Your search for: 'author:("Wang, Xu")' has returned 25 results. (0.026s) Save search

Authors: Wang, Xu | Cui, Jiuwei | Gu, Jingkai | He, Hua | Li, Biao | Li, Wei

Article Type: Research Article

Abstract: BACKGROUND: The association between vitamin D levels and lung cancer risk varies among distinct demographic populations; however, whether vitamin D levels are related to the risk of lung cancer in Chinese population is unknown. OBJECTIVE: We aimed to elucidate the association of plasma 25-hydroxyvitamin D [25(OH)D] level with the risk of non-small cell lung cancer (NSCLC) in a Chinese population. METHODS: A total of 100 NSCLC patients and, 100 age-, gender-, blood-collection-season- and resident area-matched, cancer-free controls were recruited. Plasma 25(OH)D2 and 25(OH)D3 levels were measured by LC/MS/MS mass spectrometry and HPLC. A logistic regression model was applied to estimate …the association between 25(OH)D concentrations and NSCLC risk. RESULTS: Multivariable analysis showed that smoking history, and 25(OH)D deficiency (< 20 ng/mL) were related to a higher risk of NSCLC (P= 0.03). In addition, late stage (stage IIIB-IV) NSCLC was associated with lower 25(OH)D levels, as indicated by univariate analysis. Similarly, multivariate analysis showed that late stage (IIIB-IV) NSCLC was related to 25(OH)D deficiency. CONCLUSIONS: Plasma 25(OH)D deficiency is significantly associated with a higher risk of NSCLC, specifically late stage NSCLC. Show more

Keywords: 25-hydroxyvitamin D, lung cancer, non-small cell lung cancer

DOI: 10.3233/CBM-150506

Citation: Cancer Biomarkers, vol. 15, no. 5, pp. 663-668, 2015

Authors: Su, Yunxuan | Wang, Xu An | Du, Weidong | Ge, Yu | Zhao, Kaiyang | Lv, Ming

Article Type: Research Article

Abstract: With the development of big data technology, medical data has become increasingly important. It not only contains personal privacy information, but also involves medical security issues. This paper proposes a secure data fitting scheme based on CKKS (Cheon-Kim-Kim-Song) homomorphic encryption algorithm for medical IoT. The scheme encrypts the KGGLE-HDP (Heart Disease Prediction) dataset through CKKS homomorphic encryption, calculates the data’s weight and deviation. By using the gradient descent method, it calculates the weight and bias of the data. The experimental results show that under the KAGGLE-HDP dataset,we select the threshold value is 0.7 and the parameter setting is (Poly_modulus_degree, Coeff_mod_bit_sizes, …Scale) = (16384; 43, 23, 23, 23, 23, 23, 23, 23, 23, 23, 23, 23, 43; 23), the number of iteration is 3 and the recognition accuracy of this scheme can achieve 96.7%. The scheme shows that it has a high recognition accuracy and better privacy protection than other data fitting schemes. Show more

Keywords: Cloud computing, data fitting, homomorphic encryption, gradient descent method

DOI: 10.3233/JHS-222016

Citation: Journal of High Speed Networks, vol. 29, no. 1, pp. 41-56, 2023

Authors: Li, Hong | Liu, Kaihua | Sun, Hang | Bao, Nan | Wang, Xu | Tian, Shi | Qi, Shouliang | Kang, Yan

Article Type: Research Article

Abstract: Computed tomography (CT) radiation dose can be reduced significantly by region of interest (ROI) CT scan. Automatically positioning the heart in CT scout images is an essential step to realize the ROI CT scan of the heart. This paper proposed a fully automatic heart positioning method in CT scout image, including the anteroposterior (A-P) scout image and lateral scout image. The key steps were to determine the feature points of the heart and obtaining part of the heart boundary on the A-P scout image, and then transform the part of the boundary into polar coordinate system and obtain the whole …boundary of the heart using slant elliptic equation curve fitting. For heart positioning on the lateral image, the top and bottom boundary obtained from A-P image can be inherited. The proposed method was tested on a clinical routine dataset of 30 cases (30 A-P scout images and 30 lateral scout images). Experimental results show that 26 cases of the dataset have achieved a very good positioning result of the heart both in the A-P scout image and the lateral scout image. The method may be helpful for ROI CT scan of the heart. Show more

Keywords: CT scout, heart positioning, ROI scan, automatic positioning method

DOI: 10.3233/BME-141150

Citation: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3277-3286, 2014

Authors: Wang, Xu | Zhang, Xiaochang | Jin, Lina | Yang, Zhiguang | Li, Wei | Cui, Jiuwei

