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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category)
 
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=2887}}▼
{{Infobox_gene}}
'''Growth factor receptor-bound protein 10''' is a [[protein]] that in humans is encoded by the ''GRB10'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRB10 growth factor receptor-bound protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2887| accessdate = }}</ref>
'''Growth factor receptor-bound protein 10''' also known as '''insulin receptor-binding protein Grb-IR''' is a [[protein]] that in humans is encoded by the ''GRB10'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRB10 growth factor receptor-bound protein 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2887}}</ref><ref name="pmid9070953">{{cite journal |vauthors=Jerome CA, Scherer SW, Tsui LC, Gietz RD, Triggs-Raine B | title = Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12 | journal = Genomics | volume = 40 | issue = 1 | pages = 215–6 |date=February 1997 | pmid = 9070953 | doi = 10.1006/geno.1996.4535 }}</ref><ref name="pmid9360986">{{cite journal |vauthors=Dong LQ, Du H, Porter SG, Kolakowski LF, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J | title = Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma | journal = J. Biol. Chem. | volume = 272 | issue = 46 | pages = 29104–12 |date=November 1997 | pmid = 9360986 | doi = 10.1074/jbc.272.46.29104| doi-access = free }}</ref><ref name="pmid19487367">{{cite journal |vauthors=Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE | title = Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression | journal = Hum. Mol. Genet. | volume = 18 | issue = 16 | pages = 3066–74 |date=August 2009 | pmid = 19487367 | doi = 10.1093/hmg/ddp248 | doi-access = free }}</ref>
 
== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
| summary_text = The product of this gene belongs to a small family of [[adapterSignal transducing adaptor protein|adaptor protein]]s that are known to interact with a number of [[receptor tyrosine kinaseskinase]]s and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with [[insulin receptorsreceptor]]s and insulin-like growth-factor receptors (e.g., [[insulin-like growth factor 1 receptor|IGF1R]] and [[insulin-like growth factor 2 receptor|IGF2R]]). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: GRB10 growth factor receptor-bound protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2887| accessdate = }}</ref>▼
{{PBB_Summary
 
| section_title =
== Animal studies ==
▲| summary_text = The product of this gene belongs to a small family of [[adapter protein]]s that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: GRB10 growth factor receptor-bound protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2887| accessdate = }}</ref>
Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.<ref name=Garfield_2011>{{cite journal |vauthors=Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR, Ward A | title = Distinct physiological and behavioural functions for parental alleles of imprinted Grb10 | journal = Nature | year = 2011 | volume = 469 | pages = 534–538 | doi = 10.1038/nature09651 | pmid=21270893 | issue = 7331 | pmc = 3031026 | bibcode=2011Natur.469..534G}}*{{lay source |template = cite news|vauthors = Bhanoo SN |url = https://www.nytimes.com/2011/02/01/science/01obgene.html?partner=rss&emc=rss|title = Altering a Mouse Gene Turns Up Aggression, Study Says|date = January 27, 2011 |website = New York Times}} </ref>
}}
 
==Interactions==
GRB10 has been shown to [[Protein-protein interaction|interact]] with
