Dimethyl esters

Reflux 6 8 g. of the dimethyl ester with a solution of 3 2 g. of sodium hydroxide in 150 ml. of 80 per cent, methanol for 2 hours on a water bath. When cold, filter oflF the solid and wash it with a little cold methanol. Dissolve the solid in 350 ml. of warm water, add concentrated hydrochloric acid to the solution at 60° until acidic to litmus, filter off the precipitated acid, wash with a little water and dry at 100°. The resulting hexadecane-1 16 dicarboxylic acid, m.p. 122°, weighs 5-3 g. Recrystallisation from absolute methanol raises the m.p. to 124 -5°. [Pg.940]

Acetamido-2-(7-chloroindol-3-ylmethyl)propanedioic acid dimethyl ester[6]... [Pg.62]

Tetrachloro-l,4-benzenedicarboxy[qllic acid dimethyl ester [1861-32-1]... [Pg.971]

Amidation. Heating of the diammonium salt or reaction of the dimethyl ester with concentrated ammonium hydroxide gives adipamide [628-94-4] mp 228°C, which is relatively insoluble in cold water. Substituted amides are readily formed when amines are used. The most industrially significant reaction of adipic acid is its reaction with diamines, specifically 1,6-hexanediamine. A water-soluble polymeric salt is formed initially upon mixing solutions of the two materials then hea ting with removal of water produces the polyamide, nylon-6,6. This reaction has been studied extensively, and the hterature contains hundreds of references to it and to polyamide product properties (31). [Pg.240]

Ak2o has been iastmmental ia developiag a new process for the stereospecific synthesis of 1,4-cyclohexane diisocyanate [7517-76-2] (21). This process, based on the conversion of poly(ethylene terephthalate) [25038-59-9] circumvents the elaborate fractional crystallisation procedures required for the existing -phenylenediamine [108-45-2] approaches. The synthesis starts with poly(ethylene terephthalate) (PET) (32) or phthaUc acid, which is converted to the dimethyl ester and hydrogenated to yield the cyclohexane-based diester (33). Subsequent reaction of the ester with ammonia provides the desired bisamide (34). The synthesis of the amide is the key... [Pg.455]

Phthahc anhydride (1) is the commercial form of phthaUc acid (2). The worldwide production capacity for the anhydride was ca 3.5 x 10 metric tons ia 1993, and it was used ia the manufacture of plasticizers (qv), unsaturated polyesters, and alkyd resins (qv) (see Polyesters, unsaturated). Sales of terephthahc acid (3) and its dimethyl ester are by far the largest of any of the benzenepolycarboxyhc acids 14.3 x 10 t were produced in 1993. This is 80% of the total toimage of ah. commercial forms of the benzenepolycarboxyhc acids. Terephthahc acid is used almost exclusively for the manufacture of poly(ethylene terephthalate), which then is formed into textiles, films, containers, and molded articles. Isophthahc acid (4) and trimehitic anhydride (5) are commercial products, but their worldwide production capacities are an order of magnitude smaller than for terephthahc acid and its dimethyl ester. Isophthahc acid is used primarily in the production of unsaturated polyesters and as a comonomer in saturated polyesters. Trimehitic anhydride is used mainly to make esters for high performance poly(vinyl chloride) plasticizers. Trimesic acid (6), pyromehitic dianhydride (7), and hernimehitic acid (8) have specialized commercial apphcations. The rest of the benzenepolycarboxyhc acids are not available commercially. [Pg.478]

Another problem arises from brominated aromatic species derived from inorganic bromides used as oxidation cocatalysts. As a result, the cmde NDA is converted to its dimethyl ester, DMNDA [840-65-3] and solvent recrystalHzed to give a high purity diester (36—38). A process for purifying NDA directly by hydrogenation (pure TA process) has also been described (39). [Pg.293]

