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ZipChip



CONSUMABLES GUIDE



From complex biologics to small molecules,
ZipChip has an assay kit for you.















Take the Guesswork Out of Method Development





3 Easy Steps to Selection





1.  Application





2.  Chip





3.  Kit





Assay kits come with background electrolyte and sample diluent that’s optimized for each application. Just put the bottle of background electrolyte in the autosampler, prep your samples with the sample diluent and you’re off.





1. The Application



From large to small molecule, ZipChip’s got you covered.













Protein Characterization:
ZipChip is a one-stop shop for CQA’s—from charge variant analysis to peptide mapping. You’ll get high-resolution separation coupled to MS with simple, streamlined workflows.















Metabolomics: Quickly analyze small polar analytes from a variety of matrices, or monitor dynamic levels of metabolites in real time. Sample prep is quick and easy and results are ready in minutes.

















Oligonucleotides: The characterization of nucleic acid-based drugs like oligonucleotides isn’t easy. ZipChip can offer some advantage over LC separations, particularly variations due to charge or shape.















Small Molecules: Analysis is easy and fast with ZipChip. Simply dilute and shoot; there’s no labeling or derivatization. Small polar analyte assays take as little as 2 minutes. Add internal standards for full quantitation on a variety of analytes.













2. The Chips



Choose from a range of chip options to optimize your workflow. Each chip can be used up to 125 injections.



HS: High Speed chip enables fastest separations. Matching BGE kits: Intact Antibody, Peptides, or Metabolites.

HR: High Resolution chip for applications demanding maximum separation capacities. Matching BGE kits: Intact Antibody, Peptides, or Metabolites.

HSN: High Speed chip for fast native protein analysis. Matching BGE kits: Native Antibodies or Charge Variant Analysis.

HRN: High Resolution chip with ultimate separation for native protein analysis. Matching BGE kits: Native Antibodies, or Charge Variant Analysis. 

HSB: High Speed Bare Glass chip for high throughput separations. For example: fast oligonucleotides analysis. Matching BGE kit example: Oligos BGE.

HRB: High Resolution Bare Glass chip for high resolution separation of negatively charged analytes such as oligonucleotides. Matching BGE kit example: Oligos BGE.

















3. BGE Kits



Background electrolyte (BGE) and sample diluent reduce preparation time for your samples. With ZipChip you just dilute and shoot!



Charge Variant Analysis: Formulated to provide excellent charge variant separations and MS sensitivity for antibodies and other proteins on all mass spectrometers.

Native Antibodies: Excellent charge variant separation of antibodies and other constructs to generate  native spectra.

Peptides: Fast, efficient separations of protein digests and peptides utilizing low pH.

Metabolites: Streamlined sample prep and high-speed analysis for small molecules in denaturing conditions at low pH.

Oligonucleotides: Rapid analysis of oligonucleotides without the use of ion-pairing agents.















Ordering Information



ZipChip Assay Kits*
Part Number
Samples Per Kit
Charge Variant Analysis Kit
850-00052
625
Native Antibody Assay
850-00048
625
Metabolites Assat
850-00033
625
Peptide Assay
850-00034
625
Oligos Assay
850-00066
625
Oligos Starter
850-00067
250 Tests



*All kits contain BGE and diluent, and chips need to be ordered separately. The exception is the oligos starter kit which contains BGE, Diluent, chips and a standard.







Chips
Part Number
Chips Per Box
Injections Per Chip
HS
810-00195
5
125
HR
810-00194
5
125
HSN
810-00230
5
125
HRN
810-00227
5
125
HSB
810-00237
5
125
HRB
810-00239
5
125



                    [post_title] => ZipChip Consumables Guide
                    [post_excerpt] => Learn how to take the guesswork out of method development with ZipChip. Breeze through your selection in three quick steps.
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            [1] => WP_Post Object
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                    [post_date] => 2018-06-04 04:28:30
                    [post_date_gmt] => 2018-06-04 08:28:30
                    [post_content] => 
ZipChip leverages microfluidic-based Capillary Electrophoresis (CE) and electrospray ionization technology to simplify sample preparation, perform high-resolution separations with reduced analysis times, and directly introduce samples into a Thermo Fisher Scientific or Bruker mass spectrometer. Achieve faster results with the ZipChip CE-MS device.











CE-MS DEVICE









ZipChip



ACCELERATE YOUR MS CHARACTERIZATION



Rapid protein characterization and metabolomic analysis with microfluidic technology for highly efficient separations of complex samples.

















