Liarozole: Difference between revisions

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Revision as of 14:16, 8 June 2017 edit Vanished user 0x8cSXE0x6 (talk \| contribs) Autopatrolled, Extended confirmed users 81,003 edits No edit summary ← Previous edit		Latest revision as of 08:15, 9 September 2024 edit undo JWBE (talk \| contribs) Extended confirmed users 9,145 edits removed Category:Chloroarenes; added Category:3-Chlorophenyl compounds using HotCat
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Line 3: \| ImageSize = 200px \| ImageAlt = \| ~~IUPACName~~PIN = 6-[(3-Chlorophenyl)(1''H''-imidazol-1-~~ylmethyl~~yl)methyl]-1''H''-1,3-benzimidazole \| OtherNames = \|Section1={{Chembox Identifiers \| IUPHAR_ligand = 5210 \| CASNo = 115575-11-6 \| UNII_Ref = {{fdacite\|correct\|FDA}} \| UNII = K0Q29TGV9Y \| CASNo_Ref = {{cascite\|correct\|CAS}} \| PubChem = 60652 \| SMILES =C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4 Line 28 ⟶ 31: }} '''Liarozole''' is a [[retinoic acid]] metabolism-blocking drug and [[aromatase inhibitor]].<ref>{{cite journal\|pmid=24102348\|year=2013\|last1=Vahlquist\|first1=A\|last2=Blockhuys\|first2=S\|last3=Steijlen\|first3=P\|last4=Van Rossem\|first4=K\|last5=Didona\|first5=B\|last6=Blanco\|first6=D\|last7=Traupe\|first7=H\|title=Oral liarozole in the treatment of patients with moderate/severe lamellar ichthyosis: Results of a randomized, double-blind, multinational, placebo-controlled phase II/III trial\|doi=10.1111/bjd.12626\|journal=The British ~~journal~~Journal of ~~dermatology~~Dermatology\|pages=173–81\|volume=170\|issue=1\|pmc=4232915}}</ref> Liarozole is an [[isomer]] of [[alprazolam]], but the two compounds are completely unrelated. ~~==Synthesis==~~ ~~[[File:Liarozole synthesis.png\|thumb\|left\|600px\|Liarozole synthesis from Lednicer book 6 (Drugs of the Future citation).]]{{Clear}}~~ ==References== {{Reflist\|2}} {{~~Nuclear~~Retinoid receptor modulators}}▼ ▲{{Nuclear receptor modulators}} [[Category:Aromatase inhibitors]] [[Category:Benzimidazoles]] [[Category:~~Chloroarenes~~3-Chlorophenyl compounds]] [[Category:CYP17A1 inhibitors]] [[Category:Imidazoles]]