Lipid peroxidative damage

Chow. C. K., and A. L. Tappel. An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. Lipids 7 518-524, 1972. [Pg.378]

Peroxynitrite is a nonspecific oxidant that reacts with all classes of biomolecules depleting low-molecular-weight antioxidants, initiating lipid peroxidation, damaging nucleic acids and proteins. Its reactions are much slower than those of the hydroxyl radical but are faster than those of hydrogen peroxide. Comparison of peroxynitrite reactivity with various amino acid residues of human serum albumin have shown that cysteine, methionine, and tryptophan are the most reactive... [Pg.184]

Tappel AL Lipid Peroxidation Damage to Cell Component. Fed Proc. 1973 32 1870. [Pg.163]

Van Kuijk FJGM, Sevanian A, Handeirnan GJ, Dratz EA (1987) A new role for phospholipase A2 protection of membranes from lipid peroxidation damage. Trends Biochem Sci 12 31-34... [Pg.73]

Wuweizisu B from Schisandra chinensis showed strong protective effects on lipid peroxidation damage to the surface of cultured hepatocytes of rats treated with Fe2+/cystein and also scavenger free radical properties [240], On the other hand, the oral administration of wuweizisu B increases the activities of antioxidant enzymes. [Pg.251]

Tappel, A.L. (1973) Lipid peroxidation damage to cell components. Fed. Proc. 32 1874—1879. [Pg.506]

Direct free radical damage to enzymes and proteins would appear to be very important. In his studies of organic peroxides and lipid peroxidation on enzyme inactivation, Wills (1959, 1961) found the sulfhydryl enzymes most labile. Studies have been made of lipid peroxidation damage to proteins (Tappel, 1955 Venolia and Tappel 1958). Recent studies of linolenate peroxidation damage to cytochrome c by I. D. Desai in our laboratory are shown in Table HI. The reaction system consisted of pure linolenic acid and cytochrome c in relatively high concentration. Cytochrome c catalyzed the peroxidation of linolenic acid and in turn the free radicals attacked cytochrome c. There is evidence of considerable damage as shown by the loss of solubility of the cytochrome c and the fact that radicals derived from linolenic acid added to cytochrome c and could not be re-... [Pg.499]

Subcell ular particle Evidence for lipid peroxidation Damage by in vitro Metabolic derangements in vivo which could result from peroxidation... [Pg.502]

The biological membranes of subcellular organelles are primary sites for lipid peroxidation damage (Sevanian and Ursini, 2000). Lipid hydroperoxides and aldehydic lipid peroxidation can also induce strand breaks in DNA (Yang and Schaich, 1996). 4-HNE accumulates rapidly following spinal cord injury... [Pg.58]

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