecur system for robust narcotics identification in correctional facilities.
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[post_title] => Simplifying Everyday Hazmat Calls with Advanced Technology
[post_excerpt] => From routine calls such as carbon monoxide and odor detection, to more complex incidents involving multiple chemical substances learn how hazmat response tools like XplorIR and MX908 allow responders to work smarter.
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[post_title] => Maximizing Decon Efficiency: Solutions for Dangerous Drugs
[post_excerpt] => Watch this webinar to learn how First Line Technology and 908 Devices products work together to provide robust decon solutions.
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[post_name] => maximizing-decon-efficiency-solutions-for-fentanyl-and-other-drugs
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[post_date] => 2024-04-23 09:17:43
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[post_title] => Staying Ahead of the Curve: Navigating Emerging Drugs for Law Enforcement
[post_excerpt] => Learn about diverse drug classifications and why new substances, such as xylazine and medetomidine, are emerging more frequently. Stay ahead of the curve and navigate these emerging drug trends.
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[post_title] => Keeping up with New Emerging Analytical Technology
[post_excerpt] => Explore advancements in emerging analytical technologies like Process Analytical Technology (PAT) and mass spectrometry, improving drug development through enhanced bioprocess monitoring and control.
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[post_date] => 2024-07-18 12:48:57
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[post_title] => Improving Cell Therapy Manufacturing with On-line Monitoring
[post_excerpt] => This webinar will explore how automated monitoring and control of glucose and lactate levels can significantly improve the cell therapy process.
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[post_name] => improving-cell-therapy-manufacturing-with-on-line-monitoring
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[post_date] => 2024-05-29 17:33:30
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[post_title] => Moving Towards a Scalable AAV Vector Production at High Volumetric Efficiency
[post_excerpt] => In this on-demand webinar, Graziella Piras and Prasanna Srinivasan explore approaches to facilitate a cost-effective and scalable vector production at a personalized level. You will learn how you can get the data where and when you need it.
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[post_date] => 2024-06-10 11:07:46
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[post_title] => Critical Gaps in Gas Detection Methods in Hazmat Scenarios
[post_excerpt] => This webinar will discuss the crucial role of gas detection in hazmat management, comparing existing methods and emphasizing the advanced application of handheld FTIR devices.
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[post_date] => 2024-04-05 14:56:35
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[post_title] => Grant Writing Strategies for Public Safety
[post_excerpt] => Are you seeking to enhance your department's resources or make a significant impact on the fentanyl epidemic? Watch this webinar to learn about law enforcement grant writing and applications, to aid in acquiring technologies that are used on the front lines for public safety.
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[post_date] => 2023-12-12 17:23:49
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[post_title] => Deadly Drug Investigations
[post_excerpt] => This webinar provides an overview of the rise of the opioid epidemic in the U.S.. Through the use of real-life case studies, you will learn how to safely respond and investigate the scene of an overdose.
[post_status] => publish
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[post_name] => mx908-webinars-fentanyl-and-other-deadly-drug-investigations
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[post_date] => 2023-11-20 11:47:37
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[post_title] => Suspect Fentanyl Mail Analysis and Best Practices
[post_excerpt] => Watch our quick webinar on suspect fentanyl mail analysis to learn best practices on utilizing MX908 for screening suspected mail.
[post_status] => publish
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[post_name] => suspect-fentanyl-mail-analysis-and-best-practices
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[post_title] => Responding to Chemical Warfare and Pharmaceutical Based Agents
[post_excerpt] => A must watch for CBRN first responders. Receive the latest info on dangerous chemical threats, chemical warfare, and pharmaceutical based agents.
[post_status] => publish
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[post_name] => on-demand-webinar-responding-to-chemical-warfare-and-pharmaceutical-based-agents
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[post_title] => Engineering Functionally Improved CAR T cells with a Multi-Cytokine Backpack Platform with Insights into Metabolism
[post_excerpt] => Researchers at Emory University, led by Dr. Sarwish Rafiq, have developed a novel modular multi-cytokine backpack (MCB) platform that combines the signals necessary for activation, co-stimulation, and cytokine support into a single “all-in-one” reagent for CAR T cell manufacturing.
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