BIOLOGICAL CHARACTERIZATION



IN MINUTES







GIVE YOUR MASS SPEC SOME ZIP



The ZipChip® platform prepares and separates a wide range of biological samples, then electrosprays them into your mass spec for analysis. Just clip it on. The process takes as little as a few minutes, and it results in better separation quality than most LCs in a fraction of the time. Simple workflows and multiple kit options cover a host of biotherapeutic, metabolomic, and proteomic applications.











EASY ON SAMPLES



Now the kicker. ZipChip plays well with your mass spec and your proteins. Gentle sample prep reagents preserve structural integrity without denaturing or unfolding proteins for fully native mass spectra. No need to remove detergents or desalt. Negative and neutrals are trashed. Only positive analytes head out for cleaner mass spectra and more identified peaks.







EFFICIENCY WITH ADVANCED



MICROCHIP TECHNOLOGY







WITH ZIPCHIP YOU GET THE DATA FASTER, AND BECAUSE OF THAT YOU CAN MAKE QUICK DECISIONS



Associate scientist at Amgen







Easy as 1-2-3



Pick an application, a chip, and a kit. After simply loading the premixed background electrolyte and sample into the autosampler, pop in a ZipChip, and hit run. Use vials or 96-well plates.

It’s hands-off from there. Smart chips tell the system which method to use based on your preferences. Samples are automatically loaded, separated, and electrosprayed. Integrated software cues the mass spec to start analysis.





Efficient Separations



Microfluidic technology integrates capillary electrophoresis (CE) and electrospray ionization (ESI) on the ZipChip. Junctions and dead volumes don’t exist so analytical quality stays high, and no injection bias improves repeatability.







1. Pick your application, kit, and chip













2. Simple sample prep













3. Load reagent and chip, then run

















IT'S ALL IN THE CHIP











FROM LARGE TO SMALL MOLECULES,



 ZIPCHIP’S GOT YOU COVERED

















Protein Characterization:



ZipChip is a one-stop shop for CQAs—with streamlined CE MS workflows for Charge Variant Analysis of basic and acidic species, Rapid Intact Mass Analysis, Subunit Analysis, and Peptide Mapping for deeper characterization.













Oligonucleotides:



The characterization of nucleic acid-based drugs like oligonucleotides isn’t easy. ZipChip can offer some advantage over LC separations, such as no ion-pairing agents to contaminate the instrument







Small Molecules



Analysis is easy and fast with ZipChip. Simply dilute and shoot; there’s no labeling or derivatization. Small polar analyte assays take as little as 2 minutes. Add internal standards for full quantitation on a variety of analytes.













Metabolomics:



Detect, identify and quantitate small polar analytes from a variety of matrices like cell lysates or growth media and monitor dynamic levels of metabolites in real time. Sample prep is quick and easy and results are ready in minutes.













                    [post_title] => ZipChip: Accelerate Your MS Characterization
                    [post_excerpt] => Rapid protein characterization and metabolomic analysis with microfluidic technology for highly efficient separations of complex samples.
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            [post_content] => 




ZipChip



CONSUMABLES GUIDE



From complex biologics to small molecules,
ZipChip has an assay kit for you.















Take the Guesswork Out of Method Development





3 Easy Steps to Selection





1.  Application





2.  Chip





3.  Kit





Assay kits come with background electrolyte and sample diluent that’s optimized for each application. Just put the bottle of background electrolyte in the autosampler, prep your samples with the sample diluent and you’re off.





1. The Application



From large to small molecule, ZipChip’s got you covered.













Protein Characterization:
ZipChip is a one-stop shop for CQA’s—from charge variant analysis to peptide mapping. You’ll get high-resolution separation coupled to MS with simple, streamlined workflows.















Metabolomics: Quickly analyze small polar analytes from a variety of matrices, or monitor dynamic levels of metabolites in real time. Sample prep is quick and easy and results are ready in minutes.

















Oligonucleotides: The characterization of nucleic acid-based drugs like oligonucleotides isn’t easy. ZipChip can offer some advantage over LC separations, particularly variations due to charge or shape.















Small Molecules: Analysis is easy and fast with ZipChip. Simply dilute and shoot; there’s no labeling or derivatization. Small polar analyte assays take as little as 2 minutes. Add internal standards for full quantitation on a variety of analytes.













2. The Chips



Choose from a range of chip options to optimize your workflow. Each chip can be used up to 125 injections.



