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{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox_gene}}
{{PBB_Controls
'''[[Tropomyosin]] alpha-4 chain''' is a [[protein]] that in humans is encoded by the ''TPM4'' [[gene]].<ref name="pmid8641132">{{cite journal | vauthors = Wilton SD, Lim L, Dorosz SD, Gunn HC, Eyre HJ, Callen DF, Laing NG | title = Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization | journal = Cytogenet Cell Genet | volume = 72 | issue = 4 | pages = 294–6 |date=Jul 1996 | pmid = 8641132 | doi =10.1159/000134206 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TPM4 tropomyosin 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7171}}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tropomyosin 4
| HGNCid = 12013
| Symbol = TPM4
| AltSymbols =;
| OMIM = 600317
| ECnumber =
| Homologene = 74286
| MGIid = 2449202
| GeneAtlas_image1 = PBB_GE_TPM4_212481_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TPM4_209344_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005862 |text = muscle thin filament tropomyosin}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7171
| Hs_Ensembl = ENSG00000167460
| Hs_RefseqProtein = NP_003281
| Hs_RefseqmRNA = NM_003290
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 16039348
| Hs_GenLoc_end = 16074813
| Hs_Uniprot = P67936
| Mm_EntrezGene = 326618
| Mm_Ensembl = ENSMUSG00000031799
| Mm_RefseqmRNA = NM_001001491
| Mm_RefseqProtein = NP_001001491
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 75064275
| Mm_GenLoc_end = 75082123
| Mm_Uniprot = Q6IRU2
}}
}}
'''Tropomyosin 4''', also known as '''TPM4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TPM4 tropomyosin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7171| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist}}
 
