Chemical Dimerization Technolog interaction

The yeast three-hybrid (Y3H) system is a cellular assay system designed for the identification and characterization of small molecule-protein interactions in intact cells [25]. It uses yeast Saccharomyces cerevisiae as a host system and combines aspects of the yeast two-hybrid (Y2H) system [26] with recent developments in chemical dimerizer technology [27, 28],... [Pg.1120]

With protein-protein interactions being pervasive throughout biology, chemically controlled dimerization has proved to be a remarkably versatile technology, and more than 300 papers have described use of the approach [9], These applications can be broadly separated into two classes. The first is the use of dimerization technologies in basic and applied biological research, to understand the functions of proteins or pathways, and to create... [Pg.237]

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