Aromatic residues

These properties concern paraffins that are part of food packaging materials. Their potential toxicity could be attributable to aromatic residues. The latter are thereby characterized directly or indirectly by ... [Pg.286]

The conversion takes place at high temperature (820-850°C) and very short residence time (hundredth of seconds) in the presence of steam. The by-products are hydrogen, methane and a highly aromatic residual fuel-oil. [Pg.382]

TT-stacking and charge-transfer interaction between aromatic residues in the receptor and delocalized regions of the substrate van der Waals attraction between hydrophobic regions on the two components... [Pg.175]

The group of peptides known as tachykinins include substance P, substance K or neurokinin A, and neuromedin K, ie, neurokinin B, as well as a number of nonmammalian peptides. All members of this family contain the conserved carboxy-terrninal sequence Phe-X-Gly-Leu-Met-NH2, where X is an aromatic, ie, Phe or Tyr, or branched aliphatic, eg, Val or lie, amino acid. In general, this C-terminal sequence is cmcial for tachykinin activity (33) in fact, both the methionineamide and the C-terminal amide are cmcial for activity. The nature of the X residue in this sequence determines pharmacological identity (34,35) thus the substance P group contains an aromatic residue in this position, while the substance K group contains an aliphatic residue (33). [Pg.202]

The first commercial oil-fumace process was put into operation in 1943 by the Phillips Petroleum Co. in Borger, Texas. The oil-fumace blacks rapidly displaced all other types used for the reinforcement of mbber and today account for practically all carbon black production. In the oil-fumace process heavy aromatic residual oils are atomized into a primary combustion flame where the excess oxygen in the primary zone bums a portion of the residual oil to maintain flame temperatures, and the remaining oil is thermally decomposed into carbon and hydrogen. Yields in this process are in the range of 35 to 50% based on the total carbon input. A broad range of product quaHties can be produced. [Pg.539]

The oil-fiimace process, based on the partial combustion of Hquid aromatic residual hydrocarbons, was first introduced in the United States at the end of World War II. It rapidly displaced the then dominant channel (impingement) and gas-furnace processes because it gave improved yields and better product quahties. It was also independent of the geographical source of raw materials, a limitation on the channel process and other processes dependent on natural gas, making possible the worldwide location of manufacturing closer to the tire customers. Environmentally it favored elimination of particulate air pollution and was more versatile than all other competing processes. [Pg.544]

The peptide-binding site is a hydrophobic groove flanked by the RT loop between pi and p2 and the n-Src loop between p3 and P4 (see Figure 13.28a). The latter is so named because neuronal Src has an insertion of six residues in this loop. The groove is lined with conserved aromatic residues. [Pg.274]

Cushny has compared the action of d- and Z-hyoscyamines with that of atropine, and of d-homatropine with that of dZ-homatropine in antagonising the action of pilocarpine, and finds that the order of activity of the first three is in the ratio 1 40 20, and of the second two in the ratio 4 2-5. He drew attention also to the important influence of the acyl radical in the tropeines, which exercises the maximum effect when it is a hydroxyalkyl aromatic residue and is laevorotatory and in illustration of this point gives the following table of relative activities on the basis of capacity to antagnonise pilocarpine in the salivary fistula dog —... [Pg.110]

The acyl group may be benzoyl or a substituted aromatic residue. [Pg.111]

Mammals, fungi, and higher plants produce a family of proteolytic enzymes known as aspartic proteases. These enzymes are active at acidic (or sometimes neutral) pH, and each possesses two aspartic acid residues at the active site. Aspartic proteases carry out a variety of functions (Table 16.3), including digestion pepsin and ehymosin), lysosomal protein degradation eathepsin D and E), and regulation of blood pressure renin is an aspartic protease involved in the production of an otensin, a hormone that stimulates smooth muscle contraction and reduces excretion of salts and fluid). The aspartic proteases display a variety of substrate specificities, but normally they are most active in the cleavage of peptide bonds between two hydrophobic amino acid residues. The preferred substrates of pepsin, for example, contain aromatic residues on both sides of the peptide bond to be cleaved. [Pg.519]

