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The '''high-affinity IgE receptor''', also known as '''FcεRI''', or '''Fc epsilon RI''', is the high-[[Affinity (pharmacology)|affinity]] [[receptor (biochemistry)|receptor]] for the [[Fc region]] of [[immunoglobulin E]] (IgE), an [[antibody]] [[Isotype (immunology)|isotype]] involved in the [[allergy]] disorder and [[parasitism|parasites]] immunity. FcεRI is a [[tetrameric protein|tetramer]]ic receptor complex that binds Fc portion of the ε [[Immunoglobulin heavy chain|heavy chain]] of [[IgE]].<ref>{{Cite book|url=https://www.amazon.com/Robbins-Basic-Pathology-ebook/dp/B007OMFA6Q/ref=mt_kindle?_encoding=UTF8&me=|title=Robbins Basic Pathology|last1=Kumar|first1=Vinay|last2=Abbas|first2=Abul K.|last3=Aster|first3=Jon|date=2012-05-01|publisher=Saunders|edition=9|language=en}}</ref> It consists of one alpha (FcεRIα - antibody binding site), one beta (FcεRIβ - which amplifies the downstream signal), and two gamma chains (FcεRIγ - the site where the downstream signal initiates) connected by two disulfide bridges on [[Mast cell|mast cells]] and [[Basophil|basophils]]. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils<ref name="pmid11964662">{{cite journal | author = Pawankar R | title = Mast cells as orchestrators of the allergic reaction: the IgE-IgE receptor mast cell network | journal = Current Opinion in Allergy and Clinical Immunology | volume = 1 | issue = 1 | pages = 3–6 |date=February 2001 | pmid = 11964662 | doi = 10.1097/00130832-200102000-00002}}</ref> and is inducible in [[Eosinophil|eosinophils]].
 
== Tissue distribution ==