GRB10 has been shown to [[Protein-protein_interaction|interact]] with [[C-Raf]],<ref name=pmid10585452>{{cite journal |last=Nantel |first=A |authorlink= |coauthors=Huber M, Thomas D Y |year=[[1999]]|month=Dec. |title=Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool |journal=J. Biol. Chem. |volume=274 |issue=50 |pages=35719–24 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10585452 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.50.35719 }}</ref><ref name=pmid9553107>{{cite journal |last=Nantel |first=A |authorlink= |coauthors=Mohammad-Ali K, Sherk J, Posner B I, Thomas D Y |year=[[1998]]|month=Apr. |title=Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases |journal=J. Biol. Chem. |volume=273 |issue=17 |pages=10475–84 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9553107 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.273.17.10475 }}</ref> [[RET proto-oncogene]],<ref name=pmid7665556>{{cite journal |last=Pandey |first=A |authorlink= |coauthors=Duan H, Di Fiore P P, Dixit V M |year=[[1995]]|month=Sep. |title=The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10 |journal=J. Biol. Chem. |volume=270 |issue=37 |pages=21461–3 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 7665556 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.270.37.21461 }}</ref> [[BCR gene]],<ref name=pmid9747873>{{cite journal |last=Bai |first=R Y |authorlink= |coauthors=Jahn T, Schrem S, Munzert G, Weidner K M, Wang J Y, Duyster J |year=[[1998]]|month=Aug. |title=The SH2-containing adapter protein GRB10 interacts with BCR-ABL |journal=Oncogene |volume=17 |issue=8 |pages=941–8 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 9747873 |doi = 10.1038/sj.onc.1202024 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MAP2K1]],<ref name=pmid9553107/> [[Insulin-like growth factor 1 receptor]],<ref name=pmid12697834>{{cite journal |last=Vecchione |first=Andrea |authorlink= |coauthors=Marchese Adriano, Henry Pauline, Rotin Daniela, Morrione Andrea |year=[[2003]]|month=May. |title=The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor |journal=Mol. Cell. Biol. |volume=23 |issue=9 |pages=3363–72 |publisher= |location = United States| issn = 0270-7306| pmid = 12697834 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.23.9.3363-3372.2003 |pmc=153198 }}</ref><ref name=pmid8776723>{{cite journal |last=Dey |first=B R |authorlink= |coauthors=Frick K, Lopaczynski W, Nissley S P, Furlanetto R W |year=[[1996]]|month=Jun. |title=Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10 |journal=Mol. Endocrinol. |volume=10 |issue=6 |pages=631–41 |publisher= |location = UNITED STATES| issn = 0888-8809| pmid = 8776723 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1210/me.10.6.631 }}</ref><ref name=pmid9506989>{{cite journal |last=He |first=W |authorlink= |coauthors=Rose D W, Olefsky J M, Gustafson T A |year=[[1998]]|month=Mar. |title=Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains |journal=J. Biol. Chem. |volume=273 |issue=12 |pages=6860–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9506989 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8764099>{{cite journal |last=Morrione |first=A |authorlink= |coauthors=Valentinis B, Li S, Ooi J Y, Margolis B, Baserga R |year=[[1996]]|month=Jul. |title=Grb10: A new substrate of the insulin-like growth factor I receptor |journal=Cancer Res. |volume=56 |issue=14 |pages=3165–7 |publisher= |location = UNITED STATES| issn = 0008-5472| pmid = 8764099 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Insulin receptor]],<ref name=pmid10871840>{{cite journal |last=Langlais |first=P |authorlink= |coauthors=Dong L Q, Hu D, Liu F |year=[[2000]]|month=Jun. |title=Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family |journal=Oncogene |volume=19 |issue=25 |pages=2895–903 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10871840 |doi = 10.1038/sj.onc.1203616 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8621530>{{cite journal |last=Hansen |first=H |authorlink= |coauthors=Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith R J, Riedel H |year=[[1996]]|month=Apr. |title=Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus |journal=J. Biol. Chem. |volume=271 |issue=15 |pages=8882–6 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8621530 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.15.8882 }}</ref><ref name=pmid7479769>{{cite journal |last=Liu |first=F |authorlink= |coauthors=Roth R A |year=[[1995]]|month=Oct. |title=Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=92 |issue=22 |pages=10287–91 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 7479769 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.92.22.10287 |pmc=40781 }}</ref><ref name=pmid9506989/><ref name=pmid9006901>{{cite journal |last=Frantz |first=J D |authorlink= |coauthors=Giorgetti-Peraldi S, Ottinger E A, Shoelson S E |year=[[1997]]|month=Jan. |title=Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains |journal=J. Biol. Chem. |volume=272 |issue=5 |pages=2659–67 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9006901 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.5.2659 }}</ref> [[CD117]]<ref name=pmid11809791>{{cite journal |last=Jahn |first=Thomas |authorlink= |coauthors=Seipel Petra, Urschel Susanne, Peschel Christian, Duyster Justus |year=[[2002]]|month=Feb. |title=Role for the adaptor protein Grb10 in the activation of Akt |journal=Mol. Cell. Biol. |volume=22 |issue=4 |pages=979–91 |publisher= |location = United States| issn = 0270-7306| pmid = 11809791 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.22.4.979-991.2002 |pmc=134632 }}</ref> and [[Abl gene]].<ref name=pmid9747873/><ref name=pmid9006901/>
* [[Abl gene]],<ref name=pmid9747873/><ref name=pmid9006901/>
* [[BCR gene]],<ref name="pmid9747873">{{cite journal | vauthors = Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J | title = The SH2-containing adapter protein GRB10 interacts with BCR-ABL | journal = Oncogene | volume = 17 | issue = 8 | pages = 941–8 | date = August 1998 | pmid = 9747873 | doi = 10.1038/sj.onc.1202024 | doi-access = free }}</ref>
* [[C-Raf]],<ref name="pmid10585452">{{cite journal | vauthors = Nantel A, Huber M, Thomas DY | title = Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool | journal = J Biol Chem | volume = 274 | issue = 50 | pages = 35719–24 | date = December 1999 | pmid = 10585452 | doi = 10.1074/jbc.274.50.35719 | doi-access = free }}</ref><ref name="pmid9553107">{{cite journal | vauthors = Nantel A, Mohammad-Ali K, Sherk J, Posner BI, Thomas DY | title = Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases | journal = J Biol Chem | volume = 273 | issue = 17 | pages = 10475–84 | date = April 1998 | pmid = 9553107 | doi = 10.1074/jbc.273.17.10475 |doi-access = free }}</ref>
* [[c-Kit]],<ref name="pmid11809791">{{cite journal | vauthors = Jahn T, Seipel P, Urschel S, Peschel C, Duyster J | title = Role for the adaptor protein Grb10 in the activation of Akt | journal = Mol Cell Biol | volume = 22 | issue = 4 | pages = 979–91 | date = February 2002 | pmid = 11809791 | pmc = 134632 | doi = 10.1128/MCB.22.4.979-991.2002 }}</ref>
* [[Insulin receptor]],<ref name="pmid9006901">{{cite journal | vauthors = Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE | title = Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains | journal = J Biol Chem | volume = 272 | issue = 5 | pages = 2659–67 | date = January 1997 | pmid = 9006901 | doi = 10.1074/jbc.272.5.2659 | doi-access = free }}</ref><ref name="pmid10871840">{{cite journal | vauthors = Langlais P, Dong LQ, Hu D, Liu F | title = Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family | journal = Oncogene | volume = 19 | issue = 25 | pages = 2895–903 | date = June 2000 | pmid = 10871840 | doi = 10.1038/sj.onc.1203616 | doi-access = free }}</ref><ref name="pmid8621530">{{cite journal | vauthors = Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith RJ, Riedel H | title = Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus | journal = J Biol Chem | volume = 271 | issue = 15 | pages = 8882–6 | date = April 1996 | pmid = 8621530 | doi = 10.1074/jbc.271.15.8882 | doi-access = free }}</ref><ref name="pmid7479769">{{cite journal | vauthors = Liu F, Roth RA | title = Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function | journal = Proc Natl Acad Sci U S A | volume = 92 | issue = 22 | pages = 10287–91 | date = October 1995 | pmid = 7479769 | pmc = 40781 | doi = 10.1073/pnas.92.22.10287 | bibcode=1995PNAS...9210287L|doi-access = free }}</ref>><ref name=pmid9506989/>
