Increasing evidence suggests that neurodegenerative diseases are mediated by erroneous epigenetic mechanisms. Neurodegenerative diseases include [[Huntington's disease]] and [[Alzheimer's disease]]. Neuroimmunological research into these diseases has yielded evidence including the absence of simple Mendelian inheritance patterns, global transcriptional dysregulation, multiple types of pathogenic [[RNA alterations]], and many more.<ref>{{cite journal |author1=Greene L.A. |author2=Liu D.X. |author3=Troy C.M. |author4=Biswas S.C. | year = 2007 | title = Cell cycle molecules define a pathway required for neuron death in development and disease |journal=Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | volume = 1772 | issue = 4| pages = 392–401 | doi=10.1016/j.bbadis.2006.12.003 | pmid=17229557 | pmc=1885990}}</ref> In one of the experiments, a treatment of Huntington’s disease with histone deacetylases (HDAC), an enzyme that removes acetyl groups from lysine, and DNA/RNA binding anthracylines that affect nucleosome positioning, showed positive effects on behavioral measures, neuroprotection, nuclesomenucleosome remodeling, and associated chromatin dynamics.<ref>{{cite journal |author1=Abel T. |author2=Zukin R.S. | year = 2008 | title = Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders | journal = Current Opinion in Pharmacology | volume = 8 | issue = 1| pages = 57–64 | doi=10.1016/j.coph.2007.12.002| pmc=2405764 | pmid=18206423}}</ref> Another new finding on neurodegenerative diseases involves the overexpression of HDAC6 suppresses the neurodegenerative phenotype associated with Alzheimer’s disease pathology in associated animal models.<ref>{{cite journal |author1=Pandey U.B. |author2=Nie Z. |author3=Batlevi Y. |author4=McCray B.A. |author5=Ritson G.P. |author6=Nedelsky N.B. |author7=Schwartz S.L. |author8=DiProspero N.A. |author9=Knight M.A. | year = 2007 | title = HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS | journal = Nature | volume = 447 | issue = 7146| pages = 859–863 | doi=10.1038/nature05853 | pmid=17568747|bibcode=2007Natur.447..860P |s2cid=4365061 |display-authors=etal}}</ref> Other findings show that additional mechanisms are responsible for the "underlying transcriptional and post-transcriptional dysregulation and complex chromatin abnormalities in Huntington's disease".<ref>{{cite journal |author1=Ballas N. |author2=Mandel G. | year = 2005 | title = The many faces of REST oversee epigenetic programming of neuronal genes | journal = Current Opinion in Neurobiology | volume = 15 | issue = 5| pages = 500–506 | doi=10.1016/j.conb.2005.08.015 | pmid=16150588|s2cid=32596790 }}</ref>
