Izvorni kôd stranice CXCL2

{{infokutija gen}}
{{infokutija protein
| Ime = [[Hemokin]]ski [[ligand]] 2
| caption = 
| image = 
| width = 
| HGNCid = 4603
| Symbol = CXCL2
| AltSymbols = SCYB2, GRO2, GROb, MIP-2a, MGSA-b, CINC-2a
| EntrezGene = 2920
| OMIM = 139110
| RefSeq = NM_002089
| UniProt = P19875
| PDB = 
| ECnumber = 
| Chromosome = 4
| Arm = q
| Band = 21
| LocusSupplementaryData = 
}}

'''[[Hemokin]]ski  [[ligand]] 2''' (X-C motiv) jest mali [[citokin]] koji je kod [[ljudi]] [[kodon|kodiran]] [[gen]]om  '''CXCL2''' sa [[hromosom 4|hromosoma 4]]. Pripada porodici CXC [[hemokin]]a koja se također naziva '''[[makrofag]]ni inflamatorni protein 2-alfa''' (MIP2-alfa), '''protein beta reguliran rastom''' (Gro-beta) i ''Gro [[onkogen]]- 2'' (Gro-2). CXCL2 je 90% identičan u sekvenci [[aminokiselina]] kao srodni hemokin, [[CXCL1]].

Ovaj hemokin luče [[monociti]] i [[makrofagi]] i ima [[hemotaksija|hemotaksije]]  za [[leukociti|polimorfojedarne leukocite]] i [[hematopoetske matične ćelije]]e.<ref name="pmid2643119">{{cite journal | vauthors = Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A | title = Identification and characterization of macrophage inflammatory protein 2 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 2 | pages = 612–6 | date = januar 1989 | pmid = 2643119 | pmc = 286522 | doi = 10.1073/pnas.86.2.612| bibcode = 1989PNAS...86..612W | doi-access = free }}</ref><ref name="pmid2078213">{{cite journal | vauthors = Iida N, Grotendorst GR | title = Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue | journal = Molecular and Cellular Biology | volume = 10 | issue = 10 | pages = 5596–9 | date = oktobar 1990 | pmid = 2078213 | pmc = 361282 | doi = 10.1128/mcb.10.10.5596}}</ref><ref name = pelus>{{cite journal | vauthors = Pelus LM, Fukuda S | title = Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties | journal = Experimental Hematology | volume = 34 | issue = 8 | pages = 1010–20 | date = august 2006 | pmid = 16863907 | doi = 10.1016/j.exphem.2006.04.004 }}</ref> Na hromosomu 4, gen za CXCL2 nalazi se u grupi drugih CXC hemokina.<ref name="pmid10343098">{{cite journal | vauthors = O'Donovan N, Galvin M, Morgan JG | title = Physical mapping of the CXC chemokine locus on human chromosome 4 | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 1–2 | pages = 39–42 | date = 1999 | pmid = 10343098 | doi = 10.1159/000015209 | s2cid = 8087808 }}</ref> CXCL2 mobilizira ćelije, interakcijom sa ćelijskom površinom preko [[hemokinski receptor|hemokinskog receptora]] koja se naziva [[hemokinski receptori]] ([[CXCR1]] i  CXCR2.<ref name = pelus/>

==Aminokiselinska sekvenca==
Dužina [[polipeptid]]nog lanca je 107 [[aminokiselina]], а [[molekularna masa|molekulska težina]]  11.389 [[dalton (jedinica)|Da]].<ref name="UniProt">{{cite web|url=http://www.uniprot.org/uniprot/P19875#sequences |title=UniProt, P19875 |language=en |access-date=23. 10. 2021}}</ref>
{{legenda aminokiselina}}
<table  style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MARATLSAAP</td><td style="background-color: #f9f9f9;"></td><td>SNPRLLRVAL</td><td style="background-color: #f9f9f9;"></td><td>LLLLLVAASR</td><td style="background-color: #f9f9f9;"></td><td>RAAGAPLATE</td><td style="background-color: #f9f9f9;"></td><td>LRCQCLQTLQ</td></tr>
<tr style="background-color: #eee;"><td>GIHLKNIQSV</td><td style="background-color: #f9f9f9;"></td><td>KVKSPGPHCA</td><td style="background-color: #f9f9f9;"></td><td>QTEVIATLKN</td><td style="background-color: #f9f9f9;"></td><td>GQKACLNPAS</td><td style="background-color: #f9f9f9;"></td><td>PMVKKIIEKM</td></tr>
<tr style="background-color: #eee;"><td>LKNGKSN</td></tr>
</table>

==Funkcija==
CXCL2, kao i srodni [[hemokin]]i, također je moćan hemoatraktant neutrofila i uključen je u mnoge [[imunski odgovor|imunske odgovore]], uključujući zacjeljivanje rana, [[metastaze]] raka i angiogenezu.<ref name="Al-Alwan_2017"/> Studija je objavljena 2013. testirajući ulogu CXCL2, CXCL3 i CXCL1 u [[ćelijska migracija|migraciji glatkih mišićnih ćelija]] disajnih puteva (ASMC), što ima značajnu ulogu u astmi. Rezultati ove studije pokazali su da i CXCL2 i CXCL3 pomažu u posredovanju migracije normalnnih i astmarskih  ASMC-a kroz različite mehanizme.<ref name="Al-Alwan_2017">{{cite journal | vauthors = Al-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, Rousseau S, Eidelman DH, Hamid Q | title = Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration | journal = Journal of Immunology | volume = 191 | issue = 5 | pages = 2731–41 | date = septembar 2013 | pmid = 23904157 | pmc = 3748335 | doi = 10.4049/jimmunol.1203421 }}</ref>

==Reference==
{{Reflist|2}}

{{Hemokini}}
{{Modulatori hemokinskih receptora}}

[[Kategorija:Citokini]]
[[Kategorija:Geni na hromosomu 4]]
[[Kategorija:Ljudski proteini]]
[[Kategorija:Proteomika]]