Article Type: Research Article

Abstract: OBJECTIVE: Early detection and diagnosis of lung cancer remain challenging but would improve patient prognosis. The goal of this study is to develop a model to estimate the risk of lung cancer for a given individual. METHODS: We conducted a case-control study to develop a predictive model to identify individuals at high risk for lung cancer. Clinical data from 500 lung cancer patients and 500 population-based age- and gender-matched controls were used to develop and evaluate the model. Associations between environmental variants together with single nucleotide polymorphisms (SNPs) of beta-catenin (ctnnb1 ) and lung cancer risk were analyzed using a …logistic regression model. The predictive accuracy of the model was determined by calculating the area under the receiver operating characteristic (ROC) curve. RESULTS: Prior diagnosis of chronic obstructive pulmonary disease (COPD), pulmonary tuberculosis, family history of cancer, and smoking are lung cancer risk factors. The area under the curve (AUC) was 0.740, and the sensitivity, specificity, and Youden index were 0.718, 0.660, and 0.378, respectively. CONCLUSION: Our risk prediction model for lung cancer is useful for distinguishing high-risk individuals. Show more

Keywords: ctnnb1, single nucleotide polymorphism, risk prediction model, lung cancer, Chinese population

DOI: 10.3233/CBM-170563

Citation: Cancer Biomarkers, vol. 22, no. 1, pp. 7-12, 2018

Authors: Zhang, Xing-Xian | Liu, Wenli | Wang, Xu | Zuo, Wenjin | Wang, Ying-Ming | Sun, Licheng

Article Type: Research Article

Abstract: Efficiency is a relative measure that allows assessment across different ranges. Evaluating the performance of decision-making units (DMUs) from an optimistic perspective yields the best relative efficiency (optimistic efficiency), which establishes an efficiency frontier. Conversely, evaluating from a pessimistic perspective produces the worst relative efficiency (pessimistic efficiency) and creates an inefficiency frontier. This study examines the efficiency of DMUs in two scenarios and proposes models for adjustment coefficient. The pessimistic and optimistic efficiencies are adjusted to the lower and upper bounds of the DMUs based on the adjustment coefficient, enabling determination of efficiency intervals for all DMUs, as well as …evaluation and ranking. A Hurwicz criterion-based approach is introduced and applied to compare and rank the interval efficiencies of DMUs. Two numerical examples are examined using the proposed DEA adjustment coefficient models to demonstrate its potential application and validity. Show more

Keywords: Data envelopment analysis, interval efficiency, adjustment coefficient model, ranking

DOI: 10.3233/JIFS-233051

Citation: Journal of Intelligent & Fuzzy Systems, vol. 46, no. 3, pp. 5609-5621, 2024

Authors: Wang, Xu | Zheng, Wenhu | Wang, Jinlong | Xiong, Xiaoyun | Shen, Yumin | Mu, Wei | Fan, Zengliang

Article Type: Research Article

Abstract: As an important part of digital building, building internet of things (BIoT) plays a positive role in promoting the construction of smart cities. Existing schemes utilize blockchain to achieve trusted data storage in BIoT. However, the full-copy storage mechanism of blockchain and the management requirements of massive data have brought computing and storage challenges to edge nodes with limited resources. Therefore, a data management scheme for BIoT based on blockchain sharding is proposed. The scheme proposes a hybrid storage mechanism, which uses inter-planetary file system (IPFS) to ensure the integrity and availability of data outside the chain, and reduces the …storage overhead of edge nodes. Based on the hybrid storage mechanism, the sharding algorithm is designed to divide the blockchain into multiple shards, and the storage overhead and computing overhead are offloaded to each shard, which effectively balances the computing and storage overhead of edge nodes. Finally, comparative analysis was made with existing schemes, and effectiveness of proposed scheme was verified from the perspectives of storage overhead, computation overhead, access delay and throughput. Results show that proposed scheme can effectively reduce storage overhead and computing overhead of edge nodes in BIoT scenario. Show more

Keywords: Blockchain, building internet of things (BIoT), sharding, hybrid storage, inter-planetary file system (IPFS)

DOI: 10.3233/IDA-220757

Citation: Intelligent Data Analysis, vol. 27, no. 5, pp. 1309-1330, 2023

Authors: Jiang, Donglin | Wang, Xu | Su, Qiang | Jiang, Shengyang | Yuan, Fenglai | Zhang, Caidi | Gong, Fang | Dong, Qiaojing | Shi, Jianping | Chen, Baohua

Article Type: Research Article

Abstract: Milkvetch root as a medicine has been used for more over 2000 years in China, can strengthen immune function, protect liver, promote urination, resist aging and stress, reduce blood pressure and extensively resist bacterium. This study explored the effects of milkvetch root on the immune function of patients with a definitive diagnosis of acute exacerbation of chronic obstructive pulmonary disease (COPD). The patients were randomly assigned to either the experimental or control group. All patients received conventional clinical therapy; those in the experimental group were also administered milkvetch root. The serum levels of cytokines including tumor necrosis factor alpha (TNF-α …), interleukin-8 (IL-8), IL-1β , and IL-32 and immunocytes including T helper (Th), cytotoxic T (Tc), natural killer (NK), regulatory T (Treg) and B cells were measured 1 day before treatment and 7 and 14 days post-treatment. After bronchodilator inhalation, pulmonary function was evaluated at these same time points. The serum TNF-α , IL-8, IL-1β , and IL-32 levels were significantly lower in the experimental group than in the control group 14 days post-treatment. The Th/Tc ratio and NK cell ratio was significantly higher but the Treg cell ratio was significantly lower in the experimental group than in the control group. The forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC) were significantly higher in the experimental group than in the control group 14 days post-treatment. These results indicate that milkvetch root can improve the immune function of patients with acute exacerbation of COPD. Show more

