Partition coefficients liquid chromatography

Elution volume, exclusion chromatography Flow rate, column Gas/liquid volume ratio Inner column volume Interstitial (outer) volume Kovats retention indices Matrix volume Net retention volume Obstruction factor Packing uniformity factor Particle diameter Partition coefficient Partition ratio Peak asymmetry factor Peak resolution Plate height Plate number Porosity, column Pressure, column inlet Presure, column outlet Pressure drop... [Pg.83]

By modeling the substance behavior at the interface of two liquid phases, in particular, stationary and mobile phases in liquid chromatography, 1-octanol - water partition coefficients or partition coefficients in... [Pg.392]

In contrast to straight phase or adsorption chromatography, partition chromatography involves the separation of sample molecules owing to their different partition coefficients between the liquid stationary and mobile phases. The liquid stationary phase is located in the pores of a sorbent, ideally only acting as a support, making no contribution to the retention of the sample molecules. [Pg.54]

Lipophilicity represents the affinity of a molecule or a moiety for a lipophilic environment. It is commonly measured by its distribution behavior in a biphasic system, either liquid-liquid (e.g. partition coefficient in 1-octanol-water) or solid-liquid (retention on reversed-phase high-performance liquid chromatography or thin-layer chromatography system). [Pg.35]

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In gas chromatography the value of the partition coefficient d ends only on the type of stationary phase and the column temperature. It is independent of column type and instrumental parameters. The proportionality factor in equation (l.ll) is called the phase ratio and is equal to the ratio of the volume of the gas (Vg) and liquid (V ) phases in the column. For gas-solid (adsorption) chromatography the phase ratio is given by the volume of the gas phase divided by the surface area of the stationary phase. [Pg.528]

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In lc there are other sorption mechanisms that can cause separation, depending on whether we choose to use a liquid or a solid as the stationary phase, or what kind of solid we use. Liquid-liquid chromatography (11c) uses a liquid stationary phase coated onto a finely divided inert solid support. Separation here is due to differences in the partition coefficients of solutes between the stationary liquid and the liquid mobile phase. In normal phase 11c the stationary phase is relatively polar and the mobile phase relatively non-polar, whilst... [Pg.16]

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