FCER1: Difference between revisions

FcεRI is found on epidermal [[Langerhans cell]]s, eosinophils, mast cells, and basophils.<ref>{{cite journal |vauthors=Ochiai K, Wang B, Rieger A, Kilgus O, Maurer D, Födinger D, Kinet J, Stingl G, Tomioka H |title=A review on Fc epsilon RI on human epidermal Langerhans cells |series=104 |journal=International Archives of Allergy and Immunology |volume=Suppl 1 |issue=1 |pages=63–64 |year=1994 |pmid=8156009 |doi=10.1159/000236756}}</ref><ref>{{cite journal |vauthors=Prussin C, Metcalfe D |title=5 |journal=Nature |year=1994 |volume=367 |issue=6459 |pages=183–6 |pmid=8114916 |doi=10.1038/367183a0|s2cid=4331405 }}</ref><ref>{{cite journal |last1=Gounni |first1=A. |last2=Lamkhioued |first2=B. |last3=Ochiai |first3=K. |last4=Tanaka |first4=Y. |last5=Delaporte |first5=E. |last6=Capron |first6=A. |last7=Kinet |first7=J.P. |last8=Capron |first8=M. |title=IgE, mast cells, basophils, and eosinophils |journal=Journal of Allergy and Clinical Immunology |volume=117 |issue=2 Suppl Mini–Primer |pages=S450–5456 |year=2006 |pmid=16455345 |doi=10.1016/j.jaci.2005.11.016}}</ref> As a result of its cellular distribution, this receptor plays a major role in controlling [[allergy|allergic responses]]. FcεRI is also expressed on [[antigen-presenting cell]]s, and controls the production of important immune mediators ([[cytokine]]s, [[interleukin]]s, [[leukotriene]]s, and [[prostaglandin]]s) that promote [[inflammation]].<ref>{{cite journal |vauthors=von Bubnoff D, Novak N, Kraft S, Bieber T |title=The central role of FcepsilonRI in allergy |journal=Clinical and Experimental Dermatology |volume=28 |issue=2 |pages=184–187 |year=2003 |pmid=12653710 |doi=10.1046/j.1365-2230.2003.01209.x|s2cid=2080598 }}</ref> The most known mediator is [[histamine]], which results in the five symptoms of inflammation: heat, swelling, pain, redness and loss of function.

 

 

== Mechanism of action ==