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Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex

Published online by Cambridge University Press:  03 January 2018

Françoise Biver ,
David Wikler ,
Françoise Lotstra ,
Philippe Damhaut ,
Serge Goldman  and
Julien Mendlewicz
Françoise Biver
Affiliation:
PET-Biomedical Cyclotron Unit and Department of Psychiatry
David Wikler
Affiliation:
PET-Biomedical Cyclotron Unit
Françoise Lotstra
Affiliation:
Department of Psychiatry
Philippe Damhaut
Affiliation:
PET-Biomedical Cyclotron Unit
Serge Goldman
Affiliation:
PET-Biomedical Cyclotron Unit
Julien Mendlewicz
Affiliation:
Department of Psychiatry, Erasme Hospital, Free University of Brussels
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Abstract

Background

Serotonin receptors may play an important role in the pathophysiology of affective disorders. We studied type-2 serotonin (5-HT2) receptors in the brain of patients with major depression.

Method

Using positron emission tomography (PET) and the selective radioligand [18F]altanserin, we investigated 5-HT2 receptor distribution in eight drug-free unipolar depressed patients and 22 healthy subjects. Data were analysed using Statistical Parametric Mapping 95.

Results

In depressed patients, [18F]altanserin uptake was significantly reduced in a region of the right hemisphere including the posterolateral orbitofrontal cortex and the anterior insular cortex. A trend to similar changes was found in the left hemisphere. No correlation was found between the uptake and the Hamilton rating scale score.

Conclusions

Pathophysiology of depression may involve changes in 5-HT2 receptor in brain regions selectively implicated in mood regulation.

Type
Papers
Information
The British Journal of Psychiatry , Volume 171 , Issue 5 , November 1997 , pp. 444 - 448
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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