Isopropylidene and benzylidene hydrazones of the selenazoles w hich are unsubstituted in the 5-position react with p-nitrosodiethyl-and p-nitrosodimethyl-aniline in organic solvents on heating and the addition of acetic acid or pyridine. - Thus result crystalline, deeply colored, 2-hydrazono-5-(p-dialkylaminophenylimino)selenazoles (correspondingly substituted in the 4-position), details are given in Table VII. The presence of an aromatic residue in the 4-position of the selenazole ring appears to be needed to obtain crystalline compounds. [Pg.357]

Showing the monoisotopic masses of fragments MH+ of /i-lactoglobulin A cysteine residues are shown in bold script, i.e. cysteine-C aromatic residues are underlined, i.e. phenylalanine-F, tyrosine-F, and tryptophan- mIz expected for singly charged species. [Pg.214]

Figs. 1.6 and 1.7). This type of CD spectrum is observed for certain heterooligomeric peptoid sequences with as few as 33% chiral aromatic residues, in both aqueous and polar organic solvent (acetonitrile, methanol). [Pg.16]

As such, the magainins provide a useful initial target for peptoid-based peptido-mimetic efforts. Since the helical structure and sequence patterning of these peptides seem primarily responsible for their antibacterial activity and specificity, it is conceivable that an appropriately designed, non-peptide helix should be capable of these same activities. As previously described (Section 1.6.2), peptoids have been shown to form remarkably stable hehces, with physical characterishcs similar to those of peptide polyprohne type-I hehces (e.g. cis-amide bonds, three residues per helical turn, and 6A pitch). A faciaUy amphipathic peptoid helix design, based on the magainin structural motif, would therefore incorporate cationic residues, hydrophobic aromatic residues, and hydrophobic aliphathic residues with threefold sequence periodicity. [Pg.20]

For instance, Pn-2 forms ribbons at concentrations >0.1 mM in water. At 0.6 mM, these ribbons self-assemble into fibrils and at higher concentrations into fibres. Conversely, glutamine-rich Pn-1 (Ac-QQRQQQQQEQQ-Am) forms ribbons at 1 mM and does not form fibrils, even at concentrations as high as 25 mM. Association of Pn-2 into ribbons is much more favourable due to it having hydrophobic aromatic residues arranged such that there is a large disparity between the hydrophobicity of each of its tape faces. [Pg.40]

The relatively basic (hydroxyalkyl)phosphines act toward LMCs as reductants and, compatible with this, also as strong nucleophiles. We have studied such reactions in aqueous and D2O solutions by P-, H-, and C-NMR spectroscopies (including 2D correlation methods), product isolation and, when possible, X-ray analysis of isolated compounds or their derivatives. Thus, aromatic aldehyde moieties present in lignin (e.g., 3) are reduced to the corresponding alcohols (see 4) with co-production of the phosphine oxide in D2O, -CH(D)OD is formed selectively (36). The mechanism proceeds via a phosphonium species formed by initial nucleophilic attack of the P-atom at the carbonyl C-atom, i.e., via ArCH(OH)P%, where Ar is the aromatic residue and R is the hydroxyalkyl substituent (36). When the aldehyde contains a 4-OH substituent, the alcohol product... [Pg.12]

Area analysis of chromatograms is familiar to the chromatographer. The assumption is made that the area of a peak is proportional to the mass of the component present. The spectrophotometric detector is set at about 280 nm to detect the aromatic residues or at 210 to 230 nm to detect the peptide bond. The absorbance at 280 may be influenced by peptide composition, while the absorbance near 220 nm is more closely correlated to mass. [Pg.259]

The result of a typical diffusion measurement is shown in Figure 2. In the 1H-NMR spectrum of a cubic phase of monoolein and 2H20 with 10% Desmopressin, the signals from the aromatic residues (Tyr and Phe) in Desmopressin, appear in a spectral region which does not contain any signals from the lipid. Therefore, the peptide and lipid diffusion coefficients could be determined separately (Table II), and in Figure 2 the spectra from such an experiment are shown. The lipid diffusion coefficient was also determined in a cubic phase in the absence of Desmopressin. [Pg.256]

To limit the structural flexibility of these two aromatic residues, conformationally restricted analogues of Phe and/or Tyr were substituted [28,30] (Fig. 1). [Pg.158]

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