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The resolution service at https://doi.org resolves DOIs. You have attempted to resolve jcheminf.biomedcentral.com/counter/pdf/10.1186/1758-2946-6-S1-P46.pdf, which is not a DOI.

jcheminf.biomedcentral.com/counter/pdf/10.1186/1758-2946-6-S1-P46.pdf may be a Handle (DOIs are a special sort of Handle). If jcheminf.biomedcentral.com/counter/pdf/10.1186/1758-2946-6-S1-P46.pdf is a valid Handle you should be able to resolve it at https://hdl.handle.net.

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