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Planta Med 2011; 77(5): 421-427
DOI: 10.1055/s-0030-1250462
Biological and Pharmacological Activity
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Polydatin Ameliorates DSS-Induced Colitis in Mice through Inhibition of Nuclear Factor-kappaB Activation

Jun Yao1 , Jian-Yao Wang2 , Lei Liu2 , Wei-Sen Zeng3 , Ying-Xue Li1 , An-Ying Xun4 , Li Zhao3 , Chun-Hong Jia3 , Ju-Ling Feng1 , Xiao-Xia Wei1 , Li-Sheng Wang1
  • 1Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen, Guangdong Province, P. R. China
  • 2Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong Province, P. R. China
  • 3Department of Cell Biology, Southern Medical University, Guangzhou, Guangdong Province, P. R. China
  • 4Department of Gastroenterology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, P. R. China
Further Information

Publication History

received February 2, 2010 revised August 13, 2010

accepted Sept. 28, 2010

Publication Date:
26 October 2010 (online)

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Abstract

Nuclear factor-κB (NF-κB) plays a pivotal role in the regulation of immune and inflammatory responses. The real-time expression level of NF-κB reflects the development of ulcerative colitis (UC). Polydatin has vast pharmacological activities, including inhibiting the production of inflammatory mediators, inducing the production of antioxidants, regulating immune function, etc. The purpose of this study was to investigate the potential inhibitory effects of polydatin on NF-κB pathway activation in a mouse UC model. The results showed that polydatin treatment downregulated NF-κB p65 activity and expression, blocked the expression of TNF-α, IL-6 and IL-1β at both mRNA and protein levels, decreased myeloperoxidase (MPO) activity, and alleviated inflammatory damage of colitis in mice with UC (p < 0.05), suggesting that the anti-inflammation effects of polydatin can be attributed, at least partially, to the blocking of the NF-κB pathway.

Key words

nuclear factor‐κB - polydatin - resveratrol - ulcerative colitis

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Prof. Dr. Li-Sheng Wang

Department of Gastroenterology
Shenzhen Municipal People's Hospital
Jinan University of Medical Sciences

1017 East Gate Road

Shenzhen 518020

Guangdong Province

People's Republic of China

Phone: +86 7 55 25 53 30 18

Fax: +86 75 52 55 334 97

Email: [email protected]