==Further reading==
{{refbegin | 2}}
*{{cite journal |vauthors=Rasmussen HH, van Damme J, Puype M, etal |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 |s2cid=41855774 }}
{{PBB_Further_reading
*{{cite journal | vauthors=MacLeod AR, Talbot K, Smillie LB, Houlker C |title=Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin. |journal=J. Mol. Biol. |volume=194 |issue= 1 |pages= 1–10 |year= 1987 |pmid= 3612796 |doi=10.1016/0022-2836(87)90710-8 }}
| citations =
*{{cite journal | authorvauthors=RasmussenMacLeod HHAR, van DammeHoulker JC, PuypeReinach MFC, ''et al.''etal |title=MicrosequencesA ofmuscle-type 145 proteins recordedtropomyosin in thehuman two-dimensionalfibroblasts: gelevidence proteinfor databaseexpression ofby normalan humanalternative epidermalRNA keratinocytessplicing mechanism. |journal=ElectrophoresisProc. Natl. Acad. Sci. U.S.A. |volume=1382 |issue= 1223 |pages= 960–97835–9 |year= 19931986 |pmid= 12866673865200 |doi=10.1073/pnas.82.23.7835 | pmc=390864 |doi-access=free }}
*{{cite journal | author|vauthors=MacLeodLawrence ARB, TalbotPerez-Atayde KA, SmillieHibbard LBMK, Houlker Cetal |title=CharacterizationTPM3-ALK ofand aTPM4-ALK cDNAoncogenes definingin ainflammatory genemyofibroblastic family encoding TM30p1, a human fibroblast tropomyosintumors. |journal=JAm. MolJ. BiolPathol. |volume=194157 |issue= 12 |pages= 1–10377–84 |year= 19872000 |pmid= 361279610934142 |doi= 10.1016/S0002-9440(10)64550-6| pmc=1850130 }}
*{{cite journal | author|vauthors=MacLeodMeech ARSJ, HoulkerMcGavran CL, ReinachOdom FCLF, ''et al.''etal |title=AUnusual muscle-typechildhood tropomyosinextramedullary inhematologic humanmalignancy fibroblasts:with evidencenatural forkiller expressioncell byproperties anthat alternativecontains RNAtropomyosin splicing4--anaplastic mechanism.lymphoma kinase gene fusion |journal=Proc. Natl. Acad. Sci. U.S.A.Blood |volume=8298 |issue= 234 |pages= 7835–91209–16 |year= 19862001 |pmid= 386520011493472 |doi=10.1182/blood.V98.4.1209 |doi-access=free }}
*{{cite journal | author|vauthors=WiltonYi SDJ, LimKloeker LS, DoroszJensen SDCC, ''et al.''etal |title=AssignmentMembers of the humanZyxin alpha-tropomyosinfamily geneof TPM4LIM toproteins bandinteract 19p13.1with bymembers fluorescenceof inthe situp130Cas hybridization.family of signal transducers |journal=CytogenetJ. CellBiol. GenetChem. |volume=72277 |issue= 411 |pages= 294–69580–9 |year= 19962002 |pmid= 864113211782456 |doi= 10.1074/jbc.M106922200 |doi-access= free }}
*{{cite journal | authorvauthors=LawrenceStrausberg BRL, Perez-AtaydeFeingold AEA, HibbardGrouse MKLH, ''et al.''etal |title=TPM3-ALKGeneration and TPM4initial analysis of more than 15,000 full-ALKlength oncogeneshuman inand inflammatorymouse myofibroblasticcDNA tumors.sequences |journal=AmProc. JNatl. PatholAcad. Sci. U.S.A. |volume=15799 |issue= 226 |pages= 377–8416899–903 |year= 20002003 |pmid= 1093414212477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal | authorvauthors=MeechGevaert SJK, McGavranGoethals LM, OdomMartens LFL, ''et al.''etal |title=UnusualExploring childhoodproteomes extramedullaryand hematologicanalyzing malignancyprotein withprocessing naturalby killermass cellspectrometric propertiesidentification thatof containssorted tropomyosin 4N--anaplasticterminal lymphoma kinase gene fusion.peptides |journal=BloodNat. Biotechnol. |volume=9821 |issue= 45 |pages= 1209–16566–9 |year= 20012004 |pmid= 1149347212665801 |doi= 10.1038/nbt810 |s2cid=23783563 }}
*{{cite journal | author|vauthors=YiOta JT, KloekerSuzuki SY, JensenNishikawa CCT, ''et al.''etal |title=MembersComplete ofsequencing theand Zyxin familycharacterization of LIM21,243 proteinsfull-length interacthuman with members of the p130Cas family of signal transducers.cDNAs |journal=J. BiolNat. ChemGenet. |volume=27736 |issue= 111 |pages= 9580–940–5 |year= 20022004 |pmid= 1178245614702039 |doi= 10.10741038/jbc.M106922200ng1285 |doi-access= free }}
*{{cite journal | authorvauthors=StrausbergLin RLKT, FeingoldLu EARM, GrouseTarn LH, ''et al.''WY |title=GenerationThe andWW initialdomain-containing analysisproteins ofinteract morewith thanthe 15,000early full-length humanspliceosome and mouseparticipate cDNAin sequences.pre-mRNA splicing in vivo |journal=ProcMol. NatlCell. Acad. Sci. U.S.ABiol. |volume=9924 |issue= 2620 |pages= 16899–9039176–85 |year= 20032004 |pmid= 1247793215456888 |doi= 10.10731128/pnasMCB.24260389924.20.9176-9185.2004 | pmc=517884 }}
*{{cite journal | author|vauthors=GevaertGerhard KDS, GoethalsWagner ML, MartensFeingold LEA, ''et al.''etal |title=ExploringThe proteomesstatus, quality, and analyzingexpansion proteinof processingthe byNIH massfull-length spectrometriccDNA identificationproject: ofthe sortedMammalian N-terminalGene peptides.Collection (MGC) |journal=Nat.Genome BiotechnolRes. |volume=2114 |issue= 510B |pages= 566–92121–7 |year= 2004 |pmid= 1266580115489334 |doi= 10.10381101/nbt810gr.2596504 | pmc=528928 }}
*{{cite journal | author|vauthors=OtaBruneel TA, SuzukiLabas YV, NishikawaMailloux TA, ''et al.''etal |title=CompleteProteomics sequencingof andhuman characterizationumbilical ofvein 21,243endothelial cells applied fullto etoposide-lengthinduced human cDNAs.apoptosis |journal=Nat. Genet.Proteomics |volume=365 |issue= 115 |pages= 40–53876–84 |year= 20042006 |pmid= 1470203916130169 |doi= 10.10381002/ng1285pmic.200401239 |s2cid=26007149 }}
*{{cite journal | author|vauthors=LinRual KTJF, LuVenkatesan RMK, TarnHao WYT, etal |title=TheTowards WWa domainproteome-containingscale proteinsmap interact withof the early spliceosome and participate inhuman preprotein-mRNAprotein splicinginteraction in vivo.network |journal=Mol. Cell. Biol.Nature |volume=24437 |issue= 207062 |pages= 9176–851173–8 |year= 20042005 |pmid= 1545688816189514 |doi= 10.11281038/MCBnature04209 |bibcode=2005Natur.24437.20.9176-9185.20041173R |s2cid=4427026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Bruneel A, Labas V, Mailloux A, ''et al.'' |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
 
{{Cytoskeletal Proteins}}
 
 
{{gene-19-stub}}