National Cancer Institute

The National Cancer Institute (NCI) database is a collection of more than half a million structures, assembled by NCI s Developmental Therapeutics Program (DTP) or its predecessors in the course of NCTs anti-cancer screening efforts that started in the late 1950s (plus the more recent anti-HIV screening) [37-39]. Approximately half of this database is publicly available without any usage restrictions, and is therefore called the "Open NCI Database. For each of these structures (more than 250 000) the DTP record contains at least the chemical structure as a coimection table and an NCI accession number, the NSC number. [Pg.262]

Structure and Nomenclature Search System. This system links the collection of chemical databases found in the Chemical Information System (CIS), one of the first interactive systems for stmcture and substmcture searching. References from the separate files can be retrieved by SANSS using CAS Registry Numbers, and the database of stmctures may be searched for stmctures or substmctures. An adaptation of the SANSS software for substmcture searching has been incorporated in the Dmg Information System of the National Cancer Institute for its own use (54). [Pg.118]

Based on tests with laboratory animals, aniline may cause cancer. The National Cancer Institute (NCI) and the Chemical Industry Institute of Toxicology (CUT) conducted lifetime rodent feeding studies, and both studies found tumors of the spleen at high dosage (100 —300 mg/kg pet day of aniline chloride). CUT found no tumors at the 10—30 mg/kg per day feeding rates. The latter value is equivalent to a human 8-h inhalation level of 17—50 ppm aniline vapor. In a short term (10-d) inhalation toxicity test by Du Pont, a no-effect level of 17 ppm aniline vapor was found for rats. At high levels (47—87 ppm), there were blood-related effects which were largely reversible within a 13-d recovery period (70). [Pg.233]

Bioassay of Titanium Dioxidefor Possible Carcinogenicity, National Cancer Institute Technical Report No. 97, U.S. Department of Health, Education and Welfare, Washington, D.C., 1979. [Pg.137]

Bioassay of Caprolactamfor Carcinogenicity, American National Cancer Institute DHHS PubHcation No. NIH 80-1770, Washington, D.C., 1980. [Pg.433]

En2ymes Therapeutic" in ECT 3rd ed., Vol. 9, pp. 225—240, by D. A. Cooney, G. Stergis, and H. N. Jayaram, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health. [Pg.314]

Department of Chemistry. University of Illinois, Urbana, Illinois dlSOh This research was supported by the National Science Foundation (GP 30491X) and the National Cancer Institute (CA 13963). [Pg.26]

Present address National Drug Company, Research Laboratories, Philadelphia 44, Pennsylvania. Work done in the Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Ofg. Syntheses, 81, 56 (1951). [Pg.44]

A scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). It contains some 8,000 chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primaiy journals, current awareness tools, NCI reports, and other special sources. Test results have been reviewed by experts in carcinogenesis and mutagenesis. [Pg.304]

The antineoplastic agent mitindomide (160) in fact represents the well-known product from irradiation of maleimide in benzene [30]. The activity of this old compound was uncovered by one of the large antitumor screens maintained by the National Cancer Institute, The structure is sufficiently complex and the starting materials sufficiently available to lead one to suspect that the product is still produced photochemically. The product can be rationalized by assuming successive 1,4 and 1,2 additions to benzene. Intermediate 159a involves the 1,4 followed by 1,2 addition intermediate 159b presupposes the steps occur in the reverse order. [Pg.218]

Today, 3D databases, which provide the means for storing and searching for 3D information of compounds, are proven to be useful tools in drug discovery programs. This is well exemplified with the recent discovery of novel nonpeptide HIV-1 protease inhibitors using pharmacophore searches of the National Cancer Institute 3D structural database [13-15]. [Pg.106]

Based in part on work aided by a grant (CA-07250) to the University of San Francisco from the National Cancer Institute, U.S. Public Health Service. We are greatly indebted to the scientific staff of Varian Associates, Palo Alto, for the 220 MHz proton magnetic resonance spectra, and... [Pg.61]

Received April 19, 1967. This work was supported by grants from the National Research Council of Canada and the National Cancer Institute of Canada. [Pg.261]

A comprehensive website summarizing the status of tumor antiangiogenic compounds in various stages of clinical trial is maintained by the National Cancer Institute at www.cancer.gov/clinicaltrials/developments/ anti-angio-table. Following is a survey of the most important substances currently in clinical development. [Pg.84]

Camptothecin was discovered as an active anticancer drug isolated from the bark of Camptotheca acuminata. The anticancer activity of camptothecin was discovered in the 1960s by the National Cancer Institute (NCI) as part of a systematic effort to screen for novel anticancer agents derived from natural products. Monroe Wall and Mansuhk Wani identified the chemical structure of camptothecin. They also identified the chemical structure of taxol, again under the auspices of the NCI. Susan Hoiwitz was contracted by the NCI to elucidate the anticancer mechanisms of camptothecin. She found in the early 1970s that camptothecin induced DNA breaks and attested DNA and RNA synthesis. However, it is approximately 12 years later, only after DNA topo-isomerase I (Topi) had been identified in human cells, that Leroy Liu and his coworkers found that Topi was the cellular target of camptothecin [reviewed in [1]. [Pg.315]

National Cancer Institute, National Institutes of Health... [Pg.1524]

NCI (1978) Bioassay of dibutyitin diacetate for possible carcinogenicity. Bethesda, MD, National Cancer Institute,... [Pg.48]

NCI. 1979. Bioassay of methyl parathion for possible carcinogenicity. Bethesda, MD U.S. Department of Health, Education, and Welfare, National Institutes of Health, National Cancer Institute, Carcinogenesis Testing Program. DHEW (NIH) Publication No. 79-1713 NCI-CG-TR-157, 112. [Pg.224]

Increased mortality was observed in both male rats (at doses of 20.4 mg/kg/day and above) and male mice (at doses of 0.46 mg/kg/day and above) in a 2-year bioassay conducted by the National Cancer Institute (NCI 1978). The authors attributed the excessive mortality in the male rats to treatment-related toxic nephropathy. The high mortality in male mice was possibly due to fighting since no other treatment-related cause for the deaths could be determined. Survival in females of both species was unaffected by endosulfan (NCI 1978). However, survival was significantly decreased in female rats that consumed 5 mg/kg/day for 2 years (FMC 1959b), and in female mice that consumed approximately 2.9 mg technical endosulfan/kg/day for 2 years (Hack et al. 1995 Hoechst 1988b). In these studies, survival in male rats was not affected at 5 mg/kg/day for 2 years (FMC 1959b) and survival in male mice was not affected at 2.51 mg/kg/day for 2 years (Hoechst 1988b). [Pg.49]

HSDB = Hazardous Substance Data Bank NCI = National Cancer Institute NIOSH = National Institute for Oooupational Safety and Health OHM/TADS = Oil and Hazardous Materials/Teohnical Assistance Data System RTECS = Registry of Toxio Effects of Chemioal Substances... [Pg.203]

NCI. 1968. Evaluation of carcinogenic, teratogenic and mutagenic activities of selected pesticides and industrial chemicals. Volume I Carcinogenic study. Prepared by Bionetics Research Labs, Inc., Bethesda, MD National Cancer Institute. NCI-DCCP-CG-1973-1-1. [Pg.307]

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