FGF23

FGF23
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2P39
Dynodwyr
Cyfenwau	FGF23, ADHR, FGFN, HPDR2, HYPF, PHPTC, fibroblast growth factor 23, HFTC2
Dynodwyr allanol	OMIM: 605380 HomoloGene: 10771 GeneCards: FGF23
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • fibroblast growth factor receptor binding • type 1 fibroblast growth factor receptor binding • growth factor activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular region • Golgi lumen • endoplasmic reticulum lumen • extracellular space Prosesau biolegol • cell differentiation • negative regulation of bone mineralization • cellular response to interleukin-6 • vitamin D metabolic process • regulation of bone mineralization • phosphate ion homeostasis • cellular phosphate ion homeostasis • response to magnesium ion • regulation of phosphate transport • cellular response to vitamin D • negative regulation of osteoblast differentiation • cellular response to leptin stimulus • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • fibroblast growth factor receptor signaling pathway • response to sodium phosphate • positive regulation of ERK1 and ERK2 cascade • positive regulation of vitamin D 24-hydroxylase activity • phosphate-containing compound metabolic process • vitamin D catabolic process • positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway • cellular response to parathyroid hormone stimulus • negative regulation of hormone secretion • phosphatidylinositol phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • MAPK cascade • post-translational protein modification • regulation of signaling receptor activity • positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8074	n/a
Ensembl	ENSG00000118972	n/a
UniProt	Q9GZV9	n/a
RefSeq (mRNA)	NM_020638	n/a
RefSeq (protein)	NP_065689	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF23 yw FGF23 a elwir hefyd yn Fibroblast growth factor 23 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGF23.

• ADHR
• FGFN
• HYPF
• HPDR2
• PHPTC

Llyfryddiaeth

• "C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients. ". J Am Soc Nephrol. 2017. PMID 28774998.
• "FGF23 and Nutritional Metabolism. ". Annu Rev Nutr. 2017. PMID 28715994.
• "High fibroblast growth factor 23 levels are associated with decreased ferritin levels and increased intravenous iron doses in hemodialysis patients. ". PLoS One. 2017. PMID 28475601.
• "Relationship of Fibroblast Growth Factor 23 (FGF-23) Serum Levels With Low Bone Mass in Postmenopausal Women. ". J Cell Biochem. 2017. PMID 28464278.
• "Fibroblast-growth factor 23 promotes terminal differentiation of ATDC5 cells.". PLoS One. 2017. PMID 28406928.