The study aimed to assess the usability of the PVClinical platform, which is designed for detecting and managing Adverse Drug Reactions (ADRs). A “slider” type comparative questionnaire was designed to capture the preferences of six end-users over time between PVC clinical platform and the established clinical and pharmaceutical ADR detection software tools. The results of the questionnaire were cross-examined with the results of the usability study. The questionnaire was a quick preference-capturing tool over time and provided impactful insights. Coherence in participants’ preferences for PVClinical platform was observed, but further research is needed to establish the effectiveness of the questionnaire as a preference-capturing tool.