* [[Insulin-like growth factor 1 receptor]],<ref name="pmid9506989">{{cite journal | vauthors = He W, Rose DW, Olefsky JM, Gustafson TA | title = Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains | journal = J Biol Chem | volume = 273 | issue = 12 | pages = 6860–7 | date = March 1998 | pmid = 9506989 | doi = 10.1074/jbc.273.12.6860 | doi-access = free }}</ref><ref name="pmid12697834">{{cite journal | vauthors = Vecchione A, Marchese A, Henry P, Rotin D, Morrione A | title = The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor | journal = Mol Cell Biol | volume = 23 | issue = 9 | pages = 3363–72 | date = May 2003 | pmid = 12697834 | pmc = 153198 | doi = 10.1128/MCB.23.9.3363-3372.2003 }}</ref><ref name="pmid8776723">{{cite journal | vauthors = Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW | title = Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10 | journal = Mol Endocrinol | volume = 10 | issue = 6 | pages = 631–41 | date = June 1996 | pmid = 8776723 | doi = 10.1210/mend.10.6.8776723 | doi-access = free }}</ref><ref name="pmid8764099">{{cite journal | vauthors = Morrione A, Valentinis B, Li S, Ooi JY, Margolis B, Baserga R | title = Grb10: A new substrate of the insulin-like growth factor I receptor | journal = Cancer Res | volume = 56 | issue = 14 | pages = 3165–7 | date = July 1996 | pmid = 8764099 }}</ref>
* [[MAP2K1]],<ref name=pmid9553107/> and
* [[RET proto-oncogene]].<ref name="pmid7665556">{{cite journal | vauthors = Pandey A, Duan H, Di Fiore PP, Dixit VM | title = The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10 | journal = J Biol Chem | volume = 270 | issue = 37 | pages = 21461–3 | date = September 1995 | pmid = 7665556 | doi = 10.1074/jbc.270.37.21461 | doi-access = free }}</ref>
 
==References==
{{reflist|33em}}
 
==Further reading==
{{refbegin | 233em}}
*{{cite journal |vauthors=Ramírez-Dueñas ML, Medina C, Ocampo-Campos R, Rivera H |title=Severe Silver-Russell syndrome and translocation (17;20) (q25;q13) |journal=Clin. Genet. |volume=41 |issue= 1 |pages= 51–3 |year= 1992 |pmid= 1633648 |doi=10.1111/j.1399-0004.1992.tb03630.x |s2cid=28801507 }}
{{PBB_Further_reading
*{{cite journal |vauthors=Liu F, Roth RA |title=Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10287–91 |year= 1995 |pmid= 7479769 |doi=10.1073/pnas.92.22.10287 | pmc=40781 |bibcode=1995PNAS...9210287L|doi-access =free }}
| citations =
*{{cite journal | authorvauthors=Ramírez-DueñasPandey MLA, MedinaDuan CH, Ocampo-CamposDi RFiore PP, RiveraDixit HVM |title=SevereThe Silver-RussellRet syndromereceptor andprotein translocationtyrosine (17;20)kinase (q25;q13)associates with the SH2-containing adapter protein Grb10 |journal=ClinJ. Biol. GenetChem. |volume=41270 |issue= 137 |pages= 51–321461–3 |year= 19921995 |pmid= 16336487665556 |doi=10.11111074/jjbc.1399-0004270.199237.tb03630.x21461 |doi-access=free }}
*{{cite journal | author|vauthors=LiuMidro FAT, RothDebek RAK, Sawicka A, etal |title=GrbSecond observation of Silver-IR:Russel syndrome in a SH2-domain-containingcarrier proteinof thata bindsreciprocal totranslocation thewith insulinone receptorbreakpoint andat inhibitssite its function.17q25 |journal=ProcClin. Natl. Acad. Sci. U.S.AGenet. |volume=9244 |issue= 221 |pages= 10287–9153–5 |year= 19951993 |pmid= 74797698403458 |doi=10.10731111/pnasj.921399-0004.221993.10287tb03845.x | pmcs2cid=40781 20766311 }}
