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{{Short description|Removal of pyrogens from
{{more footnotes|date=May 2012}} <!-- Image with unknown copyright status removed: [[Image:Endo1.jpeg|right]] -->
'''Depyrogenation''' refers to the removal of pyrogens from [[solution (chemistry)|solution]]s, most commonly from injectable pharmaceuticals.
A [[wikt:pyrogen|pyrogen]] is defined as any substance that can cause a fever. Bacterial pyrogens include [[endotoxins]] and [[exotoxins]], although many pyrogens are endogenous to the host. Endotoxins include [[lipopolysaccharide]] (LPS) molecules found as part of the cell wall of [[Gram-negative]] bacteria, and are released upon bacterial cell [[lysis]]. Endotoxins may become pyrogenic when released into the bloodstream or other tissue where they are not usually found. Although the colon contains Gram-negative bacteria in abundance, they do not cause a pyrogenic effect as the bacteria are not undergoing gross lysis, and the immune system is not exposed to free endotoxin while the colonic wall is intact.
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