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Authors: Tohtz, Stephan W. | Sassy, Danny | Matziolis, Georg | Preininger, Bernd | Perka, Carsten | Hasart, Olaf

Article Type: Research Article

Abstract: Background: The reorientation of the acetabular component in total hip replacement is currently carried out under consideration of the safe zone, respecting the best possible range of motion and is influenced by wear debris of different bearings. Is the prefered orientation a reconstruction of the native anatomy and are there sex-specific differences? Methods: On the basis of 168 CT datasets (72 women, 96 men) 336 native hip joints were analysed. The abduction and anteversion of the acetabulum as well as the location of the hip center were detected. As a reference the anterior pelvic plane was used. Results: The 144 …female hip joints showed a mean abduction of 53.0° (SD 6.14°) and an anteversion of 24.63° (SD 6.61°). The 192 male hip joints showed an abduction of 53.58° (SD 6.68°) and an anteversion of 21.31° (SD 6.17°). Significant differences were observed on comparison between the sexes in relation to the anteversion and the location of the hip center. Likewise, there was a significant correlation between the position of the hip center and the degree of anteversion. Conclusions: In total hip arthroplasty a reconstruction of the native acetabular orientation is not possible, gender specific characteristics should be considered. Show more

Keywords: Native acetabular orientation, anteversion, abduction, localization of hip center, gender differences

DOI: 10.3233/THC-2010-0575

Citation: Technology and Health Care, vol. 18, no. 2, pp. 129-136, 2010

Authors: Preininger, Bernd | Matziolis, Georg | Pfitzner, Tilman | Hardt, Sebastian | Perka, Carsten | Röhner, Eric

Article Type: Research Article

Abstract: Poly-Methylmethacrylate (PMMA) is widely-used in orthopaedic surgery in revision arthroplasty or as a spacer in temporary arthrodesis of periprostehtic knee joint infection during a two stage procedure. The intra-operative temperature behaviour, however, has not yet been quantified. It is known that high temperature induce thermally necrosis of surrounding bone tissue during polymerisation process. The aim was to evaluate the PMMA surface temperature during polymerisation phase in situ. We hypothesized, that temperature measured in vivo could become critical in terms of the induction of thermal bone necrosis during the polymerisation phase of PMMA. The PMMA surface was measured tele-thermographically in situ …during knee arthroplasty revision surgery. Infrared pictures were analyzed for temperature peaks and changes. Measurements yielded maximum PMMA-surface-temperatures ranging from 101 to 110 degrees and a two-minute-plateau of > 100°. Hot PMMA during the polymerisation phase could potentially induce tissue (bone) necrosis. Therefore temperature of PMMA of more than 70 degrees should be avoided. Cooling of the PMMA is highly recommendable. Show more

Keywords: PMMA, temperature, bone necrosis, tele-thermography

DOI: 10.3233/THC-2012-0679

Citation: Technology and Health Care, vol. 20, no. 4, pp. 337-341, 2012

Authors: Zippelius, Timo | Hoff, Paula | Strube, Patrick | Schiffner, René | Maslaris, Alexander | Matziolis, Georg | Röhner, Eric

Article Type: Research Article

Abstract: BACKGROUND AND OBJECTIVES: Bone marrow oedema is a multifactorial conditioned illness. Alongside any strain relief of an affected joint, treatment with Iloprost also belongs to the choice of cures. In past studies, a modulatory effect on bone could be shown. The hypothesis of the present work is that Iloprost has a growth-stimulating effect on osteoblasts in vitro . METHODS: Human osteoblasts were isolated and cultivated. Subsequently, the cells were treated with Iloprost in bioavailable concentrations. Alterations of the cell structure were examined by means of light microscopy. A regulation of the number of vital cells was carried out by using …a CASY cell counter. Possible cell impairment after Iloprost treatment was analysed by means of XTT Elisa as well as FDA and PI staining via fluorescence microscopy. RESULTS: Using light microscopy, no changes in cell structure could be observed. With the CASY cell counter, no increase in the numbers of osteoblasts appeared after Iloprost treatment. Also, XTT Elisas and fluorescence microscopy did not reveal any cell impairment due to Iloprost. CONCLUSION: Our results could not confirm a modulatory effect in mature osteoblasts. On the basis of the present work we could not verify any growth-stimulating effect by Iloprost in mature osteoblasts in vitro . Admittedly, effects had been shown previously during osteogenesis, but we do exclude an effect on mature osteoblasts which have already differentiated. Show more

Keywords: Iloprost, bone marrow edema, osteoblasts, in vitro

DOI: 10.3233/BMR-171043

Citation: Journal of Back and Musculoskeletal Rehabilitation, vol. 32, no. 6, pp. 897-903, 2019