Other approaches to (36) make use of (37, R = CH ) and reaction with a tributylstannyl allene (60) or 3-siloxypentadiene (61). A chemicoen2ymatic synthesis for both thienamycia (2) and 1 -methyl analogues starts from the chiral monoester (38), derived by enzymatic hydrolysis of the dimethyl ester, and proceeding by way of the P-lactam (39, R = H or CH ) (62,63). (3)-Methyl-3-hydroxy-2-methylpropanoate [80657-57-4] (40), C H qO, has also been used as starting material for (36) (64), whereas 1,3-dipolar cycloaddition of a chiral nitrone with a crotonate ester affords the oxa2ohdine (41) which again can be converted to a suitable P-lactam precursor (65). [Pg.8]

Furan-2,3-dicarboxylic acid, dimethyl ester UV, 4, 588 (53G340)... [Pg.24]

Furan-3,4-dicarboxylic acid, dimethyl ester microwave, 4, 6 7IBCJ928)... [Pg.24]

Furan-2-phosphonic acid P NMR, 4, 567 <69JCS(B)527) Furan-2-phosphonic acid, dimethyl ester... [Pg.24]

Malonic acid dimethyl ester, 2-(l-thienyl)-X-ray, 4, 724 (78CC83)... [Pg.34]

Oxepin-2,7-dicarboxylic acid, dimethyl ester H NMR, 7, 552 <76TL1167)... [Pg.39]

Azodne-6,7-dicarboxylic add, 1,2-dihydro-1-phenyl-dimethyl ester NMR, 7, 660... [Pg.529]

Benzo[b]thiophene-2,3-dicarboxylic acid dimethyl ester synthesis, 4, 895... [Pg.561]

Furan-2-carboxylic acid, 3,4,5-triphenyl-dimethyl ester, 4, 691 Furan-3-carboxylic acid, 2,3-dihydro-esters... [Pg.632]

Isothiazole-4,5-dicarboxylic acid, 3-phenyl-dimethyl ester synthesis, S, 150 Isothiazole-5-glyoxylic acid ethyl ester reduction, 6, 156 Isothiazole-4-mercurioacetate reactions, 6, 164 Isothiazole-5-mercurioacetate reactions, 6, 164 Isothiazoles, 6, I3I-I75 acidity, 6, 141 alkylation, 6, 148 aromaticity, S, 32 6, 144-145 basicity, 6, I4I biological activity, 6, 175 boiling points, 6, I43-I44, 144 bond fixation, 6, 145 bond orders, 6, I32-I34 calculated, 6, 133 bromination, S, 58 6, 147 charge densities, 6, 132-134 cycloaddition reactions, 6, 152 desulfurization, S, 75 6, 152 deuteration, S, 70... [Pg.683]

IsoxazoIidine-3,3-dicarboxylic acid, 2-methoxy-dimethyl ester reaction with bases, 6, 47 Isoxazolidine-3,5-diones synthesis, 6, 112, 113 Isoxazoli dines conformation, 6, 10 3,5-disubstituted synthesis, 6, 109 oxidation, 6, 45-46 PE spectra, 6, 5 photolysis, 6, 46 pyrolysis, 6, 46 reactions, 6, 45-47 with acetone, 6, 47 with bases, 6, 47 reduction, 6, 45 ring fission, S, 80 spectroscopy, 6, 6 synthesis, 6, 3, 108-112 thermochemistry, 6, 10 Isoxazolidin-3-ol synthesis, 6, 111 Isoxazolidin-5-oI synthesis, 6, 111... [Pg.690]

A -l,2,3,5-Oxatriazoline-2,3-dicarboxylic acid, 4-phenyl-dimethyl ester synthesis, 6, 609... [Pg.723]

Pyrazole-3,4-dicarboxylic acid, 1-phenyl-dimethyl ester synthesis, 5, 150 Pyrazole-3,5-dione, 1-phenyl-alkylation, 5, 230 synthesis, 5, 290... [Pg.773]

See also in sourсe #XX -- [ Pg.44 ]

See also in sourсe #XX -- [ Pg.140 ]

See also in sourсe #XX -- [ Pg.44 ]

See also in sourсe #XX -- [ Pg.12 , Pg.56 , Pg.59 , Pg.62 , Pg.77 ]

See also in sourсe #XX -- [ Pg.7 , Pg.130 ]

See also in sourсe #XX -- [ Pg.62 , Pg.77 ]

See also in sourсe #XX -- [ Pg.336 ]

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