Issue 15, 2013
From the journal:

Lab on a Chip

Miniature stick-packaging – an industrial technology for pre-storage and release of reagents in lab-on-a-chip systems†

Thomas van Oordt,*a   Yannick Barb,a   Jan Smetana,a   Roland Zengerleabc  and  Felix von Stettenab  

* Corresponding authors

a HSG-IMIT-Institut für Mikro- und Informationstechnik, Georges-Koehler-Allee 103, 79110 Freiburg, Germany
E-mail: [email protected]
Fax: +49 761 203 73299
Tel: +49 761 203 73213

b Laboratory for MEMS Applications, IMTEK - Department of Microsystems Engineering, University of Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany

c BIOSS - Centre for Biological Signalling Studies, University of Freiburg, Germany

Abstract

Stick-packaging of goods in tubular-shaped composite-foil pouches has become a popular technology for food and drug packaging. We miniaturized stick-packaging for use in lab-on-a-chip (LOAC) systems to pre-store and on-demand release the liquid and dry reagents in a volume range of 80–500 μl. An integrated frangible seal enables the pressure-controlled release of reagents and simplifies the layout of LOAC systems, thereby making the package a functional microfluidic release unit. The frangible seal is adjusted to defined burst pressures ranging from 20 to 140 kPa. The applied ultrasonic welding process allows the packaging of temperature sensitive reagents. Stick-packs have been successfully tested applying recovery tests (where 99% (STDV = 1%) of 250 μl pre-stored liquid is released), long-term storage tests (where there is loss of only <0.5% for simulated 2 years) and air transport simulation tests. The developed technology enables the storage of a combination of liquid and dry reagents. It is a scalable technology suitable for rapid prototyping and low-cost mass production.

Graphical abstract: Miniature stick-packaging – an industrial technology for pre-storage and release of reagents in lab-on-a-chip systems

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Article information

DOI
https://doi.org/10.1039/C3LC50404B
Article type
Paper
Submitted
29 Mar 2013
Accepted
07 May 2013
First published
09 May 2013

Lab Chip, 2013,13, 2888-2892

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Miniature stick-packaging – an industrial technology for pre-storage and release of reagents in lab-on-a-chip systems

T. van Oordt, Y. Barb, J. Smetana, R. Zengerle and F. von Stetten, Lab Chip, 2013, 13, 2888 DOI: 10.1039/C3LC50404B

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