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Linking Exome Sequencing Data with Drug Response Aberrations
Konstantinos Kyriakidis, Alexandra Charalampidou, Pantelis Natsiavas, Ioannis S. Vizirianakis, Andigoni Malousi
1845 - 1846
10.3233/SHTI190677
Research Article
Studies in Health Technology and Informatics
Volume 264: MEDINFO 2019: Health and Wellbeing e-Networks for All
Abstract

Next-generation sequencing has prompted the development of numerous -omics applications. Along with experimental procedures, various computational pipelines became available to address the inherent complexities concerning the volume and quality of data. These pipelines are effective and routinely applied; however, interpreting their outcomes into actionable evidence is still poorly addressed. In this context, this work proposes a method for translating patient genomic profiles to drug response aberrations by integrating pharmacogenomic data into sequencing data analysis pipelines.

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