*{{cite journal | author|vauthors=PandeyHansen AH, DuanSvensson HU, DiZhu Fiore PPJ, Dixit VMetal |title=TheInteraction Retbetween receptorthe proteinGrb10 tyrosineSH2 kinasedomain associates withand the SH2-containinginsulin adapterreceptor proteincarboxyl Grb10.terminus |journal=J. Biol. Chem. |volume=270271 |issue= 3715 |pages= 21461–38882–6 |year= 19951996 |pmid= 76655568621530 |doi=10.1074/jbc.270271.3715.214618882 |doi-access=free }}
*{{cite journal | author|vauthors=MidroMorrione ATA, DebekValentinis KB, SawickaLi AS, ''et al.''etal |title=SecondGrb10: observation of Silver-Russel syndrome inA anew carriersubstrate of athe reciprocalinsulin-like translocationgrowth withfactor oneI breakpoint at site 17q25.receptor |journal=Clin.Cancer GenetRes. |volume=4456 |issue= 114 |pages= 53–53165–7 |year= 19931996 |pmid= 8403458 |doi=10.1111/j.1399-0004.1993.tb03845.x 8764099 }}
*{{cite journal | author|vauthors=HansenO'Neill HTJ, SvenssonRose UDW, ZhuPillay JTS, ''et al.''etal |title=Interaction betweenof thea Grb10GRB-IR SH2splice domainvariant and(a human GRB10 homolog) with the insulin receptorand carboxylinsulin-like terminusgrowth factor I receptors. Evidence for a role in mitogenic signaling |journal=J. Biol. Chem. |volume=271 |issue= 1537 |pages= 8882–622506–13 |year= 1996 |pmid= 86215308798417 |doi=10.1074/jbc.271.1537.888222506 |doi-access=free }}
*{{cite journal | authorvauthors=MorrioneStein AE, ValentinisCerretti BDP, LiDaniel S, ''et al.''TO |title=Grb10:Ligand Aactivation newof substrateELK ofreceptor thetyrosine insulin-likekinase growthpromotes factorits Iassociation receptor.with Grb10 and Grb2 in vascular endothelial cells |journal=CancerJ. Biol. ResChem. |volume=56271 |issue= 1438 |pages= 3165–723588–93 |year= 1996 |pmid= 87640998798570 |doi=10.1074/jbc.271.38.23588 |doi-access=free }}
*{{cite journal | authorvauthors=O'NeillFrantz TJJD, RoseGiorgetti-Peraldi DWS, PillayOttinger TSEA, ''etShoelson al.''SE |title=Interaction of aHuman GRB-IRIRbeta/GRB10. spliceSplice variantvariants (aof human GRB10 homolog) with thean insulin and insulin-like growth factor Ireceptor-binding receptors.protein Evidencewith forPH aand roleSH2 in mitogenic signaling.domains |journal=J. Biol. Chem. |volume=271272 |issue= 375 |pages= 22506–132659–67 |year= 19961997 |pmid= 87984179006901 |doi=10.1074/jbc.271272.375.225062659 |doi-access=free }}
*{{cite journal | author|vauthors=SteinNagase ET, CerrettiSeki DPN, DanielIshikawa TOK, etal |title=LigandPrediction of the coding activationsequences of ELKunidentified receptorhuman tyrosinegenes. kinaseVI. promotesThe itscoding associationsequences withof Grb1080 andnew Grb2genes in(KIAA0201-KIAA0280) vasculardeduced endothelialby cells.analysis of cDNA clones from cell line KG-1 and brain |journal=J.DNA Biol. ChemRes. |volume=2713 |issue= 385 |pages= 23588–93321–9, 341–54 |year= 19961997 |pmid= 87985709039502 |doi=10.10741093/jbcdnares/3.2715.38.23588321 |doi-access=free }}
*{{cite journal | authorvauthors=FrantzHe JDW, Giorgetti-PeraldiRose SDW, OttingerOlefsky EAJM, ShoelsonGustafson SETA |title=HumanGrb10 GRB-IRbeta/GRB10.interacts Splicedifferentially variantswith ofthe aninsulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor-binding proteinvia withthe PHGrb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains. |journal=J. Biol. Chem. |volume=272273 |issue= 512 |pages= 2659–676860–7 |year= 19971998 |pmid= 90069019506989 |doi=10.1074/jbc.272273.512.26596860 |doi-access=free }}
*{{cite journal | author|vauthors=NagaseNantel TA, SekiMohammad-Ali NK, IshikawaSherk KJ, ''et al.''etal |title=PredictionInteraction of the codingGrb10 sequencesadapter ofprotein unidentifiedwith humanthe genes.Raf1 VI.and TheMEK1 coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.kinases |journal=DNAJ. ResBiol. Chem. |volume=3273 |issue= 517 |pages= 321–9, 341–5410475–84 |year= 19971998 |pmid= 90395029553107 |doi=10.10931074/dnares/3jbc.5273.32117.10475 |doi-access=free }}