HS: High Speed chip enables fastest separations. Matching BGE kits: Intact Antibody, Peptides, or Metabolites.

HR: High Resolution chip for applications demanding maximum separation capacities. Matching BGE kits: Intact Antibody, Peptides, or Metabolites.

HSN: High Speed chip for fast native protein analysis. Matching BGE kits: Native Antibodies or Charge Variant Analysis.

HRN: High Resolution chip with ultimate separation for native protein analysis. Matching BGE kits: Native Antibodies, or Charge Variant Analysis. 

HSB: High Speed Bare Glass chip for high throughput separations. For example: fast oligonucleotides analysis. Matching BGE kit example: Oligos BGE.

HRB: High Resolution Bare Glass chip for high resolution separation of negatively charged analytes such as oligonucleotides. Matching BGE kit example: Oligos BGE.

















3. BGE Kits



Background electrolyte (BGE) and sample diluent reduce preparation time for your samples. With ZipChip you just dilute and shoot!



Charge Variant Analysis: Formulated to provide excellent charge variant separations and MS sensitivity for antibodies and other proteins on all mass spectrometers.

Native Antibodies: Excellent charge variant separation of antibodies and other constructs to generate  native spectra.

Peptides: Fast, efficient separations of protein digests and peptides utilizing low pH.

Metabolites: Streamlined sample prep and high-speed analysis for small molecules in denaturing conditions at low pH.

Oligonucleotides: Rapid analysis of oligonucleotides without the use of ion-pairing agents.















Ordering Information



ZipChip Assay Kits*
Part Number
Samples Per Kit
Charge Variant Analysis Kit
850-00052
625
Native Antibody Assay
850-00048
625
Metabolites Assat
850-00033
625
Peptide Assay
850-00034
625
Oligos Assay
850-00066
625
Oligos Starter
850-00067
250 Tests



*All kits contain BGE and diluent, and chips need to be ordered separately. The exception is the oligos starter kit which contains BGE, Diluent, chips and a standard.







Chips
Part Number
Chips Per Box
Injections Per Chip
HS
810-00195
5
125
HR
810-00194
5
125
HSN
810-00230
5
125
HRN
810-00227
5
125
HSB
810-00237
5
125
HRB
810-00239
5
125



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About this Webinar



A broad range of separation techniques are now routinely combined with mass spectrometry for in-depth biopharmaceutical characterization. Simultaneously, MS software tools have evolved to support the storage, processing, and reporting of the expanding MS data oceans. Here recent progress, challenges, and learnings from MS-based workflows of biopharmaceutical charge variants will be presented and illustrated through case-studies.







In this webinar, you will learn:




The crucial role that CE-MS plays in a biopharma development lab for the comprehensive characterization of biopharmaceuticals.



How CE-MS can be used to improve the efficiency of characterization workflows by eliminating method development and increasing the throughput while gaining deeper insights through in-depth analysis of biopharmaceuticals.








Who should attend:




Scientists working in protein characterization labs for biotherapeutics



Analytical scientists working in biopharmaceutical labs



CDMO labs looking to optimize workflows and improve efficiency














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                    [post_title] => Fast Therapeutic Protein Characterization
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            [post_date] => 2023-07-24 11:19:48
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About this Webinar



A broad range of separation techniques are now routinely combined with mass spectrometry for in-depth biopharmaceutical characterization. Simultaneously, MS software tools have evolved to support the storage, processing, and reporting of the expanding MS data oceans. Here recent progress, challenges, and learnings from MS-based workflows of biopharmaceutical charge variants will be presented and illustrated through case-studies.







In this webinar, you will learn:




The crucial role that CE-MS plays in a biopharma development lab for the comprehensive characterization of biopharmaceuticals.



How CE-MS can be used to improve the efficiency of characterization workflows by eliminating method development and increasing the throughput while gaining deeper insights through in-depth analysis of biopharmaceuticals.








Who should attend:




Scientists working in protein characterization labs for biotherapeutics



Analytical scientists working in biopharmaceutical labs



CDMO labs looking to optimize workflows and improve efficiency














            [post_title] => Charge Variant Analysis for Intact Protein Characterization in a Biopharmaceutical Development Lab – Lessons Learned and the Road Ahead
            [post_excerpt] => How CE-MS can be used to improve the efficiency of characterization workflows by eliminating method development and increasing the throughput while gaining deeper insights through in-depth analysis of biopharmaceuticals.
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            [post_modified] => 2024-12-09 15:40:42
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