Cervical Cancer Elimination Initiative Knowledge Repository

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Primary prevention: HPV vaccination
Secondary prevention: screening and treating precancerous lesions
Tertiary prevention: invasive cancer treatment and palliative care
Capacity building
Programme management
Monitoring and evaluation

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Action plans, frameworks, tools
Strategic Framework for the Comprehensive Prevention and Control of Cervical Cancer in the Western Pacific Region 2023–2030
This Strategic Framework for the Comprehensive Prevention and Control of Cervical Cancer in the Western Pacific Region 2023–2030 was developed at the request of and in consultation with Member States in the Region. It is based on the recognition of extremely diverse social, economic, geographic, and cultural characteristics, priorities and needs, while adapting global mandates and initiatives relevant to cervical cancer to regional, subregional and national contexts.
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Action plans, frameworks, tools
Seventy-second Regional Committee for Europe: Tel Aviv, 12–14 September 2022: roadmap to accelerate the elimination of cervical cancer as a public health problem in the WHO European Region 2022–2030
This document presents a roadmap for the period 2022–2030 to accelerate the elimination of cervical cancer as a public health problem in the WHO European Region. It offers a vision for the path towards cervical cancer elimination in the Region through universal access to human papillomavirus vaccination and appropriate cervical cancer screening and treatment services for the population. The roadmap is aligned to the Global strategy to accelerate the elimination of cervical cancer as a public health problem and contextualizes the strategy’s priority actions to regional specificities.
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Fact sheets
Cervical cancer roadmap - essentials
Fact sheet accompanying Roadmap to accelerate the elimination of cervical cancer as a public health problem in the WHO European Region 2022–2030.
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Technical documents
Roadmap to accelerate the elimination of cervical cancer as a public health problem in the WHO European Region 2022–2030: draft for the Seventy-second Regional Committee for Europe Background document
Cervical cancer is a preventable and curable disease if detected early and managed effectively. Yet each year, more than 66 000 women across WHO European Region are newly diagnosed with cervical cancer and more than 30 000 die from it. The Global strategy to accelerate the elimination of cervical cancer as a public health problem was adopted by the World Health Assembly in August 2020 and marks the first time the world has committed to eliminate a cancer. This Roadmap to accelerate elimination of cervical cancer as a public health problem in the WHO European Region 2022–2030 offers a vision for the path towards cervical cancer elimination in the Region through universal access to human papillomavirus vaccination and appropriate cervical cancer screening and treatment services. Achieving the ambitious 90–70–90 global targets by 2030 will require a collective effort across countries and disciplines to ensure no one is left behind in the drive to eliminate cervical cancer.
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Technical documents
MI4A 2022 Public Database
Building on the list of products reported as purchased by countries, WHO is also leveraging other intelligence publicly available to publish a list of vaccine products available for procurement – including non-prequalified-vaccines. (As of 15 July 2022).
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WHO Guidelines
Consolidated guidelines on HIV, viral hepatitis and STI prevention, diagnosis, treatment and care for key populations
The Consolidated guidelines on HIV, viral hepatitis and STI prevention, diagnosis, treatment and care for key populations outline a public health response for 5 key populations (men who have sex with men, trans and gender diverse people, sex workers, people who inject drugs and people in prisons and other closed settings). They present and discuss new recommendations and consolidate a range of recommendations and guidance from current WHO guidelines.
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Reports
Meeting of the Strategic Advisory Group of Experts on Immunization, April 2022: conclusions and recommendations
The Strategic Advisory Group of Experts (SAGE) on Immunization held a virtual meeting on 4-7 April 2022. This report summarizes the discussions, conclusions and recommendations. It covers the following items: - Global and Regional reports - IA2030: catch up vaccination - Covid-19 vaccines - Hepatitis A vaccines - HPV vaccines - Polio - Typhoid conjugate vaccines.
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Technical documents
Cervical Cancer Screening IARC Handbooks of Cancer Prevention Volume 18
A Working Group of 27 independent international experts, convened by the International Agency for Research on Cancer (IARC) between June and October 2020, reviewed the scientific evidence and assessed the cancer-preventive and adverse effects of various methods of screening for cervical cancer. Cervical cancer is the fourth most commonly diagnosed cancer type in women worldwide, and the fourth most common cause of cancer death in women. This publication is an important update of the previous IARC Handbook on cervical cancer screening (Volume 10, published in 2005). Volume 18 provides evidence-based evaluations of the effectiveness of five methods of cervical cancer screening in reducing cervical cancer incidence and/or mortality.
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Publications
Cervical Cancer Elimination in Africa: Where Are We Now and Where Do We Need to Be?
This publication, jointly produced by the Union for International Cancer Control (UICC), IARC, and the African Cancer Registry Network (AFCRN), has been developed to reflect the status of current efforts towards elimination of cervical cancer in the African region. Each chapter describes the current situation, starting with epidemiology and progressing through an overall assessment of prevention (HPV vaccination and screening) efforts and treatment and palliative care.
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Technical documents
WHO HPV Vaccine Global Market Study, April 2022
This study provides the most up-to-date understanding of current and future global trends and drivers of HPV supply and demand to support the resolution of challenges to equitable, unrestricted and flexible access to HPV vaccines across all regions and income groups.
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Publications
Human papillomavirus (‎HPV)‎ nucleic acid amplification tests (‎NAATs)‎ to screen for cervical pre-cancer lesions and prevent cervical cancer: policy brief
This policy brief focuses on the use of and the differences between HPV DNA-based and HPV mRNA-based molecular nucleic acid amplification tests (NAATs).
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Guide
A short guide to cancer screening. Increase effectiveness, maximize benefits and minimize harm
The aim of a cancer screening programme is either to reduce mortality and morbidity in a population by early detection and early treatment of a cancer (for example, breast screening) or to reduce the incidence of a cancer by identifying and treating its precursors (such as cervical and colorectal screening). This short guide is designed to be a quick reference that contains the important ideas about cancer screening. Readers should refer to other publications for comprehensive discussion and detailed guidance on cancer screening programmes.
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Guide
Setting Up a Cancer Centre: A WHO–IAEA Framework
Cancer centres are a major resource in ensuring a comprehensive approach to cancer treatment and its planning. As part of a new roadmap developed by WHO and IAEA to help countries design national cancer control programmes, this publication proposes a framework to develop a cancer centre and/or to strengthen the provision of services in an existing cancer centre. The publication provides the features of multidisciplinary cancer care and details the infrastructure, human resources and equipment for different services. This framework is expected to be used as a guide to implementation, taking into consideration the local context and resources.
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WHO Guidelines
WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention, second edition: use of mRNA tests for human papillomavirus (‎HPV)‎: web annex: evidence-to-decision framework for mRNA testing for HPV
This WHO and HRP guideline is designed to help countries make faster progress, more equitably, on the screening and treatment of cervical cancer. This document includes guidance on an important additional option for cervical screening. use of mRNA (messenger RNA) HPV testing. This gives countries additional options when considering which type of HPV nucleic acid amplification tests (NAAT) to use in their screening programs.
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WHO Guidelines
WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention, second edition: use of mRNA tests for human papillomavirus (‎HPV)
This WHO and HRP guideline is designed to help countries make faster progress, more equitably, on the screening and treatment of cervical cancer. This document includes guidance on an important additional option for cervical screening. use of mRNA (messenger RNA) HPV testing. This gives countries additional options when considering which type of HPV nucleic acid amplification tests (NAAT) to use in their screening programs.
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Data
Cervical Cancer Country Profiles
The aim of the WHO Cervical Cancer Country Profiles is to bring out the current status of cervical cancer for each WHO Member States (194 total) curated from multiple data sources. These profiles help to establish a baseline for the country and support monitoring trends toward the achievement of the Elimination of cervical cancer as a public health problem.transmitted infections are controlled or eliminated. Drawing lessons from the shortfalls of the past and addressing the above challenges, it aims at mobilizing and guiding Member States towards achieving the sustainable development targets for control and/or elimination of these diseases.
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Guide
Generating evidence for artificial intelligence-based medical devices: a framework for training, validation and evaluation
This first-of-its-kind publication from the WHO is a framework targeted at developers and researchers of AI-based software as a medical device, as well as policy-makers and implementers. It is intended to guide those seeking to understand the evidence generation requirements from development to post-market surveillance of these devices.
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Data
HPV vaccine introduction dashboard
This dashboard provides information about the status of HPV vaccine introduction in WHO Member States. As per the Global Strategy for Cervical Cancer Elimination each country should introduce HPV in the national immunization schedule by 2030 and meet the target of 90% of girls fully vaccinated with HPV vaccine by age 15.
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Training materials
IARC Cervical Cancer Image Bank
The aim of this initiative is to create a comprehensive portal with an image bank of cervical epithelium, including normal features, benign changes, precancers, and cancers, to facilitate the development, evaluation, and validation of AI image interpretation algorithms for the early detection of cervical cancer and precancer.
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Action plans, frameworks, tools
Regional implementation framework for elimination of cervical cancer as a public health problem: 2021–2030
In 2020 the Seventy-third World Health Assembly adopted the WHO Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem. This regional framework has been developed to facilitate the implementation of the global strategy by Member States of the South-East Asia Region.
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About Cervical Cancer Repository