*{{cite journal | author|vauthors=JeromeMoutoussamy CAS, SchererRenaudie SWF, TsuiLago LCF, ''et al.''etal |title=AssignmentGrb10 ofidentified growthas factora receptor-boundpotential proteinregulator 10of growth hormone (GRB10GH) tosignaling humanby chromosomecloning 7p11.2-p12.of GH receptor target proteins |journal=GenomicsJ. Biol. Chem. |volume=40273 |issue= 126 |pages= 215–615906–12 |year= 19971998 |pmid= 90709539632636 |doi= 10.10061074/genojbc.1996273.453526.15906 |doi-access=free }}
*{{cite journal | author|vauthors=DongBai LQRY, DuJahn HT, PorterSchrem SGS, ''et al.''etal |title=Cloning,The chromosomeSH2-containing localization,adapter expression, and characterization of an Src homology 2protein andGRB10 pleckstrininteracts homologywith domainBCR-containing insulin receptor binding protein hGrb10gamma.ABL |journal=J. Biol. Chem.Oncogene |volume=27217 |issue= 468 |pages= 29104–12941–8 |year= 19971998 |pmid= 93609869747873 |doi= 10.10741038/jbcsj.272onc.46.291041202024 |doi-access= free }}
*{{cite journal | author|vauthors=HeMano WH, RoseOhya DWK, OlefskyMiyazato JMA, Gustafson TAetal |title=Grb10/GrbIR interactsas differentiallyan within thevivo insulinsubstrate receptor,of insulin-likeTec growthtyrosine factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains.kinase |journal=J.Genes Biol. Chem.Cells |volume=2733 |issue= 127 |pages= 6860–7431–41 |year= 1998 |pmid= 95069899753425 |doi=10.10741046/jbcj.2731365-2443.1998.1200201.6860x |s2cid=6391234 |doi-access=free }}
*{{cite journal | authorvauthors =Nantel((Washington A,University Mohammad-AliGenome K,Sequencing SherkCente)) J,| ''ettitle al.'' |title=Interaction ofToward thea Grb10complete adapterhuman proteingenome withsequence the Raf1 and MEK1 kinases.| |journal =J. Biol.Genome Chem.Res | volume =273 8 | issue = 1711 | pages = 10475–841097–108 |year date = November 1998 | pmid = 95531079847074 | doi = 10.10741101/jbcgr.2738.1711.104751097 | doi-access=free }}
*{{cite journal | author|vauthors=MoutoussamyAngrist SM, RenaudieBolk FS, LagoBentley FK, ''et al.''etal |title=Grb10Genomic identifiedstructure asof athe potentialgene regulatorfor ofthe growthSH2 hormoneand (GH)pleckstrin signalinghomology bydomain-containing cloningprotein GRB10 and evaluation of GHits receptorrole targetin proteins.Hirschsprung disease |journal=J. Biol. Chem.Oncogene |volume=27317 |issue= 2623 |pages= 15906–123065–70 |year= 19981999 |pmid= 96326369881709 |doi= 10.10741038/jbcsj.273onc.26.159061202226 |doi-access= free }}
*{{cite journal | author|vauthors=BaiWang RYJ, JahnDai TH, SchremYousaf SN, ''et al.''etal |title=TheGrb10, SH2-containinga positive, stimulatory signaling adapter proteinin GRB10platelet-derived interactsgrowth withfactor BCRBB-ABL., insulin-like growth factor I-, and insulin-mediated mitogenesis |journal=OncogeneMol. Cell. Biol. |volume=1719 |issue= 89 |pages= 941–86217–28 |year= 19981999 |pmid= 974787310454568 |doi= 10.10381128/sjMCB.onc19.12020249.6217| pmc=84567 }}
*{{cite journal | author=Mano H, Ohya K, Miyazato A, ''et al.'' |title=Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase. |journal=Genes Cells |volume=3 |issue= 7 |pages= 431–41 |year= 1998 |pmid= 9753425 |doi=10.1046/j.1365-2443.1998.00201.x }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= }}
*{{cite journal | author=Angrist M, Bolk S, Bentley K, ''et al.'' |title=Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. |journal=Oncogene |volume=17 |issue= 23 |pages= 3065–70 |year= 1999 |pmid= 9881709 |doi= 10.1038/sj.onc.1202226 }}
*{{cite journal | author=Wang J, Dai H, Yousaf N, ''et al.'' |title=Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 6217–28 |year= 1999 |pmid= 10454568 |doi= | pmc=84567 }}
}}
{{refend}}
{{PDB Gallery|geneid=2887}}
 
==External links==
* {{MeshName|GRB10+Protein}}
 
▲{{PBBPDB Gallery|geneid=2887}}
{{gene-7-stub}}
{{NLM content}}▼
{{Adaptor proteins}}
▲{{NLM content}}
 
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