Higher-order structure and

Histone deacetylases (HDAGs) catalyze the removal of acetyl groups from the Ne atom of histone lysines in a nucleosomal context, ensuring the reversibility of histone acetylation. Histone deacetylation is often associated vdth transcriptional repression and silencing since it promotes chromatin higher order structures and the recruitment of silencers [34]. As other enzymes involved in chromatin... [Pg.29]

At the cytological level, the power and resolution of a variety of chromosome staining and banding techniques has been increased by ihcir application to prophase chromosomes and the genetic map now locates over one thousand bands. At the nuclcosomal level, the association of DNA with histone proteins is reasonably well understood. However, knowledge of the higher order structure and the nature of the association between DNA and the acidic structural scaffold, or core proteins, of the chromosome, remains unresolved. [Pg.715]

Relationship Between Higher-Order Structures and Mechanical Properties... [Pg.74]

It is likely that cells utilize the physico-chemical properties inherent in genomic DNA molecules, which are highly charged, locally stiff, and very long in the course of their functioning. Unveiling the higher-order structure and its relation with the function of DNA and chromatin is awaited. [Pg.58]

Higher-Order Structure and Dynamics of FK506-Binding Protein Probed by Backbone Amide Hydrogen/Deuterium Exchange and Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry... [Pg.703]

A polymer whisker is a spontaneously formed assembly with a higher-ordered structure and could be used as a single fiber for amplification of the intrinsic properties of the polymer. The whiskers of aromatic polyesters such as poly(para-oxybenzoyl) and poly(2-oxo-6-naphthoyl) have been intensively investigated [31, 32], while there have been only few reports on the whiskers of conjugated polymers such as poly(3-alkylthiophene) [33]. When a helical conjugated polymer with a whisker structure is designed, the intrachain and interchain interactions must be balanced by precisely controlling the van der Waals, rr-electron overlap, and electrostatic interactions. [Pg.322]

Furuhashi Y, Imamura Y, Jikihara Y, Yamane H (2004) Higher order structures and mechtmical properties of bacterial homo poly(3-hydroxybutyrate) fibers prepared by cold-drawing and annealing processes. Polymer 45 5703-5712... [Pg.280]

Zhang, Z., Li, W., Li, M., et al. (1997) Higher-order structure and dynamics of EK506-binding protein probed by backbone amide hydrogen/deuterium exchange and electrospray ionization Eourier transform ion cyclotron resonance mass spectrometry. Tech Protein Chem VIII, 703-713. [Pg.125]

Despite the multiple challenges faced by the top-down HX-MS, the outlook for this technique remains very bright. It has already made tremendous progress in the past decade, effectively transitioning from an esoteric curiosity in the field of experimental biophysics with very few followers to a powerful tool uniquely capable of solving complex problems related to protein higher-order structure and dynamics. It is clear that further developments in the top-down HX-MS will continue to expand the boundaries of this technique and eventually transform it into a routine tool in the experimental armamentarium of structural biology and biophysics. [Pg.161]

Griffith, W.P., Mohimen, A., Abzalimov, R.R., Kaltashov, I.A. (2008) Characterization of protein higher order structure and dynamics with ESI MS, in Mass Spectrometry of Proteins (ed. J.P. Whitelegge),... [Pg.164]

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