Keywords: Chronic obstructive pulmonary disease, milkvetch root, immune function

DOI: 10.3233/BME-151517

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S2113-S2121, 2015

Authors: PAN, Gen-xing | LI, Lian-qing | ZHANG, Qi | WANG, Xu-kui | SUN, Xing-bin | XU, Xiao-bo | JIANG, Ding-an

Article Type: Research Article

Abstract: Data collection of soil organic carbon (SOC) of 154 soil series of Jiangsu, China from the second provincial soil survey and of recent changes in SOC from a number of field pilot experiments across the province were collected. Statistical analysis of SOC contents and soil properties related to organic carbon storage were performed. The provincial total topsoil SOC stock was estimated to be 0.1 Pg with an extended pool of 0.4 Pg taking soil depth of 1 m, being relatively small compared to its total land area of 101700 km^2 . One quarter of this topsoil stock was found in …the soils of the Taihu Lake region that occupied 1/6 of the provincial arable area. Paddy soils accounted for over 50% of this stock in terms of SOC distribution among the soil types in the province. Experimental data from experimental farms widely distributed in the province showed that SOC storage increased consistently over the last 20 years despite a previously reported decreasing tendency during the period between 1950–1970. The evidence indicated that agricultural management practices such as irrigation, straw return and rotation of upland crops with rice or wheat crops contributed significantly to the increase in SOC storage. The annual carbon sequestration rate in the soils was in the range of 0.3–3.5 tC/(hm^2 ·a), depending on cropping systems and other agricultural practices. Thus, the agricultural production in the province, despite the high input, could serve as one of the practical methods to mitigate the increasing air CO_2 . Show more

Keywords: soil organic carbon, soil carbon stock, agricultural practice, carbon sequestration, paddy soil, China

Citation: Journal of Environmental Sciences, vol. 17, no. 1, pp. 1-7, 2005

Authors: Ruan, Yang | Guo, Shi-Jie | Wang, Xu | Dong, Dong | Shen, Dong-Hui | Zhu, Jie | Zheng, Xiang-Yu

Article Type: Research Article

Abstract: Kainic acid (KA) was recently identified as an epileptogenic and neuroexcitotoxic agent that is responsible for inducing learning and memory deficits in various neurodegenerative diseases, such as Alzheimer’s disease (AD). However, the mechanism by which KA acts upon AD remains unclear. To this end, we presently investigated the roles of KA in processing amyloid-β protein precursor (AβPP) and amyloid-β protein (Aβ) loads during the course of AD development and progression. Specifically, KA treatment clearly caused the upregulation of tumor necrosis factor α (TNF-α) via activation of the PI3-K/AKT, ERK1/2, and p65 pathways in glial cells. TNF-α secreted from glial cells …was then found to be responsible for stimulating the expression of BACE-1 and PS1/2, which resulted in the production and deposition of Aβ in neurons. Finally, the accumulation and aggregation of Aβ lead to the cognitive decline of APP23 mice. These results indicate that KA accelerates the progression of AD by inducing the crosstalk between glial cells and neurons. Show more

Keywords: Alzheimer’s disease, BACE-1, kainic acid, presenilin, tumor necrosis factor α

DOI: 10.3233/JAD-171137

Citation: Journal of Alzheimer's Disease, vol. 64, no. 1, pp. 103-116, 2018

Authors: Wang, Xu-Liang | Wang, Yu-Yong | He, Hua-Dong | Xie, Xi | Yu, Zhi-Jian | Pan, Yu-Ming

Article Type: Research Article

Abstract: BACKGROUND: Adrenomedullin levels in the peripheral blood are associated with prognosis of some cancers. Intermedin is structural similarities to adrenomedullin. OBJECTIVE: The current study aimed to investigate the prognostic value of plasma intermedin levels for progression and distant metastasis in prostate cancers. METHODS: This study included 218 patients undergoing radical prostatectomy for localized prostatic cancer and 218 age-matched healthy men. Plasma intermedin levels were measured using radioimmunoassay. The relationships between plasma intermedin levels and 5-year progression and 5-year distant metastasis were evaluated using a multivariate analysis. RESULTS: Plasma intermedin levels were markedly higher in all patients than in healthy men. …Patients with Gleason score ≥ 7, tumor node metastasis stage T2, organ unconfined, present extra-prostatic extension, seminal vesicle invasion or positive lymph node had higher intermedin levels. Intermedin was identified as a prognostic predictor for 5-year progression and 5-year metastasis. Under receiver operating characteristic curves, intermedin had high predictive values for 5-year progression and 5-year metastasis. CONCLUSIONS: Elevated plasma intermedin levels are independently associated with long-term recurrence and distant metastasis of prostate cancer and intermedin has potential to be a prognostic predictive biomarker for prostate cancer. Show more

Keywords: Prostate cancer, recurrence, metastasis, intermedin

DOI: 10.3233/CBM-150523

Citation: Cancer Biomarkers, vol. 15, no. 6, pp. 799-805, 2015