Steroid: Difference between revisions

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===By function===
{{expand section|A more detailed explanation of function would also be beneficial|date=January 2019|small=yes}}
The major classes of [[steroid hormones]], with prominent members and examples of related functions, are:<ref name="pmid24940130">{{cite journal |vauthors=Ericson-Neilsen W, Kaye AD |title=Steroids: pharmacology, complications, and practice delivery issues |journal=Ochsner J |volume=14 |issue=2 |pages=203–7 |date=2014 |pmid=24940130 |pmc=4052587}}</ref><ref>{{cite web | url=https://www.mdpi.com/journal/ijms/special_issues/steroid_hormones_sex | title=International Journal of Molecular Sciences }}</ref>
* [[Corticosteroid]]s:
** [[Glucocorticoid]]s:
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* Progestogens are the precursors of all other human steroids, and all human tissues which produce steroids must first convert cholesterol to [[pregnenolone]]. This conversion is the rate-limiting step of steroid synthesis, which occurs inside the [[mitochondrion]] of the respective tissue.<ref name="pmid16759697">{{cite journal | vauthors = Rossier MF | title = T channels and steroid biosynthesis: in search of a link with mitochondria | journal = Cell Calcium | volume = 40 | issue = 2 | pages = 155–64 | date = Aug 2006 | pmid = 16759697 | doi = 10.1016/j.ceca.2006.04.020 }}</ref><ref name="pmid21051590" />{{better source needed|date=March 2017}}
* Cortisol, [[corticosterone]], aldosterone are produced in the [[adrenal cortex]].<ref name="pmid21051590" /><ref name="pmid38035948"/>
* Estradiol, [[estrone]] and progesterone are made primarily in the [[ovary]], estriol in [[placenta]] during pregnancy, and [[testosterone]] primarily in the [[testes]]<ref name="pmid21051590" /><ref name="endocrine-poster">{{cite web | url=https://www.endocrine.org/patient-engagement/endocrine-library/hormones-and-endocrine-function/reproductive-hormones | title=Reproductive Hormones | date=24 January 2022 }}</ref><ref name="hpa">{{cite book | chapter-url=https://link.springer.com/chapter/10.1007/978-3-319-44558-8_1"%22 | doi=10.1007/978-3-319-44558-8_1 | chapter=The Hypothalamic–Pituitary–Ovarian Axis and Oral Contraceptives: Regulation and Function | title=Sex Hormones, Exercise and Women | date=2017 | pages=1–17 | isbn=978-3-319-44557-1 | vauthors = Davis HC, Hackney AC }}</ref><ref>{{cite encyclopedia|url=https://www.britannica.com/science/androgen|title=androgen|date=19 January 2024 }}</ref> (some testosterone may also be produced in the adrenal cortex).<ref name="pmid21051590" /><ref name="pmid38035948">{{cite journal |vauthors=Oestlund I, Snoep J, Schiffer L, Wabitsch M, Arlt W, Storbeck KH |title=The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 catalyzes the activation of testosterone |journal=J Steroid Biochem Mol Biol |volume=236 |issue= |pages=106436 |date=February 2024 |pmid=38035948 |doi=10.1016/j.jsbmb.2023.106436}}</ref>
* Estradiol is converted from testosterone directly (in males), or via the primary pathway DHEA – androstenedione – estrone and secondarily via testosterone (in females).<ref name="pmid21051590" />
* [[Stromal cells]] have been shown to produce steroids in response to signaling produced by androgen-starved [[prostate cancer]] cells.<ref name="pmid27672740"/>{{primary source inline|date=March 2017}}{{better source needed|date=March 2017}}