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Research Article Free access | 10.1172/JCI105650
Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
‡Investigator, Howard Hughes Medical Institute.
Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.
*Received for publication 17 April 1967 and in revised form 23 June 1967.
This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.
A preliminary abstract of part of this work has been published (1).
Find articles by Owen, O. in: JCI | PubMed | Google Scholar
Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
‡Investigator, Howard Hughes Medical Institute.
Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.
*Received for publication 17 April 1967 and in revised form 23 June 1967.
This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.
A preliminary abstract of part of this work has been published (1).
Find articles by Morgan, A. in: JCI | PubMed | Google Scholar
Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
‡Investigator, Howard Hughes Medical Institute.
Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.
*Received for publication 17 April 1967 and in revised form 23 June 1967.
This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.
A preliminary abstract of part of this work has been published (1).
Find articles by Kemp, H. in: JCI | PubMed | Google Scholar
Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
‡Investigator, Howard Hughes Medical Institute.
Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.
*Received for publication 17 April 1967 and in revised form 23 June 1967.
This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.
A preliminary abstract of part of this work has been published (1).
Find articles by Sullivan, J. in: JCI | PubMed | Google Scholar
Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
‡Investigator, Howard Hughes Medical Institute.
Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.
*Received for publication 17 April 1967 and in revised form 23 June 1967.
This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.
A preliminary abstract of part of this work has been published (1).
Find articles by Herrera, M. in: JCI | PubMed | Google Scholar
Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
Elliott P. Joslin Research Laboratory, Department of Surgery, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts
‡Investigator, Howard Hughes Medical Institute.
Address requests for reprints to Dr. G. F. Cahill, Jr., Joslin Research Laboratory, 170 Pilgrim Road, Boston, Mass. 02215.
*Received for publication 17 April 1967 and in revised form 23 June 1967.
This study was supported in part by grants from the U. S. Public Health Service AM-09584-02, AM-09748-02, 8 MO1-FR-31-06, T1-AM-5077-11, 5-RO1-AM-02657-07, 1-T1-HE-05679-02, and HE-08591-02; the Adler Foundation, Inc., Rye, N. Y.; the U. S. Army Medical Research and Development Command (DA-49-193-MO-2337); the John A. Hartford Foundation, Inc., New York, N. Y.; and the Atomic Energy Commission.
A preliminary abstract of part of this work has been published (1).
Find articles by Cahill, G. in: JCI | PubMed | Google Scholar
Published October 1, 1967 - More info
Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that β-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.