Drugs anti-malarial

It will be interesting to see how much of this activity will survive in post-war conditions, especially in competition with new, synthetic, anti-malarial drugs developed during the war and revival of the Java cinchona industry, which is apparently making progress. [Pg.419]

Much work has also 4)een done bearing directly or indirectly on the mode of action of quinine and other anti-malarial drugs. The absorption, distribution and metabolism of quinine has been investigated by various workers of whom Kelsey, Ceiling, Oldham and Dearborn (1944)... [Pg.475]

As a practical result there are now at least six synthetic anti-malarial drugs available to malariologists, including the three pre-war drugs, pamaquln, mepacrine and plasmocide. [Pg.477]

Of the other cinchona bases, the dextrorotatory forms cinchonine and quinidine have been used as anti-malarial drugs in cases of idiosyncrasy to quinine, a subject to which Dawson has given much attention. Quinidine is used to eontrol auricular fibrillation, and its value for this purpose in comparison with dihydroquinidine has been investigated by several workers. Dawes has recently devised a method of testing... [Pg.479]

The barks of Alstoiiia species (Apocyiiaceae) had a considerable reputation throughout the tropics as effective anti-malarial drugs, which led to their inclusion in the British Pharmacopoeia, 1914, and to their chemical examination by various workers. The following is a list of the species examined and of the alkaloids found. The figures in brackets are percentages of total alkaloids. [Pg.716]

Hydrangea umbellata Rheder (Saxifragaceae). A Chinese anti-malarial drug said to contain several crystalline alkaloids. (Jang, Fu, Huang, Wang, Nature, 1948, 161, 401.)... [Pg.781]

In the course of the intensive campaign carried on in the United States of America during the war for the discovery of effective anti-malarial drugs, a team of workers made anti-malarial tests on 600 different plants belonging to 123 families of phanerogams and three families of cryptogams, and it is recorded that the suppressive activity shown by some of these plants appeared to be associated with alkaloidal fractions of their extracts. [Pg.811]

Among the many anti-malarial drugs tried in the 1940s and 1950s was (3) (cf p 104). The better C-N... [Pg.128]

The methylation of deoxyuridine monophosphate (dUMP) to thymidine monophosphate (TMP), catalyzed by thymidylate synthase, is essential for the synthesis of DNA. The one-carbon fragment of methy-lene-tetrahydrofolate is reduced to a methyl group with release of dihydrofolate, which is then reduced back to tetrahydrofolate by dihydrofolate reductase. Thymidylate synthase and dihydrofolate reductase are especially active in tissues with a high rate of cell division. Methotrexate, an analog of 10-methyl-tetrahydrofolate, inhibits dihydrofolate reductase and has been exploited as an anticancer drug. The dihydrofolate reductases of some bacteria and parasites differ from the human enzyme inhibitors of these enzymes can be used as antibacterial drugs, eg, trimethoprim, and anti-malarial drugs, eg, pyrimethamine. [Pg.494]

Nau ME et al. Technical assessment of the Aflymetrix yeast expression genechip YE6100 platform in a heterologous model of genes that confer resistance to anti-malarial drugs in yeast. J Clin Microbiol 2000 38 1901-1908. [Pg.116]

Wiesner J, Qrtmaim R, Jomaa H, et al. New anti-malarial drugs. Angew Chem Int Ed Engl 2003 42 5274-93. [Pg.74]

The anti-malarial drug chloroquine can be present in red cells at up to 200 times the concentration it achieves in plasma, one of the factors making it an effective anti-malarial, as the circulating plasmodium parasites reside largely in the red cells. [Pg.128]

It is an alkaloid obtained from the bark of cinchona and is a dextro isomer of anti-malarial drug quinine. Its sodium channel blocking property results in an increased threshold for excitability and decreased automaticity. As a consequence of its potassium channel blocking properties, it prolongs action potential in most cardiac cells. [Pg.189]

Brinen LS, Stout TJ (2003) Can mosquitoes be bitten A new hope for anti-malarial drug design. Structure 11(11) 1309-1310... [Pg.227]

A. Jaeger, et al., Clinical features and management of poisoning due to anti-malarial drugs. Med. Toxicol. 2 242-273, 1987. [Pg.315]

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