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Line 1: {{Chembox \| ImageFile = Liarozole.svg \| ImageSize = 200px \| ImageAlt = \| ~~IUPACName~~PIN = 6-[(3-Chlorophenyl)(1''H''-imidazol-1-~~ylmethyl~~yl)methyl]-1''H''-1,3-benzimidazole \| OtherNames = \| Section1 = {{Chembox Identifiers \| IUPHAR_ligand = 5210 \| CASNo = 115575-11-6 \| UNII_Ref = {{fdacite\|correct\|FDA}} \| PubChem = 60652▼ \| UNII = K0Q29TGV9Y \| SMILES =C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4 ▼ \| CASNo_Ref = {{cascite\|correct\|CAS}} \| ChemSpiderID = 54664▼ ▲\| PubChem = 60652 \| InChI = 1/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)▼ ▲\| SMILES =C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4 \| InChIKey = UGFHIPBXIWJXNA-UHFFFAOYAV▼ ▲\| ChemSpiderID = 54664 \| StdInChI = 1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)▼ ▲\| InChI = 1/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21) \| StdInChIKey = UGFHIPBXIWJXNA-UHFFFAOYSA-N}}▼ ▲\| InChIKey = UGFHIPBXIWJXNA-UHFFFAOYAV \| Section2 = {{Chembox Properties▼ ▲\| StdInChI = 1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21) \| C=17\|H=13\|Cl=1\|N=4▼ ▲\| StdInChIKey = UGFHIPBXIWJXNA-UHFFFAOYSA-N}} ~~\| Appearance =~~ ▲\| Section2 = {{Chembox Properties ~~\| Density =~~ ▲\| C=17 \| H=13 \| Cl=1 \| N=4 \| MeltingPt = ▼ \| ~~BoilingPt~~Appearance = \| ~~Solubility~~Density = }} ▲\| MeltingPt = \| Section3 = {{Chembox Hazards▼ \| ~~MainHazards~~BoilingPt = \| ~~FlashPt~~Solubility = }} ▲\| Section3 = {{Chembox Hazards ~~\| Autoignition = }}~~ \| MainHazards = \| FlashPt = \| AutoignitionPt = }} }} '''Liarozole''' is a [[retinoic acid]] metabolism-~~inhibiting~~blocking ~~chemical~~drug and [[aromatase inhibitor]].<ref>{{cite journal\|pmid=24102348\|year=2013\|last1=Vahlquist\|first1=A\|last2=Blockhuys\|first2=S\|last3=Steijlen\|first3=P\|last4=Van Rossem\|first4=K\|last5=Didona\|first5=B\|last6=Blanco\|first6=D\|last7=Traupe\|first7=H\|title=Oral liarozole in the treatment of patients with moderate/severe lamellar ichthyosis: Results of a randomized, double-blind, multinational, placebo-controlled phase II/III trial\|doi=10.1111/bjd.12626\|journal=The British ~~journal~~Journal of ~~dermatology~~Dermatology\|pages=~~n/a~~173–81\|volume=170\|issue=1\|pmc=4232915}}</ref> Liarozole is an [[isomer]] of [[alprazolam]], but the two compounds are completely unrelated. ~~==Synthesis==~~ ~~[[File:Liarozole synthesis.png\|thumb\|center\|600px\|Liarozole synthesis from Lednicer book 6 (Drugs of the Future citation).]]{{Clear}}~~ ==References== {{Reflist\|2}} {{Retinoid receptor modulators}} [[Category:Aromatase inhibitors]] [[Category:Benzimidazoles]] [[Category:3-Chlorophenyl compounds]] [[Category:~~Organochlorides~~CYP17A1 inhibitors]]▼ [[Category:Imidazoles]] ▲[[Category:Organochlorides]]