Cervical cancer is a preventable disease. It is also curable if detected early and adequately treated. Yet it remains one of the most common cancers and causes of cancer-related death in women across the globe. Cancer of the cervix is also a disease that reflects global inequity. Its burden is greatest in low- and middle-income countries, where access to public health services is limited and screening and treatment for the disease have not been widely implemented.

In August 2020, the World Health Assembly passed a resolution calling for elimination of cervical cancer and adopting a strategy to make it happen. This is the first global health strategy for the elimination of a cancer as a public health problem. It proposes 90-70-90 targets that must be met by 2030 for countries to be on the path towards cervical cancer elimination.

The Cervical Cancer Elimination Initiative Knowledge Repository is established to support the implementation of the Global Strategy by Member States. There are many sources of relevant guidance and information to guide these efforts. The Knowledge Repository is a web-based platform, which aims to map and to provide "one-stop" access to the knowledge collected from a variety of sources.

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Disclaimer

This Cervical Cancer Elimination Initiative Knowledge Repository (Knowledge Repository) was developed by the World Health Organization (WHO). It is intended to provide a "one-stop" access to information relevant to attaining the targets of the of the Global Strategy to Accelerate the Elimination of Cervical Cancer.

All reasonable precautions have been taken by WHO to verify the information contained in this platform.

The Knowledge Repository contains links to resources on external websites. Listing publications in the Knowledge Repositry and providing links to external websites does not mean that WHO endorses or recommends those publications or sites, or has verified the content contained within them. They are provided for convenience only.

The Knowledge Repository is made available without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the user. In no event shall WHO be liable for damages arising from its use.

The designations employed and the presentation of the material in publications or external web listed in the Knowledge Repository does not imply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement.

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